Effect of a Brief Mindfulness-Based Program on Stress in Health Care Professionals at a US Biomedical Research Hospital: A Randomized Clinical Trial
Open accessAbstract
Importance: Stress among health care professionals is well documented. The use of mindfulness-based interventions to reduce stress has shown promising results; however, the time commitment of typical programs can be a barrier to successful implementation in health care settings. Objective: To determine the efficacy and feasibility of a brief mindfulness-based program to reduce stress during work hours among health care professionals. Design, Setting, and Participants: This intent-to-treat randomized clinical trial was conducted among full-time health care professionals at the Clinical Center at the National Institutes of Health in Bethesda, Maryland, between September 2017 and May 2018. Participants were randomized to receive mindfulness-based self-care (MBSC) training or life-as-usual control. Data were analyzed from June 2018 to January 2020. Interventions: The MBSC intervention included 5 weekly, 1.5-hour in-class mindfulness practice sessions. Main Outcomes and Measures: Stress level was the primary outcome, assessed with the Perceived Stress Scale 10-Item version. Secondary outcomes included anxiety, burnout, positive and negative affect, mindfulness (trait and state), and self-care. Assessments were taken at baseline and at the end of the intervention (week 5) in the intervention and control groups, and at follow-up (week 13) in the intervention group to test for a maintenance effect. A postprogram evaluation was also obtained. Results: Of 82 randomized participants, 78 who completed the study at week 5 were included in the modified intent-to-treat analysis (median [interquartile range] age, 32 [23-48] years; 65 [83%] women), including 43 participants in the MBSC group and 35 participants in the control group. At the end of the intervention, compared with the control group, the MBSC group had reduced levels of stress (mean [SD] score, 17.29 [5.84] vs 18.54 [6.30]; P = .02) and anxiety (mean [SD] score, 2.58 [1.52] vs 4.23 [1.73]; P < .001), and improved positive affect (mean [SD] score, 35.69 [7.12] vs 31.42 [7.27]; P < .001), state mindfulness (mean [SD] score, 3.74 [1.18] vs 2.78 [1.16]; P < .001), and mindful self-care (mean [SD] score, 7.29 [2.44] vs 5.54 [2.77]; P < .001). Burnout, negative affect, and trait mindfulness levels did not differ between groups. Changes within the MBSC group through follow-up included sustained reductions in stress (change, -6.14; 95% CI, -7.84 to -4.44; P < .001), anxiety (change, -1.46; 95% CI, -1.97 to -0.94; P < .001), trait mindfulness (change, 0.63; 95% CI, 0.36 to 0.90; P < .001), and state mindfulness (change, 1.89; 95% CI, 1.39 to 2.39; P < .001). Conclusions and Relevance: This randomized clinical trial found that this brief mindfulness-based intervention was an effective and feasible means to reduce stress in health care professionals. Larger studies are needed to assess the effects on clinical care and patient outcomes. Trial Registration: ClinicalTrials.gov Identifier: NCT03781336.
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Brief mindfulness interventions lasting fewer than 8 weeks and with shorter daily practice recommendations are becoming more common to increase accessibility and scalability.
“Brief mindfulness interventions lasting fewer than 8 weeks and with shorter daily practice recommendations are becoming more common to increase accessibility and scalability of mindfulness interventions. 11”
From Are Formal and Informal Home Mindfulness Practice Quantities Associated With Outcomes? Results From a Pilot Study of a Four-Week Mindfulness Intervention for Chronic Pain Management. (2024) · cites this paper as [11]
The Introduction (page unavailable) says abbreviated mindfulness interventions have been introduced because the time and cost of standard 8-week programs limit their use. The Methods describe this paper’s shorter, five-session program. Our copy does not establish that such programs are becoming more common or that they recommend shorter daily practice: it says daily practice was encouraged but gives no duration. (LLM, conf=0.86)
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Quintao, G., Leite, N. C. T., Pang, N. T. P., Koh, E. B. Y., Woo, J. M., Sabri, M. A. R., Wan, K. M., Hadi, N. M. N., Tan, M. G., Kamu, A., et al. (2025) · Discover Mental Health · doi:10.1007/s44192-025-00253-y · Cited by 3 · see citing works
The Role of Mindfulness Therapy in the Treatment of Chronic Pain
Biao, D., Umoh, K., Qiguang, C., Xiaole, W., Ting, F., Yuqian, Y., Jinchao, Z., & Fushui, L. (2024) · Current Pain and Headache Reports · doi:10.1007/s11916-024-01284-w · Cited by 3 · see citing works
Mindfulness–based positive transformative leadership development for health organisations
Paul, D. (2022) · Leadership in Health Services · doi:10.1108/lhs-04-2022-0044 · Cited by 2 · see citing works
Murphy, K. M., Tucker, M., Cataldo, L., Sergeant, S., Kuklinski, B., Billings, J., & Jancsy, K. (2025) · Journal of Acute Care Physical Therapy · doi:10.1097/jat.0000000000000252 · Cited by 3 · see citing works
Chen, X., Du, A., Yu, M., Zhang, C., Zhu, X., Cao, Y., Hua, L., & Cao, X. (2025) · BMC Nursing · doi:10.1186/s12912-025-03478-y · Cited by 3 · see citing works
“For example, studies have revealed that mindfulness interventions can reduce nurses’ anxiety levels by more than 30%, reduce the incidence of depression by 40% and significantly improve mental health [9, 10].”
Steinberg, B. A., Mulugeta, Y., Quatman‐Yates, C. C., Williams, M., Gogineni, A., & Klatt, M. D. (2025) · International Journal of Mental Health Promotion · doi:10.32604/ijmhp.2025.067232 · Cited by 3 · see citing works
“For example, workplace MBIs have been shown to improve psychological symptoms and physical manifestations of stress in nurses, physicians, and other inter-professional health care providers [33–37].”
Promoting Well‐Being Among Gastroenterologists – A Call for Systemic Action
Zimmermann, K., Rodríguez–Lago, I., Sidhu, R., Heinrich, H. S., Sousa, P., Dieninytė, E., Duijvestein, M., Hann, A., Gemilyan, M., Knüttel, H., et al. (2025) · United European Gastroenterology Journal · doi:10.1002/ueg2.70149 · Cited by 3 · see citing works
“Mindfulness‐based interventions have also been found to effectively reduce stress and burnout in healthcare providers, [80, 106] even in the absence of psychologist involvement.”
Zhu, L., Xie, Y.-H., Tan, H., Wang, L., Zhou, R.-Y., Xiao, Y.-N., Liu, C. X., Peng, L.-J., Yang, X.-L., Qu, Y.-J., et al. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104418 · Cited by 2 · see citing works
Chen, A. M. (2025) · Journal of Healthcare Risk Management · doi:10.1002/jhrm.70005 · Cited by 2 · see citing works
Feasibility of a Mindfulness Education Module for Nurses: An Evidence-Based Practice Project
Looper, E. M., Gleason, P., Newnam, K. M., Talbott, E., & Rouch, T. M. (2023) · The Journal of Continuing Education in Nursing · doi:10.3928/00220124-20230918-02 · Cited by 1 · see citing works
Brotto, L. A., Basson, R. J., Grabovac, A. D., Chivers, M. L., Zdaniuk, B., Bodnar, T. S., & Weinberg, J. (2024) · Journal of Behavioral Medicine · doi:10.1007/s10865-024-00491-5 · Cited by 1 · see citing works
“Mindfulness-based interventions have been consistently shown to decrease self-reported stress, in both clinical and non-clinical populations (Ameli et al., 2020; Baer et al., 2012).”
White, P., Williams, R., & Harrington, J. (2024) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000717 · Cited by 1 · see citing works
Özçelik, A. G., Yılmaz, Z. U., Tural, E., & Dayan, A. (2025) · Discover Psychology · doi:10.1007/s44202-025-00394-9 · Cited by 1 · see citing works
“An increase in mindfulness also enhances empathy and compassion in physicians, contributing to better patient satisfaction, error recognition, and clinical insight, thereby improving the quality of care [25, 26].”
Cook-Cottone, C., Hotchkiss, J. T., Guyker, W., & Wong, M. (2025) · Mindfulness · doi:10.1007/s12671-025-02670-0
“…chaplains, healthcare workers, medical residents, refugee service providers, hospice workers, nurses, and individuals with eating disorders (Ameli et al., 2020; Cook-Cottone et al., 2024; Depner et al., 2021; Halady & Cook-Cottone, 2023; Hotchkiss, 2018; Hotchkiss & Lesher, 2018; Loi &…”
Sullins, V. F., Gonzales, P. A., Malotte, M., & Lebares, C. C. (2025) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2025.08.004 · Cited by 1 · see citing works
Queirolo, L., Boscolo, A., Tommaso, C., Otello, M., Facco, E., Zanette, G., Stellini, E., & Navalesi, P. (2026) · Scientific Reports · doi:10.1038/s41598-026-40770-6 · Cited by 1 · see citing works
Síndrome de Burnout em profissionais da área da saúde: uma revisão integrativa da literatura
Tibola, A. J., Zardo, A., de Souza, A. P., Borille, D. C., Pinculini, A. P. G., & Amaral, R. F. (2023) · Research Society and Development · doi:10.33448/rsd-v12i1.39797 · Cited by 1 · see citing works
Hemşirelerin Bilinçli Farkındalık Düzeyleri / Mindfulness Levels of Nurses
Ünsar, S., GENÇ, A., ÖZDEMİR, Ö., & KARAKOÇ, K. (2023) · Turk Nefroloji Diyaliz ve Transplantasyon Hemsireleri Dernegi · doi:10.47565/ndthdt.2023.70 · Cited by 1 · see citing works
Tang, M. J., Ann‐Yi, S., Zhukovsky, D. S., Fellman, B. M., & Bruera, E. D. (2023) · Palliative & Supportive Care · doi:10.1017/s1478951523001803 · Cited by 1 · see citing works
Organizational Vs Individual Efforts to Help Manage Stress and Burnout in Healthcare Professionals
Rosenstein, A. H. (2021) · Nursing and Health Care · doi:10.33805/2573.3877.155 · Cited by 1 · see citing works
Meditation and the Inner Life of Today’s Educator
Nicklasson, S. (2021) · doi:10.33015/dominican.edu/2021.edu.13 · Cited by 1 · see citing works
“There are numerous health benefits of meditation including reduced levels of stress and emotional regulation (Ameli et al., 2020), overall physical health and increased immunity (Barrett et al., 2018), and overall emotional wellness (Emerson et al., 2017).”
BackgroundYıldırım, D., Yıldız, C. Ç., & Özdoğan, M. H. (2023) · Research Square · doi:10.21203/rs.3.rs-2541370/v1 · Cited by 1 · see citing works
Correction of professional burnout of health workers in the process of mindfulness-based training
Popova, K., & Kuzmin, M. Y. (2024) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2024-9.4.18 · Cited by 1 · see citing works
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Tavakoli, A., Patterson, M., Atkinson, J., & Saarinen, H. (2023) · Springer eBooks · doi:10.1007/978-3-031-16983-0_5
Effectiveness of Mindfulness-Based Intervention (MBI) on Reducing Work Stress
Safitri, A. D., & Yudiarso, A. (2023) · Psikostudia Jurnal Psikologi · doi:10.30872/psikostudia.v12i3.11159
Burnout during the COVID-19 pandemic: Modulating role of mindfulness
Sampei, M., & Morisaki, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95650-5.00036-7
Sustainable Business – A Study on Employee Mindfulness in the Healthcare Sector
Narayan, U., Urs, G. B., Kalahasthi, P., & Payal, S. (2025) · Cureus Journal of Business and Economics · doi:10.7759/s44404-025-04055-x
“A study by (Ameli et al., 2020) assessed the impact of a 7.5-hour mindfulness training conducted during work hours for clinicians and healthcare staff.”
InfluentialCandido, E. D., & Kraychete, D. C. (2025) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2025.844638
Bagereka, P., Ameli, R., Sinaii, N., Vocci, M. C., Coulter, A. M., Neustedter, M., & Berger, A. M. (2025) · PeerJ · doi:10.7717/peerj.19109
“…to reduce work-related stress, anxiety, and burnout while improving measures of wellbeing including job satisfaction, empathy, and fulfillment ( Ameli et al., 2020 ; Chmielewski, Łoś & Łuczyński, 2021 ; Ghawadra et al., 2020 ; Goldhagen et al., 2015 ; Green & Kinchen, 2021 ; Krasner et al.,…”
InfluentialSelf-citationForoughi, P., Manshaee, G., & Pour, S. H. A. (2024) · Journal of Psychological Science · doi:10.61186/jps.23.142.279
Transforming Primary Care: Innovative Post Graduate PA Training for Real-World Solutions
Botelho, K., & Ali, J. (2025) · Lynchburg Journal of Medical Science · doi:10.63932/3067-7106.1040
A prática da meditação na prevenção do Burnout em profissionais de saúde: Uma revisão integrativa
Silva, J. B. M. E., Canga, B. D. G., Nunes, R. G. R., Pereira, A. C. D., Marques, D. F., & Pereira, S. A. P. (2025) · Research Society and Development · doi:10.33448/rsd-v14i8.49316
Huang, X., Hou, G., Li, H., Zhu, Y., Yin, T., Zhang, N., Liu, H., Yang, Y., Bai, L., Ban, W., et al. (2025) · Neurology and Therapy · doi:10.1007/s40120-025-00816-9
Izquierdo, W. D. C., Ordoñez, S. B., Chávez, M. A. L., & Zavaleta, M. R. M. (2025) · SAP Nursing Depths Series · doi:10.56294/nds2025229
Deckelbaum, L., Guarascio, N., Bastien, M.-P., Cloutier, A., Kondyli, M., Latour, M.-P., Rondeau, É., & Sultan, S. (2025) · Current Oncology · doi:10.3390/curroncol32110632
“This idea is supported by evidence indicating that calm provider behavior is linked to improved patient well-being [75], reduced provider stress is associated with higher patient satisfaction [76], and provider stress levels correlated with patient distress [77].”
Lheureux, F., Jollivet, M., Chiron, J., Poulet, S., Fournier, A., Capellier, G., Bodet-Contentin, L., Hérault, A., Hamam, J., Beuret, P., et al. (2025) · Annals of Intensive Care · doi:10.1186/s13613-025-01572-7
“Many authors agree in saying that s y stematically identifying stress and sources of stress within teams would make it possible to intervene more effectively with healthcare staff and prevent the consequences, such as professional burnout [6, 33, 34].”
Southwick, L., Gonzales, R. E., Bellini, L. M., Asch, D. A., Mitra, N., Balachandran, M., Wolk, C. B., Becker‐Haimes, E. M., Kishton, R. E., Beck, S., et al. (2025) · JMIR Formative Research · doi:10.2196/74086
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Vivas, V. B., & Madregón, J. E. A. (2025) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2025.07.005
Queirolo, L., Annalisa, B., Tommaso, C., Otello, M., Facco, E., Zanette, G., Stellini, E., & Navalesi, P. (2026) · Research Square · doi:10.21203/rs.3.rs-8555017/v1
The BIG Moment in Critical Care
Murphy, T., Thakral, M., Lincoln, N. M., & Brooke, W. (2026) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000780
Well-Being in GME: Finding Meaning in Medicine
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“Each question is scored on a five-point Likert scale ranging from 0 (never) to 4 (very often), generating total scores between 0 and 40, with higher scores indicating greater perceived stress [15,17].”
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Mindfulness-Based Interventions in Pediatric Surgical Nursing: A Review of Evidence and Practice
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“Studies have shown promising associations between the use of MBIs and improvements in patient-reported satisfaction and a lower incidence of medical errors (Ameli et al., 2020).”
Togo, E. (2026) · Biomedical Engineering and Computational Biology · doi:10.1177/11795972261452228
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“12 27 34–36 Our findings suggest a pragmatic ‘minimum effective dose’: self-directed, online modules alone or a single discussion alone were insufficient, whereas their combination produced sustained gains in mindfulness.”
Supervisors in Residential Care for Older Adults, Compassion Fatigue, and Leadership Self-Efficacy
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Workplace Mental Health Programs for Healthcare Workers: A Systematic Review
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“Mindfulness-based interventions have been proven beneficial for fostering healthier lifestyle patterns and improving psychological wellbeing (5, 6).”
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- Authors
- Ameli, R., Sinaii, N., West, C. P., Luna, M. J., Panahi, S., Zoosman, M., Rusch, H. L., & Berger, A.
- Affiliations
- National Institutes of Health (US)
- Mayo Clinic (US)
- Northwestern University (US)
- Corresponding author
- Ameli, Rezvan
- ORCID
- Venue
- JAMA Network Open
- Publisher
- American Medical Association (AMA)
- Published
- 2020-08-25
- Volume
- 3
- Issue
- 8
- Pages
- e2013424
- ISSN
- 2574-3805 (ISSN-L)
- PMC
- PMC7448827
- OpenAlex
- W3080562843
- Cited by
- 94
- References
- 61
- Citations by year
- 2026: 20 · 2025: 27 · 2024: 13 · 2023: 18 · 2022: 6 · 2021: 10
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JAMA Network Open (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Health Professions › General Health Professions › Healthcare professionals’ stress and burnout
- Social Sciences › Psychology › Social Psychology › Stress and Burnout Research
- Keywords
- occupational stress, healthcare workers, burnout, anxiety, positive affect, negative affect, trait mindfulness, state mindfulness, brief mindfulness intervention, intervention feasibility, maintenance effects, self-care, Perceived Stress Scale, work stress reduction, cost-effectiveness
- MeSH terms
- Academies and Institutes, Occupational Stress, Adult, Anxiety, Feasibility Studies, Female, Health Personnel, Hospitals, Humans, Male, Maryland, Middle Aged, Research Personnel, Young Adult, Mindfulness
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