The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Adult Stem Cell Therapy and Heart Failure, 2000 to 2016: A Systematic Review
Open accessAbstract
Importance: Stem cell therapy is a promising treatment strategy for patients with heart failure, which accounts for more than 10% of deaths in the United States annually. Despite more than a decade of research, further investigation is still needed to determine whether stem cell regenerative therapy is an effective treatment strategy and can be routinely implemented in clinical practice. Objective: To describe the progress in cardiac stem cell regenerative therapy using adult stem cells and to highlight the merits and limitations of clinical trials performed to date. Evidence Review: Information for this review was obtained through a search of PubMed and the Cochrane database for English-language studies published between January 1, 2000, and July 26, 2016. Twenty-nine randomized clinical trials and 7 systematic reviews and meta-analyses were included in this review. Findings: Although adult stem cells were once believed to have the ability to create new heart tissue, preclinical studies suggest that these cells release cardioprotective paracrine factors that activate endogenous pathways, leading to myocardial repair. Subsequent randomized clinical trials, most of which used autologous bone marrow mononuclear cells, have found only a modest benefit in patients receiving stem cell therapy. The lack of a significant benefit may result from variations in trial methods, discrepancies in reporting, and an overreliance on surrogate end points. Conclusions and Relevance: Although stem cell therapy for cardiovascular disease is not yet ready for routine clinical application, significant progress continues to be made. Physicians should be aware of the current status of this treatment so that they can better inform their patients who may be in search of alternative therapies.
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1 retracted
Bolli, R., Chugh, A. R., D'Amario, D., Loughran, J. H., Stoddard, M. F., Ikram, S., Beache, G. M., Wagner, S. G., Leri, A., Hosoda, T., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61590-0 · Cited by 1,288
RetractedHeart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
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Bone marrow cells regenerate infarcted myocardium
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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
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Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
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Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications
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Intracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial Infarction
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Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
Balsam, L. B., Wagers, A. J., Christensen, J. L., Kofidis, T., Weissman, I. L., & Robbins, R. C. (2004) · Nature · doi:10.1038/nature02460 · Cited by 1,736
Cited by
An acute immune response underlies the benefit of cardiac stem cell therapy
Vagnozzi, R. J., Maillet, M., Sargent, M. A., Khalil, H., Johansen, A. K. Z., Schwanekamp, J. A., York, A. J., Huang, V., Nahrendorf, M., Sadayappan, S., et al. (2020) · Nature · doi:10.1038/s41586-019-1802-2 · Cited by 554
Cardiac fibrosis – A short review of causes and therapeutic strategies
Hinderer, S., & Schenke-Layland, K. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.05.011 · Cited by 490
Zhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00071 · Cited by 394
Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
Metadata
- Authors
- Nguyen, P. K., Rhee, J.-W., & Wu, J. C.
- Venue
- JAMA Cardiology
- Publisher
- American Medical Association (AMA)
- Published
- 2016-10-01
- Volume
- 1
- Issue
- 7
- Pages
- 831
- ISSN
- 2380-6583 (ISSN-L)
- OpenAlex
- W2510906006
- Cited by
- 299
- References
- 70
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Nguyen, P. K., Rhee, J.-W., & Wu, J. C. (2016). Adult Stem Cell Therapy and Heart Failure, 2000 to 2016: A Systematic Review. JAMA Cardiology. https://doi.org/10.1001/jamacardio.2016.2225
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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