APOLIPOPROTEIN E ALLELES AS RISK FACTORS IN ALZHEIMER'S DISEASE
Abstract
Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset diseases, the genetic etiologies have been well identified. Three early onset forms of AD inherited as autosomal dominant traits account for less than 2% of prevalent AD. A major susceptibility locus, apolipoprotein E (APOE, gene; apoE, protein) is associated with risk and age of onset distributions for the common familial and sporadic late-onset AD. The identification of additional genetic susceptibility genes in the etiology of AD and the metabolic mechanisms leading to differences in age of onset and disease pathogenesis are active areas of current research.
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The APOE ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease.
“The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer’s disease (AD).”
From Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance (2011) · cites this paper as [46]
Apolipoprotein E is the principal genetic risk factor for sporadic, late-onset Alzheimer's disease.
“Apolipoprotein E (apoE) is the principal genetic risk factor for sporadic, late-onset AD (Corder et al., 1993; Roses, 1996).”
From Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease (2012) · cites this paper as Roses, 1996
Compared to individuals with no ε4 alleles, the increased risk for AD is 2-3 fold in people with one ε4 allele and about 12-fold in those with two ε4 alleles.
“As compared to individuals with no ε4 alleles, the increased risk for AD is 2–3 fold in people with one ε4 allele and about 12-fold in those with two ε4 alleles (Bertram et al., 2009; Roses, 1996).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Roses, 1996
The apoE ε4 allele is associated with an earlier age of AD onset.
“The apoE ε4 allele is also associated with an earlier age of AD onset (Gomez-Isla et al., 1996; Roses, 1996).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Roses, 1996
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- Authors
- Roses, M. D.
- Affiliations
- Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1996-02
- Volume
- 47
- Issue
- 1
- Pages
- 387-400
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2115738813
- Cited by
- 707
- References
- 7
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 26 · 2023: 19 · 2022: 24 · 2021: 18 · 2020: 27 · 2019: 29 · 2018: 13 · 2017: 25 · 2016: 28 · 2015: 26 · 2014: 31 · 2013: 23 · 2012: 19
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, apolipoprotein E, APOE alleles, genetic susceptibility, late-onset Alzheimer's disease, familial Alzheimer's disease, age of onset, sporadic Alzheimer's disease, genetic risk factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Brain, Chromosome Mapping, Female, Humans, Genetic Linkage, Male, Middle Aged, Risk Factors
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