Immunological Memory: The Role of B Cells in Long-term Protection Against Invasive Bacterial Pathogens

Kelly, Dominic F.; Pollard, Andrew J.; Moxon, E. Richard

doi:10.1001/jama.294.23.3019

Cited by 113Bacterial Infections and VaccinesImmune responses and vaccinationsT-cell and B-cell Immunology

Immunological Memory: The Role of B Cells in Long-term Protection Against Invasive Bacterial Pathogens

Kelly, Dominic F., Pollard, Andrew J., Moxon, E. Richard·2005·JAMA

DOI 10.1001/jama.294.23.3019

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Abstract

Protein-polysaccharide conjugate vaccines that protect against Haemophilus influenzae type b (Hib), serogroup C Neisseria meningitidis, and multiple capsular serotypes of Streptococcus pneumoniae have had a major impact on invasive bacterial disease in childhood when incorporated into routine infant immunization schedules. However, effectiveness data from the United Kingdom suggest that primary infant immunization alone may not be associated with long-term protection. Both immunological priming and antibody persistence are important aspects of long-term protection induced by these vaccines. An improved understanding of the immunobiology of the B-cell response to these vaccines may direct development of immunization strategies that provide sustained protection.

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It is thought that immune memory may not be sufficient for protection against rapidly invasive bacterial infections that can cause severe disease within hours or days following acquisition of the pathogen.
“it is thought that immune memory may not be sufficient for protection against rapidly invasive bacterial infections that can cause severe disease within hours or days following acquisition of the pathogen42”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [42]

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Authors: Kelly, D. F., Pollard, A. J., & Moxon, E. R.
Affiliations: University of Oxford (GB)
ORCID: Kelly, Dominic F.
Pollard, Andrew J.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2005-12-21
Volume: 294
Issue: 23
Pages: 3019
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.294.23.3019
OpenAlex: W2119514683
Cited by: 113
References: 34
Citations by year: 2026: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 10
FWCI: 6.41
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: Haemophilus influenzae type b, Neisseria meningitidis serogroup C, invasive bacterial infection, childhood immunization, long-term vaccine protection, immune priming, antibody persistence, B cell response, immunological memory
MeSH terms: Antibodies, Bacterial, Antibody Affinity, B-Lymphocytes, Bacterial Vaccines, Child, Humans, Immunization, Secondary, Immunologic Memory, Infant, Plasma Cells, Polysaccharides, Bacterial, Vaccination, B-Lymphocyte Subsets, Bacterial Capsules, Haemophilus Vaccines, Vaccines, Conjugate, Meningococcal Vaccines

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Immunological Memory: The Role of B Cells in Long-term Protection Against Invasive Bacterial Pathogens

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