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Cited by 153Cancer Risks and FactorsObesity, Physical Activity, DietGlobal Cancer Incidence and Screening

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Proportion of Cancer Cases Attributable to Excess Body Weight by US State, 2011-2015

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Islami, Farhad, Goding Sauer, Ann, Gapstur, Susan M., Jemal, Ahmedin·2019·JAMA Oncology
DOI 10.1001/jamaoncol.2018.5639PMC PMC6521676
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Abstract

Importance: Excess body weight (EBW) is an established cause of cancer. Despite variations in the prevalence of EBW among US states, there is little information on the EBW-related cancer burden by state; this information would be useful for setting priorities for cancer-control initiatives. Objective: To calculate the population attributable fraction (PAF) of incident cancer cases attributable to EBW among adults 30 years or older in 2011 to 2015 in all 50 states and the District of Columbia. Design, Setting, and Participants: State-level, self-reported body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]) data from the Behavioral Risk Factor Surveillance System were adjusted by sex, age, race/ethnicity, and education using objectively measured BMI values from the National Health and Nutrition Examination Survey. Age- and sex-specific cancer incidence data by state were obtained from the US Cancer Statistics database. All analyses were performed between February 15, 2018, and July 17, 2018. Main Outcomes and Measures: Sex-, age-, and state-specific adjusted prevalence estimates for 4 high BMI categories and corresponding relative risks from large-scale pooled analyses or meta-analyses were used to compute the PAFs for each US state for esophageal adenocarcinoma, multiple myeloma, and cancers of the gastric cardia, colorectum, liver, gallbladder, pancreas, female breast, corpus uteri, ovary, kidney and renal pelvis, and thyroid. Results: Each year, an estimated 37 670 cancer cases in men (4.7% of all cancer cases excluding nonmelanoma skin cancers) and 74 690 cancer cases in women (9.6%) 30 years or older in the United States were attributable to EBW from 2011 to 2015. In both men and women, there was at least a 1.5-fold difference in the proportions of cancers attributable to EBW between states with the highest and lowest PAFs. Among men, the PAF ranged from 3.9% (95% CI, 3.6%-4.3%) in Montana to 6.0% (95% CI, 5.6%-6.4%) in Texas. The PAF for women was approximately twice as high as for men, ranging from 7.1% (95% CI, 6.7%-7.6%) in Hawaii to 11.4% (95% CI, 10.7%-12.2%) in the District of Columbia. The largest PAFs were found mostly in southern and midwestern states, as well as Alaska and the District of Columbia. Conclusions and Relevance: The proportion of cancers attributable to EBW varies among states, but EBW accounts for at least 1 in 17 of all incident cancers in each state. Broad implementation of known community- and individual-level interventions is needed to reduce access to and marketing of unhealthy foods (eg, through a tax on sugary drinks) and to promote and increase access to healthy foods and physical activity, as well as preventive care.

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Research works printed but not linked: 1

  1. American Cancer Society Cancer Action Network. How do you measure up? A progress report on state legislative activity to reduce cancer incidence and mortality, 15th Edition. https://www.fightcancer.org/sites/default/files/National%20Documents/HDYMU-2017.pdf. Accessed March 14, 2018.

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Metadata

Authors
Islami, F., Goding Sauer, A., Gapstur, S. M., & Jemal, A.
Affiliations
  • American Cancer Society (US)
  • Surveillance and Health Services Research, American Cancer Society, Atlanta, Georgia
Corresponding author
Islami, Farhad
ORCID
Venue
JAMA Oncology
Publisher
American Medical Association (AMA)
Published
2019-03-01
Volume
5
Issue
3
Pages
384
ISSN
2374-2437 (ISSN-L)
DOI
10.1001/jamaoncol.2018.5639
PMC
PMC6521676
OpenAlex
W2906817819
Cited by
153
References
49
Citations by year
2026: 17 · 2025: 20 · 2024: 25 · 2023: 33 · 2022: 24 · 2021: 13 · 2020: 10 · 2019: 10
FWCI
3.09
Type
journal article
Language
en
Open access
Locations
  • JAMA Oncology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
overweight, obesity, cancer incidence, population attributable fraction, body mass index, state-level variation, cancer burden, esophageal adenocarcinoma, multiple myeloma, colorectal cancer, liver cancer, breast cancer, ovarian cancer, cancer prevention, sex differences in cancer risk, United States states
MeSH terms
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasms, Nutrition Surveys, Obesity, Risk Factors, Time Factors, United States, Weight Gain, Body Mass Index, Incidence, Prevalence, Age Distribution, Sex Distribution, SEER Program, Risk Assessment

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