The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Treatment of Acne Vulgaris
Abstract
CONTEXT: Management of acne vulgaris by nondermatologists is increasing. Current understanding of the different presentations of acne allows for individualized treatments and improved outcomes. OBJECTIVE: To review the best evidence available for individualized treatment of acne. DATA SOURCES: Search of MEDLINE, EMBASE, and the Cochrane database to search for all English-language articles on acne treatment from 1966 to 2004. STUDY SELECTION: Well-designed randomized controlled trials, meta-analyses, and other systematic reviews are the focus of this article. DATA EXTRACTION: Acne literature is characterized by a lack of standardization with respect to outcome measures and methods used to grade disease severity. DATA SYNTHESIS: Main outcome measures of 29 randomized double-blind trials that were evaluated included reductions in inflammatory, noninflammatory, and total acne lesion counts. Topical retinoids reduce the number of comedones and inflammatory lesions in the range of 40% to 70%. These agents are the mainstay of therapy in patients with comedones only. Other agents, including topical antimicrobials, oral antibiotics, hormonal therapy (in women), and isotretinoin all yield high response rates. Patients with mild to moderate severity inflammatory acne with papules and pustules should be treated with topical antibiotics combined with retinoids. Oral antibiotics are first-line therapy in patients with moderate to severe inflammatory acne while oral isotretinoin is indicated for severe nodular acne, treatment failures, scarring, frequent relapses, or in cases of severe psychological distress. Long-term topical or oral antibiotic therapy should be avoided when feasible to minimize occurrence of bacterial resistance. Isotretinoin is a powerful teratogen mandating strict precautions for use among women of childbearing age. CONCLUSIONS: Acne responses to treatment vary considerably. Frequently more than 1 treatment modality is used concomitantly. Best results are seen when treatments are individualized on the basis of clinical presentation.
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Cites
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
PITT, B., ZANNAD, F., REMME, W. J., CODY, R., CASTAIGNE, A., PEREZ, A., PALENSKY, J., & WITTES, J. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927
Gollnick, H., Cunliffe, W., Berson, D., Dreno, B., Finlay, A., Leyden, J. J., Shalita, A. R., & Thiboutot, D. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.618 · Cited by 817
Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms
Golub, L. M., Lee, H.-M., Ryan, M. E., Giannobile, W. V., Payne, J., & Sorsa, T. (1998) · Advances in Dental Research · doi:10.1177/08959374980120010501 · Cited by 687
Prolonged Remissions of Cystic and Conglobate Acne with 13-cis-Retinoic Acid
Peck, G. L., Olsen, T. G., Yoder, F. W., Strauss, J. S., Downing, D. T., Pandya, M., Butkus, D., & Arnaud-Battandier, J. (1979) · New England Journal of Medicine · doi:10.1056/nejm197902153000701 · Cited by 519
Acne vulgaris: a disease of Western civilization
Cordain, L., Lindeberg, S., Hurtado, M., Hill, K., Eaton, S. B., & Brand-Miller, J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.12.1584 · Cited by 500
Antibiotic-resistant acne: lessons from Europe
Ross, J. I., Snelling, A. M., Carnegie, E., Coates, P., Cunliffe, W. J., Bettoli, V., Tosti, G., Katsambas, A., Galvan Perez Del Pulgar, J. I., Rollman, O., et al. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05067.x · Cited by 360
Vowels, B. R., Yang, S., & Leyden, J. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.8.3158-3165.1995 · Cited by 330
EADY, E. A., COVE, J. H., HOLLAND, K. T., & CUNLIFFE, W. J. (1989) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1989.tb01399.x · Cited by 279
Cited by
Gierisch, J. M., Coeytaux, R. R., Urrutia, R. P., Havrilesky, L. J., Moorman, P. G., Lowery, W. J., Dinan, M., McBroom, A. J., Hasselblad, V., Sanders, G. D., et al. (2013) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0298 · Cited by 372
Large‐scale worldwide observational study of adherence with acne therapy
Dréno, B., Thiboutot, D., Gollnick, H., Finlay, A. Y., Layton, A., Leyden, J. J., Leutenegger, E., Perez, M., & on behalf of the Global Alliance to Improve Outcomes in Acne (2010) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2010.04416.x · Cited by 195
Thiboutot, D. M., Weiss, J., Bucko, A., Eichenfield, L., Jones, T., Clark, S., Liu, Y., Graeber, M., & Kang, S. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.06.006 · Cited by 183
Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M., & Suh, D. H. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.292 · Cited by 183
Gollnick, H. P. M., Draelos, Z., Glenn, M. J., Rosoph, L. A., Kaszuba, A., Cornelison, R., Gore, B., Liu, Y., Graeber, M., & for the Adapalene-BPO Study Group (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09209.x · Cited by 128
Metadata
- Authors
- Haider, A.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-08-11
- Volume
- 292
- Issue
- 6
- Pages
- 726
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1976923360
- Cited by
- 273
- References
- 91
- FWCI
- 16.95
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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