Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · cited 2× · see citing works

Toll-Like Receptor Signaling Pathways

Kawasaki, T., & Kawai, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00461 · Cited by 3,250 · see citing works

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Kwon, H. S., & Koh, S.-H. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00221-2 · Cited by 2,595 · see citing works

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · cited 1× · see citing works

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190 · see citing works

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

Jarrett, J. T., & Lansbury, P. T. (1993) · Cell · doi:10.1016/0092-8674(93)90635-4 · Cited by 2,178 · see citing works

Amyloid Precursor Protein Processing and Alzheimer's Disease

O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works

The Cellular Phase of Alzheimer’s Disease

De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990 · see citing works

Microglia in Alzheimer’s disease

Hansen, D. V., Hanson, J. E., & Sheng, M. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709069 · Cited by 1,935 · cited 1× · see citing works

Epidemiology of Alzheimer disease

Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675 · see citing works

Microglia in physiology and disease

Wolf, S. A., Boddeke, H. W. G. M., & Kettenmann, H. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034406 · Cited by 1,426 · see citing works

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

Cohen, S. I. A., Linse, S. S., Luheshi, L. M., Hellstrand, E., White, D. A., Rajah, L., Otzen, D. E., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218402110 · Cited by 1,410 · see citing works

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Chung, W.-S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12776 · Cited by 1,377 · see citing works

Gamma frequency entrainment attenuates amyloid load and modifies microglia

Iaccarino, H. F., Singer, A. C., Martorell, A. J., Rudenko, A., Gao, F., Gillingham, T. Z., Mathys, H., Seo, J., Kritskiy, O., Abdurrob, F., et al. (2016) · Nature · doi:10.1038/nature20587 · Cited by 1,328 · see citing works

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works

Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.

(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.49 · Cited by 1,288 · see citing works

Normal aging induces A1-like astrocyte reactivity

Clarke, L. E., Liddelow, S. A., Chakraborty, C., Münch, A. E., Heiman, M., & Barres, B. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800165115 · Cited by 1,237 · see citing works

Astrocyte-endothelial Interactions and Blood-Brain Barrier Permeability*

Abbott, N. J. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00064.x · Cited by 1,168 · see citing works

An Analytical Solution to the Kinetics of Breakable Filament Assembly

Knowles, T. P. J., Waudby, C. A., Devlin, G. L., Cohen, S. I. A., Aguzzi, A., Vendruscolo, M., Terentjev, E. M., Welland, M. E., & Dobson, C. M. (2009) · Science · doi:10.1126/science.1178250 · Cited by 1,141 · see citing works

Debris clearance by microglia: an essential link between degeneration and regeneration

Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111 · see citing works

Trafficking and Proteolytic Processing of APP

Haass, C., Kaether, C., Thinakaran, G., & Sisodia, S. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006270 · Cited by 1,075 · see citing works

Microglial control of astrocytes in response to microbial metabolites

Rothhammer, V., Borucki, D. M., Tjon, E. C., Takenaka, M. C., Chao, C.-C., Ardura-Fabregat, A., de Lima, K. A., Gutiérrez-Vázquez, C., Hewson, P., Staszewski, O., et al. (2018) · Nature · doi:10.1038/s41586-018-0119-x · Cited by 1,051 · see citing works

Disease-associated astrocytes in Alzheimer’s disease and aging

Habib, N., McCabe, C., Medina, S., Varshavsky, M., Kitsberg, D., Dvir-Szternfeld, R., Green, G., Dionne, D., Nguyen, L., Marshall, J. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0624-8 · Cited by 1,009 · see citing works

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.014 · Cited by 1,004 · see citing works

APP processing in Alzheimer’s disease.

Zhang, Y.-W., Thompson, R., Zhang, H., & Xu, H. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-3 · Cited by 983 · see citing works

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Venegas, C., Kumar, S., Franklin, B. S., Dierkes, T., Brinkschulte, R., Tejera, D., Vieira-Saecker, A., Schwartz, S., Santarelli, F., Kummer, M. P., et al. (2017) · Nature · doi:10.1038/nature25158 · Cited by 983 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

Chen, W.-T., Lu, A., Craessaerts, K., Pavie, B., Sala Frigerio, C., Corthout, N., Qian, X., Laláková, J., Kühnemund, M., Voytyuk, I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.038 · Cited by 949 · cited 1× · see citing works

Review: Activation patterns of microglia and their identification in the human brain

Boche, D., Perry, V. H., & Nicoll, J. A. R. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12011 · Cited by 911 · see citing works

Origin and differentiation of microglia

Ginhoux, F., Lim, S., Hoeffel, G., Low, D., & Huber, T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00045 · Cited by 905 · cited 1× · see citing works

Astrocytes: Key Regulators of Neuroinflammation

Colombo, E., & Farina, C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.06.006 · Cited by 901 · see citing works

Microglia-mediated neuroinflammation in neurodegenerative diseases

Subhramanyam, C. S., Wang, C., Hu, Q., & Dheen, S. T. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.004 · Cited by 875 · see citing works

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

Kametani, F., & Hasegawa, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00025 · Cited by 836 · see citing works

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.003 · Cited by 817 · see citing works

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I., Martínez, C. M., Amores-Iniesta, J., Compan, V., Barberà-Cremades, M., Yagüe, J., Ruiz-Ortiz, E., Antón, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2919 · Cited by 790 · cited 1× · see citing works

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Weinhard, L., di Bartolomei, G., Bolasco, G., Machado, P., Schieber, N. L., Neniskyte, U., Exiga, M., Vadisiute, A., Raggioli, A., Schertel, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03566-5 · Cited by 790 · see citing works

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2615-05.2006 · Cited by 768 · see citing works

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge

Nugent, A. A., Lin, K., van Lengerich, B., Lianoglou, S., Przybyla, L., Davis, S. S., Llapashtica, C., Wang, J., Kim, D. J., Xia, D., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.007 · Cited by 745 · see citing works

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

Condello, C., Yuan, P., Schain, A., & Grutzendler, J. (2015) · Nature Communications · doi:10.1038/ncomms7176 · Cited by 718 · see citing works

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Moussa, C., Hebron, M. L., Huang, X., Ahn, J., Rissman, R. A., Aisen, P. S. S., & Turner, R. S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0779-0 · Cited by 712 · see citing works

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Leissring, M. A., Farris, W., Chang, A. Y., Walsh, D. M., Wu, X., Sun, X., Frosch, M. P., & Selkoe, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00787-6 · Cited by 708 · see citing works

The role of microglia in amyloid clearance from the AD brain

Lee, C. Y. D., & Landreth, G. E. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0433-4 · Cited by 701 · see citing works

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

Filipello, F., Morini, R., Corradini, I., Zerbi, V., Canzi, A., Michalski, B., Erreni, M., Markicevic, M., Starvaggi-Cucuzza, C., Otero, K., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.016 · Cited by 695 · see citing works

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

Vainchtein, I. D., Chin, G., Cho, F. S., Kelley, K. W., Miller, J. G., Chien, E. C., Liddelow, S. A., Nguyen, P. T., Nakao-Inoue, H., Dorman, L. C., et al. (2018) · Science · doi:10.1126/science.aal3589 · Cited by 657 · see citing works

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

Zeppenfeld, D. M., Simon, M., Haswell, J. D., D’Abreo, D., Murchison, C., Quinn, J. F., Grafe, M. R., Woltjer, R. L., Kaye, J., & Iliff, J. J. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.4370 · Cited by 651 · see citing works

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

He, Z., Guo, J. L., McBride, J. D., Narasimhan, S., Kim, H., Changolkar, L., Zhang, B., Gathagan, R. J., Yue, C., Dengler, C., et al. (2018) · Nature Medicine · doi:10.1038/nm.4443 · Cited by 645 · see citing works

Microglia mediate forgetting via complement-dependent synaptic elimination

Wang, C., Yue, H., Hu, Z., Shen, Y., Ma, J., Li, J., Wang, X.-D., Wang, L., Sun, B., Shi, P., et al. (2020) · Science · doi:10.1126/science.aaz2288 · Cited by 629 · see citing works

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

Jucker, M., & Walker, L. C. (2011) · Annals of Neurology · doi:10.1002/ana.22615 · Cited by 622 · cited 2× · see citing works

Alzheimer’s disease hypothesis and related therapies

Du, X., Wang, X., & Geng, M. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0107-y · Cited by 609 · see citing works

The development of brain white matter microstructure

Lebel, C., & Deoni, S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.12.097 · Cited by 602 · see citing works

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M.-M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M.-È., & Rivest, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141656 · Cited by 595 · see citing works

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

Atagi, Y., Liu, C.-C., Painter, M. M., Chen, X.-F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R., Kang, S. S., Xu, H., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.679043 · Cited by 587 · see citing works

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, B., Huntley, M. A., De Mazière, A., Meilandt, W. J., Wu, T., Srinivasan, K., Jiang, Z., Gandham, V., Friedman, B. A., Ngu, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.014 · Cited by 575 · see citing works

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease

Singh, D. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02565-0 · Cited by 569 · see citing works

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0296-9 · Cited by 555 · see citing works

Microglia regulation of synaptic plasticity and learning and memory

Zhou, M., Cornell, J., Salinas, S., & Huang, H.-Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.322423 · Cited by 548 · see citing works

Microglial subtypes: diversity within the microglial community

Stratoulias, V., Venero, J. L., Tremblay, M., & Joseph, B. (2019) · The EMBO Journal · doi:10.15252/embj.2019101997 · Cited by 536 · see citing works

Brain Photobiomodulation Therapy: a Narrative Review

Salehpour, F., Mahmoudi, J., Kamari, F., Sadigh‐Eteghad, S., Rasta, S. H., & Hamblin, M. R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0852-4 · Cited by 534 · see citing works

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

Olmos-Alonso, A., Schetters, S. T. T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V. H., & Gomez-Nicola, D. (2016) · Brain · doi:10.1093/brain/awv379 · Cited by 532 · see citing works

Mechanisms of Aβ Clearance and Degradation by Glial Cells

Ries, M., & Sastre, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00160 · Cited by 527 · see citing works

TREM2 sustains microglial expansion during aging and response to demyelination

Poliani, P. L., Wang, Y., Fontana, E., Robinette, M. L., Yamanishi, Y., Gilfillan, S., & Colonna, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77983 · Cited by 525 · see citing works

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

Heckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503 · see citing works

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

Xu, Z., Xiao, N., Chen, Y., Huang, H., Marshall, C., Gao, J., Cai, Z., Wu, T., Hu, G., & Xiao, M. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0056-1 · Cited by 500 · see citing works

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

Kaur, D., Sharma, V., & Deshmukh, R. R. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00580-x · Cited by 493 · see citing works

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

Fakhoury, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170720095240 · Cited by 482 · see citing works

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

Mueller-Steiner, S., Zhou, Y.-G., Arai, H., Roberson, E., Sun, B.-G., Chen, J., Wang, X., Yu, G.-Q., Esposito, L., Mucke, L., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.027 · Cited by 466 · see citing works

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Wu, T., Dejanovic, B., Gandham, V. D., Gogineni, A., Edmonds, R., Schauer, S., Srinivasan, K., Huntley, M. A., Wang, Y., Wang, T.-M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.060 · Cited by 466 · see citing works

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

Lehrman, E. K., Wilton, D. K., Litvina, E. Y., Welsh, C. A., Chang, S. T., Frouin, A., Walker, A. J., Heller, M. D., Umemori, H., Chen, C., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.017 · Cited by 464 · see citing works

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

Jay, T. R., Hirsch, A. M., Broihier, M. L., Miller, C. M., Neilson, L. E., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2110-16.2016 · Cited by 457 · see citing works

Cholinergic modulation of the hippocampal region and memory function

Haam, J., & Yakel, J. L. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14052 · Cited by 446 · see citing works

Crosstalk Between Astrocytes and Microglia: An Overview

Matejuk, A., & Ransohoff, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01416 · Cited by 445 · see citing works

TREM2, microglia, and neurodegenerative diseases

Yeh, F. L., Hansen, D. V., & Sheng, M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.008 · Cited by 440 · cited 2× · see citing works

Astrocytes in physiological aging and Alzheimer’s disease

Rodríguez-Arellano, J. J., Parpura, V., Zorec, R., & Verkhratsky, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.007 · Cited by 439 · see citing works

The role of astrocytes in amyloid production and Alzheimer's disease

Frost, G. R., & Li, Y. (2017) · Open Biology · doi:10.1098/rsob.170228 · Cited by 435 · see citing works

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

Scott‐Hewitt, N., Perrucci, F., Morini, R., Erreni, M., Mahoney, M., Witkowska, A., Carey, A. E., Faggiani, E., Schuetz, L. T., Mason, S., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020105380 · Cited by 425 · see citing works

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

Stephan, A. H., Madison, D. V., Mateos, J. M., Fraser, D. A., Lovelett, E. A., Coutellier, L., Kim, L., Tsai, H.-H., Huang, E. J., Rowitch, D. H., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1333-13.2013 · Cited by 423 · see citing works

Pathological mechanisms and therapeutic strategies for Alzheimer’s disease

Tam, K. Y., & Ju, Y. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320970 · Cited by 416 · see citing works

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

Bartels, T., De Schepper, S., & Hong, S. (2020) · Science · doi:10.1126/science.abb8587 · Cited by 412 · see citing works

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Morizawa, Y. M., Hirayama, Y., Ohno, N., Shibata, S., Shigetomi, E., Sui, Y., Nabekura, J., Sato, K., Okajima, F., Takebayashi, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00037-1 · Cited by 411 · see citing works

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403 · see citing works

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

Varnum, M. M., & Ikezu, T. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0181-2 · Cited by 393 · see citing works

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Cignarella, F., Filipello, F., Bollman, B., Cantoni, C., Locca, A., Mikesell, R., Manis, M., Ibrahim, A., Deng, L., Benitez, B. A., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02193-z · Cited by 392 · cited 2× · see citing works

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

Lee, J.-H., Kim, J. S., Noh, S., Lee, H., Lee, S. Y., Mun, J. Y., Park, H., & Chung, W. (2020) · Nature · doi:10.1038/s41586-020-03060-3 · Cited by 387 · see citing works

MMP ‐9 in translation: from molecule to brain physiology, pathology, and therapy

Vafadari, B., Salamian, A., & Kaczmarek, L. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13415 · Cited by 381 · see citing works

Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

Yin, K.-J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., Bateman, R., Song, H., Hsu, F.-F., Turk, J., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2085-06.2006 · Cited by 381 · see citing works

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375 · cited 2× · see citing works

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

Zhao, J. J., O’Connor, T., & Vassar, R. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-150 · Cited by 370 · see citing works

The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease

Sun, E., Motolani, A., Campos, L., & Lu, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168972 · Cited by 369 · see citing works

Complement<i>C3</i>-Deficient Mice Fail to Display Age-Related Hippocampal Decline

Shi, Q., Colodner, K. J., Matousek, S. B., Merry, K., Hong, S., Kenison, J. E., Frost, J. L., Le, K. X., Li, S., Dodart, J.-C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1698-15.2015 · Cited by 368 · see citing works

Interferon-γ and Tumor Necrosis Factor-α Regulate Amyloid-β Plaque Deposition and β-Secretase Expression in Swedish Mutant APP Transgenic Mice

Yamamoto, M., Kiyota, T., Horiba, M., Buescher, J. L., Walsh, S. M., Gendelman, H. E., & Ikezu, T. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060378 · Cited by 367 · see citing works

Identification of a microglia phenotype supportive of remyelination

Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012) · Glia · doi:10.1002/glia.21266 · Cited by 358 · see citing works

Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

Stanimirovic, D. B., & Friedman, A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.25 · Cited by 352 · see citing works

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deußing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., et al. (2019) · doi:10.7892/boris.125653 · Cited by 352 · see citing works

Microglia in the Neuroinflammatory Pathogenesis of Alzheimer’s Disease and Related Therapeutic Targets

Cai, Y., Liu, J., Wang, B., Sun, M., & Yang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856376 · Cited by 351 · see citing works

New Insights Into the Pathogenesis of Alzheimer's Disease

Fan, L., Mao, C., Hu, X., Zhang, S., Yang, Z., Hu, Z., Sun, H., Fan, Y., Dong, Y., Yang, J., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2019.01312 · Cited by 349 · see citing works

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346 · see citing works

Astrocytes: Role and Functions in Brain Pathologies

Siracusa, R., Fusco, R., & Cuzzocrea, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01114 · Cited by 342 · see citing works

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

Fonseca, M. I., Chu, S.-H., Hernandez, M. X., Fang, M. J., Modarresi, L., Selvan, P., MacGregor, G. R., & Tenner, A. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0814-9 · Cited by 337 · see citing works

Microglia Phenotypes in Aging and Neurodegenerative Diseases

Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336 · see citing works

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.024 · Cited by 334 · see citing works

Neuroinflammation in Alzheimer’s Disease

Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330 · see citing works

A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease

Lozano, A. M., Fosdick, L., Chakravarty, M. M., Leoutsakos, J., Munro, C. A., Oh, E. S., Drake, K. E., Lyman, C. H., Rosenberg, P. B., Anderson, W. S., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160017 · Cited by 329 · see citing works

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-208660 · Cited by 324 · cited 1× · see citing works

Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., et al. (2021) · Nature · doi:10.1038/s41586-021-03734-6 · Cited by 322 · see citing works

Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease

Patel, N. S., Paris, D., Mathura, V. S., Quadros, A., Crawford, F., & MULLAN, M. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-9 · Cited by 318 · see citing works

Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies

Gao, Y., Tan, L., Yu, J., & Tan, L. (2018) · Current Alzheimer Research · doi:10.2174/1567205014666170417111859 · Cited by 316 · see citing works

A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?

Fan, Y., & Huo, J. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105080 · Cited by 310 · see citing works

Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial

Gonzales, M. M., Garbarino, V. R., Kautz, T. F., Palavicini, J. P., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J. J., Zare, H., Xu, P., Zhang, B., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02543-w · Cited by 310 · see citing works

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Kimura, T., Whitcomb, D. J., Jo, J., Regan, P., Piers, T., Heo, S., Brown, C., Hashikawa, T., Murayama, M., Seok, H., et al. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0144 · Cited by 307 · see citing works

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

Hu, Y., Fryatt, G. L., Ghorbani, M., Obst, J., Menassa, D. A., Martin-Estebane, M., Muntslag, T. A. O., Olmos-Alonso, A., Guerrero-Carrasco, M., Thomas, D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109228 · Cited by 298 · see citing works

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

De Schepper, S., Ge, J. Z., Sierksma, A., Crowley, G., Ferreira, L. S. S., Garceau, D., Toomey, C. E., Sokolova, D., Rueda-Carrasco, J., Shin, S.-H., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01257-z · Cited by 295 · see citing works

Deciphering the astrocyte reaction in Alzheimer's disease

Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282 · see citing works

Resveratrol for Alzheimer's disease

Sawda, C. N., Moussa, C., & Turner, R. S. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13431 · Cited by 281 · see citing works

Astrocyte senescence: Evidence and significance

Cohen, J., & Torres, C. (2019) · Aging Cell · doi:10.1111/acel.12937 · Cited by 281 · see citing works

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280 · see citing works

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

Liu, C.-C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3442-16.2017 · Cited by 267 · see citing works

Aging, Cellular Senescence, and Alzheimer’s Disease

Liu, R.-M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041989 · Cited by 267 · see citing works

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257 · see citing works

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., Aamir, K., & Shaikh, M. F. (2020) · Cells · doi:10.3390/cells9020383 · Cited by 257 · see citing works

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

Martini-Stoica, H., Cole, A. L., Swartzlander, D. B., Chen, F., Wan, Y.-W., Bajaj, L., Bader, D. A., Lee, V. M. Y., Trojanowski, J. Q., Liu, Z., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20172158 · Cited by 253 · see citing works

Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

Dean, D. C., Hurley, S. A., Kecskemeti, S. R., O’Grady, J. P., Canda, C., Davenport-Sis, N. J., Carlsson, C. M., Zetterberg, H., Blennow, K., Asthana, S., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3232 · Cited by 252 · cited 1× · see citing works

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

Jouanne, M., Rault, S., & Voisin‐Chiret, A. S. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.070 · Cited by 252 · see citing works

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease

Cheng-Hathaway, P. J., Reed-Geaghan, E. G., Jay, T. R., Casali, B. T., Bemiller, S. M., Puntambekar, S. S., von Saucken, V. E., Williams, R. Y., Karlo, J. C., Moutinho, M., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0262-8 · Cited by 252 · see citing works

Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients

Ojala, J., Alafuzoff, I., Herukka, S.-K., van Groen, T., Tanila, H., & Pirttilä, T. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.06.006 · Cited by 235 · see citing works

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model: Aβ Plaque Formation and Microglial Activation

Baik, S. H., Kang, S., Son, S. M., & Mook-Jung, I. (2016) · Glia · doi:10.1002/glia.23074 · Cited by 234 · see citing works

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

Ponath, G. D., Ramanan, S., Mubarak, M., Housley, W., Lee, S., Sahinkaya, F. R., Vortmeyer, A. O., Raine, C. S., & Pitt, D. (2016) · Brain · doi:10.1093/brain/aww298 · Cited by 228 · see citing works

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

Gomez‐Arboledas, A., Davila, J. C., Sanchez‐Mejias, E., Navarro, V., Nuñez‐Diaz, C., Sanchez‐Varo, R., Sanchez‐Mico, M. V., Trujillo‐Estrada, L., Fernandez‐Valenzuela, J. J., Vizuete, M., et al. (2018) · Glia · doi:10.1002/glia.23270 · Cited by 220 · see citing works

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

Tamboli, I. Y., Barth, E., Christian, L., Siepmann, M., Kumar, S., Singh, S., Tolksdorf, K., Heneka, M. T., Lütjohann, D., Wunderlich, P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149468 · Cited by 219 · see citing works

TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.016 · Cited by 219 · see citing works

Activated microglia mitigate Aβ-associated tau seeding and spreading

Gratuze, M., Chen, Y., Parhizkar, S., Jain, N., Strickland, M. R., Serrano, J. R., Colonna, M., Ulrich, J. D., & Holtzman, D. M. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20210542 · Cited by 215 · see citing works

Treadmill Exercise Exerts Neuroprotection and Regulates Microglial Polarization and Oxidative Stress in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer’s Disease

Lu, Y., Dong, Y., Tucker, D., Wang, R., Ahmed, M. E., Brann, D. W., & Zhang, Q. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160869 · Cited by 214 · see citing works

Microglia contribute to the propagation of Aβ into unaffected brain tissue

d’Errico, P., Ziegler-Waldkirch, S., Aires, V., Hoffmann, P., Mezö, C., Erny, D., Monasor, L. S., Liebscher, S., Ravi, V. M., Joseph, K., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00951-0 · Cited by 214 · see citing works

Microglia in Brain Development, Homeostasis, and Neurodegeneration

Bohlen, C. J., Friedman, B. A., Dejanovic, B., & Sheng, M. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043515 · Cited by 212 · see citing works

Astrocyte-derived endothelin-1 inhibits remyelination through notch activation

Hammond, T. R., Gadea, A., Dupree, J., Kerninon, C., Nait-Oumesmar, B., Aguirre, A., & Gallo, V. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.015 · Cited by 206 · see citing works

Synapse pathology in Alzheimer’s disease

Griffiths, J., & Grant, S. G. N. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.05.028 · Cited by 203 · see citing works

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial

Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.62 · Cited by 203 · see citing works

Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial

Howard, R., Zubko, O., Bradley, R., Harper, E., Pank, L., O’Brien, J., Fox, C., Tabet, N., Livingston, G., Bentham, P., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2019.3762 · Cited by 194 · see citing works

Deep learning for Alzheimer's disease diagnosis: A survey

Khojaste-Sarakhsi, M., Haghighi, S. S., Ghomi, S. M. T. F., & Marchiori, E. (2022) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2022.102332 · Cited by 194 · see citing works

Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions

Traiffort, É., Kassoussi, A., Zahaf, A., & Laouarem, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00079 · Cited by 189 · see citing works

Differential regulation of BACE1 promoter activity by nuclear factor‐κB in neurons and glia upon exposure to β‐amyloid peptides

Bourne, K. Z., Ferrari, D. C., Lange‐Dohna, C., Roßner, S., Wood, T. G., & Perez-Polo, J. R. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21252 · Cited by 188 · see citing works

The role of myelin damage in Alzheimer’s disease pathology

Papuć, E., & Rejdak, K. (2020) · Archives of Medical Science · doi:10.5114/aoms.2018.76863 · Cited by 188 · see citing works

Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease

Wilkinson, K., & Khoury, J. B. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489456 · Cited by 186 · see citing works

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

Györffy, B. A., Kun, J., Török, G., Bulyáki, É., Borhegyi, Z., Gulyássy, P., Kis, V., Szocsics, P., Micsonai, A., Matkó, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722613115 · Cited by 186 · see citing works

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

Gouna, G., Klose, C., Bosch-Queralt, M., Liu, L., Gokce, O., Schifferer, M., Cantuti-Castelvetri, L., & Simons, M. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20210227 · Cited by 186 · see citing works

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

Fu, H., Liu, B., Frost, J. L., Hong, S., Jin, M., Ostaszewski, B., Shankar, G. M., Costantino, I. M., Carroll, M. C., Mayadas, T. N., et al. (2012) · Glia · doi:10.1002/glia.22331 · Cited by 180 · see citing works

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Ding, X., Wang, J., Huang, M., Chen, Z., Liu, J., Zhang, Q., Zhang, C., Xiang, Y., Zen, K., & Li, L. (2021) · Nature Communications · doi:10.1038/s41467-021-22301-1 · Cited by 180 · see citing works

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

Konishi, H., Okamoto, T., Hara, Y., Komine, O., Tamada, H., Maeda, M., Osako, F., Kobayashi, M., Nishiyama, A., Kataoka, Y., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020104464 · Cited by 179 · see citing works

Galantamine for Alzheimer's disease

Loy, C. T., & Schneider, L. S. S. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001747.pub2 · Cited by 178 · see citing works

Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease

Hamelin, L., Lagarde, J., Dorothée, G., Potier, M. C., Corlier, F., Kuhnast, B., Caillé, F., Dubois, B., Fillon, L., Chupin, M., et al. (2018) · Brain · doi:10.1093/brain/awy079 · Cited by 177 · see citing works

Astrocyte Senescence and Alzheimer’s Disease: A Review

Han, X., Zhang, T., Liu, H., Mi, Y., & Gou, X. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00148 · Cited by 177 · see citing works

Astrocytes in Alzheimer's disease: pathological significance and molecular pathways

Preman, P., Alfonso-Triguero, M., Alberdi, E., Verkhratsky, A., & Arranz, A. M. (2021) · Cells · doi:10.3390/cells10030540 · Cited by 176 · see citing works

Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes

Iram, T., Ramirez‐Ortiz, Z. G., Byrne, M. H., Coleman, U. A., Kingery, N. D., Means, T. K., Frenkel, D., & Khoury, J. B. E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3850-15.2016 · Cited by 175 · see citing works

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

Campanella, C., Pace, A., Bavisotto, C. C., Marzullo, P., Marino, A., Buscemi, S., & Piccionello, A. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092603 · Cited by 175 · see citing works

Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer's disease rat model

Lin, W., Chen, R.-C., Lu, W.-W., Liu, S., & Yang, F. (2015) · Scientific Reports · doi:10.1038/srep09671 · Cited by 173 · see citing works

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

Brück, W., Pförtner, R., Pham, T., Zhang, J., Hayardeny, L., Piryatinsky, V., Hanisch, U., Regen, T., van Rossum, D., Brakelmann, L., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1009-1 · Cited by 168 · see citing works

Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells

Yang, L., Tucker, D., Dong, Y., Wu, C., Lu, Y., Li, Y., Zhang, J., Liu, T. C., & Zhang, Q. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.013 · Cited by 168 · see citing works

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis

Sen, M. K., Mahns, D. A., Coorssen, J. R., & Shortland, P. J. (2022) · Glia · doi:10.1002/glia.24148 · Cited by 166 · see citing works

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

Srinivasan, M., & Lahiri, D. K. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.989834 · Cited by 164 · see citing works

Clearance of Amyloid-β Peptides By Microglia and Macrophages: the Issue of What, When and Where

Lai, A. Y., & McLaurin, J. (2012) · Future Neurology · doi:10.2217/fnl.12.6 · Cited by 161 · see citing works

Glial phagocytic clearance in Parkinson’s disease

Tremblay, M., Cookson, M., & Civiero, L. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0314-8 · Cited by 159 · see citing works

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

Zhou, J., Wade, S. D., Graykowski, D., Xiao, M.-F., Zhao, B., Giannini, L. A. A., Hanson, J. E., van Swieten, J. C., Sheng, M., Worley, P. F., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf0141 · Cited by 152 · see citing works

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Lessard, C. B., Malnik, S. L., Zhou, Y., Ladd, T. B., Cruz, P. E., Ran, Y., Chakrabaty, P., Mahan, T. E., Holtzman, D. M., Ulrich, J. D., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809027 · Cited by 151 · see citing works

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

Berghoff, S. A., Gerndt, N., Winchenbach, J., Stumpf, S. K., Hosang, L., Odoardi, F., Ruhwedel, T., Böhler, C., Barrette, B., Stassart, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms14241 · Cited by 151 · see citing works

Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications

Uddin, M. S., & Lim, L. W. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101622 · Cited by 149 · see citing works

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

Gitik, M., Zaltsman, S. L., Oldenborg, P., Reichert, F., & Rotshenker, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-24 · Cited by 148 · see citing works

Activated microglia drive demyelination via <scp>CSF1R</scp> signaling

Marzan, D. E., Brügger‐Verdon, V., West, B. L., Liddelow, S., Samanta, J., & Salzer, J. L. (2021) · Glia · doi:10.1002/glia.23980 · Cited by 147 · cited 2× · see citing works

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

Jones, R. S., Minogue, A. M., Connor, T. J., & Lynch, M. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9427-3 · Cited by 147 · see citing works

Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase

Eguchi, K., Shindo, T., Ito, K., Ogata, T., Kurosawa, R., Kagaya, Y., Monma, Y., Ichijo, S., Kasukabe, S., Miyata, S., et al. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.05.012 · Cited by 145 · see citing works

Transforming Growth Factor-β1 Potentiates Amyloid-β Generation in Astrocytes and in Transgenic Mice

Lesné, S., Docagne, F., Gabriel, C., Liot, G., Lahiri, D. K., Buée, L., Plawinski, L., Delacourte, A., MacKenzie, E. T., Buisson, A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300819200 · Cited by 142 · see citing works

Aging-related down-regulation of neprilysin, a putative β-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of β-amyloid plaques

Apelt, J., Ach, K., & Schliebs, R. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00030-2 · Cited by 140 · see citing works

Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

Yang, L., Wu, C., Parker, E., Li, Y., Dong, Y., Tucker, L. D., Brann, D. W., Lin, H. W., & Zhang, Q. (2022) · Theranostics · doi:10.7150/thno.70756 · Cited by 137 · see citing works

The Role of Microglial Phagocytosis in Ischemic Stroke

Jia, J., Yang, L., Chen, Y., Zheng, L., Chen, Y., Xu, Y., & Zhang, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.790201 · Cited by 136 · see citing works

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice

Wan, T., Zhu, W., Zhao, Y., Zhang, X., Ye, R., Zuo, M., Xu, P., Huang, Z., Zhang, C., Xie, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28777-9 · Cited by 136 · see citing works

Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned?

Hamblin, M. R. (2019) · Photonics · doi:10.3390/photonics6030077 · Cited by 133 · see citing works

Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model

Tao, L., Liu, Q., Zhang, F., Fu, Y., Zhu, X. D., Weng, X., Han, H., Huang, Y., Suo, Y., Chen, L., et al. (2021) · Light Science & Applications · doi:10.1038/s41377-021-00617-3 · Cited by 133 · see citing works

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease

Vanzulli, I., Papanikolaou, M., De-La-Rocha, I. C., Pieropan, F., Rivera, A. D., Gomez-Nicola, D., Verkhratsky, A., Rodríguez, J. J., & Butt, A. M. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.05.016 · Cited by 130 · see citing works

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

Cong, Q., Soteros, B. M., Wollet, M., Kim, J. H., & Sia, G.-M. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0672-0 · Cited by 129 · see citing works

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Czirr, E., Castello, N. A., Mosher, K. I., Castellano, J. M., Hinkson, I. V., Lucin, K. M., Baeza-Raja, B., Ryu, J. K., Li, L., Farina, S. N., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162011 · Cited by 126 · see citing works

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

Vergara, C., Houben, S., Suain, V., Yilmaz, Z., Decker, R. D., Dries, V. V., Boom, A., Mansour, S., Leroy, K., Ando, K., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1953-5 · Cited by 125 · see citing works

Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

Jensen, C. S., Bahl, J. M. C., Østergaard, L. B., Høgh, P., Wermuth, L., Heslegrave, A., Zetterberg, H., Heegaard, N. H. H., Hasselbalch, S. G., & Simonsen, A. H. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.04.003 · Cited by 120 · see citing works

Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer’s Disease

Wong, K. Y., Roy, J., Fung, M., Heng, B. C., Zhang, C., & Lim, L. W. (2020) · Aging and Disease · doi:10.14336/ad.2019.1125 · Cited by 119 · see citing works

Myelin lipid metabolism and its role in myelination and myelin maintenance

Barnes-Vélez, J. A., Yasar, F. B. A., & HU, J. L. (2022) · The Innovation · doi:10.1016/j.xinn.2022.100360 · Cited by 117 · see citing works

IFN‐γ‐induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes

Cho, H. J., Kim, S., Jin, S. M., Hwang, E., Kim, Y. S., Huh, K., & Mook‐Jung, I. (2006) · Glia · doi:10.1002/glia.20451 · Cited by 115 · see citing works

IL (Interleukin)-15 Bridges Astrocyte-Microglia Crosstalk and Exacerbates Brain Injury Following Intracerebral Hemorrhage

Shi, S. X.-Y., Li, Y.-J., Shi, K., Wood, K., Ducruet, A. F., & Liu, Q. (2020) · Stroke · doi:10.1161/strokeaha.119.028638 · Cited by 114 · see citing works

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

Puntambekar, S. S., Moutinho, M., Lin, P. B.-C., Jadhav, V., Tumbleson-Brink, D., Balaji, A., Benito, M. A., Xu, G., Oblak, A., Lasagna-Reeves, C. A., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00545-9 · Cited by 113 · see citing works

Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer’s Rat Model

Wu, C., Yang, L., Tucker, D., Dong, Y., Zhu, L., Duan, R., Liu, T. C., & Zhang, Q. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001519 · Cited by 113 · see citing works

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and <scp>A</scp>lzheimer disease

Agosta, F., Dalla Libera, D., Spinelli, E. G., Finardi, A., Canu, E., Bergami, A., Bocchio Chiavetto, L., Baronio, M., Comi, G., Martino, G., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24235 · Cited by 113 · see citing works

Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural Products

Rather, M. A., Khan, A., Alshahrani, S., Rashid, H., Qadri, M. M., Rashid, S., Alsaffar, R. M., Kamal, M. A., & Rehman, M. U. (2021) · Mediators of Inflammation · doi:10.1155/2021/9982954 · Cited by 112 · see citing works

Microglia Polarization in Alzheimer’s Disease: Mechanisms and a Potential Therapeutic Target

Wang, Q., Yao, H., Liu, W., Ya, B., Cheng, H., Xing, Z., & Wu, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.772717 · Cited by 109 · see citing works

Role of Glia in Memory Deficits Following Traumatic Brain Injury: Biomarkers of Glia Dysfunction

Sajja, V. S. S. S., Hlavac, N., & VandeVord, P. J. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2016.00007 · Cited by 108 · see citing works

Ultrasound Enhances the Expression of Brain-Derived Neurotrophic Factor in Astrocyte Through Activation of TrkB-Akt and Calcium-CaMK Signaling Pathways

Liu, S., Lai, Y.-L., Chen, B.-L., & Yang, F. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw169 · Cited by 108 · see citing works

Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly via Hippocampal Microglia Modifications

Zhang, X., He, Q., Huang, T., Zhao, N., Liang, F., Xu, B., Chen, X., Li, T., & Bi, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00078 · Cited by 107 · see citing works

Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry

Mankin, E. A., & Fried, I. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.024 · Cited by 107 · see citing works

Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies

Sun, Z., Zhang, X., So, K.-F., Jiang, W., & Chiu, K. (2024) · Biomolecules · doi:10.3390/biom14070833 · Cited by 71 · see citing works

Unveiling the role of astrocytes in postoperative cognitive dysfunction

He, L., Duan, X., Li, S., Zhang, R., Dai, X., & Lu, M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102223 · Cited by 65 · see citing works

Research progress in Alzheimer's disease and bone-brain axis

Zhang, F., & Zhang, W. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102341 · Cited by 62 · see citing works

Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteostatic Collapse, and Network Failure Across the CNS

Voicu, V. A., Toader, C., Șerban, M., Covache-Busuioc, R.-A., & Ciurea, A. V. (2025) · Biomedicines · doi:10.3390/biomedicines13082025 · Cited by 54 · see citing works

Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response

Wang, Z., Zhang, L., & Qin, C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00857-6 · Cited by 54 · see citing works

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

Wahl, D., Risen, S. J., Osburn, S. C., Emge, T., Sharma, S., Gilberto, V. S., Chatterjee, A., Nagpal, P., Moreno, J. A., & LaRocca, T. J. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03182-9 · Cited by 40 · see citing works

Oxidative Stress, Advanced Glycation End Products (AGEs), and Neurodegeneration in Alzheimer’s Disease: A Metabolic Perspective

Boccardi, V., Mancinetti, F., & Mecocci, P. (2025) · Antioxidants · doi:10.3390/antiox14091044 · Cited by 40 · see citing works

The role of estrogen in Alzheimer’s disease pathogenesis and therapeutic potential in women

Wang, X., Feng, S., Deng, Q., Wu, C., Duan, R., & Yang, L. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05071-4 · Cited by 33 · see citing works

Glial cell nutrient sensing: mechanisms of nutrients regulating Alzheimer’s pathogenesis and precision intervention

Yan, Q., Qin, Q., Zhang, S., Chen, F., Ru, Y., Zhong, Y., & Wu, G. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2568606 · Cited by 27 · see citing works

Extracellular vesicles as therapeutic modulators of neuroinflammation in Alzheimer’s disease: a focus on signaling mechanisms

Han, J., Zhang, X., Kang, L., & Guan, J. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03443-1 · Cited by 26 · see citing works

Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape

Sugandhi, V. V., Gadhave, D. G., Ugale, A. R., Kulkarni, N. N., Nangare, S., Patil, H. P., Rath, S., Saxena, R., Lavate, A., Patel, A. T., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102775 · Cited by 31 · see citing works

Efficacy and molecular mechanisms of hesperidin in mitigating Alzheimer's disease: A systematic review

Han, X., Zhang, Y., Zhang, L., Zhang, L., & Wang, Y. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117144 · Cited by 22 · see citing works

Glycolytic dysregulation in Alzheimer’s disease: unveiling new avenues for understanding pathogenesis and improving therapy

Wu, Y., Yang, L., Jiang, W., Zhang, X., & Yao, Z. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00190 · Cited by 19 · see citing works

Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non‐human primate models

Jin, Z., Lu, Y., Tang, H., & Cui, H. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70472 · Cited by 23 · see citing works

Beyond the blood–brain barrier: unraveling T cell subsets in CNS immunity and disease

Shokr, M. M. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01955-z · Cited by 18 · see citing works

Gallic acid ameliorates LPS-induced memory decline by modulating NF-κB, TNF-α, and Caspase 3 gene expression and attenuating oxidative stress and neuronal loss in the rat hippocampus

Dastan, M., Rajaei, Z., Sharifi, M., & Salehi, H. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01441-5 · Cited by 17 · see citing works

Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)

Tolédano, A., Rodríguez‐Casado, A., Álvarez, M., & Toledano‐Díaz, A. (2024) · Brain Sciences · doi:10.3390/brainsci14111101 · Cited by 19 · see citing works

Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential

Wu, J., Xu, W., Su, Y., Wang, G., & Ma, J. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01416-3 · Cited by 17 · see citing works

The Role of Astrocytes in Synaptic Dysfunction and Memory Deficits in Alzheimer’s Disease

de León-López, C. A. M., Navarro‐Lobato, I., & Khan, Z. U. (2025) · Biomolecules · doi:10.3390/biom15070910 · Cited by 19 · see citing works

Role of MARK2 in the nervous system and cancer

Lei, Y., Zhang, R., & Cai, F. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00737-z · Cited by 15 · see citing works

Refining the interactions between microglia and astrocytes in Alzheimer’s disease pathology

Chen, J., Xu, S., Wang, L., Liu, X., Liu, G., Tan, Q., Li, W., Zhang, S., & Du, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.033 · Cited by 16 · see citing works

The role of peripheral innate immune cells in Alzheimer’s disease progression

Cao, Y., Tang, K., Ma, P., Zhang, R., Yang, Y., Li, T., Zhang, Y., & Peng, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1616939 · Cited by 13 · see citing works

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer’s Disease and HIV-Associated Neurocognitive Disorders

Njoku, G. C., & Kanmogne, G. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189069 · Cited by 15 · see citing works

Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K. L., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · BMC Biology · doi:10.1186/s12915-024-01867-4 · Cited by 13 · see citing works

Neobavaisoflavone Ameliorates Memory Deficits and Brain Damage in Aβ25‐35‐Induced Mice by Regulating SIRT1

Hao, F., Zeng, M., Cao, B., Liang, X., Ye, K., Jiao, X., Feng, W., & Zheng, X. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70068 · Cited by 11 · see citing works

Targeting autophagy in astrocytes: a potential for neurodegenerative disease intervention

Potokar, M., & Jorgačevski, J. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1584767 · Cited by 13 · see citing works

Vascular Contributions to Healthy Aging and Dementia

Ge, Y. (2024) · Aging and Disease · doi:10.14336/ad.2023.1719 · Cited by 10 · see citing works

Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation

Brezáni, V., Joshi, R., Ortega‐Ribera, M., Nagesh, P. T., Brezáni, V., Zivny, A., Kurt‐Jones, E. A., Golenbock, D. T., & Szabó, G. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03501-8 · Cited by 10 · see citing works

Beyond amyloid: nanobody-mediated neuroinflammatory therapy for Alzheimer’s disease

Amniouel, S., Suh, J., Zheng, W. H., & Zhang, Q. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00513-5 · Cited by 11 · see citing works

Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential

Deng, Q., Parker, E., Wu, C., Zhu, L., Liu, T. C., Duan, R., & Yang, L. (2024) · Aging and Disease · doi:10.14336/ad.2024.0239 · Cited by 10 · see citing works

Exercise-induced upregulation of TRIM9 attenuates neuroinflammation in Alzheimer’s disease-like rat

Zhang, X.-Y., Zhang, J., Li, X.-C., Lu, H., & Liu, T. C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113676 · Cited by 9 · see citing works

The aggregation propensity of Tau and amyloid-β in Alzheimer’s disease

Chinnathambi, S., Kumarappan, M., Chandrshekar, M., & Malik, S. (2025) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.10.004 · Cited by 9 · see citing works

Astrocyte-microglia crosstalk in the hippocampus mediates cognitive impairments induced by chronic intermittent hypoxia

Wu, Z., Zhai, M., Wang, Y., Ren, L., Pan, J., Xiao, L., & Liu, Y. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107117 · Cited by 11 · see citing works

Comparative analysis of nuclei isolation methods for brain single-nucleus RNA sequencing

Kersey, H. N., Acri, D. J., Dabin, L. C., Hartigan, K. A., Mustaklem, R., Park, J. H., & Kim, J. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101337 · Cited by 8 · see citing works

The role of TREM2 in myelin sheath dynamics: A comprehensive perspective from physiology to pathology

Que, X., Zhang, T., Liu, X. Y., Yin, Y., Xia, X., Gong, P., Song, W., Qin, Q., Xu, Q., & Tang, Y. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102732 · Cited by 8 · see citing works

Neuroimmune Dysregulation and AI-Driven Therapeutic Strategies in Alzheimer’s Disease

Ghosh, S., Bhaskar, R., Singh, D. K. K., Sharma, S., Yarlagadda, B., Sinha, J. K., & Han, S. S. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01651-0 · Cited by 10 · see citing works

Alzheimer’s Disease and Other Dementias

Brugulat‐Serrat, A., Shaaban, C. E., Emrani, S., & Sundermann, E. E. (2025) · Springer eBooks · doi:10.1007/978-3-031-87228-0_5 · Cited by 7 · see citing works

Multi-Faceted Role of Histone Methyltransferase Enhancer of Zeste 2 (EZH2) in Neuroinflammation and Emerging Targeting Options

Moraitis, S., & Piperi, C. (2025) · Biology · doi:10.3390/biology14070749 · Cited by 7 · see citing works

Neuroprotective effects of Chlorella vulgaris loaded niosomes via SIRT1 activation in aluminum chloride-induced Alzheimer’s model

Radi, R. A., Kandeil, M. A., Mohammed, E. T., Ibrahim, M. A., Fouad, A. G., Abdel‐Razik, A. H., Khalıl, F., & Sabry, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-25892-7 · Cited by 7 · see citing works

Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer’s Disease

Patil, V., Sharma, A., Parekh, B. K., Farah, H., Jyothi, S. R., Mishra, S. S., Nanda, A., Al-Hasnaawei, S., & Mishra, M. K. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08898-2 · Cited by 9 · see citing works

Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway

Xu, J., Zhao, Y., Wang, G., & Tian, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114281 · Cited by 6 · see citing works

Magnolol acts as a neurorestorative agent in an Aβ1‑42‑induced mouse model of Alzheimer's disease

Qian, Y., Shi, Y., Wu, Y., Liu, R., Zhang, H., Wu, L., & Ding, M. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12762 · Cited by 5 · see citing works

Curcuma longa L. extract and residue prevent Alzheimer’s disease in mice by regulating microglia and TLR4/NF-κB signaling pathway

Xu, Z., Li, J., Liu, X., Liu, L., Lin, W., Sun, D., & Zeng, Y. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf034 · Cited by 5 · see citing works

Role of astrocytes in Alzheimer's disease pathogenesis and the impact of exercise-induced remodeling

Shao, J., Deng, Q., Feng, S., Wu, C., Liu, X., & Yang, L. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150418 · Cited by 5 · see citing works

Boosting Neurogenesis as a Strategy in Treating Alzheimer’s Disease

Dwamena, A., Arachchi, R. Y. B., & Wang, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188926 · Cited by 4 · see citing works

Glial Plasticity and Dysfunction: Mechanistic Insights and Therapeutic Opportunities in Neurodegeneration

Correale, J. D. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70414 · Cited by 4 · see citing works

Inhibition of neuroinflammation and neuronal damage by the selective non-steroidal ERβ agonist AC-186

Katola, F. O., Adana, M. Y., & Olajide, O. A. (2024) · Inflammation Research · doi:10.1007/s00011-024-01952-y · Cited by 4 · see citing works

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening

Wu, L., Zhang, R., Wang, Y., Dai, S., & Yang, N. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1571783 · Cited by 4 · see citing works

Tacrolimus mitigates pathological patterns in mouse models of Alzheimer’s disease

Gomes, G. F., Batista, C. R. Á., da Silva, M. C. M., Ferrari, C. Z., Koerich, S., Brant, M. L., Saliba, S. W., Perez, V. G., Lima, A. L. D., Ribeiro, R., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118168 · Cited by 4 · see citing works

Cardiovascular-kidney-metabolic syndrome, systemic inflammation, and incident dementia: evidence from 400,740 UK Biobank participants

Li, P., Zhang, H., Ma, J., Wang, J., Lv, S., Zhao, X., Yang, X., Luo, Y., Guo, X., Tao, L., et al. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01805-6 · Cited by 3 · see citing works

Targeting Oligodendrocyte Dysfunction in Alzheimer’s Disease: a New Frontier for Drug Repurposing with Antihistamines and Serotonin Receptor Agonists

Gurikar, S., Ahmed, S. S., & Raghunatahanaidu, B. D. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02433-5 · Cited by 3 · see citing works

Microglial TREM2 and cognitive impairment: insights from Alzheimer’s disease with implications for spinal cord injury and AI-assisted therapeutics

Wu, Z., Yu, S., Tian, D., Li, C., & Jing, J. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1705069 · Cited by 3 · see citing works

The dual effects of anesthetics on glial cells: a review of neuroprotection and neurotoxicity

Wang, X., Zhao, M., & Liu, Z. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1724695 · Cited by 3 · see citing works

Glial cells in dementia: From cellular dysfunction to therapeutic frontiers

Jubair, H. (2026) · Cell Transplantation · doi:10.1177/09636897251414216 · Cited by 3 · see citing works

Far-Infrared Radiation Ameliorates the Cognitive Dysfunction in an Alzheimer’s Disease Transgenic Mouse via Modulating Jak-2/Stat3 and Nrf-2/HO-1 Pathways

Yang, W., Yu, Q., Wang, N., Lam, K. K. Y., Lin, Z., & Xian, Y. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08860-2 · Cited by 4 · see citing works

Mechanistic Role of Astrocytic Rac1 Protein in Alzheimer's Disease

Jiang, F., Wang, N., & Meng, Q. (2025) · Aging and Disease · doi:10.14336/ad.2025.0502 · Cited by 2 · see citing works

Distinct glial functions are associated with Alzheimer's disease based on cell-type- and pathway-specific polygenic risk score analysis

Pratt, T., Lee, A., Zheng, J., Tavacoli, F., Ho, H., Liu, T., Zhan, H., Chen, J., & Initiative, A. D. N. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251362258 · Cited by 2 · see citing works

Functions of the basal lamina and ApoE in cerebral amyloid angiopathy

Juan-Palencia, A., & Yao, Y. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00734-w · Cited by 2 · see citing works

Amelioration of Symptomatic Alzheimer’s Disease after Selective Impairment of p75 NTR Function in Adult Forebrain Excitatory Neurons

Li, X., Xie, M., & Ibáñez, C. F. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.1939-25.2026 · Cited by 1 · see citing works

Single-cell analysis of Powassan virus-infected brains reveals age-dependent neuroinflammatory crosstalk and progressive Alzheimer’s-like APP/Aβ accumulation

de Souza, M. R. M., Lindner, M. R., Mladinich, M. C., Gorbunova, E. E., Kirillov, V., Byrne, A. G., Laird, A. Y., Finnerty, C. E., Ikeda, P., Vorkas, C. K., et al. (2026) · mBio · doi:10.1128/mbio.01294-26 · Cited by 2 · see citing works

Microglia–astrocyte crosstalk as a key organizing principle of Alzheimer’s disease: from homeostatic cooperation to maladaptive signaling loops

Gong, M., Lan, J. X., & Miao, J. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1908574 · Cited by 2 · see citing works

3-N-Butylphthalide alleviate Aβ-induced cellular senescence through the CDK2-pRB1-Caspase3 axis

Tian, Y., Li, W., & Zhang, Y. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149435 · Cited by 1 · see citing works

Asparaginase-like protein 1 and human endogenous retroviruses link immune and gene dysregulation in dementia

Simula, E. R., Ercoli, T., Ruiu, E., Fais, M., Noli, M., Solla, P., & Sechi, L. A. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1777560 · Cited by 1 · see citing works

Intranasal administration of neural stem cell-derived extracellular vesicles prevents cognitive decline in both male and female 3×Tg-AD mice by dampening neuroinflammation and epigenetically regulating amyloid β metabolism

Natale, F., Dellaria, A., Sarrapochiello, I. N., Leone, L., Spinelli, M., Rinaudo, M., Garofalo, N., Grassi, C., & Fusco, S. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02014-7 · Cited by 1 · see citing works

Oleic acid improves pathological changes in Aβ1–42-induced astrocytes and Alzheimer’s disease mouse models through PKA/ACACB/CPT1A

Xie, Y., Tian, J., Li, H., Peng, Y., Li, M., & Wu, Y. H. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1771310 · Cited by 1 · see citing works

Mechanisms and Therapeutic Targeting of the Gut Microbiota-Immune-Brain Axis in Alzheimer’s Disease

Wang, S., Yuan, X., Wang, T., Yang, M., Dong, P., & Han, H. (2026) · Immunological Investigations · doi:10.1080/08820139.2026.2669375 · Cited by 1 · see citing works

Photobiomodulation in stroke prevention and treatment: neuroprotective mechanisms and therapeutic challenges

Li, Y., Zhang, L., Lin, J., Yang, L., & Duan, R. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149981 · Cited by 1 · see citing works

SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brainPreprint

Huang, H., Shi, C. H., Yang, W., Piña-Crespo, J., Bhatnagar, J., Curatolo, J., Murad, R., Shah, P. M., Campos, A. R., Houser, A. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.25.661599 · Cited by 1 · see citing works

Targeting CHI3L1 in Alzheimer’s Disease: Optimization of G721-0282 and Functional Evaluation in Astrocyte ModelsPreprint

Kaur, B., Nada, H., Zhang, L., & Gabr, M. T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.13.699206 · Cited by 1 · see citing works

Histologically validated diffusion MRI signatures of neuroinflammation and neurodegeneration in Alzheimer diseasePreprint

Wang, Q. L., Jiang, M., Luna, A., Niu, X., Yuan, N., Sun, Q., Perrin, R. J., Franklin, E. E., Cruchaga, C., Flores, S. E., et al. (2026) · medRxiv · doi:10.64898/2026.06.11.26354743 · Cited by 1 · see citing works

Immune cells and Alzheimer's disease: a bidirectional two-sample Mendelian randomization studyPreprint

Zhang, J., Zhang, Y., Wang, H., Huang, Z., Xie, S., Fan, D., Chen, Y., Zhong, C., Chen, L., Kong, D., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3831902/v1

Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, Pharmacological, Nanoparticle, and Gene Therapy Approaches

Raghuvanshi, S., Mazumder, A., & Das, S. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273378092250623064748

GSDME unlocks astrocyte-driven neurotoxicity in Alzheimer’s DiseasePreprint

Xie, X., Ji, C., Xu, J., Lu, X., Guo, G., Wu, X., Liu, W., Chen, Y., Zhang, Y., Wang, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.28.672784

Assessment of Mitochondrial Network Remodeling and Colocalization with Lysosomes in Primary Astrocyte Cultures from 5xFAD Mice

Okhalnikov, A. D., Anastasia, M., Ermoshina, A. A., & Maria, G. B. (2025) · International Conference Neurotechnologies and Neurointerfaces (CNN) · doi:10.1109/cnn67635.2025.11177480

Asrij/OCIAD1 contributes to age-associated microglial activation and neuroinflammation in mice

Dongre, P., Ramesh, M., Govindaraju, T., & Inamdar, M. S. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1674136

Long-term locus coeruleus stimulation exacerbates tau pathology in PS19 mice

Nong, Y., Wellman, S. M., Zhang, H., Liu, Y., Argyrousi, E. K., Arancio, O., & Wang, Q. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261468577

Neural Stem Cell-conditioned Medium Protected Against Cognitive Dysfunction in APP/PS1 Mice

Zheng, X., Xiang, Q., Dong, X., Shen, Y., Qu, T., Fang, W., & Yang, H. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05282-w

Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats

Garcia, M. L., Denton, A. R., Jackson, N. L., Scofield, M. D., & McMahon, L. L. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1690410

Neuroinflammatory Modulation and Potential Photocompounds

Anuradha, K., Perera, D., & Gunasekara, P. (2026) · Springer eBooks · doi:10.1007/978-981-95-4751-7_3

Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024

Huang, Z., Liu, W., Zhang, Y., Zha, B., Wang, P., & Yang, J. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1708008

A Cross Talk Between Natural Biomolecules and Neuroglia

Iman, T., Akram, R., Tehreem, A., Asghar, A., Mustafa, M., & Iqbal, J. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-4139-2.ch001

Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNSPreprint

Wang, Y., Zhu, M., Park, J., Kim, H. K., Ge, X., Chen, X., Chen, B., Ding, S., Lin, W., & Guo, F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.29.702669

Caveolin-1–Mediated Blood-brain Barrier Transcytosis Promotes Porphyromonas gingivalis Invasion and Alzheimer’s Disease-Like ChangesPreprint

Chenghan, M., Zhong, Q., Xiaojie, L., Yao, H., Zhang, T., Zhao, B., Jiangshang, L., & Zhihui, Z. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.17.706258

How Glial Cell Dysfunction Fuels Neurodegeneration in Alzheimer’s and Prion Diseases? Emerging Targets for Therapy

Zafar, S., Rasheed, U., & Zerr, I. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1013648

Traditional Chinese Medicine and Ferroptosis in Alzheimer’s Disease: A Potential Therapeutic Approach

Liu, A., Xing, L., Li, J., Yao, M., Song, J., Guo, W., Duan, P., & Li, H. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s590868

Glial and BBB modifications correlate with early anxio-depressive-like behaviors and cognitive inflexibility in 3xTg-AD micePreprint

Benhora-Chabeaux, G., MORISSET, C., NICOD, T., Mor, D., DELABROUILLE-CAULIEZ, S., Cabeza, L., Etiévant, A., & Bourasset, F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.13.711598

BDCD: a comprehensive Brain Disease Cell-cell communication Database

Liu, X., Citu, C., Qu, G., Liu, W., Enduru, N., Liu, A., Tung, C.-H., & Zhao, Z. (2026) · Database · doi:10.1093/database/baag017

Targeted Inhibition of MEGF10 ‐Mediated Astrogliosis Reduces Glial Scar Formation and Promotes Neurofunction Recovery in Mice After Stroke

Xu, J.-J., Xu, T., Gan, L., Deng, S., Lian, Q., Ye, J., Guo, Y., Li, H., Geng, Y., Yao, H., et al. (2026) · Glia · doi:10.1002/glia.70159

Structure-Guided Optimization of CHI3L1 Modulators Reveals G721–0377 as a Lead Compound for Restoring Astrocyte Function in Alzheimer’s Disease

Kaur, B., Nada, H., Zhang, L., & Gabr, M. T. (2026) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.5c00279 · Cited by 1 · see citing works

Cognitive decline and reduced bone mineral density under the bone-brain axis: mechanistic insights and imaging evaluation strategies

Mao, Y., Sui, Z., Zhang, M., & M, Y. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1799025

Insights into the Comprehensive Role of Free Radicals in the Development of Alzheimer’s Disease: A Review

Ansari, S., Khali, A., Joshi, B. C., & Uniyal, S. (2026) · Physiological Mini Reviews · doi:10.2174/0116695410415209251114033740

Predicting the risk of neurodegenerative diseases based on clinical microsignals

Bondarenko, Y. D., & Kauk, O. I. (2026) · Ukrainian Neurosurgical Journal · doi:10.25305/unj.341180

Ratanasampil alleviates cognitive impairment in mice induced by chronic hypoxia by modulating inflammatory responses

Meng, J., Liang, H., Wu, X.-D., Liu, Q., & Zhu, A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1872294

Clinical Indication of the Role of Inflammation in Alzheimer’s Disease

Kumar, A., Sarkar, N., Kundu, M., Singh, V., & Dasgupta, D. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898815646126010010

Anemia, iron deficiency, and blood biomarkers for Alzheimer disease: clinical interpretation and dementia risk stratification

Li, Z., Ming, Q., Fu, L., Yang, J., Lv, Y., Chen, B., Qiu, X., & Lu, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1897378

OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins

Wang, Z., Huang, Y., & Bian, J. (2026) · IEEE International Conference on Healthcare Informatics (ICHI) · doi:10.1109/ichi69079.2026.00266

P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure

Li, Y., Liu, S., & 蓝娇 (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1915244

Proteostasis dysregulation is associated with astrocyte dysfunction and a KLF15–LRRTM4 regulatory axis in Alzheimer’s diseasePreprint

Peng, W., Wu, X., & Sun, L. (2026) · Research Square · doi:10.21203/rs.3.rs-10351234/v1

Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammationPreprint

Kim, T. Y., Bhalla, M., Park, U., Hyeon, S. J., Hwang, I., Seo, Y., Youn, W., Lee, J.-A., Lee, J.-H., Lee, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.23.746508

Age-dependent associations of peripheral inflammatory biomarkers with cognition and brain structural abnormalities in patients with Alzheimer’s disease and Alzheimer’s disease-related mild cognitive impairment

Wang, Y., Cheng, M., & Liu, Z. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1868357

Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications

Uddin, M. S., & Lim, L. W. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101622 · Cited by 149 · see citing works

Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?

Sharma, A., Parekh, B. K., Patil, V., Renuka Jyothi, S., Nayak, P. P., Janney, J. B., Singh, G., & Al-Hasnaawei, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23015 · Cited by 17 · see citing works

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

Fakhoury, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170720095240 · Cited by 482 · see citing works

The role of glial cells in Alzheimer disease: potential therapeutic implications

Cabezas, I. L., Batista, A. H., & Rol, G. P. (2014) · Neurología (English Edition) · doi:10.1016/j.nrleng.2012.10.009 · Cited by 57 · see citing works

Role of astroglia and microglia in Alzheimer's disease and multiple therapeutic interventions

Li, L., Wang, Y., Feng, Q., Ma, C., He, C., Wan, W., & Tang, L. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251335572 · Cited by 9 · see citing works