Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring: A Systematic Review and Meta-analysis
Open accessAbstract
Importance: Although research suggests an association between hypertensive disorders of pregnancy (HDP) and autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and other neurodevelopmental disorders in offspring, consensus is lacking. Given the increasing prevalence of hypertension in pregnancy, it is important to examine the association of HDP with neurodevelopmental outcome. Objective: To synthesize the published literature on the association between HDP and risk of neurodevelopmental disorders in offspring in a systematic review and meta-analysis. Data Sources: On the basis of a preprepared protocol, a systematic search of PubMed, CINAHL, Embase, PsycINFO, and Web of Science was performed from inception through June 7, 2017, supplemented by hand searching of reference lists. Study Selection: Two investigators independently reviewed titles, abstracts, and full-text articles. English-language cohort and case-control studies were included in which HDP and neurodevelopmental disorders were reported. Data Extraction and Synthesis: Data extraction and quality appraisal were performed independently by 2 reviewers. Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines were followed throughout. Main Outcomes and Measures: Random-effects meta-analyses of estimated pooled odds ratios (ORs) for HDP and ASD and for HDP and ADHD. Stand-alone estimates were reported for all other neurodevelopmental disorders. Results: Of 1166 studies identified, 61 unique articles met inclusion criteria. Twenty studies reported estimates for ASD. Eleven of these (including 777 518 participants) reported adjusted estimates, with a pooled adjusted OR of 1.35 (95% CI, 1.11-1.64). Ten studies reported estimates for ADHD. Six of these (including 1 395 605 participants) reported adjusted estimates, with a pooled adjusted OR of 1.29 (95% CI, 1.22-1.36). Subgroup analyses according to type of exposure (ie, preeclampsia or other HDP) showed no statistically significant differences for ASD or ADHD. Thirty-one studies met inclusion criteria for all other neurodevelopmental disorders. Individual estimates reported for these were largely inconsistent, with few patterns of association observed. Conclusions and Relevance: Exposure to HDP may be associated with an increase in the risk of ASD and ADHD. These findings highlight the need for greater pediatric surveillance of infants exposed to HDP to allow early intervention that may improve neurodevelopmental outcome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maternal hypertensive disorders during pregnancy are linked to 25% higher ADHD rate.
“A meta-analysis of six studies combining 1.4 million people found that children whose mothers had hypertensive disorders during pregnancy had a 25% increase in the rate of ADHD (Maher et al., 2018).”
From The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder (2021) · cites this paper as Maher et al., 2018
The ADHD: Primary Analysis reports adjusted estimates from six studies including 1,395,605 participants and an association between maternal hypertensive disorders and offspring ADHD. Its pooled estimate is an odds ratio of 1.29 (95% CI, 1.22–1.36), not a 25% increase in the ADHD rate; an odds ratio does not directly measure a rate increase. No page number is available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredOffspring of women with HDP are reported to be at greater risk of developing cognitive and psychiatric disorders such as ASD, ADHD or epilepsy later in life.
“The offspring of women with HDP are reported to be at a greater risk of developing cognitive and psychiatric disorders, such as autism spectrum disorder (ASD), attention-deficit–hyperactivity disorder (ADHD)217–219 or epilepsy during their later life220.”
From A global view of hypertensive disorders and diabetes mellitus during pregnancy (2022) · cites this paper as [217]
Hypertensive disorders of pregnancy are associated with increased risk of ASD in offspring (pooled OR 1.35, 95% CI 1.11-1.64).
“with a pooled OR of 1.35 for ASD risk (95% CI 1.11–1.64) [93].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [93]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Magee, L. A., Kenny, L. C., Karumanchi, S. A., McCarthy, F. P., Saito, S., Hall, D. R., Warren, C., Adoyi, G., & Ishaku, S. (2018) · Pregnancy Hypertension · doi:10.1016/j.preghy.2018.01.005 · Cited by 8 · see citing works
Self-citationRetractedDermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,577 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
Sterne, J. A. C., Sutton, A. J., Ioannidis, J. P. A., Terrin, N., Jones, D. R., Lau, J., Carpenter, J., Rucker, G., Harbord, R. M., Schmid, C. H., et al. (2011) · BMJ · doi:10.1136/bmj.d4002 · Cited by 7,709 · see citing works
Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371 · see citing works
Brown, M. A., Magee, L. A., Kenny, L. C., Karumanchi, S. A., McCarthy, F. P., Saito, S., Hall, D. R., Warren, C., Adoyi, G., & Ishaku, S. (2018) · Pregnancy Hypertension · doi:10.1016/j.preghy.2018.05.004 · Cited by 1,089 · see citing works
Self-citationAttention deficit hyperactivity disorder
Thapar, A., & Cooper, M. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00238-x · Cited by 1,081 · see citing works
Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C. M., & Reichenberg, A. (2014) · JAMA · doi:10.1001/jama.2014.4144 · Cited by 1,073 · see citing works
Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017) · Molecular Autism · doi:10.1186/s13229-017-0121-4 · Cited by 809 · see citing works
The Heritability of Autism Spectrum Disorder
Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Hultman, C., Larsson, H., & Reichenberg, A. (2017) · JAMA · doi:10.1001/jama.2017.12141 · Cited by 776 · see citing works
Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi123 · Cited by 727 · see citing works
Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders
Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2583 · Cited by 675 · see citing works
Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-analysis
Gardener, H., Spiegelman, D., & Buka, S. L. (2011) · Pediatrics · doi:10.1542/peds.2010-1036 · Cited by 665 · see citing works
Perinatal risk factors for infantile autism
Hultman, C. M., Sparén, P., & Cnattingius, S. (2002) · Epidemiology · doi:10.1097/00001648-200207000-00009 · Cited by 561 · see citing works
Davis, E., Lazdam, M., Lewandowski, A. J., Worton, S. A., Kelly, B., Kenworthy, Y., Adwani, S., Wilkinson, A. R., McCormick, K. P., Sargent, I. L., et al. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3093 · Cited by 522 · see citing works
Perinatal Factors and the Development of Autism
Glasson, E. J., Bower, C. I., Petterson, B., de Klerk, N. H., Chaney, G., & Hallmayer, J. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.6.618 · Cited by 520 · see citing works
McDonald, S. D., Han, Z., Mulla, S. M., Murphy, K. E., Beyene, J., & Ohlsson, A. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.05.035 · Cited by 436 · see citing works
Elevated maternal C-reactive protein and autism in a national birth cohort
Brown, A. S., Sourander, A., Hinkka-Yli-Salomäki, S., McKeague, I. W., Sundvall, J., & Surcel, H.-M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.197 · Cited by 343 · see citing works
Advancing Maternal Age Is Associated With Increasing Risk for Autism: A Review and Meta-Analysis
Sandin, S., Hultman, C. M., Kolevzon, A. L., Gross, R., MacCabe, J. H., & Reichenberg, A. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.02.018 · Cited by 333 · see citing works
Preeclampsia, Placental Insufficiency, and Autism Spectrum Disorder or Developmental Delay
Walker, C. K., Krakowiak, P., Baker, A., Hansen, R. L., Ozonoff, S., & Hertz-Picciotto, I. (2015) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2014.2645 · Cited by 292 · see citing works
The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism
Dodds, L., Fell, D., Shea, S., Armson, B., Allen, A., & Bryson, S. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1114-8 · Cited by 286 · see citing works
Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study
Johnson, S. J., Evans, T. A., Draper, E. S., Field, D. J., Manktelow, B. N., Marlow, N., Matthews, R. J., Petrou, S., Seaton, S. E., Smith, L. K., et al. (2015) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2014-307684 · Cited by 279 · see citing works
Curran, E. A., O'Neill, S. M., Cryan, J. F., Kenny, L. C., Dinan, T. G., Khashan, A. S., & Kearney, P. M. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12351 · Cited by 250 · see citing works
Self-citationPrenatal, perinatal, and neonatal factors associated with autism spectrum disorders
Bilder, D., Pinborough-Zimmerman, J., Miller, J., & McMahon, W. (2009) · Pediatrics · doi:10.1542/peds.2008-0927 · Cited by 222 · see citing works
The familial co-aggregation of ASD and ADHD: a register-based cohort study
Ghirardi, L., Brikell, I., Kuja-Halkola, R., Freitag, C. M., Franke, B., Asherson, P., Lichtenstein, P., & Larsson, H. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.17 · Cited by 220 · see citing works
Can association between preterm birth and autism be explained by maternal or neonatal morbidity?
Buchmayer, S., Johansson, S., Johansson, A., Hultman, C. M., Sparén, P., & Cnattingius, S. (2009) · Pediatrics · doi:10.1542/peds.2008-3582 · Cited by 215 · see citing works
Gillon, T. E. R., Pels, A., von Dadelszen, P., MacDonell, K., & Magee, L. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113715 · Cited by 210 · see citing works
Pre- and Perinatal Risk Factors in Adults with Attention-Deficit/Hyperactivity Disorder
Halmøy, A., Klungsøyr, K., Skjærven, R., & Haavik, J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.013 · Cited by 201 · see citing works
Environmental risk factors by gender associated with attention-deficit/hyperactivity disorder
Silva, D., Colvin, L., Hagemann, E., & Bower, C. (2014) · PEDIATRICS · doi:10.1542/peds.2013-1434 · Cited by 201 · see citing works
Health of children born to mothers who had preeclampsia: a population-based cohort study
Wu, C. S., Nohr, E. A., Bech, B. H., Vestergaard, M., Catov, J. M., & Olsen, J. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.06.060 · Cited by 200 · see citing works
Pregnancy, Delivery, and Neonatal Complications Among Autistic Children
Deykin, E. Y. (1980) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1980.02130210044012 · Cited by 186 · see citing works
Hypertensive disorders during pregnancy and health outcomes in the offspring: a systematic review
Pinheiro, T. V., Brunetto, S., Ramos, J. G. L., Bernardi, J. R., & Goldani, M. Z. (2016) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174416000209 · Cited by 161 · see citing works
Burstyn, I., Sithole, F., & Zwaigenbaum, L. (2010) · Chronic Diseases and Injuries in Canada · doi:10.24095/hpcdp.30.4.04 · Cited by 159 · see citing works
Langridge, A., Glasson, E. J., Nassar, N., Jacoby, P. A., Pennell, C. E., Hagan, R., Bourke, J., Leonard, H., & Stanley, F. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0050963 · Cited by 151 · see citing works
Pre-Eclampsia, Birth Weight, and Autism Spectrum Disorders
Mann, J. R., McDermott, S. W., Bao, H., Hardin, J. W., & Gregg, A. R. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0903-4 · Cited by 145 · see citing works
Obstetric Complications and Risk for Severe Psychopathology in Childhood
Eaton, W. W., Mortensen, P. B., Thomsen, P. H., & Frydenberg, M. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010743203048 · Cited by 135 · see citing works
Seidman, D. S., Laor, A., Gale, R., Stevenson, D. K., Mashiach, S., & Danon, Y. L. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb15339.x · Cited by 135 · see citing works
In Utero Exposure to Ischemic-Hypoxic Conditions and Attention-Deficit/Hyperactivity Disorder
Getahun, D., Rhoads, G., Demissie, K., Lu, S.-E., Quinn, V. P., Fassett, M., Wing, D., & Jacobsen, S. (2013) · Pediatrics · doi:10.1542/peds.2012-1298 · Cited by 132 · see citing works
Leversen, K. T., Sommerfelt, K., Rønnestad, A. E., Kaaresen, P. I., Farstad, T., Skranes, J. H., Støen, R. Ø., Elgen, I. B., Rettedal, S., Eide, G. E., et al. (2011) · PEDIATRICS · doi:10.1542/peds.2010-1001 · Cited by 128 · see citing works
Schneider, M., Retz, W., Coogan, A. N., Thome, J., & Rösler, M. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-1005-3 · Cited by 127 · see citing works
Sex-specific gene–environment interactions underlying ASD-like behaviors
Schaafsma, S. M., Gagnidze, K., Reyes, A., Norstedt, N., Månsson, K., Francis, K., & Pfaff, D. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619312114 · Cited by 126 · see citing works
MASON-BROTHERS, A., RITVO, E. R., Pingree, C., Petersen, P. B., Jenson, W. R., McMahon, W. M., Freeman, B. J., Jorde, L. B., Spencer, M. J., Mo, A., et al. (1990) · PEDIATRICS · doi:10.1542/peds.86.4.514 · Cited by 124 · see citing works
Are Maternal Genitourinary Infection and Pre-Eclampsia Associated With ADHD in School-Aged Children?
Mann, J. R., & McDermott, S. W. (2010) · Journal of Attention Disorders · doi:10.1177/1087054710370566 · Cited by 118 · see citing works
Lyall, K., Pauls, D. L., Spiegelman, D. L., Ascherio, A., & Santangelo, S. L. (2011) · Autism Research · doi:10.1002/aur.228 · Cited by 111 · see citing works
Many, A., Fattal, A., Leitner, Y., Kupferminc, M. J., Harel, S., & Jaffa, A. J. (2003) · Hypertension in Pregnancy · doi:10.1081/prg-120016791 · Cited by 111 · see citing works
Rätsep, M. T., Paolozza, A., Hickman, A. F., Maser, B., Kay, V. R., Mohammad, S., Pudwell, J., Smith, G. N., Brien, D. C., Stroman, P. W., et al. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4640 · Cited by 111 · see citing works
Cheng, S., Chou, H., Tsou, K.-I., Fang, L.-J., & Tsao, P. (2004) · Early Human Development · doi:10.1016/j.earlhumdev.2003.10.004 · Cited by 104 · see citing works
Lawlor, D. A., Batty, G. D., Morton, S. M. B., Deary, I. J., Macintyre, S., Ronalds, G., & Leon, D. A. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.030205 · Cited by 95 · see citing works
McCowan, L. M. E., Pryor, J. E., & Harding, J. E. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.122292 · Cited by 94 · see citing works
Maternal Health in Pregnancy and Intellectual Disability in the Offspring: A Population-Based Study
Leonard, H., de Klerk, N. H., Bourke, J., & Bower, C. I. (2005) · Annals of Epidemiology · doi:10.1016/j.annepidem.2005.05.002 · Cited by 92 · see citing works
Do hypertensive diseases of pregnancy disrupt neurocognitive development in offspring?
Whitehouse, A., Robinson, M., Newnham, J. P., & Pennell, C. E. (2012) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2011.01257.x · Cited by 91 · see citing works
Obstetric Risk Factors and Autism Spectrum Disorders in Finland
Polo‐Kantola, P., Lampi, K. M., Hinkka‐Yli‐Salomäki, S., Gissler, M., Brown, A. S., & Sourander, A. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.09.044 · Cited by 91 · see citing works
A Method for Detection of Residual Confounding in Time-series and Other Observational Studies
Flanders, W. D., Klein, M., Darrow, L. A., Strickland, M. J., Sarnat, S., Sarnat, J. A., Waller, L. A., Winquist, A. G., & Tolbert, P. E. (2010) · Epidemiology · doi:10.1097/ede.0b013e3181fdcabe · Cited by 91 · see citing works
Gustafsson, P., & Källén, K. (2010) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2010.03820.x · Cited by 86 · see citing works
Genetics of attention-deficit/hyperactivity disorder: an update
Akutagava-Martins, G. C., Rohde, L., & Hutz, M. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1130626 · Cited by 86 · see citing works
Maternal hypertension and neurodevelopmental outcome in very preterm infants
Gray, P. H., O'Callaghan, M. J., Mohay, H. A., BURNS, Y. R., & King, J. F. (1998) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.79.2.f88 · Cited by 85 · see citing works
Tuovinen, S., Eriksson, J. G., Kajantie, E., & Räikkönen, K. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.09.005 · Cited by 83 · see citing works
Warshafsky, C., Pudwell, J., WALKER, M. C., Wen, S. W., & Smith, G. N. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010884 · Cited by 82 · see citing works
Diagnostic heterogeneity in psychiatry: towards an empirical solution
Wardenaar, K. J., & de Jonge, P. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-201 · Cited by 81 · see citing works
Infant sex, obstetric risk factors, and 2‐year neurodevelopmental outcome among preterm infants
Spinillo, A., Montanari, L., Gardella, B., Roccio, M., Stronati, M., & Fazzi, E. M. (2009) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2009.03273.x · Cited by 78 · see citing works
Severe pre-eclampsia and infants of very low birth weight.
Szymonowicz, W., & YU, V. Y. H. (1987) · Archives of Disease in Childhood · doi:10.1136/adc.62.7.712 · Cited by 78 · see citing works
C-reactive protein and later preeclampsia
Rebelo, F. M., Schlüssel, M. M., Vaz, J. D. S., Franco‐Sena, A. B., Pinto, T. J. P., Bastos, F. I., Adegboye, A. R. A., & Kac, G. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835b0556 · Cited by 77 · see citing works
Robinson, M., Mattes, E., Oddy, W. H., de Klerk, N. H., Li, J., McLean, N. J., Silburn, S., Zubrick, S. R., Stanley, F. J., & Newnham, J. P. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.07.061 · Cited by 75 · see citing works
Schlapbach, L. J., Ersch, J., Adams, M., Bernet, V., Bucher, H. U., & Latal, B. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2010.01861.x · Cited by 74 · see citing works
Morsing, E., & Maršál, K. (2014) · Early Human Development · doi:10.1016/j.earlhumdev.2013.12.002 · Cited by 74 · see citing works
Hakim, J. C.-E., Senterman, M. K., & Hakim, A. M. (2013) · International Journal of Pediatrics · doi:10.1155/2013/953150 · Cited by 73 · see citing works
Pregnancy-associated Hypertensive Disorders and Adult Cognitive Function Among Danish Conscripts
Ehrenstein, V., Rothman, K. J., Pedersen, L. H., Hatch, E. E., & Sørensen, H. T. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp223 · Cited by 73 · see citing works
Tuovinen, S., Eriksson, J. G., Kajantie, E., Lahti, J. M. T., Pesonen, A., Heinonen, K., Osmond, C., Barker, D. J. P., & Räikkönen, K. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.12.017 · Cited by 71 · see citing works
Hypertensive Emergencies in Pregnancy
Olson‐Chen, C., & Seligman, N. S. (2015) · Critical Care Clinics · doi:10.1016/j.ccc.2015.08.006 · Cited by 67 · see citing works
Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age
Tuovinen, S., Räikkönen, K., Kajantie, E., HENRIKSSON, M. M., Leskinen, J. T., Pesonen, A., Heinonen, K., Lahti, J. M. T., Pyhälä, R., Alastalo, H., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31826e2606 · Cited by 60 · see citing works
Spinillo, A., Iasci, A., Capuzzo, E., Egbe, T. O., Colonna, L., & Fazzi, E. (1994) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349409013455 · Cited by 59 · see citing works
Maternal Hypertensive Disorders during Pregnancy and Mild Cognitive Limitations in the Offspring
Heikura, U., Hartikainen, A., Nordström, T., Pouta, A. M., Taanila, A. M., & Järvelin, M. (2012) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12028 · Cited by 58 · see citing works
Nomura, Y., John, R. M., Janssen, A. B., Davey, C., Finik, J. M., Buthmann, J. L., Glover, V. A. S., & Lambertini, L. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4347-3 · Cited by 56 · see citing works
The joint effect of air pollution exposure and copy number variation on risk for autism
Kim, D., Volk, H. E., Girirajan, S., Pendergrass, S. A., Hall, M. A., Verma, S. S., Schmidt, R. J., Hansen, R. L., Ghosh, D., Ludeña, Y., et al. (2017) · Autism Research · doi:10.1002/aur.1799 · Cited by 56 · see citing works
Silveira, R. C., Procianoy, R. S., Koch, M. S., Benjamin, A. C. W., & Schlindwein, C. F. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00552.x · Cited by 56 · see citing works
Matsuishi, T., Yamashita, Y., OHTANI, Y., Ornitz, E. M., Kuriya, N., Murakami, Y., Fukuda, S., Hashimoto, T., & Yamashita, F. (1999) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1023048812202 · Cited by 53 · see citing works
Zhu, T., Gan, J., Huang, J., Li, Y., Qu, Y., & Mu, D. (2016) · Journal of Child Neurology · doi:10.1177/0883073816650039 · Cited by 51 · see citing works
Curran, E. A., O’Keeffe, G. W., Looney, A.-M., Moloney, G. M., Hegarty, S. V., Murray, D. M., Khashan, A. S., & Kenny, L. C. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0794-x · Cited by 50 · see citing works
Self-citationGriffith, M. I., Mann, J. R., & McDermott, S. W. (2010) · Hypertension in Pregnancy · doi:10.3109/10641955.2010.507837 · Cited by 50 · see citing works
Four- to seven-year evaluation in two groups of small-for-gestational age infants
Winer, E. K., Tejani, N. A., Atluru, V. L., Digiuseppe, R. A., & Borofsky, L. G. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(82)90085-0 · Cited by 49 · see citing works
Spencer, R. N., Carr, D. J., & David, A. L. (2014) · Prenatal Diagnosis · doi:10.1002/pd.4401 · Cited by 48 · see citing works
Amiri, S., Malek, A., Sadegfard, M., & Abdi, S. (2012) · ISRN Pediatrics · doi:10.5402/2012/458064 · Cited by 44 · see citing works
Obstetric complications and school performance.
BARKER, D. J. P., & Edwards, J. (1967) · BMJ · doi:10.1136/bmj.3.5567.695 · Cited by 44 · see citing works
Ketzer, C. R., Gallois, C. B., Martinez, A. L. B., Rohde, L. A., & Schmitz, M. D. (2012) · Brazilian Journal of Psychiatry · doi:10.1016/j.rbp.2012.01.001 · Cited by 43 · see citing works
Tuovinen, S., Räikkönen, K., Kajantie, E., Leskinen, J. T., HENRIKSSON, M. M., Pesonen, A., Heinonen, K., Osmond, C., Barker, D. J. P., & Eriksson, J. G. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.573497 · Cited by 43 · see citing works
Evaluation of Attention-Deficit Hyperactivity Disorder Risk Factors
Golmirzaei, J., Namazi, S., Amiri, S., Zare, S., Rastikerdar, N., Hesam, A. A., Rahami, Z., Ghasemian, F., Namazi, S. S., Paknahad, A., et al. (2013) · International Journal of Pediatrics · doi:10.1155/2013/953103 · Cited by 36 · see citing works
The Effect of Hypertensive Disorders of Pregnancy on the Risk of ADHD in the Offspring
Böhm, S., Curran, E. A., Kenny, L. C., O’Keeffe, G. W., Murray, D. M., & Khashan, A. S. (2017) · Journal of Attention Disorders · doi:10.1177/1087054717690230 · Cited by 33 · see citing works
Self-citationMaher, G. M., O’Keeffe, G. W., Kenny, L. C., Kearney, P. M., Dinan, T. G., & Khashan, A. S. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-018313 · Cited by 30 · see citing works
Self-citationThe neurocognitive outcome of IUGR children born to mothers with and without preeclampsia
Leitner, Y., Harel, S., Geva, R., Eshel, R., Yaffo, A., & Many, A. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.684164 · Cited by 30 · see citing works
Making valid causal inferences from observational data
Martin, W. (2013) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2013.09.006 · Cited by 28 · see citing works
Bánhidy, F. G., Ács, N., Horváth–Puhó, E., & Czeizel, A. E. (2010) · Hypertension Research · doi:10.1038/hr.2010.17 · Cited by 26 · see citing works
Prenatal, perinatal and neonatal risk factors for autism - study in Poland
Mrozek‐Budzyn, D., Majewska, R., & Kiełtyka, A. (2013) · Open Medicine · doi:10.2478/s11536-013-0174-5 · Cited by 26 · see citing works
Love, E., Crum, J., & Bhattacharya, S. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.08.015 · Cited by 21 · see citing works
Neurodevelopmental and cognitive assessment of 6‐year‐old children born growth restricted
Many, A., Fattal‐Valevski, A., & Leitner, Y. (2005) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2005.01.022 · Cited by 18 · see citing works
Nath, S., Roy, R., & Mukherjee, S. (2012) · PubMed · Cited by 15 · see citing works
MENTAL RETARDATION AND MOTHER'S HYPERTENSION DURING PREGNANCY
Salonen, J. T., & Heinonen, O. P. (1984) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1984.tb01601.x · Cited by 13 · see citing works
Attention deficit hyperactivity disorder and associated perinatal risk factors in preterm children
Esen, H. T. Ç., & Gökler, B. (2013) · Türk Pediatri Arşivi · doi:10.4274/tpa.682 · Cited by 12 · see citing works
Warshafsky, C., Pudwell, J., Walker, M., Wen, S., & Smith, G. N. (2015) · Paediatrics & Child Health · doi:10.1093/pch/20.5.e40a · Cited by 7 · see citing works
Spinillo, A., Iasci, A., Capuzzo, E., Egbe, T. O., Colonna, L., & Fazzi, E. M. (1995) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199505000-00011 · Cited by 5 · see citing works
Flagged first, then by citations
7 of the 106 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [9]9. Lai MC, Lombardo MV, Baron-Cohen S. Autism. Lancet. 2014;383(9920):896-910.
- [30]30. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting: Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283 (15):2008-2012.
Cited by
Sorted by citations
Faraone, S. V., Banaschewski, T., Coghill, D., Zheng, Y., Biederman, J., Bellgrove, M. A., Newcorn, J. H., Gignac, M., Al Saud, N. M., Manor, I., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.022 · Cited by 1,545 · see citing works
“4 million people found that children whose mothers had hypertensive disorders during pregnancy had a 25 % increase in the rate of ADHD (Maher et al., 2018).”
InfluentialThe contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works
Han, V. X., Patel, S., Jones, H. F., Nielsen, T. C., Mohammad, S. S., Hofer, M. J., Gold, W. A., Brilot, F., Lain, S. J., Nassar, N., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01198-w · Cited by 385 · see citing works
A global view of hypertensive disorders and diabetes mellitus during pregnancy
Jiang, L., Tang, K., Magee, L. A., von Dadelszen, P., Ekeroma, A., Li, X., Zhang, E., & Bhutta, Z. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00734-y · Cited by 314 · see citing works
Kim, J. H., Kim, J. Y., Lee, J., Jeong, G. H., Lee, E., Lee, S., Lee, K. H., Kronbichler, A., Stubbs, B., Solmi, M., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30312-6 · Cited by 258 · see citing works
Cardiovascular System in Preeclampsia and Beyond
Thilaganathan, B., & Kalafat, E. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.11191 · Cited by 235 · see citing works
Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure
Gumusoglu, S. B., Chilukuri, A. S. S., Santillan, D. A., Santillan, M. K. O., & Stevens, H. E. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.02.003 · Cited by 162 · see citing works
Association of Preeclampsia in Term Births With Neurodevelopmental Disorders in Offspring
Sun, B. Z., Moster, D., Harmon, Q. E., & Wilcox, A. J. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.0306 · Cited by 141 · see citing works
Pre‐eclampsia and long‐term health outcomes for mother and infant: an umbrella review
Pittara, T., Vyrides, A., Lamnisos, D., & Giannakou, K. (2021) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16683 · Cited by 125 · see citing works
Metoki, H., Iwama, N., Hamada, H., Satoh, M., Murakami, T., Ishikuro, M., & Obara, T. (2022) · Hypertension Research · doi:10.1038/s41440-022-00965-6 · Cited by 135 · see citing works
The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis
Rowland, J., & Wilson, C. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-84573-3 · Cited by 120 · see citing works
Prevalence and correlates of autism spectrum disorder in Qatar: a national study
Alshaban, F., Aldosari, M., Al‐Shammari, H., El‐Hag, S., Ghazal, I., Tolefat, M., Ali, M., Kamal, M., Abdel Aati, N., Abeidah, M., et al. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13066 · Cited by 122 · see citing works
Preeclampsia epidemiology(ies) and pathophysiology(ies)
Roberts, J. M. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2024.102480 · Cited by 127 · see citing works
Vornic, I., Buciu, V. B., Furau, C. G., Gaje, P. N., Ceauşu, R. A., Dumitru, C. Ș., Barb, A. C., Novacescu, D., Cumpănaş, A. A., Latcu, S. C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212195 · Cited by 114 · see citing works
Distinct placental molecular processes associated with early-onset and late-onset preeclampsia
Ren, Z., Gao, Y., Gao, Y., Liang, G., Chen, Q., Jiang, S., Yang, X., Fan, C.-X., Wang, H., Wang, J., et al. (2021) · Theranostics · doi:10.7150/thno.56141 · Cited by 89 · see citing works
Chen, H. J., Antonson, A. M., Rajasekera, T. A., Patterson, J. M., Bailey, M. T., & Gur, T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00876-5 · Cited by 88 · see citing works
Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link
Hanswijk, S. I., Spoelder, M., Shan, L., Verheij, M. M. M., Muilwijk, O. G., Li, W., Liu, C., Kolk, S. M., & Homberg, J. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165850 · Cited by 86 · see citing works
Shay, M., MacKinnon, A., Metcalfe, A., Giesbrecht, G. F., Campbell, T. S., Nerenberg, K. A., Tough, S., & Tomfohr‐Madsen, L. M. (2020) · Psychological Medicine · doi:10.1017/s0033291720003062 · Cited by 86 · see citing works
Huang, C., Wei, K., Lee, P. M. Y., Qin, G., Yu, Y., & Li, J. (2022) · BMJ · doi:10.1136/bmj-2022-072157 · Cited by 87 · see citing works
Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children
Lahti‐Pulkkinen, M., Girchenko, P. V., Tuovinen, S., Sammallahti, S., Reynolds, R. M., Lahti, J. M. T., Heinonen, K., Lipsanen, J. O., Hämäläinen, E. K., Villa, P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14140 · Cited by 81 · see citing works
Role of neurotrophins in pregnancy and offspring brain development
Sahay, A. S., Kale, A. A., & Joshi, S. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102075 · Cited by 76 · see citing works
Barron, A., McCarthy, C., & O’Keeffe, G. W. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02290-4 · Cited by 72 · see citing works
Self-citationWang, H., László, K. D., Gissler, M., Li, F. R., Zhang, J., Yu, Y., & Li, J. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-021-00756-2 · Cited by 69 · see citing works
Where Do Neurodevelopmental Disorders Go? Casting the Eye Away from Childhood towards Adulthood
Antolini, G., & Colizzi, M. (2023) · Healthcare · doi:10.3390/healthcare11071015 · Cited by 75 · see citing works
Brand, J. S., Lawlor, D. A., Larsson, H., & Montgomery, S. (2021) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2020.6856 · Cited by 62 · see citing works
Association between preeclampsia and autism spectrum disorder: a population‐based study
Maher, G. M., O’Keeffe, G. W., Dalman, C., Kearney, P. M., McCarthy, F. P., Kenny, L. C., & Khashan, A. S. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13127 · Cited by 62 · see citing works
Self-citationCaparrós-González, R. A., de la Torre‐Luque, A., Romero‐Gonzalez, B., Quesada-Soto, J. M., Alderdice, F. A., & Peralta‐Ramírez, M. I. (2021) · Midwifery · doi:10.1016/j.midw.2021.102939 · Cited by 61 · see citing works
Kittel-Schneider, S., Arteaga-Henríquez, G., Vasquez, A., Asherson, P., Banaschewski, T., Brikell, I., Buitelaar, J., Cormand, B., Faraone, S., Freitag, C., et al. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.035 · Cited by 52 · see citing works
Jain, V. G., Kline, J. E., He, L., Kline‐Fath, B. M., Altaye, M., Muglia, L. J., DeFranco, E., Ambalavanan, N., & Parikh, N. A. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.05.042 · Cited by 55 · see citing works
Brain Vascular Dysfunction in Mothers and Their Children Exposed to Preeclampsia
Escudero, C., Kupka, E., Ibáñez, B., Sandoval, H., Troncoso, F., Wikström, A., López-Espíndola, D., Acurio, J., Torres‐Vergara, P., & Bergman, L. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19408 · Cited by 53 · see citing works
Hanley, G. E., Bickford, C., Ip, A., Lanphear, N. E., Lanphear, B. P., Weikum, W., Zwaigenbaum, L., & Oberlander, T. F. (2021) · JAMA · doi:10.1001/jama.2021.14986 · Cited by 54 · see citing works
Kong, L., Chen, X., Liang, Y., Forsell, Y., Gissler, M., & Lavebratt, C. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.45719 · Cited by 51 · see citing works
Dachew, B. A., Scott, J. G., Mamun, A. A., & Alati, R. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.123 · Cited by 47 · see citing works
Liu, D., Gao, Q., Wang, Y., & Xiong, T. (2022) · Placenta · doi:10.1016/j.placenta.2022.07.014 · Cited by 45 · see citing works
Mandakh, Y., Rittner, R., Flanagan, E., Oudin, A., Isaxon, C., Familari, M., Hansson, S. R., & Malmqvist, E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051744 · Cited by 46 · see citing works
Placental genomic risk scores and early neurodevelopmental outcomes
Ursini, G., Punzi, G., Langworthy, B., Chen, Q., Xia, K., Cornea, E. A., Goldman, B. D., Styner, M. A., Knickmeyer, R. C., Gilmore, J. H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019789118 · Cited by 45 · see citing works
Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
Koulouraki, S., Paschos, V., Pervanidou, P., Christopoulos, P., Gerede, A., & Eleftheriades, M. I. (2023) · Children · doi:10.3390/children10050826 · Cited by 43 · see citing works
Prenatal air pollution, maternal immune activation, and autism spectrum disorder
Yu, X., Rahman, M. M., Carter, S., Lin, J. C., Zhuang, Z., Chow, T., Lurmann, F., Kleeman, M. J., Martinez, M. P., van Donkelaar, A., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108148 · Cited by 43 · see citing works
The Serotonin-Immune Axis in Preeclampsia
Gumusoglu, S. B., Scroggins, S. M., Vignato, J. A., Santillan, D. A., & Santillan, M. K. O. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01155-4 · Cited by 43 · see citing works
Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model
Gumusoglu, S. B., Chilukuri, A. S. S., Hing, B. W. Q., Scroggins, S. M., Kundu, S., Sandgren, J. A., Santillan, M. K. O., Santillan, D. A., Grobe, J. L., & Stevens, H. E. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01205-0 · Cited by 39 · see citing works
Childhood neurodevelopmental disorders and maternal hypertensive disorder of pregnancy
Chen, K., Yu, T., Kang, L., Lien, Y.-J., & Kuo, P. (2021) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14893 · Cited by 36 · see citing works
Maher, G. M., Dalman, C., O’Keeffe, G. W., Kearney, P. M., McCarthy, F. P., Kenny, L. C., & Khashan, A. S. (2020) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13162 · Cited by 35 · see citing works
Self-citationPerinatal Micro-Bleeds and Neuroinflammation in E19 Rat Fetuses Exposed to Utero-Placental Ischemia
Giambrone, A. B., Logue, O. C., Shao, Q., Bidwell, G. L., & Warrington, J. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164051 · Cited by 34 · see citing works
Naheed, A., Islam, M. S., Hossain, S. W., Ahmed, H. U., Uddin, M. J., Tofail, F., Hamadani, J. D., Hussain, A., & Münir, K. (2019) · Autism Research · doi:10.1002/aur.2227 · Cited by 34 · see citing works
Katz, J., Reichenberg, A., & Kolevzon, A. L. (2020) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000673 · Cited by 34 · see citing works
Ren, T., Zhang, J., Yu, Y., Pedersen, L. H., Wang, H., Li, F. R., Henriksen, T. B., & Li, J. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.10.042 · Cited by 34 · see citing works
Lampiasi, N., Bonaventura, R., Deidda, I., Zito, F., & Russo, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032703 · Cited by 38 · see citing works
de Moura, M. D. R., Margotto, P. R., Costa, K. N., & Novaes, M. R. C. G. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255783 · Cited by 33 · see citing works
Future Prospects for Epigenetics in Autism Spectrum Disorder
Williams, L. A., & LaSalle, J. M. (2022) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-022-00608-z · Cited by 34 · see citing works
Neonates at Risk: Understanding the Impact of High-Risk Pregnancies on Neonatal Health
Sokou, R., Lianou, A., Lampridou, M., Panagiotounakou, P., Kafalidis, G., Paliatsiou, S., Volaki, P., Tsantes, A. G., Boutsikou, Τ., Iliodromiti, Z., et al. (2025) · Medicina · doi:10.3390/medicina61061077 · Cited by 53 · see citing works
Maher, G. M., McCarthy, F. P., McCarthy, C., Kenny, L. C., Kearney, P. M., Khashan, A. S., & O’Keeffe, G. W. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.10.004 · Cited by 32 · see citing works
Self-citationOverview and Introduction to Autism Spectrum Disorder (ASD)
Al-Dewik, N. I. E., Al‐Jurf, R., Styles, M., Tahtamouni, S., Al‐Sharshani, D., Alsharshani, M., Ahmad, A. I., Khattab, A., Rifai, H. A., & Qoronfleh, M. W. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_1 · Cited by 33 · see citing works
Nakamura, N., Ushida, T., Nakatochi, M., Kobayashi, Y., Moriyama, Y., Imai, K., Nakano‐Kobayashi, T., Hayakawa, M., Kajiyama, H., Kikkawa, F., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81292-7 · Cited by 32 · see citing works
Lin, Y.-W., Lin, M.-H., Pai, L., Fang, J.-W., Mou, C.-H., Sung, F., & Tzeng, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-96345-0 · Cited by 32 · see citing works
Majhi, S., Kumar, S., & Singh, L. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220428134802 · Cited by 32 · see citing works
Louis, J. M., Parchem, J. G., Vaught, A. “. J., Tesfalul, M. A., Kendle, A. M., & Tsigas, E. Z. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.06.038 · Cited by 32 · see citing works
Maternal obesity and long-term neuropsychiatric morbidity of the offspring
Neuhaus, Z. F., Gutvirtz, G., Pariente, G., Wainstock, T., Landau, D., & Sheiner, E. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05432-6 · Cited by 30 · see citing works
Rethinking autism: the impact of maternal risk factors on autism development.
Lu, J., Wang, Z., Liang, Y., & Yao, P. (2022) · PubMed Central · Cited by 30 · see citing works
Neurobiology of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Radonjić, N. V. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_33-1 · Cited by 31 · see citing works
Infertility and Risk of Autism Spectrum Disorder in Children
Vélez, M. P., Dayan, N., Shellenberger, J. P., Pudwell, J., Kapoor, D., Vigod, S. N., & Ray, J. G. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.43954 · Cited by 30 · see citing works
Basso, A., Youssef, L., Nakaki, A., Paulés, C., Miranda, J., Casu, G., Salazar, L., Gratacós, E., Eixarch, E., Crispi, F., et al. (2022) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.24853 · Cited by 31 · see citing works
Maternal adverse childhood experiences and infant subcortical brain volume
Demers, C. H., Hankin, B. L., Hennessey, E. P., Haase, M. H., Bagonis, M. M., Kim, S. H., Gilmore, J. H., Hoffman, M. C., Styner, M. A., & Davis, E. P. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100487 · Cited by 29 · see citing works
Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome
Troncoso, F., Sandoval, H., Ibáñez, B., López-Espíndola, D., Bustos, F., Tapia, J. C., Sandaña, P., Escudero-Guevara, E., Nualart, F., Ramírez, E., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21756 · Cited by 29 · see citing works
Maternal steroid levels and the autistic traits of the mother and infant
Tsompanidis, A., Aydin, E., Padaigaitė, E., Richards, G., Allison, C. L., Hackett, G. A., Austin, T., Holt, R., & Baron‐Cohen, S. (2021) · Molecular Autism · doi:10.1186/s13229-021-00453-7 · Cited by 27 · see citing works
Korzeniewski, S. J., Sutton, E., Escudero, C., & Roberts, J. M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.984291 · Cited by 26 · see citing works
Mabry, S., Wilson, E. N., Bradshaw, J. L., Gardner, J. J., Fadeyibi, O., Vera, E., Osikoya, O., Cushen, S. C., Karamichos, D., Goulopoulou, S., et al. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00557-0 · Cited by 26 · see citing works
Sun, Y., Zhang, M., Chen, S., Zhang, W., Zhang, Y., Su, S., Zhang, E., Sun, L., Yang, K., Wang, J., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115733 · Cited by 27 · see citing works
Preeclampsia, Fetal Growth Restriction, and 24-Month Neurodevelopment in Very Preterm Infants
Check, J., Shuster, C. L., Hofheimer, J. A., Camerota, M., Dansereau, L. M., Smith, L. M., Carter, B. S., DellaGrotta, S. A., Helderman, J., Kilbride, H. W., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.20382 · Cited by 27 · see citing works
Wilson, E. N., Mabry, S., Bradshaw, J. L., Gardner, J. J., Rybalchenko, N., Engelland, R. E., Fadeyibi, O., Osikoya, O., Cushen, S. C., Goulopoulou, S., et al. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00463-x · Cited by 25 · see citing works
Kaminski, V. D. L., Michita, R. T., Ellwanger, J. H., Veit, T. D., Schuch, J. B., Riesgo, R. D. S., Roman, T., & Chies, J. A. B. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15593 · Cited by 27 · see citing works
Approach to Evaluating and Managing Adult Attention-Deficit/Hyperactivity Disorder in Primary Care
Huang, H. Y., Huang, H., Spottswood, M., & Ghaemi, S. N. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000248 · Cited by 25 · see citing works
Iwama, N., Sugiyama, T., Metoki, H., Saito, M., Hoshiai, T., Watanabe, Z., Tanaka, K., Sasaki, S., Sakurai, K., Ishikuro, M., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108377 · Cited by 24 · see citing works
Nidey, N., Momany, A. M., Strathearn, L., Carter, K. D., Wehby, G. L., Bao, W., Xu, G., Scheiber, F. A., Tabb, K. M., Froehlich, T. E., et al. (2021) · Annals of Epidemiology · doi:10.1016/j.annepidem.2021.06.005 · Cited by 23 · see citing works
Role of Maternal Immune Factors in Neuroimmunology of Brain Development
Mohebalizadeh, M., Babapour, G., Aghdam, M. M., Mohammadi, T., Jafari, R., & Shafiei‐Irannejad, V. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03749-2 · Cited by 25 · see citing works
Atkinson, J., Gordon, H. G., Tong, S. Y. C., Walker, S. P., Mehdipour, P., Lindquist, A., & Hastie, R. M. (2025) · PLoS Medicine · doi:10.1371/journal.pmed.1004558 · Cited by 22 · see citing works
Chen, S., Fan, M., Lee, B. K., Dalman, C., Karlsson, H., & Gardner, R. M. (2023) · BMC Medicine · doi:10.1186/s12916-023-02799-6 · Cited by 22 · see citing works
Firestein, M. R., Romeo, R. D., Winstead, H., Goldman, D. A., Grobman, W. A., Haas, D., Mercer, B., Parker, C., Parry, S., Reddy, U., et al. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105125 · Cited by 22 · see citing works
González, A., & Valencia, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073632 · Cited by 21 · see citing works
Ma, J., Zhang, H., Zheng, T., Zhang, W., Yang, C., Yu, L., Sun, X., Xia, W., Xu, S., & Li, Y. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119439 · Cited by 21 · see citing works
Elevated Familial Cardiovascular Burden Among Adolescents With Familial Bipolar Disorder
Toma, S., Fıksenbaum, L., Omrin, D. S., & Goldstein, B. I. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00008 · Cited by 20 · see citing works
Lim, T. X. Z., Pickering, T. A., Lee, R. H., Hauptman, I., & Wilson, M. L. (2023) · Pregnancy Hypertension · doi:10.1016/j.preghy.2023.06.002 · Cited by 19 · see citing works
Developmental vitamin D deficiency increases foetal exposure to testosterone
Ali, A. A., Cui, X., Pértile, R. A. N., Li, X., Medley, G., Alexander, S., Whitehouse, A., McGrath, J. J., & Eyles, D. W. (2020) · Molecular Autism · doi:10.1186/s13229-020-00399-2 · Cited by 20 · see citing works
Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling
Liu, X., Liu, H., Gu, N.-H., Pei, J., Lin, X.-H., & Zhao, W. (2023) · Life Science Alliance · doi:10.26508/lsa.202301957 · Cited by 19 · see citing works
Lebeña, A., Faresjö, Å., Jones, M. P., Bengtsson, F., Faresjö, T., & Ludvigsson, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-65067-4 · Cited by 19 · see citing works
(2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.05.043 · Cited by 18 · see citing works
Scime, N. V., Hetherington, E., Tomfohr‐Madsen, L. M., Nettel‐Aguirre, A., Chaput, K. H., & Tough, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260590 · Cited by 19 · see citing works
Robinson, R., Lähdepuro, A., Tuovinen, S., Girchenko, P. V., Rantalainen, V. J., Heinonen, K., Lahti, J. M. T., Räikkönen, K., & Lahti‐Pulkkinen, M. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01141-w · Cited by 18 · see citing works
Dayan, N., Smith, G. N., Nedelchev, A., Abenhaim, H. A., Brown, R. N., Costa, D. D., Ali, S., Perlman, J., Nguyen, T. V., Dennis, C., et al. (2023) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-05325-3 · Cited by 16 · see citing works
Atallah, M. N., Yamashita, T., Hu, X. F., Hu, X., & Abe, K. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10095-6 · Cited by 16 · see citing works
Preconception Risk Factors for Autism Spectrum Disorder—A Pilot Study
Hankus, M., Kazek, B., Paprocka, J., Kapinos-Gorczyca, A., Szczepara-Fabian, M., Buczek, A., & Emich‐Widera, E. (2020) · Brain Sciences · doi:10.3390/brainsci10050293 · Cited by 16 · see citing works
Río, J. P. D., Tsompanidis, A., Gaspar, P., Maturana, A., Rojas, G., Dagnino-Subiabre, A., Olea, A., Maliqueo, M., Echiburú, B., de Guevara, A. L., et al. (2025) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2025.101188 · Cited by 14 · see citing works
Maternal Hypertension and Adverse Neurodevelopment in a Cohort of Preterm Infants
Jain, S., Fu, T. T., Barnes‐Davis, M. E., Sahay, R. D., Ehrlich, S. R., Liu, C., Habli, M. A., Parikh, N. A., Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators, Illapani, P. V., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.7788 · Cited by 15 · see citing works
Katoh, Y., Iriyama, T., Yano, E., Sayama, S., Seyama, T., Kotajima‐Murakami, H., Sato, A., Sakuma, H., Iguchi, Y., Yoshikawa, M., et al. (2022) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2022.103752 · Cited by 14 · see citing works
Xing, Q., Liu, Y., Xuan, D., Shang, H., Zhao, X., & Zhang, X. (2021) · Contrast Media & Molecular Imaging · doi:10.1155/2021/5545178 · Cited by 14 · see citing works
Brikell, I., Wimberley, T., Albiñana, C., Vilhjálmsson, B. J., Agerbo, E., Børglum, A. D., Demontis, D., Schork, A. J., LaBianca, S., Werge, T. M., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21111105 · Cited by 14 · see citing works
Dachew, B. A., Scott, J. G., Mamun, A. A., Fetene, D. M., & Alati, R. (2020) · Annals of Epidemiology · doi:10.1016/j.annepidem.2020.08.015 · Cited by 14 · see citing works
The Impact of Preeclampsia on Women’s Health: Cardiovascular Long-term Implications
Orabona, R., Sciatti, E., Sartori, E., Vizzardi, E., & Prefumo, F. (2020) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000846 · Cited by 14 · see citing works
Yu, T., Chang, K., & Kuo, P. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.05.009 · Cited by 13 · see citing works
Cochran, D., Jensen, E. T., Frazier, J. A., Jalnapurkar, I. R., Kim, S., Roell, K. R., Joseph, R. M., Hooper, S. R., Junior, H. P. D. O. S., Kuban, K., et al. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.911098 · Cited by 13 · see citing works
Leffa, D. T., Caye, A., Belangero, S. I., Gadelha, A., Pan, P. M., Salum, G. A., & Rohde, L. A. (2023) · Development and Psychopathology · doi:10.1017/s0954579423000366 · Cited by 14 · see citing works
- Authors
- Maher, G. M., O’Keeffe, G. W., Kearney, P. M., Kenny, L. C., Dinan, T. G., Mattsson, M., & Khashan, A. S.
- Affiliations
- University College Cork (IE)
- University of Liverpool (GB)
- Royal College of Surgeons in Ireland (IE)
- Corresponding author
- Khashan, Ali S.
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2018-08-01
- Volume
- 75
- Issue
- 8
- Pages
- 809
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC6143097
- OpenAlex
- W2807447863
- Semantic Scholar
- ba3650aa55b2b292f27ad45f2a1a91216af80bb4
- Cited by
- 271
- References
- 106
- Citations by year
- 2026: 20 · 2025: 31 · 2024: 29 · 2023: 51 · 2022: 44 · 2021: 40 · 2020: 36 · 2019: 15 · 2018: 5
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board (SPHeRE/2013/1)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- hypertensive disorders of pregnancy, preeclampsia, autism spectrum disorder, attention deficit hyperactivity disorder, neurodevelopmental disorders, offspring, maternal hypertension, prenatal exposure
- MeSH terms
- Correlation of Data, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Hypertension, Pregnancy-Induced, Neurodevelopmental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
