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Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance: A Meta-analysis
Open accessAbstract
Context: Ephedra and ephedrine sometimes are used for weight loss or enhanced athletic performance, but the efficacy and safety of these compounds are uncertain. Objective: To assess the efficacy and safety of ephedra and ephedrine used for weight loss and enhanced athletic performance. Data Sources: We searched 9 databases using the terms ephedra , ephedrine , adverse effect , side effect , efficacy , effective , and toxic . We included unpublished trials and non–English-language documents. Adverse events reported to the US Food and Drug Administration MedWatch program were assessed. Study Selection: Eligible studies were controlled trials of ephedra or ephedrine used for weight loss or athletic performance and case reports of adverse events associated with such use. Eligible studies for weight loss were human studies with at least 8 weeks of follow-up; and for athletic performance, those having no minimum follow-up. Eligible case reports documented that ephedra or ephedrine was consumed within 24 hours prior to an adverse event or that ephedrine or an associated product was found in blood or urine, and that other potential causes had been excluded. Of the 530 articles screened, 52 controlled trials and 65 case reports were included in the adverse events analysis. Of more than 18 000 other case reports screened, 284 underwent detailed review. Data Extraction: Two reviewers independently identified trials of efficacy and safety of ephedra and ephedrine on weight loss or athletic performance; disagreements were resolved by consensus. Case reports were reviewed with explicit and implicit methods. Data Synthesis: No weight loss trials assessed duration of treatment greater than 6 months. Pooled results for trials comparing placebo with ephedrine (n = 5), ephedrine and caffeine (n = 12), ephedra (n = 1), and ephedra and herbs containing caffeine (n = 4) yielded estimates of weight loss (more than placebo) of 0.6 (95% confidence interval, 0.2-1.0), 1.0 (0.7-1.3), 0.8 (0.4-1.2), and 1.0 (0.6-1.3) kg/mo, respectively. Sensitivity analyses did not substantially alter the latter 3 results. No trials of ephedra and athletic performance were found; 7 trials of ephedrine were too heterogeneous to synthesize. Safety data from 50 trials yielded estimates of 2.2- to 3.6-fold increases in odds of psychiatric, autonomic, or gastrointestinal symptoms, and heart palpitations. Data are insufficient to draw conclusions about adverse events occurring at a rate less than 1.0 per thousand. The majority of case reports are insufficiently documented to allow meaningful assessment. Conclusions: Ephedrine and ephedra promote modest short-term weight loss (≈0.9 kg/mo more than placebo) in clinical trials. There are no data regarding long-term weight loss, and evidence to support use of ephedra for athletic performance is insufficient. Use of ephedra or ephedrine and caffeine is associated with increased risk of psychiatric, autonomic, or gastrointestinal symptoms, and heart palpitations.
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“Unfortunately, ephedrine is associated with increased risk of psychiatric, autonomic, gastrointestinal, and cardiovascular symptoms 134, which likely will preclude the use of ephedrine itself for the treatment of obesity.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [134]
In the citing paper
“A meta-analysis of several dozen trials showed that ephedrine promotes modest short-term weight loss, but there are no data on longer-term efficacy 134.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [134]
In the citing paper
“Unfortunately, ephedrine is associated with increased risk of psychiatric, autonomic, gastrointestinal, and cardiovascular symptoms 134, which likely will preclude the use of ephedrine itself for the treatment of obesity.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [134]
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Citations
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Moher, D., Pham, B., Jones, A., Cook, D. J., Jadad, A. R., Moher, M., Tugwell, P., & Klassen, T. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01085-x · Cited by 3,560
Higgins (2002) · doi:10.1002/(issn)1097-0258 · Cited by 1,248
Haller, C. A., & Benowitz, N. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432502 · Cited by 956
A random‐effects regression model for meta‐analysis
Berkey, C. S., Hoaglin, D. C., Mosteller, F. C., & Colditz, G. A. (1995) · Statistics in Medicine · doi:10.1002/sim.4780140406 · Cited by 896
Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: a 1-y study.
Hill, J. O., Hauptman, J., Anderson, J. W., Fujioka, K., O'Neil, P. M., Smith, D. K., Zavoral, J. H., & Aronne, L. J. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1108 · Cited by 287 · cited 8×
“Molnar et al,27 2000 4 Ephedrine (30-60) and caffeine (100 for 1 wk) 20 wk 16 16 0.”
InfluentialLong-term Weight Loss With Sibutramine
Wirth, A. G., & Krause, J. (2001) · JAMA · doi:10.1001/jama.286.11.1331 · Cited by 267
Research works printed but not linked: 13
- Abrahamson, 2001, Wheeler used supplement., Los Angeles Times
- Carey, 2001, Risks of ephedra usage in spotlight., Los Angeles Times
- Marsa, 2002, A tug of war in a larger battle: ephedra is now under intense scrutiny., Los Angeles Times
- Moheb, 1998, Effect of ephedrine, caffeine, and aspirin, in combinations of weight loss in obese women [abstract]., Int J Obes Relat Metab Disord, 22, S264
- Colker, 2001, A pilot study evaluating the effects of an ephedrine and forskolin-based product on body weight and body composition in overweight, healthy women [abstract]., J Am Coll Nutr, 20, 98
- Jensen, 1980, Elsinore tablets and ephedrine as slimming agents [in Danish]., Ugeskr Laeger, 142, 1499
- Kettle, 1998, Ephedrine/caffeine enhances abdominal fat loss in females., Int J Obes Relat Metab Disord, 22, S264
- Lumholtz, 1980, Ephedrine in the treatment of obesity [in Danish]., Ugeskr Laeger, 142, 1487
- Quaade, 1992, The effect of an ephedrine/caffeine combination as a supplement to a weight-reducing diet [in Danish]., Ugeskr Laeger, 154, 1258
- Roed, 1980, Elsinore banting tablets [in Danish]., Ugeskr Laeger, 142, 1491
- Breum, 1994, Comparison of an ephedrine/caffeine combination and dexfenfluramine in the treatment of obesity., Int J Obes Relat Metab Disord, 18, 99
- Not Available, 2001, >Stata [computer program].
- Not Available, 2000, StatXact 4 [computer program].
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Klein, S., Burke, L. E., Bray, G. A., Blair, S., Allison, D. B., Pi-Sunyer, X., Hong, Y., & Eckel, R. H. (2004) · Circulation · doi:10.1161/01.cir.0000145546.97738.1e · Cited by 934
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Adverse Effects of Nutraceuticals and Dietary Supplements
Ronis, M. J. J., Pedersen, K. B., & Watt, J. D. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052844 · Cited by 393
Total Phenolic Contents and Antioxidant Capacities of Selected Chinese Medicinal Plants
Song, F.-L., Gan, R.-Y., Zhang, Y., Xiao, Q., Kuang, L., & Li, H.-B. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11062362 · Cited by 346
Diepvens, K., Westerterp, K. R., & Westerterp‐Plantenga, M. S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00832.2005 · Cited by 344
An Overview of the Evidence and Mechanisms of Herb–Drug Interactions
Fasinu, P. S., Bouic, P. J., & Rosenkranz, B. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00069 · Cited by 221
Review article: herbal and dietary supplement hepatotoxicity
Bunchorntavakul, C., & Reddy, K. R. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12109 · Cited by 249
Cold but not sympathomimetics activates human brown adipose tissue in vivo
Cypess, A. M., Chen, Y., Sze, C., Wang, K., English, J., Chan, O., Holman, A. R., Tal, I., Palmer, M. R., Kolodny, G. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207911109 · Cited by 312
Anti-obesogenic and antidiabetic effects of plants and mushrooms
Martel, J., Ojcius, D. M., Chang, C., Lin, C.-S., Lu, C., Ko, Y., Tseng, S., Lai, H., & Young, J. D. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.142 · Cited by 270
Use of Dietary Supplements for Weight Loss in the United States: Results of a National Survey
Pillitteri, J. L., Shiffman, S. M., Rohay, J. M., Harkins, A. M., Burton, S. L., & Wadden, T. A. (2008) · Obesity · doi:10.1038/oby.2007.136 · Cited by 237
The vascular effects of trace amines and amphetamines
Broadley, K. J. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.11.005 · Cited by 217
Health risks of herbal remedies: an update
Desmet, P. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.03.005 · Cited by 213
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Adverse events of herbal food supplements for body weight reduction: systematic review*
Pittler, M. H., Schmidt, K., & Ernst, E. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00169.x · Cited by 191
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Sellami, M., Slimeni, O., Pokrywka, A., Kuvačić, G., Hayes, L. D., Milić, M., & Padulo, J. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0218-y · Cited by 189
Onakpoya, I. J., Heneghan, C. J., & Aronson, J. K. (2016) · BMC Medicine · doi:10.1186/s12916-016-0735-y · Cited by 171
Pharmacological Treatment of the Overweight Patient
Bray, G. A., & Greenway, F. L. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.2 · Cited by 169
Ioannides‐Demos, L. L., Proietto, J., & McNeil, J. J. (2005) · Drugs · doi:10.2165/00003495-200565100-00006 · Cited by 165
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Cafri, G., van den Berg, P., & Thompson, J. K. (2006) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3502_12 · Cited by 157
Systematic review and aggregation of empirical studies on elicitation techniques
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Safety of Drug Therapies Used for Weight Loss and Treatment of Obesity
Ioannides‐Demos, L. L., Proietto, J., Tonkin, A. M., & McNeil, J. J. (2006) · Drug Safety · doi:10.2165/00002018-200629040-00001 · Cited by 152
Centrally Acting Agents for Obesity: Past, Present, and Future
Coulter, A. A., Rebello, C. J., & Greenway, F. L. (2018) · Drugs · doi:10.1007/s40265-018-0946-y · Cited by 151
Taheri, J. B., Azimi, S., Rafieian, N., & Zanjani, H. A. (2011) · International Dental Journal · doi:10.1111/j.1875-595x.2011.00064.x · Cited by 151
Neuropeptide Y, α-melanocyte–stimulating hormone, and monoamines in food intake regulation
Ramos, E. J. B., Meguid, M. M., Campos, A. C. L., & Coelho, J. C. U. (2005) · Nutrition · doi:10.1016/j.nut.2004.06.021 · Cited by 148
Payab, M., Hasani‐Ranjbar, S., Shahbal, N., Qorbani, M., Aletaha, A., Haghi‐Aminjan, H., Soltani, A., Khatami, F., Nikfar, S., Hassani, S., et al. (2019) · Phytotherapy Research · doi:10.1002/ptr.6547 · Cited by 148
Vasopressors in obstetrics: what should we be using?
Kee, W. D. N., & Khaw, K. S. (2006) · Current Opinion in Anaesthesiology · doi:10.1097/01.aco.0000192816.22989.ba · Cited by 142
Position Stand on Androgen and Human Growth Hormone Use
Hoffman, J. R., Kraemer, W. J., Bhasin, S., Storer, T. W., Ratamess, N. A., Haff, G. G., Willoughby, D. S., & Rogol, A. D. (2009) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31819df2e6 · Cited by 143
Hemodynamic effects of ephedra-free weight-loss supplements in humans
HALLER, C. A., Benowitz, N. L., & Jacob, P. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.02.034 · Cited by 138
Integrating Complementary Medicine Into Cardiovascular Medicine
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Momaya, A. M., Fawal, M., & Estes, R. (2015) · Sports Medicine · doi:10.1007/s40279-015-0308-9 · Cited by 142
Hector, A. J., & Phillips, S. M. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0273 · Cited by 137
Maciejewski, M. L., Patrick, D. L., & Williamson, D. F. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.10.015 · Cited by 127
Safety and efficacy of citrus aurantium for weight loss
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Dhar, R., Stout, C. W., Link, M. S., Homoud, M. K., Weinstock, J., & Estes, N. A. M. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.10.1307 · Cited by 122
Obesity – A neuropsychological disease? Systematic review and neuropsychological model
Jauch‐Chara, K., & Oltmanns, K. M. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.001 · Cited by 136
Seeff, L. B. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.06.005 · Cited by 120
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Magkos, F., & Kavouras, S. A. (2004) · Sports Medicine · doi:10.2165/00007256-200434130-00002 · Cited by 116
Cardiovascular Effects of Ephedra Alkaloids: A Comprehensive Review
Andraws, R., Chawla, P., & Brown, D. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2004.07.006 · Cited by 118
Natural products in anti-obesity therapy
Vermaak, I., Viljoen, A. M., & Hamman, J. H. (2011) · Natural Product Reports · doi:10.1039/c1np00035g · Cited by 117
Chen, K. Y., Brychta, R. J., Sater, Z. A., Cassimatis, T. M., Cero, C., Fletcher, L. A., Israni, N. S., Johnson, J. W., Lea, H. J., Linderman, J. D., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007363 · Cited by 121
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Thuyne, W. V., Eenoo, P. V., & Delbeke, F. T. (2006) · Nutrition Research Reviews · doi:10.1079/nrr2006122 · Cited by 110
Dietary supplements in weight reduction
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Wilson, K. M., Klein, J. D., Sesselberg, T. S., Yussman, S. M., Markow, D. B., Green, A. E., West, J. C., & Gray, N. J. (2006) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2005.01.010 · Cited by 110
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Bray, G. A. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0680124 · Cited by 110
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Fontanarosa, P., Rennie, D., & DeAngelis, C. D. (2003) · JAMA · doi:10.1001/jama.289.12.1568 · Cited by 107
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Davis, E. A., Loiacono, R. E., & Summers, R. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.164 · Cited by 103
Gout, B., Bourges, C., & Paineau-Dubreuil, S. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.04.008 · Cited by 108
McBride, B. F., Karapanos, A. K., Krudysz, A., Kluger, J., Coleman, C. I., & White, C. M. (2004) · JAMA · doi:10.1001/jama.291.2.216 · Cited by 102
Gossellin, J., Wren, J. A., & SUNDERLAND, S. J. (2007) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2007.00863.x · Cited by 104
Multi-ingredient, Caffeine-containing Dietary Supplements: History, Safety, and Efficacy
Gurley, B. J., Steelman, S. C., & Thomas, S. L. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.08.012 · Cited by 96
Hackman, R. M., Havel, P. J., Schwartz, H. J., Rutledge, J. C., Watnik, M., Noceti, E. M., Stohs, S. J., Stern, J. S., & Keen, C. L. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803283 · Cited by 94
The anti-obesity effect of Ephedra sinica through modulation of gut microbiota in obese Korean women
Kim, B. S., Song, M., & Kim, H. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.01.038 · Cited by 95
Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise
Josse, A. R., Sherriffs, S. S., Holwerda, A. M., Andrews, R. V., Staples, A. W., & Phillips, S. M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-65 · Cited by 94
Dietary supplements for football
Hespel, P., Maughan, R., & Greenhaff, P. L. (2006) · Journal of Sports Sciences · doi:10.1080/02640410500482974 · Cited by 91
Unpredictable adverse effects of herbal products
Başaran, N., Paslı, D., & Başaran, A. A. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112762 · Cited by 100
Eliason, M. J., Eichner, A., Cancio, A. T., Bestervelt, L., Adams, B. D., & Deuster, P. A. (2012) · Military Medicine · doi:10.7205/milmed-d-12-00265 · Cited by 89
Challenges in Systematic Reviews of Complementary and Alternative Medicine Topics
Shekelle, P., Morton, S. C., Suttorp, M. J., Buscemi, N., & Friesen, C. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-12_part_2-200506211-00003 · Cited by 86
Self-citationEvidence-based toxicity evaluation and scheduling of Chinese herbal medicines
Kim, E. J. Y., Chen, Y., Huang, J. Q., Li, K. M., Razmovski‐Naumovski, V., Poon, J., Chan, K., Roufogalis, B. D., McLachlan, A. J., Mo, S., et al. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.12.027 · Cited by 90
Contribution of brown adipose tissue to human energy metabolism
Fernández‐Verdejo, R., Marlatt, K. L., Ravussin, É., & Galgani, J. E. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.07.003 · Cited by 85
Knapik, J. J., Trone, D. W., Austin, K. G., Steelman, R. A., Farina, E. K., & Lieberman, H. R. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.02.015 · Cited by 86
Diagnostic approach to palpitations.
Abbott, A. V. (2005) · PubMed · Cited by 83
Pharmacological and surgical treatment of obesity.
Shekelle, P., Morton, S. C., Maglione, M., Suttorp, M. J., Tu, W., Li, Z., Maggard, M. A., Mojica, W., Shugarman, L. R., & Solomon, V. (2004) · PubMed · Cited by 80
Self-citationRoy, S., Rink, C. L., Khanna, S., Phillips, C., Bagchi, D., Bagchi, M., & Sen, C. K. (2003) · Gene Expression · doi:10.3727/000000003783992289 · Cited by 82
Marques-Vidal, P. M., Pécoud, A. R., Hayoz, D., Paccaud, F. M., Mooser, V., Waeber, G., & Vollenweider, P. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602932 · Cited by 81
Central Nervous System Biogenic Amine Targets for Control of Appetite and Energy Expenditure
Nelson, D. L., & Gehlert, D. R. (2006) · Endocrine · doi:10.1385/endo:29:1:49 · Cited by 78
Controversies surrounding xanthine therapy
Millar, D., & Schmidt, B. K. (2004) · Seminars in Neonatology · doi:10.1016/j.siny.2003.11.008 · Cited by 77
The Use of Alternative Medicine in Pediatric Patients with Atopic Dermatitis
Hughes, R., Ward, D., Tobin, A., Keegan, K., & Kirby, B. (2007) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2007.00355.x · Cited by 76
Greenway, F. L., de Jonge, L., Blanchard, D., Frisard, M. I., & Smith, S. R. (2004) · Obesity Research · doi:10.1038/oby.2004.144 · Cited by 76
Gutiérrez‐Hellín, J., & Varillas‐Delgado, D. (2021) · Nutrients · doi:10.3390/nu13030715 · Cited by 93
Hildebrandt, T., Langenbucher, J. W., Carr, S. J., & Sanjuan, P. M. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.4.717 · Cited by 74
The state of dietary supplement adverse event reporting in the United States
Gardiner, P. M., Sarma, D. N., Dog, T. L., Barrett, M. L., Chavez, M. L., Ko, R., Mahady, G. B., Marles, R. J., Pellicore, L. S., & Giancaspro, G. I. (2008) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1627 · Cited by 73
Tang, L., & Song, P. X. ‐. (2016) · PubMed · Cited by 74
Supplemental Products Used for Weight Loss
Lenz, T. L., & Hamilton, W. R. (2004) · Journal of the American Pharmacists Association · doi:10.1331/154434504322713246 · Cited by 73
Medication and supplement use by athletes
Ciocca, M. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2005.03.005 · Cited by 72
Drug Use in Sports: A Veritable Arena for Pharmacists
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HALLER, C. A., Duan, M., Jacob, P., & Benowitz, N. L. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2008.03144.x · Cited by 71
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Greenway, F. L., & Caruso, M. K. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.6.1083 · Cited by 62
Dodge, T. L., Litt, D., & Kaufman, A. R. (2010) · Journal of Health Communication · doi:10.1080/10810730.2010.529493 · Cited by 61
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Metadata
- Authors
- Shekelle, P. G., Hardy, M. L., Morton, S. C., Maglione, M., Mojica, W. A., Suttorp, M. J., Rhodes, S. L., Jungvig, L., & Gagné, J.
- Affiliations
- RAND Corporation (US)
- Cedars-Sinai Medical Center (US)
- University of Southern California (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2003-03-26
- Volume
- 289
- Issue
- 12
- Pages
- 1537
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1999289755
- Cited by
- 511
- References
- 43
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 16 · 2016: 19 · 2015: 21 · 2014: 20 · 2013: 17 · 2012: 23
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- VTechWorks (Virginia Tech) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Health Services Research and Development
- U.S. Public Health Service (290-97-0001)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Social Sciences › Sociology and Political Science › Doping in Sports
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Pharmacological Effects and Assays
- Keywords
- Ephedra, ephedrine, weight loss, athletic performance, stimulants, caffeine, adverse events, drug safety, efficacy, herbal supplements, performance-enhancing drugs
- MeSH terms
- Caffeine, Ephedrine, Humans, Physical Endurance, Risk, Sports, Weight Loss, Randomized Controlled Trials as Topic, Controlled Clinical Trials as Topic, Anti-Obesity Agents, Dietary Supplements, Plant Preparations, Ephedra
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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