The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
What Do Imaging Studies Tell Us about the Neural Basis of Autism?
Abstract
There is no clear evidence from imaging studies for specific structural abnormalities in the brains of people with autism. The most robust observation is of greater total brain volume. There is evidence that this greater volume is not present at birth, but appears during the first few years. This brain enlargement might be a marker of abnormal connectivity due to lack of pruning. While abnormalities have often been reported in the cerebellum and the amygdala, these are difficult to interpret since both increases and decreases in the size of these structures have been observed. Another way of identifying the neural basis of autism is to investigate brain systems underlying cognitive functions compromised in this disorder such as face perception and 'theory of mind'. Autistic people fail to activate the 'fusiform face area' during face perception tasks and show weak activation of medial frontal cortex and superior temporal gyrus when performing theory of mind tasks. These problems stem from a lack of integration of sensory processing with cognitive evaluation. I speculate that this problem reflects a failure of top-down modulation of early sensory processing. The problem could result from abnormal connectivity and lack of pruning.
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Self-citationUnusual brain growth patterns in early life in patients with autistic disorder: An MRI study
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Cited by
The weak coherence account: detail-focused cognitive style in autism spectrum disorders
Happé, F., & Frith, U. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0039-0 · Cited by 2,884
Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception
Mottron, L., Dawson, M., Soulières, I., Hubert, B., & Burack, J. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0040-7 · Cited by 1,957
Executive dysfunction in autism☆
Hill, E. L. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2003.11.003 · Cited by 1,468
Evaluating the theory of executive dysfunction in autism
Hill, E. L. (2004) · Developmental Review · doi:10.1016/j.dr.2004.01.001 · Cited by 846
Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
Hutsler, J. J., & Zhang, H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.120 · Cited by 765
Metadata
- Authors
- Frith, C.
- Venue
- Novartis Foundation Symposia
- Publisher
- Wiley
- Published
- 2003-01-07
- Volume
- 251
- Pages
- 149-176
- ISSN
- 1528-2511 (ISSN-L)
- 1935-4657
- OpenAlex
- W1587884197
- Cited by
- 168
- References
- 13
- Type
- other
- Language
- en
- Open access
- closed
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