Cited by 252Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAdvanced Neuroimaging Techniques and Applications

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Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

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Dean, Douglas C., Hurley, Samuel A., Kecskemeti, Steven R., O’Grady, J. Patrick, Canda, Cristybelle, Davenport-Sis, Nancy J., Carlsson, Cynthia M., Zetterberg, Henrik, Blennow, Kaj, Asthana, Sanjay, Sager, Mark A., Johnson, Sterling C., Alexander, Andrew L., Bendlin, Barbara B.·2017·JAMA Neurology

DOI 10.1001/jamaneurol.2016.3232PMC PMC5195903

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Abstract

IMPORTANCE: The accumulation of aggregated β-amyloid and tau proteins into plaques and tangles is a central feature of Alzheimer disease (AD). While plaque and tangle accumulation likely contributes to neuron and synapse loss, disease-related changes to oligodendrocytes and myelin are also suspected of playing a role in development of AD dementia. Still, to our knowledge, little is known about AD-related myelin changes, and even when present, they are often regarded as secondary to concomitant arteriosclerosis or related to aging. OBJECTIVE: To assess associations between hallmark AD pathology and novel quantitative neuroimaging markers while being sensitive to white matter myelin content. DESIGN, SETTING, AND PARTICIPANTS: Magnetic resonance imaging was performed at an academic research neuroimaging center on a cohort of 71 cognitively asymptomatic adults enriched for AD risk. Lumbar punctures were performed and assayed for cerebrospinal fluid (CSF) biomarkers of AD pathology, including β-amyloid 42, total tau protein, phosphorylated tau 181, and soluble amyloid precursor protein. We measured whole-brain longitudinal and transverse relaxation rates as well as the myelin water fraction from each of these individuals. MAIN OUTCOMES AND MEASURES: Automated brain mapping algorithms and statistical models were used to evaluate the relationships between age, CSF biomarkers of AD pathology, and quantitative magnetic resonance imaging relaxometry measures, including the longitudinal and transverse relaxation rates and the myelin water fraction. RESULTS: The mean (SD) age for the 19 male participants and 52 female participants in the study was 61.6 (6.4) years. Widespread age-related changes to myelin were observed across the brain, particularly in late myelinating brain regions such as frontal white matter and the genu of the corpus callosum. Quantitative relaxometry measures were negatively associated with levels of CSF biomarkers across brain white matter and in areas preferentially affected in AD. Furthermore, significant age-by-biomarker interactions were observed between myelin water fraction and phosphorylated tau 181/β-amyloid 42, suggesting that phosphorylated tau 181/β-amyloid 42 levels modulate age-related changes in myelin water fraction. CONCLUSIONS AND RELEVANCE: These findings suggest amyloid pathologies significantly influence white matter and that these abnormalities may signify an early feature of the disease process. We expect that clarifying the nature of myelin damage in preclinical AD may be informative on the disease's course and lead to new markers of efficacy for prevention and treatment trials.

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“before the onset of clinical symptoms (Dean et al., 2017).”
Background
CSF β-amyloid and white matter damage: a new perspective on Alzheimer’s disease
Pietroboni, A. M., Scarioni, M., Carandini, T., Basilico, P., Cadioli, M., Giulietti, G., Arighi, A., Caprioli, M., Serra, L., Sina, C., et al. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316603 · Cited by 47
“In any case, our findings confirm, along with previously published data,9 11 12 19 20 that WMHs should be regarded as a crucial feature of AD.”
BackgroundInfluential
Noninvasive Gamma Sensory Stimulation May Reduce White Matter and Myelin Loss in Alzheimer’s Disease
Da, X., Hempel, E., Ou, Y., Rowe, O., Malchano, Z., Hajós, M., Kern, R. Z., Megerian, J. T., & Cimenser, A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230506 · Cited by 47
Nonlinear associations of neurite density and myelin content with age revealed using multicomponent diffusion and relaxometry magnetic resonance imaging
Qian, W., Khattar, N., Cortina, L. E., Spencer, R. G. S., & Bouhrara, M. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117369 · Cited by 45
Astrocyte and oligodendrocyte pathology in Alzheimer's disease
Ziar, R., Tesar, P. J., & Clayton, B. L. L. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00540 · Cited by 47
“Importantly, many studies have shown that myelin damage occurs in the preclinical phase of AD [74,75].”
Longitudinal associations between white matter maturation and cognitive development across early childhood
Dai, X., Hadjipantelis, P. Z., Wang, J., Deoni, S., & Müller, H. (2019) · Human Brain Mapping · doi:10.1002/hbm.24690 · Cited by 41
“…mcDESPOT has also been used to investigate myelin change in known white matter demyelinating and dysmyelinating disorders, for example, multiple sclerosis (Kitzler et al., 2012; Kolind et al., 2012; Kolind et al., 2013), Alzheimer's disease (Dean et al., 2017), and dementia (Bouhrara et al., 2018).”
BackgroundMethod
The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial
Mercer, J., Erickson‐Owens, D. A., Deoni, S., Dean, D., Tucker, R. J., Parker, A. B., Joelson, S., Mercer, E. N., Collins, J. A., & Padbury, J. F. (2020) · American Journal of Perinatology · doi:10.1055/s-0040-1714258 · Cited by 43
Self-citation
Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects
Operto, G., Molinuevo, J. L., Cacciaglia, R., Falcon, C., Brugulat-Serrat, A., Suárez-Calvet, M., Grau-Rivera, O., Bargalló, N., Morán, S., Esteller, M., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101983 · Cited by 40
“Dean et al. (2017) in a recent study report widespread age-related changes especially in late-myelinating brain regions and negative associations between relaxometry measures across WM and levels of CSF biomarkers in cognitively asymptomatic participants.”
Background
Myelin injury in the central nervous system and Alzheimer's disease.
Wang, S.-S., Zhang, Z., Zhu, T., Chu, S.-F., He, W.-B., & Chen, N.-H. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.05.003 · Cited by 40
Myelin loss in white matter hyperintensities and normal-appearing white matter of cognitively impaired patients: a quantitative synthetic magnetic resonance imaging study
Park, M., Moon, Y., Han, S., Kim, H. K., & Moon, W. (2018) · European Radiology · doi:10.1007/s00330-018-5836-x · Cited by 42
Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders
Ijomone, O. K., Inelo, U. I., Aneke, V. O., Olajide, T. S., Inyang, H. O., Omotosho, O. I., Oyerinde, T. O., Anadu, V. E., Gbayisomore, T. J., Okeowo, O. M., et al. (2025) · Neuroglia · doi:10.3390/neuroglia6010004 · Cited by 42
Quantitative age-dependent differences in human brainstem myelination assessed using high-resolution magnetic resonance mapping
Bouhrara, M., Cortina, L. E., Rejimon, A. C., Khattar, N., Bergeron, C. M., Bergeron, J., Melvin, D. L., Zukley, L. M., & Spencer, R. G. S. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116307 · Cited by 40
Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics
Hirschfeld, L. R., Risacher, S. L., Nho, K. T., & Saykin, A. J. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00321-1 · Cited by 41
“In cognitively normal older adults at risk for AD, evidence supports the association of MWF with cerebrospinal fluid biomarkers of AD such as phosphorylated tau 181, total tau, and Aβ [6].”
Background
Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review
Faulkner, M. E., Gong, Z., Guo, A., Laporte, J. P., Bae, J., & Bouhrara, M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16170 · Cited by 39
MR approaches in neurodegenerative disorders
Blamire, A. M. (2018) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2018.11.001 · Cited by 37
Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle‐Aged Adults
O’Grady, J. P., Dean, D., Yang, K. L., Canda, C., Hoscheidt, S. M., Starks, E. J., Merluzzi, A. P., Hurley, S. A., Davenport, N. J., Okonkwo, O. C., et al. (2019) · Obesity · doi:10.1002/oby.22558 · Cited by 37
“We and others have also shown frontal and temporal white matter regions to exhibit extensive white matter alterations in aging populations (9-11); however, less is known about how myelinated fibers of these regions, particularly within the cortex, are affected by insulin and IR.”
BackgroundMethodInfluentialSelf-citation
Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease
Tardif, C. L., Devenyi, G. A., Amaral, R. S. C., Pelleïeux, S., Poirier, J., Rosa‐Neto, P., Breitner, J. C. S., & Chakravarty, M. M. (2017) · Human Brain Mapping · doi:10.1002/hbm.23897 · Cited by 36
“…elevated concentration of CSF biomarkers have recently been associated with decreased myelin water fraction, measured using MRI, in several brain regions preferentially affected in AD (Dean et al., 2017), providing strong support for the early role of myelin in preclinical AD (Bartzokis, 2011).”
Background
Age and Alzheimer’s Disease-Related Oligodendrocyte Changes in Hippocampal Subregions
DeFlitch, L., González‐Fernández, E., Crawley, I., & Kang, S. H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.847097 · Cited by 34
Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer’s disease
Rubinski, A., Franzmeier, N., Dewenter, A., Luan, Y., Smith, R. A., Strandberg, O. T., Ossenkoppele, R., Dichgans, M., Hansson, O., Ewers, M., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01074-9 · Cited by 41
“While the use of a template reflects more accurately pre-morbid inter-regional differences in myelination, demyelination has been observed in aging [73], small vessel disease [74], and AD [75] in association with amyloid plaques [48] and fibrillar tau [46].”
Background
18F-florbetapir PET as a marker of myelin integrity across the Alzheimer’s disease spectrum
Moscoso, A., Silva‐Rodríguez, J., Aldrey, J. M., Cortés, J., Peleteiro, J. M. P., Ruibal, Á., Aguiar, P., & Initiative, A. D. N. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05493-y · Cited by 37
Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease
Zhang, J., Wu, N., Wang, S., Yao, Z., Xiao, F., Lu, J., & Chen, B. (2021) · Aging Cell · doi:10.1111/acel.13380 · Cited by 33
“While some researchers reported that Aβ deposits were correlated well with losses of axons or the myelin sheath (Dean et al., 2017; Kaya et al., 2020; Marin et al., 2016; van Westen et al., 2016), other studies indicated that Aβ deposits were not correlated with the loss of axons or the myelin…”
Background
Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19
Khodanovich, M. Y., Kamaeva, D. A., & Naumova, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911291 · Cited by 32
“This is in good agreement with changes recently observed in healthy aging [84,85].”
Result
SIRT2 as a potential new therapeutic target for Alzheimer’s disease
Sola-Sevilla, N., & Puerta, E. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.375315 · Cited by 35
“Myelin impairment is another characteristic of AD brains (Desai et al., 2009; Dean et al., 2017), but it is unclear if this process is a primary or a secondary injury in AD.”
Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
Liu, Z., Chao, J., Wang, C., Sun, G., Roeth, D., Liu, W., Chen, X., Li, L., Tian, E., Feng, L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112841 · Cited by 30
“15 29–32 Although there is a strong association of the C allele of the rs11136000 SNP with increased risk for AD, mechanisms underlying the risk effect of this CLU SNP remain to be determined.”
Influential
The Role of Amyloid-β in White Matter Damage: Possible Common Pathogenetic Mechanisms in Neurodegenerative and Demyelinating Diseases
Pietroboni, A. M., Colombi, A., Carandini, T., Scarpini, E. A., Galimberti, D., & Bozzali, M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200868 · Cited by 30
White Matter and Neuroprotection in Alzheimer’s Dementia
Lorenzini, L., Fernández, M., Baldassarro, V. A., Bighinati, A., Giuliani, A., Calzà, L., & Giardino, L. (2020) · Molecules · doi:10.3390/molecules25030503 · Cited by 33
“Notably, these degenerative changes have not been associated with a high amyloid plaque burden [26,27], while other studies correlates WM pathology in preclinical AD with biomarkers in the cerebrospinal fluid [28].”
Background
Repeatability and reproducibility of human brain morphometry using three‐dimensional magnetic resonance fingerprinting
Fujita, S., Buonincontri, G., Cencini, M., Fukunaga, I., Takei, N., Schulte, R. F., Hagiwara, A., Uchida, W., Hori, M., Kamagata, K., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25232 · Cited by 28
“Individual and specific regional cortical thickness defined in the Desikan–Killiany Atlas (Desikan et al., 2006), was obtained using FreeSurfer (Version 6.0) (Dale, Fischl, & Sereno, 1999; Fischl, 2012) with the default recon-all command.”
MethodInfluential
Quantitative Analysis of Synthetic Magnetic Resonance Imaging in Alzheimer’s Disease
Lou, B., Jiang, Y., Li, C., Wu, P., Li, S., Qin, B., Chen, H., Wang, R., Wu, B., & Chen, M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.638731 · Cited by 29
“Specifically, quantitative relaxometry can potentially reflect the changes in tissue characteristics (Deoni, 2010; Callaghan et al., 2014; Knight et al., 2016; Blamire, 2018).”
Background
Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases
Zhou, W., Xia, S., Wang, C., Yang, Q., Verkhratsky, A., & Niu, J. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07893-6 · Cited by 31
“Recent studies demonstrated abnormal oligodendroglia and myelin in the brains of patients with AD [152 – 155], suggesting that myelin degeneration may be a key pathophysiological aspect of AD, potentially occurring before the onset of amyloid pathology and cognitive decline [156, 157].”
MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging
Walker, K. A., Duggan, M. R., Gong, Z., Dark, H. E., Laporte, J. P., Faulkner, M. E., An, Y., Lewis, A., Moghekar, A., Resnick, S. M., et al. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51730 · Cited by 25
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
Cai, Y., Pinheiro‐de‐Sousa, I., Slobodyanyuk, M., Chen, F., Huynh, T., Kanyo, J. E., Tang, P., Fuentes, L. A., Braker, A., Welch, R., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01973-8 · Cited by 34
“The patchy myelin density and altered white matter magnetic resonance imaging signals reported in AD 27–30, Paranodal and juxtaparanodal vulnerability likely arise from two factors.”
Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway
Zheng, M., Liu, Z., Mana, L., Qin, G., Huang, S., Gong, Z., Tian, M., He, Y., & Wang, P. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114264 · Cited by 25
Greater Diffusion Restriction in White Matter in Preclinical Alzheimer Disease
Benitez, A. M., Jensen, J. H., Thorn, K. E., Dhiman, S., Fountain‐Zaragoza, S., Rieter, W. J., Spampinato, M. V., Hamlett, E. D., Nietert, P. J., Falangola, M. F., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26353 · Cited by 29
Impaired metabolism of oligodendrocyte progenitor cells and axons in demyelinated lesion and in the aged CNS
Zhao, J., Wang, D.-X., Ma, X.-R., Dong, Z.-J., Wu, J., Wang, F., & Wu, Y. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102205 · Cited by 24
27‐hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia‐associated brain white matter changes
Alanko, V., Gaminde‐Blasco, A., Quintela‐López, T., Loera‐Valencia, R., Solomon, A., Björkhem, I., Cedazo-Mı́nguez, Á., Maioli, S., Tabacaru, G., Latorre‐Leal, M., et al. (2023) · Glia · doi:10.1002/glia.24348 · Cited by 25
“For instance, in studies conducted on asymptomatic subjects with an increased risk of developing AD, a decline in white matter integrity has been associated with pathological AD biomarker levels (Dean et al., 2017).”
Background
Functional gradients reveal altered functional segregation in patients with amnestic mild cognitive impairment and Alzheimer’s disease
He, Y., Li, Q., Fu, Z., Zeng, D., Han, Y., & Li, S. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad328 · Cited by 25
Use of the NESMA Filter to Improve Myelin Water Fraction Mapping with Brain MRI
Bouhrara, M., Reiter, D. A., Maring, M. C., Bonny, J.-M., & Spencer, R. G. S. (2018) · Journal of Neuroimaging · doi:10.1111/jon.12537 · Cited by 23
“45,67 .”
Effect of QTC-4-MeOBnE Treatment on Memory, Neurodegeneration, and Neurogenesis in a Streptozotocin-Induced Mouse Model of Alzheimer’s Disease
Fronza, M. G., Baldinotti, R., Sacramento, M., Gutierres, J. M., Carvalho, F. B., Fernandes, M. D. C., Sousa, F. S. S., Seixas, F. K., Collares, T. V., Alves, D. A. C., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00615 · Cited by 23
Myelin Lipid Alterations in Neurodegenerative Diseases: Landscape and Pathogenic Implications
Xu, Z., He, S., Begum, M. M., & Han, X. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0676 · Cited by 24
“Advanced imaging techniques, such as magnetic resonance imaging (MRI), have also been used to detect myelin loss in patients with AD (Dean et al., 2017).”
Remyelination: A Potential Therapeutic Strategy for Alzheimer’s Disease?
Sun, J., Zhou, H., Bai, F., Zhang, Z., & Ren, Q. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170036 · Cited by 22
Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging
Triebswetter, C., Kiely, M., Khattar, N., Ferrucci, L., Resnick, S. M., Spencer, R. G. S., & Bouhrara, M. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.118988 · Cited by 21
“Using advanced MRI physics and technology, a whole-brain MWF map can now be obtained in less than 15 min using the multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) analysis (21-24).”
Method
Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer’s Disease
Facchinetti, R., Valenza, M., Gomiero, C., Mancini, G. F., Steardo, L., Campolongo, P., & Scuderi, C. (2022) · Biomedicines · doi:10.3390/biomedicines10061236 · Cited by 23
“Myelin damage coincides indeed with Aβ accumulation and concurrent impairment in OPCs maturation in the brains of AD patients [21].”
Background
Changes of Myelin Organization in Patients with Alzheimer’s Disease Shown by q-Space Myelin Map Imaging
Ota, M., Sato, N., Kimura, Y., Shigemoto, Y., Kunugi, H., & Matsuda, H. (2019) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000493937 · Cited by 22

Authors: Dean, D. C., Hurley, S. A., Kecskemeti, S. R., O’Grady, J. P., Canda, C., Davenport-Sis, N. J., Carlsson, C. M., Zetterberg, H., Blennow, K., Asthana, S., Sager, M. A., Johnson, S. C., Alexander, A. L., & Bendlin, B. B.
Affiliations: University of Wisconsin–Madison (US)
University of Oxford (GB)
Alzheimer Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison4Wisconsin Alzheimer Institute, University of Wisconsin School of Medicine and Public Health, Madison
UCL Queen Square Institute of Neurology (GB)
University of Gothenburg (SE)
Corresponding author: Dean, Douglas C.
ORCID: Dean, Douglas C.
Hurley, Samuel A.
Kecskemeti, Steven R.
Carlsson, Cynthia M.
Zetterberg, Henrik
Blennow, Kaj
Asthana, Sanjay
Johnson, Sterling C.
Alexander, Andrew L.
Bendlin, Barbara B.
Venue: JAMA Neurology
Publisher: American Medical Association (AMA)
Published: 2017-01-01
Volume: 74
Issue: 1
Pages: 41
ISSN: 2168-6149 (ISSN-L)
DOI: 10.1001/jamaneurol.2016.3232
PMC: PMC5195903
OpenAlex: W2554389950
Cited by: 252
References: 44
Citations by year: 2026: 26 · 2025: 40 · 2024: 33 · 2023: 36 · 2022: 34 · 2021: 17 · 2020: 19 · 2019: 16 · 2018: 17 · 2017: 13
FWCI: 13.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institutes of Health (UL1TR000427)
National Institute on Aging (R01AG037639, P50AG033514, R01AG021155, R01AG027161, R56AG037639)
National Center for Research Resources (UL1RR025011)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD078119, P30HD003352, T32HD007489)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: preclinical Alzheimer's disease, amyloid pathology, white matter, myelin water fraction, relaxometry, cerebrospinal fluid biomarkers, phosphorylated tau 181, amyloid-beta 42, tau protein, corpus callosum, neuroimaging biomarkers
MeSH terms: Age Factors, Aged, Alzheimer Disease, Apolipoproteins E, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Myelin Sheath, Peptide Fragments, Phosphorylation, Statistics as Topic, Water, Cohort Studies, Biomarkers, Amyloid beta-Peptides, tau Proteins, Disease Progression, Plaque, Amyloid

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Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

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