The DOI matches its Crossref record; 448 of the 448 references it cites were found in a registry or an index.
Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics
Abstract
Owing to their unique chemical and physical properties, hydrogels are attracting increasing attention in both basic and translational biomedical studies. Although the classical hydrogels with static networks have been widely reported for decades, a growing number of recent studies have shown that structurally dynamic hydrogels can better mimic the dynamics and functions of natural extracellular matrix (ECM) in soft tissues. These synthetic materials with defined compositions can recapitulate key chemical and biophysical properties of living tissues, providing an important means to understanding the mechanisms by which cells sense and remodel their surrounding microenvironments. This review begins with the overall expectation and design principles of dynamic hydrogels. We then highlight recent progress in the fabrication strategies of dynamic hydrogels including both degradation-dependent and degradation-independent approaches, followed by their unique properties and use in biomedical applications such as regenerative medicine, drug delivery, and 3D culture. Finally, challenges and emerging trends in the development and application of dynamic hydrogels are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Alginate: Properties and biomedical applications
Lee, K. Y., & Mooney, D. J. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.003 · Cited by 8,095
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
Neelapu, S. S., Locke, F. L., Bartlett, N. L., Lekakis, L. J., Miklos, D. B., Jacobson, C. A., Braunschweig, I., Oluwole, O. O., Siddiqi, T., Lin, Y., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707447 · Cited by 6,030
Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
Hydrogels for Tissue Engineering
Lee, K. Y., & Mooney, D. J. (2001) · Chemical Reviews · doi:10.1021/cr000108x · Cited by 5,277
Introduction and General Overview of Cyclodextrin Chemistry
Szejtli, J. (1998) · Chemical Reviews · doi:10.1021/cr970022c · Cited by 5,016
New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,865
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
Bioinspired structural materials
Wegst, U. G. K., Bai, H., Saiz, E., Tomsia, A. P., & Ritchie, R. O. (2015) · Nature Materials · doi:10.1038/nmat4089 · Cited by 4,721
Cited by
Stimuli‐Responsive Hydrogels for Antibacterial Applications
Hao, Z., Li, X., Zhang, R., & Zhang, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400513 · Cited by 135
Lei, X., Zou, C., Hu, J., Fan, M., Jiang, Y., Xiong, M., Han, C., Zhang, X., Li, Y., Zhao, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202306289 · Cited by 70
Hafeez, S., Decarli, M. C., Aldana, A., Ebrahimi, M., Ruiter, F. A. A., Duimel, H., van Blitterswijk, C., Pitet, L. M., Moroni, L., & Baker, M. B. (2023) · Advanced Materials · doi:10.1002/adma.202301242 · Cited by 48
Xu, L., Jiao, G., Huang, Y., Ren, P., Liang, M., Wei, D., & Zhang, T. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128288 · Cited by 24
Metadata
- Authors
- Zhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-06-30
- Volume
- 121
- Issue
- 18
- Pages
- 11149-11193
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3175170665
- Cited by
- 394
- References
- 448
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics. https://app.cochat.ai/papers/10.1021/acs.chemrev.1c00071
- The paper
- Zhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L. (2021). Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.1c00071
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
