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Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring
Abstract
CONTEXT: Atrial fibrillation (AF) is the most common cardiac dysrhythmia in the United States. Whereas rare cases of familial AF have been reported, it is unknown if AF among unselected individuals is a heritable condition. OBJECTIVE: To determine whether parental AF increases the risk for the development of offspring AF. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study (1983-2002) within the Framingham Heart Study, a population-based epidemiologic study. Participants were 2243 offspring (1165 women, 1078 men) at least 30 years of age and free of AF whose parents had both been evaluated in the original cohort. MAIN OUTCOME MEASURES: Development of new-onset AF in the offspring was prospectively examined in association with previously documented parental AF. RESULTS: Among 2243 offspring participants, 681 (30%) had at least 1 parent with documented AF; 70 offspring participants (23 women; mean age, 62 [range, 40-81] years) developed AF in follow-up. Compared with no parental AF, AF in at least 1 parent increased the risk of offspring AF (multivariable-adjusted odds ratio [OR], 1.85; 95% confidence interval [CI], 1.12-3.06; P =.02). These results were stronger when age was limited to younger than 75 years in both parents and offspring (multivariable-adjusted OR, 3.23; 95% CI, 1.87-5.58; P<.001) and when the sample was further limited to those without antecedent myocardial infarction, heart failure, or valve disease (multivariable-adjusted OR, 3.17; 95% CI, 1.71-5.86; P<.001). CONCLUSIONS: Parental AF increases the future risk for offspring AF, an observation supporting a genetic susceptibility to developing this dysrhythmia. Further research into the genetic factors predisposing to AF is warranted.
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In the citing paper
“AF, especially early-onset AF, has a strong heritable component, independent of concomitant cardiovascular conditions.58,59”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [58]
In the citing paper
“Several studies evaluating familial aggregation of AF have reported substantially increased risk of AF in individuals with affected family members.8,9,50–55”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [55]
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Self-citation
Metadata
- Authors
- Fox, C. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Fox, Caroline S.
- ORCID
- Fox, Caroline S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-06-16
- Volume
- 291
- Issue
- 23
- Pages
- 2851
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2065958606
- Cited by
- 600
- References
- 29
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 17 · 2021: 27 · 2020: 34 · 2019: 31 · 2018: 24 · 2017: 35 · 2016: 37 · 2015: 26 · 2014: 44 · 2013: 36 · 2012: 47
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k23hl074077-03, n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (K23 HL074077-01, K23 HL04253, K-24-HL-04334, N01‐HC25195, K24HL004334, K23HL004253)
- National Institute of Neurological Disorders and Stroke (5-R01-NS-17950, R01NS017950)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- atrial fibrillation, familial atrial fibrillation, offspring risk, heritability, genetic susceptibility, new-onset atrial fibrillation, Framingham Heart Study
- MeSH terms
- Adult, Aged, Atrial Fibrillation, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Adult Children
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