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Plasma Natriuretic Peptides for Community Screening for Left Ventricular Hypertrophy and Systolic Dysfunction: The Framingham Heart Study
Abstract
CONTEXT: Several reports have suggested the usefulness of plasma brain natriuretic peptide (BNP) as a screening test for left ventricular hypertrophy (LVH) and systolic dysfunction (LVSD). Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women. OBJECTIVES: To examine the usefulness of natriuretic peptides for screening for elevated LV mass and LVSD in the community. DESIGN, SETTING, AND PARTICIPANTS: Community-based prospective cohort study of 3177 participants (1707 women) from the Framingham Study who attended a routine examination in 1995-1998. MAIN OUTCOME MEASURES: Receiver operating characteristic (ROC) curves, test sensitivity, specificity, positive and negative predictive values, and likelihood ratios for identifying elevated LV mass (sex-specific 90th percentile or higher of LV mass/[height](2)), LVSD (ejection fraction < or = 50% and/or fractional shortening <29%), and moderate to severe LVSD (ejection fraction < or = 40% and/or fractional shortening <22%) at different discrimination limits of plasma BNP and N-terminal proatrial natriuretic peptide (NT-ANP), with echocardiography as the criterion standard. RESULTS: The areas under the ROC curves for elevated LV mass or LVSD were at or below 0.75 for both peptides, were higher for men compared with women, and were similar for BNP and NT-ANP. The diagnostic performance of natriuretic peptides for LVSD improved in women but not…
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“but LVSD is frequently diagnosed only after patients develop symptomatic disease due to the lack of effective screening strategies5–7.”
From Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devices (2023) · cites this paper as [6]
Citations
Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430
Hanley, J. A., & McNeil, B. J. (1983) · Radiology · doi:10.1148/radiology.148.3.6878708 · Cited by 7,016
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Self-citation(1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440420033005 · Cited by 3,777
(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725
Users' Guides to the Medical Literature
Jaeschke, R. (1994) · JAMA · doi:10.1001/jama.271.9.703 · Cited by 2,688
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,639
Biochemical detection of left-ventricular systolic dysfunction
McDonagh, T., Robb, S., Murdoch, D. R., Morton, J. J., Ford, I., Morrison, C., Tunstall‐Pedoe, H., McMurray, J. J. V., & Dargie, H. (1998) · The Lancet · doi:10.1016/s0140-6736(97)03034-1 · Cited by 949
Cowie, M., Struthers, A. D., Wood, D. A., Coats, A. J. S., Thompson, S. G., Poole-Wilson, P. A., & Sutton, G. C. (1997) · The Lancet · doi:10.1016/s0140-6736(97)06031-5 · Cited by 869
Omland, T., Aakvaag, A., Bonarjee, V., Caidahl, K., Lie, R. T., Nilsen, D. W. T., Sundsfjord, J., & Dickstein, K. (1996) · Circulation · doi:10.1161/01.cir.93.11.1963 · Cited by 698
Meta-analysis of Pap Test Accuracy
Fahey, M. T., Irwig, L., & Macaskill, P. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117485 · Cited by 690
Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population
McDonagh, T. A., Morrison, C., Lawrence, A., Ford, I., Tunstall-Pedoe, H., McMurray, J. J. V., & Dargie, H. J. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03033-x · Cited by 628
Yamamoto, K., Burnett, J. C. J., Jougasaki, M., Nishimura, R. A., Bailey, K. R., Saito, Y., Nakao, K., & Redfield, M. M. (1996) · Hypertension · doi:10.1161/01.hyp.28.6.988 · Cited by 518
Impact of age and sex on plasma natriuretic peptide levels in healthy adults
Wang, T. J., Larson, M. G., Levy, D. A., Leip, E. P., Benjamin, E. J., Wilson, P. W. F., Sutherland, P. A., Omland, T., & Vasan, R. S. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02464-5 · Cited by 471
Self-citationMaisel, A. S., Koon, J., Krishnaswamy, P., Kazenegra, R., Clopton, P., Gardetto, N. J., Morrisey, R., Garcia, A., Chiu, A., & DeMaria, A. N. (2001) · American Heart Journal · doi:10.1067/mhj.2001.113215 · Cited by 377
Fouad, F. M., Słomiński, J. M., & Tarazi, R. C. (1984) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(84)80289-2 · Cited by 352
When can a risk factor be used as a worthwhile screening test?
Wald, N., Hackshaw, A., & Frost, C. D. (1999) · BMJ · doi:10.1136/bmj.319.7224.1562 · Cited by 342
Lerman, A., Gibbons, R. J., Rodeheffer, R. J., Bailey, K. R., McKinley, L. J., Heublein, D. M., & Burnett, J. C. J. (1993) · The Lancet · doi:10.1016/0140-6736(93)93125-k · Cited by 313
Asada, J., & 渡邊, 潤. (2003) · Medical Entomology and Zoology · Cited by 251
Echocardiographic assessment of left ventricular hypertrophy
Reichek, N. (1982) · European Heart Journal · doi:10.1093/eurheartj/3.suppl_a.49 · Cited by 233
Davidson, N. C., Naas, A. A., Hanson, J., Kennedy, N. S. J., Coutie, W. J., & Struthers, A. D. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89176-x · Cited by 183
Luchner, A., Burnett, J. C. J., Jougasaki, M., Hense, H. W., Heid, I. M., Muders, F., Riegger, G. N. A. J., & Schunkert, H. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018080-00018 · Cited by 177
Percentage of Shortening of the Echocardiographic Left Ventricular Dimension
Quiñones, M. A., Pickering, E., & Alexander, J. K. (1978) · CHEST Journal · doi:10.1378/chest.74.1.59 · Cited by 152
Should we screen for asymptomatic left ventricular dysfunction to prevent heart failure?
McMurray, J. J. V., McDonagh, T., Davie, A. P., Cleland, J. G. F., Francis, C. M., & Morrison, C. E. (1998) · European Heart Journal · doi:10.1093/eurheartj/19.6.842 · Cited by 151
Ruling Out or Ruling In Disease with the Most sensitiue or Specific Diagnostic Test
Boyko, E. J. (1994) · Medical Decision Making · doi:10.1177/0272989x9401400210 · Cited by 124
Luchner, A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00510-7 · Cited by 116
Clinical criteria and biochemical markers for the detection of systolic dysfunction
Yamamoto, K., Burnett, J. C. J., Bermudez, E. A., Jougasaki, M., Bailey, K. R., & Redfield, M. M. (2000) · Journal of Cardiac Failure · doi:10.1054/jcaf.2000.9676 · Cited by 116
Enhancing and Evaluating Diagnostic Accuracy
Swets, J. A., Getty, D. J., Pickett, R. M., D’Orsi, C. J., Seltzer, S. E., & McNeil, B. J. (1991) · Medical Decision Making · doi:10.1177/0272989x9101100102 · Cited by 116
Smith, H. E. (2000) · BMJ · doi:10.1136/bmj.320.7239.906 · Cited by 97
McClure, S. J., Caruana, L., Davie, A. P., GOLDTHORP, S. L., & McMurray, J. J. V. (1998) · BMJ · doi:10.1136/bmj.317.7157.516 · Cited by 85
Predictive properties of serum prostate-specific antigen testing in a community setting.
Jacobsen, S. J., Bergstralh, E. J., Guess, H. A., Katusic, S. K., Klee, G. G., Oesterling, J. E., & Lieber, M. M. (1996) · PubMed · doi:10.1001/archinte.157.15.1765b · Cited by 66
Cupples, L. A. (1987) · Medical Entomology and Zoology · Cited by 64
Limited Echocardiography for Hypertensive Left Ventricular Hypertrophy
Sheps, S. G., & Frohlich, E. D. (1997) · Hypertension · doi:10.1161/01.hyp.29.2.560 · Cited by 51
Schirmer, H. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1396 · Cited by 43
Simplified Echocardiography in the Diagnosis of Heart Failure
Willenheimer, R. B., Israelsson, B. A., Cline, C. M. J., & Erhardt, L. (1997) · Scandinavian Cardiovascular Journal · doi:10.3109/14017439709058063 · Cited by 38
Remaley, A. T., Sampson, M. L., DeLeo, J. M., Remaley, N. A., Farsi, B. D., & ZWEIG, M. H. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.7.934 · Cited by 30
Suzuki, T., Yamaoki, K., NAKAJIMA, O., Yamazaki, T., Yamada, Y., Akioka, H., Yazaki, Y., & Nagai, R. (2000) · Japanese Heart Journal · doi:10.1536/jhj.41.205 · Cited by 25
Harrell, F., Jr. (1996) · doi:10.1002/(sici)1097-0258(19960229)15:4
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Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
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Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,137
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,739
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
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Redfield, M. M., Jacobsen, S. J., Burnett, J. C. J., Mahoney, D. W., Bailey, K. R., & Rodeheffer, R. J. (2003) · JAMA · doi:10.1001/jama.289.2.194 · Cited by 2,989
Metadata
- Authors
- Vasan, R. S., Benjamin, E. J., Larson, M. G., Leip, E. P., Wang, T. J., Wilson, P. W. F., & Levy, D.
- Affiliations
- Framingham Heart Study (US)
- Boston University (US)
- National Institutes of Health (US)
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2002-09-11
- Volume
- 288
- Issue
- 10
- Pages
- 1252
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2059920038
- Cited by
- 493
- References
- 42
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 14 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 16 · 2014: 14 · 2013: 20 · 2012: 29
- FWCI
- 27.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (K24-HL-04334-01A1, N01‐HC25195, R01HL067288, K24HL004334, 1R01HL67288-01)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- natriuretic peptides, brain natriuretic peptide, N-terminal proatrial natriuretic peptide, left ventricular hypertrophy, left ventricular systolic dysfunction, left ventricular mass, cardiovascular screening, diagnostic performance, sex differences, Framingham Heart Study, echocardiography
- MeSH terms
- Echocardiography, Female, Humans, Male, Mass Screening, Middle Aged, Atrial Natriuretic Factor, Phenotype, Predictive Value of Tests, Prospective Studies, Protein Precursors, ROC Curve, Sensitivity and Specificity, Systole, Biomarkers, Likelihood Functions, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Natriuretic Peptide, Brain
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