Projected estimates of opioid mortality after community-level interventions.
Open accessAbstract
Importance: The United States is experiencing a crisis of opioid overdose. In response, the US Department of Health and Human Services has defined a goal to reduce overdose mortality by 40% by 2022. Objective: To identify specific combinations of 3 interventions (initiating more people to medications for opioid use disorder [MOUD], increasing 6-month retention with MOUD, and increasing naloxone distribution) associated with at least a 40% reduction in opioid overdose in simulated populations. Design, Setting, and Participants: This decision analytical model used a dynamic population-level state-transition model to project outcomes over a 2-year horizon. Each intervention scenario was compared with the counterfactual of no intervention in simulated urban and rural communities in Massachusetts. Simulation modeling was used to determine the associations of community-level interventions with opioid overdose rates. The 3 examined interventions were initiation of more people to MOUD, increasing individuals' retention with MOUD, and increasing distribution of naloxone. Data were analyzed from July to November 2020. Main Outcomes and Measures: Reduction in overdose mortality, medication treatment capacity needs, and naloxone needs. Results: No single intervention was associated with a 40% reduction in overdose mortality in the simulated communities. Reaching this goal required use of MOUD and naloxone. Achieving a 40% reduction required that 10% to 15% of the estimated OUD population not already receiving MOUD initiate MOUD every month, with 45% to 60%% retention for at least 6 months, and increased naloxone distribution. In all feasible settings and scenarios, attaining a 40% reduction in overdose mortality required that in every month, at least 10% of the population with OUD who were not currently receiving treatment initiate an MOUD. Conclusions and Relevance: In this modeling study, only communities with increased capacity for treating with MOUD and increased MOUD retention experienced a 40% decrease in overdose mortality. These findings could provide a framework for developing community-level interventions to reduce opioid overdose death.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sordo, L., Barrio, G., Bravo, M. J., Indave, B. I., Degenhardt, L., Wiessing, L., Ferri, M., & Pastor-Barriuso, R. (2017) · BMJ · doi:10.1136/bmj.j1550 · Cited by 1,816 · cited 1× · see citing works
“In simulated calendar year 2020, we adjusted parameters to estimate the outcomes associated with implementing 3 strategies to prevent opioid misuse and overdose: (1) initiate more people to MOUD, (2) improve 6-month retention with MOUD, and (3) increase distribution of naloxone to the community.”
Drug Overdose Deaths in the United States, 1999–2020
Hedegaard, H., Miniño, A., Spencer, M. R., & Warner, M. (2021) · doi:10.15620/cdc:112340 · Cited by 1,283 · see citing works
Larochelle, M. R., Bernson, D., Land, T., Stopka, T. J., Wang, N., Xuan, Z., Bagley, S. M., Liebschutz, J. M., & Walley, A. Y. (2018) · Annals of Internal Medicine · doi:10.7326/m17-3107 · Cited by 1,076 · see citing works
Walley, A. Y., Xuan, Z., Hackman, H. H., Quinn, E., Doe-Simkins, M., Sorensen-Alawad, A., Ruiz, S., & Ozonoff, A. (2013) · BMJ · doi:10.1136/bmj.f174 · Cited by 999 · see citing works
Comparative effectiveness of different treatment pathways for opioid use disorder.
Wakeman, S. E., Larochelle, M. R., Ameli, O., Chaisson, C. E., McPheeters, J. T., Crown, W. H., Azocar, F., & Sanghavi, D. M. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.20622 · Cited by 995 · see citing works
Contingency management for treatment of substance use disorders: a meta‐analysis
Prendergast, M., Podus, D., Finney, J., Greenwell, L., & Roll, J. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01581.x · Cited by 877 · see citing works
Lee, J. D., Nunes, E. V., Novo, P., Bachrach, K., Bailey, G. L., Bhatt, S., Farkas, S., Fishman, M., Gauthier, P., Hodgkins, C. C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32812-x · Cited by 700 · see citing works
Massachusetts Department of Public Health
Gallagher, S. S., Guyer, B., Kotelchuck, M., Bass, J. L., Lovejoy, F. H., McLoughlin, E., & Mehta, K. A. (1982) · New England Journal of Medicine · doi:10.1056/nejm198210143071613 · Cited by 591 · see citing works
(2022) · doi:10.15620/cdc:122556 · Cited by 562 · see citing works
McDonald, R., & Strang, J. (2016) · Addiction · doi:10.1111/add.13326 · Cited by 472 · see citing works
Morgan, J. R., Schackman, B. R., Leff, J. A., Linas, B. P., & Walley, A. Y. (2018) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2017.07.001 · Cited by 332 · see citing works
Goedel, W. C., Shapiro, A. M., Cerdá, M., Tsai, J. W., Hadland, S. E., & Marshall, B. D. L. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.3711 · Cited by 298 · see citing works
Haffajee, R. L., Lin, L. A., Bohnert, A. S. B., & Goldstick, J. E. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.6373 · Cited by 266 · see citing works
Bird, S. M., McAuley, A., Perry, S., & Hunter, C. (2016) · Addiction · doi:10.1111/add.13265 · Cited by 248 · see citing works
Madras, B. K., Ahmad, N. J., Wen, J., Sharfstein, J., & Prevention, T. (2020) · NAM Perspectives · doi:10.31478/202004b · Cited by 241 · see citing works
Irvine, M. A., Kuo, M. E., Buxton, J. A., Balshaw, R. F., Otterstatter, M. C., MacDougall, L., Milloy, M., Bharmal, A., Henry, B., TYNDALL, M. W., et al. (2019) · Addiction · doi:10.1111/add.14664 · Cited by 233 · see citing works
Friedmann, P. D., Hoskinson, R. A., Gordon, M., Schwartz, R. P., Kinlock, T. W., Knight, K. K., Flynn, P. M., Welsh, W. N., Stein, L. A. R., Sacks, S., et al. (2012) · Substance Abuse · doi:10.1080/08897077.2011.611460 · Cited by 224 · see citing works
Davoli, M., Bargagli, A. M., Perucci, C. A., Schifano, P., Belleudi, V., Hickman, M., Salamina, G., Diecidue, R., Vigna‐Taglianti, F., Faggiano, F., et al. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02025.x · Cited by 220 · see citing works
Soyka, M., Zingg, C., Koller, G., & Küfner, H. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570700836x · Cited by 184 · see citing works
Shah, N. G., Galai, N., Celentano, D. D., Vlahov, D., & Strathdee, S. A. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.11.007 · Cited by 174 · see citing works
Distance traveled to outpatient drug treatment and client retention
Beardsley, K. C., Wish, E. D., Fitzelle, D. B., O’Grady, K. E., & Arria, A. M. (2003) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(03)00188-0 · Cited by 172 · see citing works
Barocas, J. A., White, L. F., Wang, J., Walley, A. Y., LaRochelle, M. R., Bernson, D., Land, T., Morgan, J. R., Samet, J. H., & Linas, B. P. (2018) · American Journal of Public Health · doi:10.2105/ajph.2018.304673 · Cited by 164 · see citing works
Transitions to Injecting Drug Use Among Noninjecting Heroin Users
Neaigus, A., Gyarmathy, V. A., Miller, M., Frajzyngier, V., Friedman, S. R., & Jarlais, D. C. D. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000186391.49205.3b · Cited by 162 · see citing works
Saxon, A. J., Ling, W. W., Hillhouse, M. P., Thomas, C., Hasson, A. L., Ang, A., Doraimani, G., Tasissa, G., Lokhnygina, Y. V., Leimberger, J., et al. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.08.002 · Cited by 120 · see citing works
Irvine, M. A., Buxton, J. A., Otterstatter, M. C., Balshaw, R. F., Gustafson, R., TYNDALL, M. W., Kendall, P., Kerr, T. H., Gilbert, M., & Coombs, D. (2018) · The Lancet Public Health · doi:10.1016/s2468-2667(18)30044-6 · Cited by 104 · see citing works
Sharp, A. R., Jones, A. T., Sherwood, J., Kutsa, O., Honermann, B., & Millett, G. A. (2018) · American Journal of Public Health · doi:10.2105/ajph.2018.304338 · Cited by 96 · see citing works
Parmar, M., Strang, J., Choo, L., Meade, A. M., & Bird, S. M. (2016) · Addiction · doi:10.1111/add.13668 · Cited by 79 · see citing works
Public sector low threshold office-based buprenorphine treatment: outcomes at year 7
Bhatraju, E. P., Grossman, E., Tofighi, B., McNeely, J., DiRocco, D., Flannery, M., Garment, A. R., Goldfeld, K. S., Gourevitch, M. N., & Lee, J. D. (2017) · Addiction Science & Clinical Practice · doi:10.1186/s13722-017-0072-2 · Cited by 64 · see citing works
Walley, A. Y., Lodi, S., Li, Y., Bernson, D., Babakhanlou‐Chase, H., Land, T. G., & Larochelle, M. R. (2020) · Addiction · doi:10.1111/add.14964 · Cited by 56 · see citing works
County‐level access to opioid use disorder medications in medicare Part D (2010‐2015)
Abraham, A. J., Adams, G. B., Bradford, A. C., & Bradford, W. D. (2019) · Health Services Research · doi:10.1111/1475-6773.13113 · Cited by 46 · see citing works
Nosyk, B., Li, L., Evans, E., Huang, D. Y. C., Min, J. E., Kerr, T. H., Brecht, M., & Hser, Y. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.03.029 · Cited by 33 · see citing works
Lin, L. A., & Knudsen, H. K. (2019) · The Annals of Family Medicine · doi:10.1370/afm.2384 · Cited by 24 · see citing works
Ling, W. W., Nadipelli, V. R., Ronquest, N. A., Albright, V. A., Aldridge, A., Learned, S. M., Mehra, V., & Heidbreder, C. A. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.11.015 · Cited by 20 · see citing works
Psychiatry and the Opioid Overdose Crisis
Madras, B. K., & Connery, H. S. (2019) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20190003 · Cited by 10 · see citing works
Commentary on Piske et al. (2020): Medication initiation is key to reduce deaths amid opioid crisis
Williams, A. R. (2020) · Addiction · doi:10.1111/add.15022 · Cited by 1 · see citing works
Flagged first, then by citations
7 of the 42 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Irvine, M. A., Oller, D., Boggis, J., Bishop, B., Coombs, D., Wheeler, E., Doe-Simkins, M., Walley, A. Y., Marshall, B. D. L., Bratberg, J., et al. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00304-2 · Cited by 127 · see citing works
Self-citationModeling the evolution of the US opioid crisis for national policy development
Lim, T. Y., Stringfellow, E. J., Stafford, C. A., DiGennaro, C., Homer, J. B., Wakeland, W. W., Eggers, S. L., Kazemi, R., Glos, L. J., Ewing, E. G., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115714119 · Cited by 89 · see citing works
Reducing opioid use disorder and overdose deaths in the United States: A dynamic modeling analysis
Stringfellow, E. J., Lim, T. Y., Humphreys, K. N., DiGennaro, C., Stafford, C. A., Beaulieu, É., Homer, J. B., Wakeland, W. W., Bearnot, B. I., McHugh, R. K., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm8147 · Cited by 73 · see citing works
Morgan, J. R., Walley, A. Y., Murphy, S. M., Chatterjee, A., Hadland, S. E., Barocas, J., Linas, B. P., & Assoumou, S. A. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108764 · Cited by 67 · see citing works
Chhatwal, J., Mueller, P. P., Chen, Q., Kulkarni, N. S., Adee, M. G., Zarkin, G. A., Larochelle, M. R., Knudsen, A. B., & Barbosa, C. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.14925 · Cited by 42 · see citing works
Trends in Out-of-Pocket Costs for Naloxone by Drug Brand and Payer in the US, 2010-2018
Peet, E. D., Powell, D., & Pacula, R. L. (2022) · JAMA Health Forum · doi:10.1001/jamahealthforum.2022.2663 · Cited by 42 · see citing works
Chandler, R. K., Nunes, E. V., Tan, S., Freeman, P. R., Walley, A. Y., Lofwall, M. R., Oga, E. A., Glasgow, L., Brown, J. L., Fanucchi, L. C., et al. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.109804 · Cited by 41 · see citing works
Zang, X., Macmadu, A., Krieger, M. S., Behrends, C. N., Green, T. C., Morgan, J. R., Murphy, S. M., Nolen, S., Walley, A. Y., Schackman, B. R., et al. (2021) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2021.103435 · Cited by 36 · see citing works
Data needs and models for the opioid epidemic
Blanco, C., Wall, M. M., & Olfson, M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01356-y · Cited by 29 · see citing works
Chatterjee, A., Weitz, M., Savinkina, A. A., Macmadu, A., Madushani, R. W. M. A., Potee, R. A., Ryan, D., Murphy, S. M., Walley, A. Y., & Linas, B. P. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.7036 · Cited by 27 · see citing works
The Effect of Naloxone Access Laws on Fatal Synthetic Opioid Overdose Fatality Rates
Tabatabai, M., Cooper, R. L., Wilus, D. M., Edgerton, R. D., Ramesh, A., MacMaster, S. A., Patel, P. N., & Singh, K. P. (2023) · Journal of Primary Care & Community Health · doi:10.1177/21501319221147246 · Cited by 26 · see citing works
Public Health Interventions and Overdose-Related Outcomes Among Persons With Opioid Use Disorder
Nataraj, N., Rikard, S. M., Zhang, K., Jiang, X., Guy, G. P., Rice, K., Mattson, C. L., Gladden, R. M., Mustaquim, D., Illg, Z. N., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.4617 · Cited by 24 · see citing works
Economic Evaluation of Extended-Release Buprenorphine for Persons With Opioid Use Disorder
Flam-Ross, J. M., Marsh, E., Weitz, M., Savinkina, A., Schackman, B. R., Wang, J., Madushani, R. W. M. A., Morgan, J. R., Barocas, J. A., Walley, A. Y., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.29583 · Cited by 21 · see citing works
Ostrach, B. M. M., Hixon, V., & Bryce, A. (2024) · Health & Justice · doi:10.1186/s40352-023-00256-3 · Cited by 18 · see citing works
The relationship between felt stigma and non-fatal overdose among rural people who use drugs
Sibley, A. L., Klein, E., Cooper, H. L. F., Livingston, M. D., Baker, R., Walters, S. M., Gicquelais, R. E., Ruderman, S. A., Friedmann, P. D., Jenkins, W. D., et al. (2024) · Harm Reduction Journal · doi:10.1186/s12954-024-00988-x · Cited by 18 · see citing works
Interventions to Address the Opioid Crisis—Modeling Predictions and Consequences of Inaction
Volkow, N. D., & Blanco, C. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.37385 · Cited by 18 · see citing works
Harris, R. A., Campbell, K., Calderbank, T., Dooley, P., Aspero, H., Maginnis, J., O'Donnell, N., Coviello, D., French, R., Bao, Y., et al. (2022) · Healthcare · doi:10.1016/j.hjdsi.2022.100641 · Cited by 17 · see citing works
Harm reduction in the Heartland: public knowledge and beliefs about naloxone in Nebraska, USA
Schlosser, A. V., Habecker, P., & Bevins, R. A. (2022) · Harm Reduction Journal · doi:10.1186/s12954-022-00606-8 · Cited by 16 · see citing works
Freeman, P. R., Walley, A. Y., Winhusen, T. M., Oga, E. A., Villani, J., Hunt, T., Chandler, R. K., Oyler, D. R., Reilly, B., Gelberg, K. H., et al. (2024) · American Journal of Public Health · doi:10.2105/ajph.2024.307845 · Cited by 15 · see citing works
Adams, J. W., Savinkina, A. A., Fox, A. D., Behrends, C. N., Madushani, R. W. M. A., Wang, J., Chatterjee, A., Walley, A. Y., Barocas, J. A., & Linas, B. P. (2022) · Addiction · doi:10.1111/add.15883 · Cited by 17 · see citing works
Naloxone Distribution Models in the United States: A Scoping Review
Vadiei, N., Axon, D. R., & Eckert, B. (2024) · Substance Use & Addiction Journal · doi:10.1177/29767342241289008 · Cited by 15 · see citing works
Freiermuth, C. E., Ancona, R. M., Brown, J. L., Punches, B. E., Ryan, S. A., Ingram, T., & Lyons, M. S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289959 · Cited by 14 · see citing works
Knudsen, H. K., Freeman, P. R., Oyler, D. R., Oser, C. B., & WALSH, S. L. (2023) · Addiction Science & Clinical Practice · doi:10.1186/s13722-023-00426-6 · Cited by 13 · see citing works
Dickson‐Gómez, J., Krechel, S., Ohlrich, J., Montaque, H. D. G., Weeks, M. R., Li, J., Havens, J. R., & Spector, A. L. (2024) · Harm Reduction Journal · doi:10.1186/s12954-024-00964-5 · Cited by 13 · see citing works
Morgan, J. R., Freibott, C. E., Jalali, A., Jeng, P. J., Walley, A. Y., Chatterjee, A., Green, T. C., Nolan, M. L., Linas, B. P., Marshall, B. D. L., et al. (2022) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2022.100083 · Cited by 12 · see citing works
Savinkina, A. A., Madushani, R. W. M. A., Yazdi, G. E., Wang, J., Barocas, J. A., Morgan, J. R., Assoumou, S. A., Walley, A. Y., Linas, B. P., & Murphy, S. M. (2022) · Addiction · doi:10.1111/add.15879 · Cited by 12 · see citing works
Taylor, R. A., Gilson, A., Schulz, W. L., Lopez, K., Young, P., Pandya, S., Coppi, A. C., Chartash, D., Fiellin, D. A., & D’Onofrio, G. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291572 · Cited by 11 · see citing works
Claypool, A. L., DiGennaro, C., Russell, W. A., Yildirim, M., Zhang, A., Reid, Z., Stringfellow, E. J., Bearnot, B. I., Schackman, B. R., Humphreys, K. N., et al. (2023) · JAMA Health Forum · doi:10.1001/jamahealthforum.2023.1080 · Cited by 11 · see citing works
Reducing overdose deaths among persons with opioid use disorder in connecticut
Scheidell, J. D., Townsend, T., Zhou, Q., Manandhar-Sasaki, P., Rodriguez-Santana, R., Jenkins, M. G., Buchelli, M., Charles, D. L., Frechette, J. M., Su, J. I.-S., et al. (2024) · Harm Reduction Journal · doi:10.1186/s12954-024-01026-6 · Cited by 10 · see citing works
Using Data Science to Improve Outcomes for Persons with Opioid use Disorder
Hayes, C. J., Cucciare, M. A., Martin, B. C., Hudson, T. J., Bush, K., Lo‐Ciganic, W., Yu, H. Q., Charron, E. M., & Gordon, A. J. (2022) · Substance Abuse · doi:10.1080/08897077.2022.2060446 · Cited by 10 · see citing works
Cerdá, M., Hamilton, A. D., Hyder, A., Rutherford, C. G., Bobashev, G., Epstein, J. M., Hatna, E., Krawczyk, N., El‐Bassel, N., Feaster, D. J., et al. (2024) · Epidemiology · doi:10.1097/ede.0000000000001703 · Cited by 9 · see citing works
Prescribing Naloxone to High-Risk Patients in the Emergency Department: Is it Enough?
Weiner, S. G., & Hoppe, J. A. (2021) · The Joint Commission Journal on Quality and Patient Safety · doi:10.1016/j.jcjq.2021.03.012 · Cited by 9 · see citing works
King, C. A., Cook, R., Wheelock, H., Korthuis, P. T., Leahy, J. M., Goff, A., Morris, C. D., & Englander, H. L. (2021) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2021.103525 · Cited by 9 · see citing works
Morgan, J. R., & Larochelle, M. R. (2022) · Addiction · doi:10.1111/add.15977 · Cited by 8 · see citing works
Conceptualizing and Measuring Abatement from the Opioid Epidemic: A Case Study from Pennsylvania
Rhubart, D. C., CHEN, Q., Sterner, G., NEWTON, R., Shaw, B. W., & Scanlon, D. P. (2022) · Milbank Quarterly · doi:10.1111/1468-0009.12589 · Cited by 6 · see citing works
Shearer, R. D., Segel, J. E., Howell, B. A., Jones, A. A., Khatri, U. G., da Silva, D. T., Vest, N. A., & Winkelman, T. N. A. (2024) · Medical Care · doi:10.1097/mlr.0000000000001969 · Cited by 5 · see citing works
Pharmacy harm reduction practices to help reduce opioid overdoses, Arizona 2023
Meyerson, B. E., Richter, S., Gordon, R., Chang, E. P. Y., Vadiei, N., Eldridge, L. A., Higbie, E. O., Pal, A. A., Seckar-Martinez, A., Newgass, K., et al. (2025) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2025.102348 · Cited by 5 · see citing works
Health and Economic Outcomes of Offering Buprenorphine in Homeless Shelters in Massachusetts
Chatterjee, A., Stewart, E. A., Assoumou, S. A., Chrysanthopoulou, S. A., Zwick, H. C., Harris, R. A., O’Dea, R., Schackman, B. R., White, L. F., & Linas, B. P. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.37233 · Cited by 5 · see citing works
Marshall, B. D. L., PENDERGRASS, K., & Whaley, S. (2025) · Milbank Quarterly · doi:10.1111/1468-0009.70036 · Cited by 4 · see citing works
Leech, A. A., Garbett, S. P., Yu, H. A., McNeer, E. A., Bharadwaj, R. R., Linas, B. P., Graves, J. A., Young, J. L., Su, L., Martin, P., et al. (2025) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2025.3067 · Cited by 4 · see citing works
Health and Economic Outcomes of Addressing Encampments of Individuals Using Opioids
Zwick, H. C., O’Dea, R., Barocas, J. A., Flam-Ross, J. M., Chatterjee, A., Walley, A. Y., Harris, R. A., Schackman, B. R., White, L. F., Chrysanthopoulou, S. A., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.17095 · Cited by 7 · see citing works
Tin, Y., Castry, M., Bowers-Sword, R., Shantharam, S., Aldridge, A., Zarkin, G. A., Starbird, L. E., Linas, B. P., Barocas, J. A., & Morgan, J. R. (2023) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001218 · Cited by 4 · see citing works
Dickson‐Gómez, J., Krechel, S., Ohlrich, J., Hernandez-Meier, J., & Kostelac, C. A. (2025) · Harm Reduction Journal · doi:10.1186/s12954-025-01284-y · Cited by 2 · see citing works
Alexander, S. P., Shelton, E., Lee, M., Tharp, G., McNeil, M. P., Bernitz, M., Graves, K., Metsch, L. R., & Shelton, R. C. (2026) · Harm Reduction Journal · doi:10.1186/s12954-025-01379-6 · Cited by 3 · see citing works
Irvine, M. A., Oller, D., Boggis, J. S., Bishop, B., Coombs, D., Wheeler, E., Doe-Simkins, M., Walley, A. Y., Marshall, B. D. L., Bratberg, J. P., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3929585 · Cited by 2 · see citing works
Shojaati, N., & Osgood, N. D. (2023) · Systems · doi:10.3390/systems11080391 · Cited by 1 · see citing works
Shah, R., & Wurcel, A. G. (2024) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2024.04.008 · Cited by 1 · see citing works
Vu, T. T., Bluthenthal, R. N., Huh, J., Corsi, K. F., Simpson, K. A., Ganesh, S. S., & Walters, S. M. (2025) · Substance Use & Misuse · doi:10.1080/10826084.2025.2506135 · Cited by 1 · see citing works
Liao, C.-Y., Dong, Z., Garcia, G. P., Paynabar, K., Xie, Y., & Jalali, M. S. (2025) · Manufacturing & Service Operations Management · doi:10.1287/msom.2024.0946 · Cited by 1 · see citing works
Chrysanthopoulou, S. A., Wang, J., Nolen, S., Madushani, A. R. W. M., Murphy, S. M., Linas, B. P., & White, L. F. (2025) · Medical Decision Making · doi:10.1177/0272989x251395679 · Cited by 1 · see citing works
Nataraj, N., Chen, Y., Stewart, A., Rikard, S. M., Zhang, K., Rice, K., Jiang, X., Mattson, C. L., Ko, J. Y., Guy, G. P., et al. (2026) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2026.101435 · Cited by 1 · see citing works
Challenges of Opioid Use Disorder in Rural Settings
Sigmon, S. C., & Havens, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197618431.013.35 · Cited by 1 · see citing works
Bystanders Saving Lives with Naloxone: A Scoping Review on Methods to Estimate Overdose Reversals
Kinoshita, A. T., Saadat, S., & Chakravarthy, B. (2024) · Western Journal of Emergency Medicine · doi:10.5811/westjem.18037 · Cited by 1 · see citing works
Marshall, B. D. L. (2024) · American Journal of Public Health · doi:10.2105/ajph.2024.307887 · Cited by 1 · see citing works
Assessment of Same-Day Naloxone Availability in New Mexico Pharmacies
Haponyuk (2021) · Journal of clinical outcomes management · doi:10.12788/jcom.0070
Reimagining Education and Patient Care: Access, Equity, and Resilience
Rickert, J., & Freedy, J. R. (2022) · The International Journal of Psychiatry in Medicine · doi:10.1177/00912174221118060
Commentary on Grove et al.: a progress report on the US overdose response
Linas, B. P. (2022) · Addiction · doi:10.1111/add.16013
Naloxone Distribution in Texas 2018-2022: A State-Wide Program for Opioid Overdose PreventionPreprint
Irwin, K. S., Mathias, C. W., Wang, Z., Emmerich, A. L., & Cleveland, L. M. (2023) · Research Square · doi:10.21203/rs.3.rs-3483277/v1
Scoping Literature Review of Disease Modeling of the Opioid Crisis
Spence, C., Kurz, M. E., Sharkey, T. C., & Miller, B. L. (2024) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2024.2367617
Valenzi, N. (2024) · Western Journal of Emergency Medicine · doi:10.5811/westjem.25368
MOUD use among Hispanic clients increased post-ACA, yet differed by heritage and geographic location
Herrera, C., Choi, S., & Johnson, N. L. (2024) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2024.112509
Special Issue on Substance Misuse and Addiction Disorders
Saucedo, C. (2025) · Western Journal of Emergency Medicine · doi:10.5811/westjem.41988
Empirical calibration of a simulation model of opioid use disorder
Madushani, R. W. M. A., Wang, J., Weitz, M., Linas, B. P., White, L. F., & Chrysanthopoulou, S. A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0310763
Cerdá, M., Neill, D. B., Matthay, E. C., JENKINS, J. A., Marshall, B. D. L., & Keyes, K. M. (2025) · Milbank Quarterly · doi:10.1111/1468-0009.70025
Lessons Learned from a Grassroots Harm Reduction Effort to Prevent Drug Overdose Deaths
Vuong, N., Davis, P., Lemus, L., Ream, N., & Lewis, R. K. (2025) · Journal of Prevention & Intervention in the Community · doi:10.1080/10852352.2025.2526236
Scheidell, J. D., Frechette, J. M., Townsend, T., Zhou, Q., Manandhar-Sasaki, P., Fiellin, D. A., Heimer, R., Puglisi, L. B., Charles, D. L., Su, J. I.-S., et al. (2025) · BMC Public Health · doi:10.1186/s12889-025-24432-2
Allocative efficiency of opioid overdose prevention strategies for people incarcerated in New Jersey
Scheidell, J. D., Frechette, J. M., Townsend, T., Zhou, Q., Manandhar-Sasaki, P., Kaldany, H., Connelly, K. L., Cortes, A. P., Su, J. I.-S., Charles, D. L., et al. (2025) · Harm Reduction Journal · doi:10.1186/s12954-025-01327-4
Knudsen, H. K., Freeman, P. R., Oyler, D. R., Oser, C. B., & WALSH, S. L. (2024) · Figshare · doi:10.6084/m9.figshare.26647320
Additional file 1 of Reducing overdose deaths among persons with opioid use disorder in connecticut
Scheidell, J. D., Townsend, T., Zhou, Q., Manandhar-Sasaki, P., Rodriguez-Santana, R., Jenkins, M. G., Buchelli, M., Charles, D. L., Frechette, J. M., Su, J. I.-S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26726441
Nataraj, N., Chen, Y., Stewart, A., Rikard, S. M., Zhang, K., Rice, K., Jiang, X., Mattson, C. L., Ko, J. Y., Guy, G. P., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5391644
Walley, A. Y., Cheng, D. M., Vandergrift, N., Larochelle, M. R., Holloway, J., Brown, J. L., Chandler, R. K., Fanucchi, L. C., Feaster, D. J., Freeman, P. R., et al. (2026) · Addiction · doi:10.1111/add.70478
Christie, A. C., Idowu, E. O., Udayan, U., Rafee, A. R., Allen, D. H., Madavan3, S., Grimadeau, C., Loyd, K., Whitley, K., & Tanwar, A. (2026) · Research Square · doi:10.21203/rs.3.rs-9486873/v1
- Authors
- Linas, B. P., Savinkina, A., Madushani, R. W. M. A., Wang, J., Eftekhari Yazdi, G., Chatterjee, A., Walley, A. Y., Morgan, J. R., Epstein, R. L., Assoumou, S. A., Murphy, S. M., Schackman, B. R., Chrysanthopoulou, S. A., White, L. F., & Barocas, J. A.
- Affiliations
- Boston University (US)
- Boston Medical Center (US)
- Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts
- Brown University (US)
- Corresponding author
- Linas, Benjamin P.
- ORCID
- Venue
- JAMA Network Open
- Publisher
- American Medical Association (AMA)
- Published
- 2021-02-15
- Volume
- 4
- Issue
- 2
- Pages
- e2037259
- ISSN
- 2574-3805 (ISSN-L)
- PMC
- PMC7885041
- OpenAlex
- W3132147424
- Cited by
- 72
- References
- 42
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 18 · 2023: 13 · 2022: 14 · 2021: 8
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JAMA Network Open (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DP2DA051864, K01DA051684, R01DA046527, P30DA040500)
- National Institute of Allergy and Infectious Diseases (P30AI042853)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- opioid overdose deaths, opioid use disorder, medication-assisted treatment, naloxone distribution, treatment retention, community-level interventions, overdose prevention, state transition model, rural and urban communities, Massachusetts
- MeSH terms
- Retention in Care, Opiate Overdose, Computer Simulation, Decision Support Techniques, Humans, Massachusetts, Naloxone, Narcotic Antagonists, Rural Population, Urban Population, Opiate Substitution Treatment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
