Effectiveness of Tocilizumab in Patients Hospitalized With COVID-19: A Follow-up of the CORIMUNO-TOCI-1 Randomized Clinical Trial
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This follow-up study of the CORIMUNO-TOCI-1 randomized clinical trial examines the association between survival and C-reactive protein levels in patients hospitalized with COVID-19 who were treated with tocilizumab.
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Abani, O., Abbas, A., Abbas, F., Abbas, M., Abbasi, S., Abbass, H., Abbott, A., Abdallah, N., Abdelaziz, A., Abdelfattah, M., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00676-0 · Cited by 1,983 · see citing works
Interleukin-6 receptor antagonists in critically ill patients with Covid-19.
The REMAP-CAP Investigators (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2100433 · Cited by 1,962 · see citing works
Efficacy of Tocilizumab in Patients Hospitalized with Covid-19
Stone, J. H., Frigault, M. J., Serling-Boyd, N. J., Fernandes, A. D., Harvey, L., Foulkes, A. S., Horick, N. K., Healy, B. C., Shah, R., Bensaci, A. M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2028836 · Cited by 1,362 · see citing works
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
Salama, C., Han, J., Yau, L., Reiss, W. G., Krämer, B., Neidhart, J. D., Criner, G. J., Kaplan‐Lewis, E., Baden, R. P., Pandit, L. M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2030340 · Cited by 1,285 · see citing works
Hermine, O., Mariette, X., Tharaux, P.-L., Resche-Rigon, M., Porcher, R., Ravaud, P., CORIMUNO-19 Collaborative Group, Bureau, S., Dougados, M., Tibi, A., et al. (2021) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.6820 · Cited by 734 · see citing works
Self-citationSalvarani, C., Dolci, G., Massari, M., Merlo, D. F., Cavuto, S., Savoldi, L., Bruzzi, P., Boni, F., Braglia, L., Turrà, C., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.6615 · Cited by 684 · see citing works
Abaleke, E., Abbas, M. A., Abbasi, S., Abbott, A., Abdelaziz, A., Abdelbadiee, S., Abdelfattah, M., Abdul, B., Rasheed, A. A., Kadir, R. A., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00149-5 · Cited by 549 · see citing works
Horby, P., Campbell, M., Staplin, N., et al. (2021) · medRxiv · doi:10.1101/2021.02.11.21249258 · Cited by 286 · see citing works
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Senescence as a therapeutic target in cancer and age-related diseases
McHugh, D., Durán, I., & Gil, J. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01074-4 · Cited by 199 · see citing works
Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19
Khan, F., Stewart, I. D., Fabbri, L., Moss, S., Robinson, K. A., Smyth, A. R., & Jenkins, G. R. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-215266 · Cited by 145 · see citing works
Impact of COVID-19 in solid organ transplant recipients
Danziger‐Isakov, L. A., Blumberg, E. A., Manuel, O., & Sester, M. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16449 · Cited by 137 · see citing works
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – Preliminary reportPreprint
The REMAP-CAP Investigators, Gordon, A. C., Mouncey, P. R., Al-Beidh, F., Rowan, K., Nichol, A., Arabi, Y. M., Annane, D., Beane, A., van Bentum-Puijk, W., et al. (2021) · medRxiv · doi:10.1101/2021.01.07.21249390 · Cited by 130 · see citing works
Kreiner, F. F., Kraaijenhof, J. M., von Herrath, M., Hovingh, G. K., & von Scholten, B. J. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2045952 · Cited by 105 · see citing works
Rodrigues, L. A., Cunha, R. B., Vassilevskaia, T. D., Viveiros, M., & Cunha, C. V. (2022) · Molecules · doi:10.3390/molecules27092723 · Cited by 86 · see citing works
A global picture: therapeutic perspectives for COVID-19
Chavda, V., Kapadia, C., Soni, S., Prajapati, R., Chauhan, S., Yallapu, M., & Apostolopoulos, V. (2022) · Immunotherapy · doi:10.2217/imt-2021-0168 · Cited by 66 · see citing works
Therapeutic monoclonal antibodies for COVID-19 management: an update
Chavda, V. P., Prajapati, R., Lathigara, D., Nagar, B., Kukadiya, J., Redwan, E. M. M. M., Uversky, V. N., Kher, M. N., & Patel, R. (2022) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.2078160 · Cited by 70 · see citing works
Kellum, J. A., Formeck, C. L., Kernan, K. F., Gómez, H., & Carcillo, J. A. (2022) · Critical Care Clinics · doi:10.1016/j.ccc.2021.11.013 · Cited by 64 · see citing works
Practicing With Uncertainty: Kidney Transplantation During the COVID-19 Pandemic
Lentine, K. L., Mannon, R. B., & Josephson, M. A. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.12.003 · Cited by 48 · see citing works
Kalimuddin, S., Chia, P. Y., Low, J. G. H., & Ooi, E. E. (2025) · Clinical Microbiology Reviews · doi:10.1128/cmr.00244-24 · Cited by 50 · see citing works
A digital protein microarray for COVID-19 cytokine storm monitoring
Song, Y., Ye, Y., Su, S., Stephens, A., Cai, T., Chung, M. T., Han, M. K., Newstead, M. W., Yessayan, L., Frame, D. G., et al. (2020) · Lab on a Chip · doi:10.1039/d0lc00678e · Cited by 45 · see citing works
Efficacy of COVID-19 Treatments: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
Zhang, C., Jin, H., Wen, Y. F., & Yin, G. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.729559 · Cited by 44 · see citing works
Hermine, O., Xavier Mariette, A., Porcher, R., Resche‐Rigon, M., Tharaux, P., & Ravaud, P. (2022) · European Respiratory Journal · doi:10.1183/13993003.02523-2021 · Cited by 40 · see citing works
Self-citationThe AI-Assisted Identification and Clinical Efficacy of Baricitinib in the Treatment of COVID-19
Richardson, P. J., Robinson, B. W. S., Smith, D. P., & Stebbing, J. (2022) · Vaccines · doi:10.3390/vaccines10060951 · Cited by 43 · see citing works
2021 update of the EULAR points to consider on the use of immunomodulatory therapies in COVID-19
Alunno, A., Najm, A., Machado, P., Bertheussen, H., Burmester, G. R., Carubbi, F., Marco, G. D., Giacomelli, R., Hermine, O., Isaacs, J. D., et al. (2021) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-221366 · Cited by 38 · see citing works
Self-citationStrohl, W. R., Ku, Z., An, Z., Carroll, S. F., Keyt, B. A., & Strohl, L. M. (2022) · BioDrugs · doi:10.1007/s40259-022-00529-7 · Cited by 34 · see citing works
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Girolamo, F. G. D., Fiotti, N., Sisto, U. G., Nunnari, A., Colla, S., Mearelli, F., Vinci, P., Schincariol, P., & Biolo, G. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.865402 · Cited by 41 · see citing works
Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway
Dritsoula, A., Dowsett, L., Pilotti, C., O’Connor, M. N., Moss, S. E., & Greenwood, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-08516-2 · Cited by 35 · see citing works
Zeraatkar, D., Cusano, E., Martinez, J. P. D., Qasim, A., Mangala, S., Kum, E., Bartoszko, J. J., Devji, T., Agoritsas, T., Guyatt, G. H., et al. (2022) · BMJ Medicine · doi:10.1136/bmjmed-2021-000036 · Cited by 34 · see citing works
Colás-Algora, N., Muñoz-Pinillos, P., Cacho-Navas, C., Ortiz, J. A., de Rivas, G., Barroso, S., López‐Collazo, E., & Millán, J. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319695 · Cited by 32 · see citing works
Transcriptional response modules characterize IL-1β and IL-6 activity in COVID-19
Bell, L. C. K., Meydan, C., Kim, J., Foox, J., Butler, D., Mason, C. E., Shapira, S. D., Noursadeghi, M., & Pollara, G. (2020) · iScience · doi:10.1016/j.isci.2020.101896 · Cited by 33 · see citing works
Dey, A., Vaishak, K., Deka, D., Radhakrishnan, A., Paul, S., Shanmugam, P., Selvabai, R. A. P., Pathak, S., Duttaroy, A. K., & Banerjee, A. (2023) · Infection · doi:10.1007/s15010-023-02017-8 · Cited by 33 · see citing works
Latreille, E., & Lee, W. L. (2021) · Viruses · doi:10.3390/v13020161 · Cited by 30 · see citing works
Bowel ischemia in COVID‐19: A systematic review
Patel, S., Parikh, C., Verma, D., Sundararajan, R., Agrawal, U., Bheemisetty, N., Akku, R., Sánchez‐Velazco, D., & Waleed, M. S. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14930 · Cited by 31 · see citing works
Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics
Kumar, S., Çalışkan, D. M., Janowski, J., Faist, A., Conrad, B. C. G., Lange, J., Ludwig, S., & Brunotte, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.752227 · Cited by 28 · see citing works
Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 Pneumonia
Shakaroun, D., Lazar, M. H., Horowitz, J. C., & Jennings, J. H. (2022) · Journal of Intensive Care Medicine · doi:10.1177/08850666221113252 · Cited by 28 · see citing works
Bruse, N., Motos, A., van Amstel, R. B. E., Bie, E. M. D. D. D., Kooistra, E. J., Jansen, A., van Lier, D. P. T., Kennedy, J. N., Schwarzkopf, D., Thomas-Rüddel, D. O., et al. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07593-3 · Cited by 26 · see citing works
Hermine, O., Xavier Mariette, A., Porcher, R., Djossou, F., Nguyen, Y., Arlet, J., Savale, L., Diehl, J., Georgin‐Lavialle, S., Cadranel, J. L., et al. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101362 · Cited by 25 · see citing works
Self-citationAkinosoglou, K., Kotsaki, A., Gounaridi, M. I., Christaki, E., Metallidis, S., Adamis, G., Fragkou, A., Fantoni, M., Rapti, A., Kalomenidis, I., et al. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101785 · Cited by 24 · see citing works
Gupta, S., Padappayil, R. P., Bansal, A., Daouk, S., & Brown, B. R. (2021) · Journal of Investigative Medicine · doi:10.1136/jim-2021-002001 · Cited by 24 · see citing works
da Silva, K. N., Gobatto, A. L. N., Costa‐Ferro, Z. S. M., Cavalcante, B. R. R., Caria, A. C. I., França, L. S. D. A., Nonaka, C. K. V., Lima, F. D. M., Lopes‐Pacheco, M., Rocco, P. R. M., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02502-7 · Cited by 22 · see citing works
Zielińska, A., Eder, P., Karczewski, J., Szalata, M., Hryhorowicz, S., Wielgus, K., Szalata, M., Dobrowolska, A., Atanasov, A. G., Słomski, R., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147991 · Cited by 21 · see citing works
COVID-19, what could sepsis, severe acute pancreatitis, gender differences, and aging teach us?
Gallo, C. G., Fiorino, S., Posabella, G., Antonacci, D., Tropeano, A., Pausini, E., Pausini, C., Guarniero, T., Hong, W., Giampieri, E., et al. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155628 · Cited by 17 · see citing works
Immunomodulatory therapies for COVID-19
Mathur, P., & Kottilil, S. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.921452 · Cited by 17 · see citing works
Tocilizumab in patients with COVID-19: which patient, time, and dose?
Hasanin, A. M., & Mostafa, M. M. A. (2021) · Journal of Anesthesia · doi:10.1007/s00540-021-02974-0 · Cited by 15 · see citing works
Fuja, C., Kothary, V., Carll, T. C., Singh, S., Mansfield, P., & Wool, G. D. (2022) · Transfusion · doi:10.1111/trf.16932 · Cited by 14 · see citing works
Gil-Manso, S., Alonso, R., Catalán, P., Sánchez-Arcilla, I., Marzola, M., Correa‐Rocha, R., Pion, M., Muñóz, P., & Gregorio Marañón Microbiology-ID COVID-19 Study Group (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1035155 · Cited by 13 · see citing works
Temesgen, Z., Kelley, C. F., Cerasoli, F., Kilcoyne, A., Chappell, D. B., Durrant, C., Ahmed, O., Chappell, G., Catterson, V. M., Polk, C. M., et al. (2022) · Thorax · doi:10.1136/thoraxjnl-2022-218744 · Cited by 12 · see citing works
Lescure, F.-X., Honda, H., Fowler, R., Lazar, J. S., Shi, G., Wung, P. K., Patel, N. R., & HAGINO, O. R. (2021) · medRxiv · doi:10.1101/2021.02.01.21250769 · Cited by 13 · see citing works
Camon, A. M., Alonso, R., Muñoz, F. J. T., Cardozo, C., Bernal-Maurandi, J., Albiach, L., Agüero, D. L., Marcos, M. Á., Ambrosioni, J., Bodro, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08882-x · Cited by 12 · see citing works
Alunno, A., Najm, A., Xavier Mariette, A., Marco, G. D., Emmel, J., Mason, L., McGonagle, D., & Machado, P. (2021) · RMD Open · doi:10.1136/rmdopen-2021-001899 · Cited by 11 · see citing works
Role of cytokine storm in coronavirus infections: culprit or accomplice?
Xu, R., Liu, C., Xu, X., Hu, Y., Zhu, B., & Yang, C. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2703102 · Cited by 10 · see citing works
Masso-Silva, J. A., Sakoulas, G., Olay, J., Groysberg, V. M., Geriak, M., Nizet, V., Alexander, L. E. C., & Meier, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.993720 · Cited by 10 · see citing works
Walczak, P., & Janowski, M. (2021) · Global Challenges · doi:10.1002/gch2.202100004 · Cited by 9 · see citing works
Tocilizumab for COVID-19: A systematic review and meta-analysis of randomized controlled trials
Boppana, T. K., Mittal, S., Madan, K., Mohan, A., Hadda, V., & Guleria, R. (2022) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2022.2136 · Cited by 10 · see citing works
Maity, S., Santra, A., Hebbani, A. V., Pulakuntla, S., Chatterjee, A., Badri, K. R., & Reddy, V. D. (2023) · Gene · doi:10.1016/j.gene.2023.147612 · Cited by 9 · see citing works
Park, H., Lewis, C. M., Dadgar, N., Sherry, C., Evans, S., Ziobert, S., Omstead, A. N., Zaidi, A. H., Xiao, K., Ghosh, S., et al. (2024) · Surgical Oncology Insight · doi:10.1016/j.soi.2024.100045 · Cited by 9 · see citing works
Camelo, S., Latil, M., Agus, S., Dioh, W., Veillet, S., Lafont, R., & Dilda, P. J. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.2006579 · Cited by 9 · see citing works
Page, J. H., Londhe, A. A., Brooks, C. G., Zhang, J., Sprafka, J. M., Bennett, C., Braunlin, M., Brown, C., Charuworn, P., Cheng, A., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-055137 · Cited by 9 · see citing works
How We Have Treated Severe to Critically Ill Patients With Coronavirus Disease 2019 in Korea
Park, D. H., Kang, C. K., Choe, P. G., Kim, N. J., Park, W. B., & Oh, M. (2022) · Journal of Korean Medical Science · doi:10.3346/jkms.2022.37.e353 · Cited by 9 · see citing works
Wang, B., Li, D., Fiselier, A., Kovalchuk, I., & Kovalchuk, O. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18817 · Cited by 8 · see citing works
Ho, J., Mok, B. W.-Y., Campisi, L., Jordan, T. X., Yildiz, S., Parameswaran, S., Wayman, J. A., Gaudreault, N. N., Meekins, D. A., Indran, S. V., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.01.404483 · Cited by 8 · see citing works
Chauvin, C., Levillayer, L., Roumier, M., Nielly, H., Roth, C., Karnam, A., Bonam, S. R., Bourgarit, A., Dubost, C., Bousquet, A., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106124 · Cited by 7 · see citing works
COVID-19 Pneumonia and Cytokine Storm Syndrome
van de Veerdonk, F. L. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-59815-9_22 · Cited by 7 · see citing works
Chen, J., & Ostermann, M. (2022) · Critical Care Clinics · doi:10.1016/j.ccc.2022.02.002 · Cited by 10 · see citing works
COVID-19 subphenotypes at hospital admission are associated with mortality: a cross-sectional study
Dubowski, K., Braganza, G. T., Bozack, A. K., Colicino, E., DeFelice, N., McGuinn, L. A., Maru, D., & Lee, A. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2148733 · Cited by 7 · see citing works
Treatment options for patients with severe COVID-19
Morishita, M., & Hojo, M. (2023) · Global Health & Medicine · doi:10.35772/ghm.2023.01024 · Cited by 8 · see citing works
Saleh, M. N., Sharma, K., Shah, J., Karsan, F., Waweru, A., Musumbi, M., Shah, R., Sayed, S., Abayo, I., Karimi, N., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270594 · Cited by 7 · see citing works
Shanthikumar, S., Gubbels, L., Davies, K., Walker, H., Wong, A. T. C., Levi, E., Saffery, R., Ranganathan, S., & Neeland, M. R. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.12.008 · Cited by 5 · see citing works
Barry, K., Fernández-García, S., Khashaba, A., Ruiz‐Calvo, G., Redín, M. R., Mahmoud, G., Yap, M., King, Y., Zhou, D., Mamey, M., et al. (2025) · BMJ Global Health · doi:10.1136/bmjgh-2024-015815 · Cited by 5 · see citing works
Nosocomial Infections in COVID-19 Patients Treated with Immunomodulators: A Narrative Review
Ramasamy, C., Narayan, G., Mishra, A. K., John, K., & Lal, A. (2022) · Frontiers in Bioscience-Scholar · doi:10.31083/j.fbs1404026 · Cited by 5 · see citing works
The COVID-19 Pandemic and Adult Cardiac Transplantation: Impact, Interventions, and Implications
Chih, S., Clarke, B. A., Albert, M., Buchan, C. A., Kafil, T. S., Kim, D. H., Kumar, D., Smith, S. J., Solera, J. T., Stubbs, M. J., et al. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.03.014 · Cited by 5 · see citing works
Negi, V., Gavlock, D. C., Miedel, M. T., Lee, J. K., Shun, T., Gough, A., Vernetti, L. A., Stern, A. M., Taylor, D. L., & Yechoor, V. K. (2023) · Lab on a Chip · doi:10.1039/d3lc00285c · Cited by 5 · see citing works
Jiang, W., Li, W., Wu, Q., Han, Y., Zhang, J., Luo, T., Guo, Y., Yang, Y., Zhu, P., & Xia, X. (2021) · Infectious Diseases and Therapy · doi:10.1007/s40121-021-00483-x · Cited by 5 · see citing works
Andaluz‐Ojeda, D., Vidal, P., Sanz, Á. A., Suberviola, B., Carbajo, L. D. R., Martín, L. N., Silva, E. P., Olmo, J. N.-D., Barberán, J., & Cusácovich, I. (2022) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v11.i4.269 · Cited by 5 · see citing works
Real-Life Use of Tocilizumab in the Treatment of Severe COVID-19 Pneumonia
Alex, R., Gulam, S. M., & Kumar, K. (2022) · Advances in Virology · doi:10.1155/2022/7060466 · Cited by 4 · see citing works
Cheok, K. P. L., Kirkwood, A. A., Creasey, T., Tholouli, E., Chaganti, S., Mathew, A., Dulobdas, V., Irvine, D. A., Besley, C., Neil, L., et al. (2023) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2023.2248329 · Cited by 4 · see citing works
Interleukin-6 blocking therapy for COVID-19: From immune pathogenesis to clinical outcomes
Xiao, F., Wu, L., Zhu, X., Zhang, L., Liu, D. J., Wu, L., Zou, H., & Lu, L. (2022) · Rheumatology and Immunology Research · doi:10.2478/rir-2022-0002 · Cited by 4 · see citing works
COVID-19: individual and herd immunity
Bach, J., Berche, P., Chatenoud, L., Costagliola, D. G., & Valleron, A. (2021) · Comptes Rendus Biologies · doi:10.5802/crbiol.41 · Cited by 4 · see citing works
Mazzotta, E. A., Fiorda‐Diaz, J., Echeverria-Villalobos, M., Eisinger, G. J., Sprauer, S., Singha, A., & Lyaker, M. R. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1053012 · Cited by 4 · see citing works
Mussini, C., Cozzi‐Lepri, A., Meschiari, M., Franceschini, E., Burastero, G. J., Faltoni, M., Franceschi, G., Iadisernia, V., Volpi, S., Dessilani, A., et al. (2023) · Viruses · doi:10.3390/v15020294 · Cited by 4 · see citing works
Drug repurposing for respiratory infections
Israr, J., Alam, S., & Kumar, A. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.03.033 · Cited by 3 · see citing works
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity 2258066
Slowikowski, K., Sen, P., Cosgriff, C. V., Tantivit, J., Eisenhaure, T., LaSalle, T. J., Manakongtreecheep, K., Tirard, A. J., Arnold, B. Y., Pacheco-Navarro, A. E., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag141.533 · Cited by 3 · see citing works
Skarbinski, J., Fischer, H. J., Hong, V. X., Liu, L., Yau, V., Incerti, D., Qian, L., Ackerson, B. K., Amsden, L. B., Shaw, S. F., et al. (2023) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3020 · Cited by 3 · see citing works
Miller, G. M., Ellis, J. A., Sarangarajan, R., Parikh, A., Rodrigues, L. O., Bruce, C., Chand, N. M., Smith, S. R., Richardson, K., Vazquez, R., et al. (2022) · Drugs - Real World Outcomes · doi:10.1007/s40801-022-00303-9 · Cited by 3 · see citing works
Early Multidrug Treatment of SARS-Cov-2 (COVID-19) and Decreased Case Fatality Rates in Honduras
Ontai, S. C., Zeng, L., Hoffman, M. S., Pascua, F. V., VanBuren, V., & McCullough, P. A. (2022) · Epidemiology International Journal · doi:10.23880/eij-16000217 · Cited by 3 · see citing works
Application of LRG mechanism in normal pressure hydrocephalus
Ma, L., Wang, W., Zhao, Y., Liu, M., Ye, W., & Li, X. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23940 · Cited by 3 · see citing works
Elik, D. B., Kaya, Ş., Alkan, S., Demırdal, T., Şener, A., Kaya, S., Tunçcan, Ö. G., Kayaaslan, B., Güner, R., Eser, F., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-55886-w · Cited by 5 · see citing works
Calderón-Ochoa, C., Plamenov-Donchev, N., Hernández-Quiñones, F., Mendoza-López, O., Hinojos-Gallardo, L. C., Longino-Gómez, A. J., Hernández-Saldaña, R., Duque-Rodríguez, J., & Ishida-Gutiérrez, M. C. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.02498-23 · Cited by 3 · see citing works
Tocilizumab, blood cells, and mild COVID-19: delayed vascular protection by interleukin blockade?
Buryachkovskaya, L. I., Lomakin, N. V., Melkumyants, A. M., Docenko, J., & Serebruany, V. L. (2021) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvab051 · Cited by 3 · see citing works
Drugs repurposing for SARS-CoV-2: new insight of COVID-19 druggability
Debnath, S. K., Debnath, M., Srivastava, R., & Omri, A. (2022) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2022.2082944 · Cited by 3 · see citing works
Muravyeva, N., & Belov, B. (2022) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2022-16-11-88-94
The use of tocilizumab in severe COVID-19: A comprehensive review
Milošević, I., & Beronja, B. (2024) · Medicinska istrazivanja · doi:10.5937/medi57-48405 · Cited by 2 · see citing works
Ouali, C. O., Ladjouzi, N., Tamas, K., Raveloson, H., Hassen, J. B., Omeiri, N. E., Zouloumis, G., Zoabi, M. M. A., Asadi, M., Jhouri, A., et al. (2022) · Geriatrics · doi:10.3390/geriatrics7010022 · Cited by 2 · see citing works
Mettananda, C. D., Peiris, C., Abeyrathna, D., Gunasekara, A., Egodage, T., Dantanarayana, C., Pathmeswaran, A., & Ranasinha, C. D. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-075803 · Cited by 2 · see citing works
Tocilizumab in COVID-19 management: addressing time of starting treatment
Khiali, S., & Entezari‐Maleki, T. (2022) · European Journal of Hospital Pharmacy · doi:10.1136/ejhpharm-2021-003149 · Cited by 2 · see citing works
Lenoir, O., Morin, F., Walter‐Petrich, A., Resmini, L., Zaidan, M., Mahtal, N., Ferlicot, S., Puelles, V. G., Wanner, N., Dang, J., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.198244 · Cited by 1 · see citing works
Self-citationPharmacotherapy for COVID-19: A Ray of Hope
Kapoor, M., Panda, P. K., & Mohanty, V. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97012 · Cited by 1 · see citing works
Holroyd, K. B., Conway, S. E., Bhattacharyya, S., & Galetta, K. M. (2022) · Neuroimmunology Reports · doi:10.1016/j.nerep.2022.100061 · Cited by 1 · see citing works
A novel logical model of COVID-19 intracellular infection to support therapies development
Piretto, E., Selvaggio, G., Bragantini, D., Domenici, E., & Marchetti, L. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010443 · Cited by 1 · see citing works
Immunosuppressive drugs and their aerosol delivery for COVID-19 treatment
Kobylyansky, V. I. (2022) · Fundamental and Clinical Medicine · doi:10.23946/2500-0764-2022-7-3-74-84 · Cited by 1 · see citing works
Interventions reducing mortality in COVID-19 patients: a systematic review of randomized evidence
Maimeri, N., Marmiere, M., Losiggio, R., Nardelli, P., Redaelli, M. B., Fresilli, S., D’Amico, F., Zangrillo, A., Hajjar, L. A., & Landoni, G. (2023) · Minerva Medica · doi:10.23736/s0026-4806.23.08590-7 · Cited by 1 · see citing works
Tocilizumab in ICU-admitted COVID-19 Patients: A Retrospective Study
Siami, Z., Yaghoobi, M. H., & Karimi, P. (2023) · Medical Journal of the Islamic Republic of Iran · doi:10.47176/mjiri.37.92 · Cited by 1 · see citing works
A systematic review and meta-analysis of the safety of anti-interleukin therapy in COVID-19
Gomon, Y. М., Колбин, А. С., Strizheletsky, V. V., Ivanov, I., Sultanova, F. М., & Balykina, Y. Е. (2022) · Clinical Microbiology and Antimicrobial Chemotherapy · doi:10.36488/cmac.2022.2.93-107 · Cited by 1 · see citing works
“L’histoire se répète”, one size does not fit all
Kuindersma, M., & Spronk, P. E. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06483-2 · Cited by 1 · see citing works
La, J., Fillmore, N. R., Do, N., Brophy, M. T., Monach, P. A., & Branch‐Elliman, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1899144/v2 · Cited by 1 · see citing works
Tocilizumab in COVID-19: Is the Temptation Worthwhile?
Gupta, S., & Tomar, D. S. (2021) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-23750
COVID-19 TEDAVİSİNDE İLAÇ-İLAÇ ETKİLEŞİMLERİNİN FARMAKOKİNETİK AÇIDAN DEĞERLENDİRİLMESİ
COŞKUN, N., & Lalegül‐Ülker, Ö. (2021) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.881317
Tocilizumab and SARS-CoV-2 (COVID-19): An Evolving Story, the Picture Is Clearer
Bush, L. M., Williams, J., & Stutchin, E. (2021) · Infectious Diseases in Clinical Practice · doi:10.1097/ipc.0000000000001063
- Authors
- Mariette, X., Hermine, O., Tharaux, P.-L., Resche-Rigon, M., Steg, P. G., Porcher, R., & Ravaud, P.
- Affiliations
- Department of Rheumatology, Hôpital Bicêtre, Assistance Publique–Hôpitaux de Paris, Le Kremlin Bicêtre, France
- Hôpital Necker-Enfants Malades (FR)
- Inserm (FR)
- Université de Paris, ECSTRRA Team, Centre of Research Epidemiology and Statistics, INSERM UMR1153, Paris, France
- Department of cardiology, Hôpital Bichat, Assistance Publique–Hôpitaux de Paris, Paris, France
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2021-09-01
- Volume
- 181
- Issue
- 9
- Pages
- 1241
- ISSN
- 2168-6106 (ISSN-L)
- PMC
- PMC8145157
- OpenAlex
- W3165791173
- Cited by
- 140
- References
- 7
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 15 · 2023: 31 · 2022: 50 · 2021: 31 · 2020: 5
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Internal Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Sanofi
- Amarin Corporation
- Agence Nationale de la Recherche (ANR-10-IAHU-0001)
- Fondation pour la Recherche Médicale
- Servier
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- tocilizumab, COVID-19 pandemic, C-reactive protein, survival, hospitalized patients, IL-6 receptor inhibition, cytokine storm
- MeSH terms
- COVID-19 Drug Treatment, Dose-Response Relationship, Drug, Follow-Up Studies, Humans, Intensive Care Units, Severity of Illness Index, Time Factors, Randomized Controlled Trials as Topic, Treatment Outcome, Antibodies, Monoclonal, Humanized
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