Familial aggregation in lone atrial fibrillation
Abstract
Atrial fibrillation (AF) is the most common clinical arrhythmia and a major risk factor for stroke. To investigate the role of genetic factors in a typical clinical population, we determined the extent of familial aggregation in patients with lone AF. To estimate the relative risk to family members, the prevalence of AF for each class of relative was compared to the prevalence in the comparable age and sex group from the general population. Family members had an increased relative risk of AF compared to the general population (risk ratio; 95% confidence intervals): sons (8.1; 2.0-32), daughters (9.5; 1.3-67), brothers (70; 47-102), sisters (34; 14-80), mothers (4.0; 2.5-6.5) and fathers (2.0; 1.2-3.6). Relatives of probands with lone AF are at a substantially increased risk of developing this arrhythmia suggesting a Mendelian genetic contribution to the etiology of this common trait.
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Several studies evaluating familial aggregation of AF have reported substantially increased risk of AF in individuals with affected family members.
“Several studies evaluating familial aggregation of AF have reported substantially increased risk of AF in individuals with affected family members.8,9,50–55”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [54]
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- Authors
- Ellinor, P. T., Yoerger, D. M., Ruskin, J. N., & MacRae, C. A.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- MacRae, Calum A.
- Venue
- Human Genetics
- Published
- 2005-08-25
- Volume
- 118
- Issue
- 2
- Pages
- 179-184
- ISSN
- 0018-7348 (ISSN-L)
- 0340-6717
- 1432-1203
- OpenAlex
- W1970044685
- Cited by
- 260
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 12 · 2019: 6 · 2018: 7 · 2017: 13 · 2016: 22 · 2015: 10 · 2014: 19 · 2013: 23 · 2012: 23
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Richard and Susan Smith Family Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL075431, HL71632, K23HL071632, R01HL075431)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- lone atrial fibrillation, familial aggregation, genetic susceptibility, Mendelian inheritance, relatives of probands, relative risk, atrial fibrillation etiology, stroke risk
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Atrial Fibrillation, Family, Female, Humans, Male, Middle Aged, Pedigree, Risk Factors, Cohort Studies, Prevalence, Stroke, Quantitative Trait Loci
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