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Cited by 780Parkinson's Disease Mechanisms and TreatmentsCoffee research and impactsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Association of Coffee and Caffeine Intake With the Risk of Parkinson Disease

Ross, G. Webster·2000·JAMA
DOI 10.1001/jama.283.20.2674
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Abstract

CONTEXT: The projected expansion in the next several decades of the elderly population at highest risk for Parkinson disease (PD) makes identification of factors that promote or prevent the disease an important goal. OBJECTIVE: To explore the association of coffee and dietary caffeine intake with risk of PD. DESIGN, SETTING, AND PARTICIPANTS: Data were analyzed from 30 years of follow-up of 8004 Japanese-American men (aged 45-68 years) enrolled in the prospective longitudinal Honolulu Heart Program between 1965 and 1968. MAIN OUTCOME MEASURE: Incident PD, by amount of coffee intake (measured at study enrollment and 6-year follow-up) and by total dietary caffeine intake (measured at enrollment). RESULTS: During follow-up, 102 men were identified as having PD. Age-adjusted incidence of PD declined consistently with increased amounts of coffee intake, from 10.4 per 10,000 person-years in men who drank no coffee to 1.9 per 10,000 person-years in men who drank at least 28 oz/d (P<.001 for trend). Similar relationships were observed with total caffeine intake (P<.001 for trend) and caffeine from non-coffee sources (P=.03 for trend). Consumption of increasing amounts of coffee was also associated with lower risk of PD in men who were never, past, and current smokers at baseline (P=.049, P=.22, and P=.02, respectively, for trend). Other nutrients in coffee, including niacin, were unrelated to PD incidence. The relationship between caffeine and PD was unaltered by intake of milk and sugar. CONCLUSIONS: Our findings indicate that higher coffee and caffeine intake is associated with a significantly lower incidence of PD. This effect appears to be independent of smoking. The data suggest that the mechanism is related to caffeine intake and not to other nutrients contained in coffee. JAMA. 2000;283:2674-2679.

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Metadata

Authors
Ross, G. W.
Affiliations
United States Department of Veterans Affairs (US)
Corresponding author
Ross, G. Webster
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2000-05-24
Volume
283
Issue
20
Pages
2674
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.283.20.2674
OpenAlex
W2128822428
Cited by
778
References
35
Citations by year
2026: 8 · 2025: 24 · 2024: 28 · 2023: 34 · 2022: 22 · 2021: 39 · 2020: 26 · 2019: 35 · 2018: 26 · 2017: 36 · 2016: 24 · 2015: 29 · 2014: 39 · 2013: 37 · 2012: 36
FWCI
17.73
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc005102-027, DAMD17-98-1-8621)
  • National Institute on Aging (N01‐AG‐4‐2149)
  • National Heart, Lung, and Blood Institute (N01 HC 05102, NO1-HC-05102)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Parkinson's disease, coffee consumption, dietary caffeine, caffeine consumption, smoking, nicotinic acid, Honolulu Heart Program, Japanese-American men, disease incidence
MeSH terms
Aged, Caffeine, Coffee, Diet Surveys, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease, Regression Analysis, Risk Factors, Incidence

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