The role of myelin damage in Alzheimer’s disease pathology
Open accessAbstract
Although Alois Alzheimer described myelin disruption in Alzheimer's disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time. Alzheimer's disease has been mainly considered as a grey matter disorder; nevertheless, recent evidence suggests that myelin impairment may play an important role in AD pathology. Classical neuropathological changes in AD, e.g. the accumulation of aggregated Aβ 42 and the presence of neurofibrillary tangles, are responsible for neuronal loss, but they may also induce death of oligodendrocytes and myelin damage. There is also evidence that myelin pathology may even precede Aβ and tau pathologies in AD. The state of the art does not allow us to determine whether myelin damage is a primary or a secondary injury in AD subjects. The article presents an overview of current knowledge on the role of myelin in AD pathology and its interactions with Aβ and tau pathologies.
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Myelin damage likely precedes and contributes to amyloid plaque buildup in early AD.
“This is notable because myelin damage likely precedes and contributes to amyloid plaque buildup in early AD.55–57”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [56]
The 'Myelin damage in AD' section says some studies suggest myelin damage precedes Aβ pathology. It also proposes that myelin loss could accelerate plaque deposition, but presents that contribution as possible; the animal-model section says it remains unclear whether myelin damage triggers AD pathology. Thus the claim is stronger than the source on contribution to plaque buildup. (LLM, conf=0.82)
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- Authors
- Papuć, E., & Rejdak, K.
- Affiliations
- Medical University of Lublin (PL)
- Corresponding author
- Papuć, Ewa
- Venue
- Archives of Medical Science
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2020
- Volume
- 16
- Issue
- 2
- Pages
- 345-341
- ISSN
- 1734-1922 (ISSN-L)
- PMC
- PMC7069444
- OpenAlex
- W2898142024
- Cited by
- 188
- References
- 73
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 31 · 2023: 33 · 2022: 40 · 2021: 20 · 2020: 8 · 2019: 1
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Archives of Medical Science (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, myelin damage, oligodendrocyte death, amyloid-beta, tau pathology, neurofibrillary tangles, myelin pathology, grey matter
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