New Genetic Links Between Alzheimer Disease and Immune-Mediated Diseases Revealed by Overlapping Genome-wide Association Study Hits
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Overlap in the genetic architecture between AD and other diseases has been reported, including type 2 diabetes and immune-mediated diseases such as Crohn's disease.
“Overlap in the genetic architecture between AD and other diseases has also been reported, including type 2 diabetes [124] and immune-mediated diseases such as Crohn’s disease [125, 126], although the precise mechanisms underlying this overlap remain to be elucidated.”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [126]
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
<i>TREM2</i> Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works
Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503 · see citing works
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · see citing works
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157 · see citing works
Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid
Wisniewski, T., & Frangione, B. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90444-c · Cited by 802 · see citing works
APOLIPOPROTEIN E ALLELES AS RISK FACTORS IN ALZHEIMER'S DISEASE
Roses, M. D. (1996) · Annual Review of Medicine · doi:10.1146/annurev.med.47.1.387 · Cited by 707 · see citing works
Andreassen, O. A., Thompson, W. K., Schork, A. J., Ripke, S., Mattingsdal, M., Kelsoe, J. R., Kendler, K. S., O’Donovan, M. C., Rujescu, D., Werge, T. M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003455 · Cited by 402 · see citing works
Association between genetic traits for immune-mediated diseases and Alzheimer disease
Yokoyama, J. S., Wang, Y., Schork, A. J., Thompson, W. K., Karch, C. M., Cruchaga, C., McEvoy, L. K., Witoelar, A., Chen, C.-H., Holland, D., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0150 · Cited by 176 · see citing works
Mak, A. C. Y., Pullinger, C. R., Tang, L. F., Wong, J. S., Deo, R. C., Schwarz, J.-M., Gugliucci, A., Movsesyan, I., Ishida, B. Y., Chu, C., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2011 · Cited by 96 · see citing works
Apolipoprotein E: Essential Catalyst of the Alzheimer Amyloid Cascade
Potter, H., & Wısnıewskı, T. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489428 · Cited by 80 · see citing works
Self-citationPotter, H. (1998) · Frontiers in bioscience · doi:10.2741/a290 · Cited by 35 · see citing works
Self-citationIntravenous immunoglobulin for Alzheimer's disease
Relkin, N. R. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12500 · Cited by 17 · see citing works
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Genetic architecture of Alzheimer's disease
Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works
“Overlap in the genetic architecture between AD and other diseases has also been reported, including type 2 diabetes [124] and immune-mediated diseases such as Crohn’s disease [125, 126], although the precise mechanisms underlying this overlap remain to be elucidated.”
Wu, Y., Yan, Y., Qi, J., Liu, Y., Wang, T., Chen, H., Guan, X., Chu, Z., & Zeng, P. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111203 · Cited by 1 · see citing works
Yokoyama, J. S., & Desikan, R. S. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2799 · Cited by 1 · see citing works
- Authors
- Potter, H.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Potter, Huntington
- ORCID
- Potter, Huntington
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2016-06-01
- Volume
- 73
- Issue
- 6
- Pages
- 638
- ISSN
- 2168-6149 (ISSN-L)
- OpenAlex
- W2337645931
- Cited by
- 3
- References
- 15
- Citations by year
- 2024: 1 · 2020: 1 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, immune-mediated diseases, genetic association, shared genetic risk, autoimmunity, neuroinflammation
- MeSH terms
- Alzheimer Disease, Humans, Immune System Diseases, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study
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