Epigallocatechin-3-Gallate Improves Acne in Humans by Modulating Intracellular Molecular Targets and Inhibiting P. acnes
Open accessAbstract
Acne vulgaris is a highly prevalent skin disorder characterized by hyperseborrhea, inflammation, and Propionibacterium acnes overgrowth. Only isotretinoin and hormonal therapy reduce sebum production. To identify a new drug candidate that modulates sebum, we examined the effects of EGCG, the major polyphenol in green tea, on human SEB-1 sebocytes and in patients with acne. In SEB-1 sebocytes, we found that EGCG reduced sebum by modulating the AMPK-SREBP-1 signaling pathway. EGCG also reduces inflammation by suppressing the NF-κB and AP-1 pathways. EGCG also induces cytotoxicity of SEB-1 sebocytes via apoptosis and decreases the viability of P. acnes, thus targeting almost all the pathogenic features of acne. Finally, and most importantly, EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated. Our data provide a therapeutic rationale for the use of EGCG in acne.
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Among the randomized controlled trials on global acne severity, three showed that dermocosmetics were significantly superior to comparators or placebo in improving acne.
“three showed that dermocosmetics were significantly superior in improving acne versus comparators or placebo”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [20]
Two randomized controlled trials had numerically but not statistically superior reductions in acne lesion counts with dermocosmetics.
“two RCTs had numerically but not statistically superior reductions”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [20]
Among the randomized controlled trials on global acne severity, two showed that dermocosmetic products had an effect on acne severity comparable to benzoyl peroxide 2.5% or 5% and retinoic acid 0.025%.
“two showed that dermocosmetic products had an effect on acne severity comparable to BPO 2.5% or 5% and retinoic acid 0.025%.”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [20]
Five randomized controlled trials showed significantly superior reductions in acne lesion counts with dermocosmetics versus comparators.
“Five RCTs showed significantly superior reductions in acne lesion counts with dermocosmetics versus comparators”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [20]
Two randomized controlled trials showed reductions in acne lesion counts comparable to benzoyl peroxide 2.5% and 5% and retinoic acid 0.025%.
“two showed reductions comparable to BPO 2.5% and 5% and retinoic acid 0.025%.”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [20]
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- Authors
- Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M., & Suh, D. H.
- Affiliations
- Seoul National University Hospital (KR)
- Seoul National University (KR)
- Pennsylvania State University (US)
- Corresponding author
- Suh, Dae Hun
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 133
- Issue
- 2
- Pages
- 429-440
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2021214999
- Cited by
- 183
- References
- 61
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 21 · 2023: 13 · 2022: 16 · 2021: 15 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 9 · 2013: 3 · 2012: 1
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- epigallocatechin gallate, acne, Propionibacterium acnes, sebocytes, sebum production, NF-κB, AP-1, apoptosis, anti-inflammatory activity, green tea polyphenols, acne treatment
- MeSH terms
- Acne Vulgaris, Antioxidants, Catechin, Cell Line, Transformed, Child, Dermatitis, Double-Blind Method, Female, Humans, Male, Propionibacterium acnes, Sebum, Signal Transduction, NF-kappa B, Treatment Outcome, Gram-Positive Bacterial Infections, Apoptosis, Transcription Factor AP-1, Lipogenesis, AMP-Activated Protein Kinases
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