Association of Exercise Preconditioning With Immediate Cardioprotection: A Review
Open accessAbstract
Importance: Exercise reduces the risk of cardiovascular events, including through an underrecognized, clinically useful form of acute cardioprotection accessible after a single episode of exercise, which is called cardiovascular preconditioning. Observations: Preclinical evidence shows that 1 to 3 episodes of exercise per week will provide strong cardioprotection; gradual, modest cardiovascular risk factor modification or physiological artery remodeling cannot fully explain these benefits. This review highlights preclinical evidence that acute exercise-induced cardiac preconditioning has the ability to activate multiple pathways to confer immediate protection against ischemic events, reduce the severity of potentially lethal ischemic myocardiac injury, and act as a physiological first line of defense. Conclusions and Relevance: Independent of the protective benefits of long-term exercise training on risk factors and adaptation of the cardiovascular system, cardiovascular preconditioning may contribute to the immediate cardioprotection of exercise. In practical terms, this means that 1 episode of exercise can create clinically relevant cardioprotection.
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Regular exercise can prevent fatal arrhythmias by inducing cardiac preconditioning.
“Regular exercise can prevent fatal arrhythmias by inducing cardiac preconditioning-a phenomenon whereby brief periods of myocardial ischaemia before prolonged coronary occlusion are cardioprotective against subsequent ischaemia/reperfusion injury--which reduces the size of the MI lesion and the risk of ventricular fibrillation.193”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [193]
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- Authors
- Thijssen, D. H. J., Redington, A., George, K. P., Hopman, M. T. E., & Jones, H.
- Affiliations
- Radboud University Medical Center (NL)
- Cincinnati Children's Hospital Medical Center (US)
- Liverpool John Moores University (GB)
- Venue
- JAMA Cardiology
- Publisher
- American Medical Association (AMA)
- Published
- 2018-02-01
- Volume
- 3
- Issue
- 2
- Pages
- 169
- ISSN
- 2380-6583 (ISSN-L)
- OpenAlex
- W2768251835
- Cited by
- 107
- References
- 79
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 5 · 2023: 13 · 2022: 16 · 2021: 18 · 2020: 14 · 2019: 15 · 2018: 8
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- Locations
- JAMA Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Liverpool John Moores University (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- exercise preconditioning, myocardial ischemia, myocardial ischemic injury, exercise-induced cardioprotection, exercise training, cardiovascular risk factors, arterial remodeling
- MeSH terms
- Animals, Disease Models, Animal, Exercise Therapy, Forecasting, Humans, Risk Factors, Myocardial Reperfusion Injury, Myocardial Ischemia, Ischemic Preconditioning, Myocardial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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