Aβ oligomers promote oligodendrocyte differentiation and maturation via integrin β1 and Fyn kinase signaling
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Abstract Alzheimer´s disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid β-peptide (Aβ) oligomers. Strong evidences connect changes of oligodendrocyte function with the onset of neurodegeneration in AD. However, the mechanisms controlling oligodendrocyte responses to Aβ are still elusive. Here, we tested the role of Aβ in oligodendrocyte differentiation, maturation, and survival in isolated oligodendrocytes and in organotypic cerebellar slices. We found that Aβ peptides specifically induced local translation of 18.5-kDa myelin basic protein (MBP) isoform in distal cell processes concomitant with an increase of process complexity of MBP-expressing oligodendrocytes. Aβ oligomers required integrin β1 receptor, Src-family kinase Fyn and Ca2+/CaMKII as effectors to modulate MBP protein expression. The pharmacological inhibition of Fyn kinase also attenuated oligodendrocyte differentiation and survival induced by Aβ oligomers. Similarly, using ex vivo organotypic cerebellar slices Aβ promoted MBP upregulation through Fyn kinase, and modulated oligodendrocyte population dynamics by inducing cell proliferation and differentiation. Importantly, application of Aβ to cerebellar organotypic slices enhanced remyelination and oligodendrocyte lineage recovery in lysolecithin (LPC)-induced demyelination. These data reveal an important role of Aβ in oligodendrocyte lineage function and maturation, which may be relevant to AD pathogenesis.
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In the later epoch, there is an exponential rise in Aβ and pTau pathology, continued increases in inflammatory microglia and astrocyte states, and a decrease in the expression of both the OPC differentiation program and oligodendrocyte expression of myelin-associated proteins.
“In the later epoch, there is an exponential rise in Aβ and pTau pathology, continued increases in inflammatory microglia and astrocyte states, and a decrease in the expression of both the OPC differentiation program and oligodendrocyte expression of myelin-associated proteins (previously characterized using quantitative PCR95).”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [95]
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Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer’s disease
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Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy
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Mechanosensitivity of Human Oligodendrocytes
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Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications
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Na,K-ATPase Acts as a Beta-Amyloid Receptor Triggering Src Kinase Activation
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Brain region-specific myelinogenesis is not directly linked to amyloid-β in APP/PS1 transgenic mice
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Neuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease
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Roles of Ion Channels in Oligodendrocyte Precursor Cells: From Physiology to Pathology
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Advances in Alzheimer’s disease: mechanistic insights and therapeutic targets
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Disruption of hnRNP A2-mediated RNA dynamics by amyloid-β drives MBP increase in Alzheimer’s disease
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Molecular mechanisms of the effects of photodynamic therapy on the brain: A review of the literature
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The Interaction between Oligodendrocytes and Aβ in Alzheimer's Disease
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Oligodendroglia in Ageing and Age-Dependent Neurodegenerative Diseases
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XIth Cajal Conference: New frontiers in neuron‐glial plasticity in health and disease
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Oligodendrocytes and myelin in aging and disease
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Cx47 Phosphorylation Exacerbates White Matter Damage and Kainic Acid Induced Epilepsy
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Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimer’s diseasePreprint
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- Authors
- Quintela-López, T., Ortiz-Sanz, C., Serrano-Regal, M. P., Gaminde-Blasco, A., Valero, J., Baleriola, J., Sánchez-Gómez, M. V., Matute, C., & Alberdi, E.
- Affiliations
- University of the Basque Country (ES)
- Ikerbasque (ES)
- Corresponding author
- Matute, Carlos
- Alberdi, Elena
- ORCID
- Venue
- Cell Death & Disease
- Published
- 2019-06-06
- Volume
- 10
- Issue
- 6
- Pages
- 445-445
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC6554322
- OpenAlex
- W2948989680
- Cited by
- 80
- References
- 63
- Citations by year
- 2026: 5 · 2025: 21 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 2
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Gredos (University of Salamanca) (publishedVersion, other-oa)
- Hispana (publishedVersion, other-oa)
- Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, other-oa)
- Communities in ADDI (University of the Basque Country) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Hispana (submittedVersion, cc-by)
- Funders
- Eusko Jaurlaritza
- Euskal Herriko Unibertsitatea
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, oligodendrocyte differentiation, oligodendrocyte maturation, beta1 integrin, Fyn, CaMKII, myelin basic protein, local translation, oligodendrocyte survival, remyelination, demyelination, oligodendrocyte lineage
- MeSH terms
- Alzheimer Disease, Animals, Calcium, Cell Differentiation, Cell Survival, Cells, Cultured, Demyelinating Diseases, Myelin Basic Protein, Oligodendroglia, Organoids, Signal Transduction, Amyloid beta-Peptides, Rats, Sprague-Dawley, Integrin beta1, Cell Proliferation, Proto-Oncogene Proteins c-fyn, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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