Functional magnetic resonance imaging-guided personalization of transcranial magnetic stimulation treatment for depression
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This study assesses whether treatment response for depression could be improved via a single one-site-fits-all dorsolateral prefrontal cortex target, representing the group average optimal site of subgenual cingulate cortex functional connectivity, or whether target site personalization is necessary.
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Two recent papers found that clinical efficacy of rTMS for depression was greater when the scalp-targeted stimulation site was incidentally closer to the optimal rsfMRI-derived site.
“Two recent papers found that clinical efficacy of rTMS for depression was greater when the scalp-targeted stimulation site was incidentally closer to the optimal rsfMRI-derived site (38, 39).”
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Using brain imaging to improve spatial targeting of transcranial magnetic stimulation for depression
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- [5]Cash R, Cocchi L, Lv J, Fitzgerald P, Zalesky A. Toward state-of-the-art connectivity-guided TMS: personalization, precision & clinical response. Paper presented at: 26th Annual Meeting of the Organization For Human Brain Mapping; June 23-July 3, 2020; virtual meeting. Accessed October 22, 2020. https://www.humanbrainmapping.org/files/2020/OHBM_2020_Virtual_Abstracts_2.pdf [Google Scholar]
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Dijkstra, E., Frandsen, S. B., van Dijk, H., Duecker, F., Taylor, J. J., Sack, A. T., Arns, M., & Siddiqi, S. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00248-8 · Cited by 17 · see citing works
Oliver, L. D., Hawco, C. S., Viviano, J. D., & Voineskos, A. N. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.09.007 · Cited by 17 · see citing works
Neural mechanisms and neuromodulation therapies for non-suicidal self-injury
Wu, D., Wang, S., Wang, H., Zhang, J., & Tian, Y. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03125-7 · Cited by 17 · see citing works
Circuit-Targeted Neuromodulation for Anhedonia
Siddiqi, S., Haddad, N. R., & Fox, M. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_350 · Cited by 16 · see citing works
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Targeting VMPFC‐amygdala circuit with TMS in substance use disorder: A mechanistic framework
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A New Angle on Transcranial Magnetic Stimulation Coil Orientation: A Targeted Narrative Review
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Neurocomputational model of compulsivity: deviating from an uncertain goal-directed system
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Analgesic efficacy of theta-burst stimulation for postoperative pain
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Self-citationHitting the Target of Image-Guided Psychiatry?
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The Location Reliability of the Resting-State fMRI FC of Emotional Regions Towards rTMS Therapy
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- Authors
- Cash, R. F. H., Cocchi, L., Lv, J., Fitzgerald, P. B., & Zalesky, A.
- Affiliations
- The University of Melbourne (AU)
- QIMR Berghofer Medical Research Institute (AU)
- The University of Sydney (AU)
- Epworth Hospital (AU)
- Corresponding author
- Cash, Robin F. H.
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2021-03-01
- Volume
- 78
- Issue
- 3
- Pages
- 337
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC7689561
- OpenAlex
- W3109502500
- Cited by
- 291
- References
- 5
- Citations by year
- 2026: 60 · 2025: 63 · 2024: 63 · 2023: 46 · 2022: 33 · 2021: 25 · 2020: 1
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- transcranial magnetic stimulation, depression, treatment response, dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, functional connectivity, personalized treatment
- MeSH terms
- Dorsolateral Prefrontal Cortex, Adult, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Outcome and Process Assessment, Health Care, Transcranial Magnetic Stimulation
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