Establishment, maintenance and in vitro and in vivo applications of primary human glioblastoma multiforme (GBM) xenograft models for translational biology studies and drug discovery

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

Pollard, S. M., Yoshikawa, K., Clarke, I. D., Danovi, D., Stricker, S., Russell, R., Bayani, J., Head, R., Lee, M., Bernstein, M., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.03.014 · Cited by 1,025

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

Pegg, A. E. (1990) · PubMed · Cited by 730

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

Frederick, L. A., Wang, X. Y., Eley, G. D., & James, C. D. (2000) · PubMed · Cited by 661

PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme

Smith, J. S., Tachibana, I., Passe, S. M., Huntley, B. K., Borell, T. J., Iturria, N. L., O'Fallon, J. R., Schaefer, P., Scheithauer, B. W., James, C. D., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.16.1246 · Cited by 630

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

Kitange, G. J., Carlson, B. L., Schroeder, M. A., Grogan, P. T., Lamont, J. D., Decker, P. A., Wu, W., James, C. D., & Sarkaria, J. N. (2008) · Neuro-Oncology · doi:10.1215/15228517-2008-090 · Cited by 387

Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

Giannini, C., Sarkaria, J. N., Saito, A., Uhm, J. H., Galanis, E., Carlson, B. L., Schroeder, M. A., & James, C. D. (2005) · Neuro-Oncology · doi:10.1215/s1152851704000821 · Cited by 326

Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response

Sarkaria, J. N., Carlson, B. L., Schroeder, M. A., Grogan, P., Brown, P. D., Giannini, C., Ballman, K. V., Kitange, G. J., Guha, A., Pandita, A., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2510 · Cited by 270

Genomic Changes and Gene Expression Profiles Reveal That Established Glioma Cell Lines Are Poorly Representative of Primary Human Gliomas

Li, A., Walling, J., Kotliarov, Y., Steed, M. E., Ahn, S. J., Rosenblum, M., Mikkelsen, T., Zenklusen, J. C., & Fine, H. A. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0280 · Cited by 264

Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR

Pandita, A., Aldape, K., Zadeh, G. M., Guha, A., & James, C. D. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10300 · Cited by 212

Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

Cheng, Z., Gong, Y., Ma, Y., Lu, K., Lu, X., Pierce, L. A., Thompson, R. C., Müller, S., Knapp, S., & Wang, J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3066 · Cited by 305

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Chen, X., Zhang, M., Gan, H., Wang, H., Lee, J., Fang, D., Kitange, G. J., He, L., Hu, Z., Parney, I. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05373-4 · Cited by 270

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Zhou, W., Yao, Y., Scott, A. J., Wilder-Romans, K., Dresser, J., Werner, C. K., Sun, H., Pratt, D. W., Sajjakulnukit, P., Zhao, S. G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17512-x · Cited by 251

Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma

Vaubel, R. A., Tian, S., Remonde, D., Schroeder, M. A., Mladek, A. C., Kitange, G. J., Caron, A., Kollmeyer, T. M., Grove, R., Peng, S., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0909 · Cited by 227

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

Stafford, J. H., Hirai, T., Deng, L., Chernikova, S. B., Urata, K., West, B. L., & Brown, J. M. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov272 · Cited by 233

p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

Cen, L., Carlson, B. L., Schroeder, M. A., Ostrem, J. L., Kitange, G. J., Mladek, A. C., Fink, S. R., Decker, P. A., Wu, W., Kim, J.-S., et al. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos114 · Cited by 194

Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

Wang, Y., Jiang, Y., Wei, D., Singh, P., Yu, Y., Lee, T., Zhang, L., Mandl, H. K., Piotrowski-Daspit, A. S., Chen, X., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00728-7 · Cited by 190

Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O 6-Benzylguanine to Brain Tumors

Stephen, Z. R., Kievit, F. M., Omid Veiseh, A., Chiarelli, P. A., Fang, C., Wang, K., Hatzinger, S. J., Ellenbogen, R. G., Silber, J. R., & Zhang, M. (2014) · ACS Nano · doi:10.1021/nn503735w · Cited by 187

Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations

Zhang, D. Y., Dmello, C., Chen, L., Arrieta, V. A., González-Buendía, E., KANE, J. R., Magnusson, L. P., Baran, A. H., James, C. D., Horbinski, C., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2182 · Cited by 176

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Golebiewska, A., Hau, A., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02226-7 · Cited by 161

A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles

Straehla, J. P., Hajal, C., Safford, H. C., Offeddu, G. S., Boehnke, N., Dacoba, T. G., Wyckoff, J. B., Kamm, R. D., & Hammond, P. T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118697119 · Cited by 164

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M. L., Penas, C., Volmar, C., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B. K., Sarkaria, J. N., Komotar, R. J., et al. (2014) · Epigenetics · doi:10.4161/epi.27906 · Cited by 147

Immunovirotherapy with measles virus strains in combination with anti–PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment

Hardcastle, J. J., Mills, L., Malo, C. S., Jin, F., Kurokawa, C., Geekiyanage, H., Schroeder, M. A., Sarkaria, J. N., Johnson, A. J., & Galanis, E. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now179 · Cited by 129

Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood–brain barrier

Parrish, K., Sarkaria, J. N., & Elmquist, W. F. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.71 · Cited by 131

Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma

Gupta, S. K., Kizilbash, S. H., Carlson, B. L., Mladek, A. C., Boakye‐Agyeman, F., Bakken, K. K., Pokorny, J. L., Schroeder, M. A., Decker, P. A., Cen, L., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv369 · Cited by 128

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

Allen, C., Opyrchal, M., Aderca, I., Schroeder, M. A., Sarkaria, J. N., Domingo‐Musibay, E., Federspiel, M. J., & Galanis, E. (2012) · Gene Therapy · doi:10.1038/gt.2012.62 · Cited by 107

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W. M., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07659-z · Cited by 101

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J., Qiu, J., Schwartz, P. H., Sarkaria, J. N., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1420-6 · Cited by 97

Efflux Transporters at the Blood-Brain Barrier Limit Delivery and Efficacy of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib (PD-0332991) in an Orthotopic Brain Tumor Model

Parrish, K. E., Pokorny, J. L., Mittapalli, R. K., Bakken, K. K., Sarkaria, J. N., & Elmquist, W. F. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.228213 · Cited by 98

Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages

Chuang, H.-Y., Su, Y.-K., Liu, H.-W., Chen, C., Chiu, S., Cho, D., Lin, S., Chen, Y.-S., & Lin, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8070959 · Cited by 94

Molecular Characterization of EGFR and EGFRvIII Signaling Networks in Human Glioblastoma Tumor Xenografts

Johnson, H., Rosario, A. M. D., Bryson, B. D., Schroeder, M. A., Sarkaria, J. N., & White, F. M. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.019984 · Cited by 96

Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents

Agarwal, S., Mittapalli, R. K., Zellmer, D. M., Gallardo, J. L., Donelson, R., Seiler, C., Decker, S. A., SantaCruz, K. S., Pokorny, J. L., Sarkaria, J. N., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0552 · Cited by 92

The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood–Brain Barrier in Glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D. J., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2588 · Cited by 91

Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System

Parrish, K. E., Cen, L., Murray, J., Calligaris, D., Kizilbash, S. H., Mittapalli, R. K., Carlson, B. L., Schroeder, M. A., Sludden, J., Boddy, A. V., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0553 · Cited by 93

Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma

Marin, B. M., Porath, K. A., Jain, S., Kim, M., Conage‐Pough, J. E., Oh, J., Miller, C. L., Talele, S., Kitange, G. J., Tian, S., et al. (2021) · Neuro-Oncology · doi:10.1093/neuonc/noab133 · Cited by 84

InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma

Ma, Y., Tang, N., Thompson, R. C., Mobley, B. C., Clark, S. W., Sarkaria, J. N., & Wang, J. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1677 · Cited by 84

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

Gupta, S. K., Smith, E. J., Mladek, A. C., Tian, S., Decker, P. A., Kizilbash, S. H., Kitange, G. J., & Sarkaria, J. N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2018.00670 · Cited by 82

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

Deborah, H., Lewis‐Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodríguez, F. J., Giannini, C., Galanis, E., Sarkaria, J. N., & Anastasiadis, P. Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056505 · Cited by 81

Culture on 3D Chitosan‐Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells

Wang, K., Kievit, F. M., Erickson, A. E., Silber, J. R., Ellenbogen, R. G., & Zhang, M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600684 · Cited by 80

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Randall, E. C., Emdal, K. B., Laramy, J. K., Kim, M., Roos, A., Calligaris, D., Regan, M. S., Gupta, S. K., Mladek, A. C., Carlson, B. L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07334-3 · Cited by 77

Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma

Miklja, Z., Yadav, V. N., Cartaxo, R. T., Siada, R. G., Thomas, C., Cummings, J. R., Mullan, B. P., Stallard, S., Paul, A., Bruzek, A. K., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133310 · Cited by 75

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D. S., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T. P., Futalan, D., Akers, J. C., Sarkaria, J. N., Jiang, T., Chowdhury, D., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1974 · Cited by 74

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Kitange, G. J., Mladek, A. C., Schroeder, M. A., Pokorny, J. C., Carlson, B. L., Zhang, Y., Nair, A., Lee, J., Yan, H., Decker, P. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.045 · Cited by 73

Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier

Salphati, L., Heffron, T. P., Alicke, B., Nishimura, M. C., Barck, K. H., Carano, R. A. D., Cheong, J., Edgar, K. A., Greve, J. M., Kharbanda, S., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0720 · Cited by 73

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma

An, Z., Knobbe-Thomsen, C. B., Wan, X., Fan, Q. W., Reifenberger, G., & Weiss, W. A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3551 · Cited by 66

Three-dimensional microscale hanging drop arrays with geometric control for drug screening and live tissue imaging

Ganguli, A., Mostafa, A., Saavedra, C., Kim, Y., Le, P., Faramarzi, V., Feathers, R. W., Berger, J., Ramos-Cruz, K. P., Adeniba, O. O., et al. (2021) · Science Advances · doi:10.1126/sciadv.abc1323 · Cited by 66

The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival

Thompson, E. M., Keir, S. T., Venkatraman, T. N., Lascola, C. D., Yeom, K. W., Nixon, A. B., Liu, Y., Picard, D. J., Remke, M., Bigner, D. D., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox033 · Cited by 65

The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13

Hu, Y., Zhang, M., Tian, N., Li, D., Wu, F., Hu, P., Wang, Z., Wang, L., Hao, W., Kang, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124979 · Cited by 64

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

Pedrón, S., Wolter, G. L., Chen, J.-W. E., Laken, S. E., Sarkaria, J. N., & Harley, B. A. C. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119371 · Cited by 65

RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials

Lozada-Delgado, E. L., Grafals‐Ruiz, N., & Vivas‐Mejía, P. E. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.08.027 · Cited by 65

Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas

Ramakrishnan, V., Xu, B., Akers, J. C., Nguyen, T. P., Ma, J., Dhawan, S., Ning, J., Mao, Y. Q., Hua, W., Kokkoli, E., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102736 · Cited by 68

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition

Rahman, M., Olson, I., Mansour, M. A., Carlstrom, L. P., Sutiwisesak, R., Saber, R., Rajani, K. R., Warrington, A. E., Howard, A., Schroeder, M. A., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0029 · Cited by 67

Src family kinases differentially influence glioma growth and motility

Lewis‐Tuffin, L. J., Feathers, R. W., Hari, P., Durand, N., Li, Z., Rodríguez, F. J., Bakken, K., Carlson, B. L., Schroeder, M. A., Sarkaria, J. N., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.06.001 · Cited by 63

Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data

Abdelmoula, W. M., Regan, M. S., Lopez, B. G. C., Randall, E. C., Lawler, S., Mladek, A. C., Nowicki, M. O., Marin, B. M., Agar, J. N., Swanson, K. R., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00854 · Cited by 62

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

McNeill, R. S., Canoutas, D. A., Stuhlmiller, T. J., Dhruv, H., Irvin, D., Bash, R., Angus, S. P., Herring, L. E., Simon, J. M., Skinner, K., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox044 · Cited by 61

Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells

Lee, E.-J., Rath, P., Liu, J., Ryu, D., Pei, L., Noonepalle, S. K. R., Shull, A. Y., Feng, Q., Litofsky, N. S., Miller, D. C., et al. (2015) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2015.06.003 · Cited by 58

Characterization and comparison of human glioblastoma models

Schulz, J., Rodgers, L. T., Kryscio, R. J., Hartz, A. M. S., & Bauer, B. (2022) · BMC Cancer · doi:10.1186/s12885-022-09910-9 · Cited by 59

SDF-1 Blockade Enhances Anti-VEGF Therapy of Glioblastoma and Can Be Monitored by MRI

Deng, L., Stafford, J. H., Liu, S.-C., Chernikova, S. B., Merchant, M. J., Recht, L. D., & Brown, J. M. (2016) · Neoplasia · doi:10.1016/j.neo.2016.11.010 · Cited by 62

Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas

Chandramohan, V., Bryant, J. D., Piao, H., Keir, S. T., Lipp, E., Lefaivre, M., Perkinson, K. R., Bigner, D. D., Gromeier, M., & McLendon, R. E. (2017) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2016-0580-oa · Cited by 59

Injectable Hydrogels for Localized Chemotherapy and Radiotherapy in Brain Tumors

de la Puente, P., Fettig, N. M., Luderer, M. J., Jin, A. Y., Shah, S., Muz, B., Kapoor, V., Goddu, S. M., Salama, N. N., Tsien, C. I., et al. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.10.042 · Cited by 59

Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo

Karpel‐Massler, G., Ramani, D., Shu, C., Halatsch, M., Westhoff, M., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2016) · Oncotarget · doi:10.18632/oncotarget.9257 · Cited by 59

Effective Radiovirotherapy for Malignant Gliomas by Using Oncolytic Measles Virus Strains Encoding the Sodium Iodide Symporter (MV-NIS)

Opyrchal, M., Allen, C., Iankov, I. D., Aderca, I., Schroeder, M. A., Sarkaria, J. N., & Galanis, E. (2011) · Human Gene Therapy · doi:10.1089/hum.2011.158 · Cited by 57

Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1

Ranjan, A., & Srivastava, S. (2017) · Oncotarget · doi:10.18632/oncotarget.16515 · Cited by 57

Gene therapy for brain tumors: Basic developments and clinical implementation

Assi, H. H., Candolfi, M., Baker, G. J., Mineharu, Y., Lowenstein, P. R., & Castro, M. G. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.08.003 · Cited by 55

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma

Loskutov, Y. V., Griffin, C. L., Marinak, K. M., Bobko, A. A., Margaryan, N. V., Geldenhuys, W. J., Sarkaria, J. N., & Pugacheva, E. N. (2018) · Oncogene · doi:10.1038/s41388-017-0049-3 · Cited by 57

In Vitro/In Silico Study on the Role of Doubling Time Heterogeneity among Primary Glioblastoma Cell Lines

Oraiopoulou, M., Tzamali, E., Tzedakis, G., Vakis, A. F., Papamatheakis, J. D., & Sakkalis, V. (2017) · BioMed Research International · doi:10.1155/2017/8569328 · Cited by 56

Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma

Salphati, L., Alicke, B., Heffron, T. P., Shahidi-Latham, S. K., Nishimura, M. C., Cao, T. C., Carano, R. A. D., Cheong, J., Greve, J. M., Koeppen, H., et al. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.071423 · Cited by 53

Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma

Pedrón, S., Hanselman, J. S., Schroeder, M. A., Sarkaria, J. N., & Harley, B. A. C. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700529 · Cited by 54

p53 isoform profiling in glioblastoma and injured brain

Takahashi, R., Giannini, C., Sarkaria, J. N., Schroeder, M., Rogers, J., Mastroeni, D., & Scrable, H. J. (2012) · Oncogene · doi:10.1038/onc.2012.322 · Cited by 52

Brain Tumor Stem Cell Multipotency Correlates with Nanog Expression and Extent of Passaging in Human Glioblastoma Xenografts

Higgins, D. M. O., Wang, R., Milligan, B. D., Schroeder, M. A., Carlson, B. L., Pokorny, J. L., Cheshier, S. H., Meyer, F. B., Weissman, I. L., Sarkaria, J. N., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.1059 · Cited by 52

siRNA Nanoparticle Suppresses Drug‐Resistant Gene and Prolongs Survival in an Orthotopic Glioblastoma Xenograft Mouse Model

Wang, K., Kievit, F. M., Chiarelli, P. A., Stephen, Z. R., Lin, G., Silber, J. R., Ellenbogen, R. G., & Zhang, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007166 · Cited by 52

synNotch-programmed iPSC-derived NK cells usurp TIGIT and CD73 activities for glioblastoma therapy

Lupo, K. B., Yao, X., Borde, S., Wang, J., Torregrosa‐Allen, S. E., Elzey, B. D., Utturkar, S. M., Lanman, N. A., McIntosh, M., & Matosevic, S. (2024) · Nature Communications · doi:10.1038/s41467-024-46343-3 · Cited by 51

The Role of Factor Inhibiting HIF (FIH-1) in Inhibiting HIF-1 Transcriptional Activity in Glioblastoma Multiforme

Wang, E., Zhang, C., Polavaram, N. S., Liu, F., Wu, G., Schroeder, M. A., Lau, J. S., Mukhopadhyay, D., Jiang, S., O’Neill, B. P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086102 · Cited by 49

Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme

Wang, L., Gundelach, J. H., & Bram, R. J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.217 · Cited by 50

Combination therapy in a xenograft model of glioblastoma: Enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Wang, H., Cai, S., Bailey, B. J., Reza Saadatzadeh, M., Ding, J., Tonsing-Carter, E., Georgiadis, T. M., Zachary Gunter, T., Long, E. C., Minto, R. E., et al. (2017) · Journal of Neurosurgery · doi:10.3171/2016.1.jns152513 · Cited by 49

Preclinical Models and Technologies in Glioblastoma Research: Evolution, Current State, and Future Avenues

Slika, H., Karimov, Z., Alimonti, P., Abou‐Mrad, T., Fazio, E. D., Alomari, S., & Tyler, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216316 · Cited by 52

In Vivo c-Met Pathway Inhibition Depletes Human Glioma Xenografts of Tumor-Propagating Stem-Like Cells

Rath, P., Lal, B., Ajala, O., Li, Y.-Q., Xia, S., Kim, J., & Laterra, J. (2013) · Translational Oncology · doi:10.1593/tlo.13127 · Cited by 49

Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain

Pickering, A. J., Lamson, N. G., Marand, M. H., Hwang, W., Straehla, J. P., & Hammond, P. T. (2023) · ACS Nano · doi:10.1021/acsnano.3c09273 · Cited by 46

Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization

Chen, J., Laverty, D. J., Talele, S., Bale, A. A., Carlson, B. L., Porath, K. A., Bakken, K. K., Burgenske, D. M., Decker, P. A., Vaubel, R. A., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj5962 · Cited by 51

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D. C., Millard, N., Yin, H., Kloss, J. M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14685 · Cited by 48

Cyclophilin B Supports Myc and Mutant p53-Dependent Survival of Glioblastoma Multiforme Cells

Choi, J. W., Schroeder, M. A., Sarkaria, J. N., & Bram, R. J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0771 · Cited by 48

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

Wang, Y., Malik, S., Suh, H., Xiao, Y., Deng, Y., Fan, R., Huttner, A. J., Bindra, R. S., Singh, V., Saltzman, W. M., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq7459 · Cited by 45

EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation

Guo, G., Gong, K., Beckley, N. A., Zhang, Y., Yang, X., Chkheidze, R., Hatanpaa, K. J., Garzón-Muvdi, T., Koduru, P. R. K., Nayab, A., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00962-4 · Cited by 45

Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies

William, D., Mullins, C. S., Schneider, B., Orthmann, A., Lamp, N., Krohn, M., Hoffmann, A., Classen, C.-F., & Linnebacher, M. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1128-5 · Cited by 43

Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts

Almstedt, E., Rosén, E., Gloger, M., Stockgard, R., Hekmati, N., Koltowska, K., Krona, C. C., & Nelander, S. (2021) · Neuro-Oncology · doi:10.1093/neuonc/noab264 · Cited by 42

Combination Treatment with Theranostic Nanoparticles for Glioblastoma Sensitization to TMZ

Yoo, B., Ifediba, M. A., Ghosh, S. K., Medarova, Z. O., & Moore, A. V. (2014) · Molecular Imaging and Biology · doi:10.1007/s11307-014-0734-3 · Cited by 41

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

Karpel‐Massler, G., Banu, M. A., Shu, C., Halatsch, M., Westhoff, M., Bruce, J. N., Canoll, P., & Siegelin, M. D. (2016) · Oncotarget · doi:10.18632/oncotarget.7302 · Cited by 40

EGFR Signals through a DOCK180-MLK3 Axis to Drive Glioblastoma Cell Invasion

Misek, S. A., Chen, J., Schroeder, L. E., Rattanasinchai, C., Sample, A., Sarkaria, J. N., & Gallo, K. A. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0318 · Cited by 40

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition

Herrera-Perez, R. M., Voytik‐Harbin, S. L., Sarkaria, J. N., Pollok, K. E., Fishel, M. L., & Rickus, J. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194183 · Cited by 40

Time-Resolved MRI Assessment of Convection-Enhanced Delivery by Targeted and Nontargeted Nanoparticles in a Human Glioblastoma Mouse Model

Stephen, Z. R., Chiarelli, P. A., Revia, R. A., Wang, K., Kievit, F. M., Dayringer, C., Jeon, M., Ellenbogen, R. G., & Zhang, M. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2998 · Cited by 41

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma

Gupta, K., Vučković, I., Zhang, S., Xiong, Y., Carlson, B. L., Jacobs, J., Olson, I., Petterson, X.-M. T., Macura, S. I., Sarkaria, J. N., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00535 · Cited by 40

ROCK Inhibition Facilitates In Vitro Expansion of Glioblastoma Stem-Like Cells

Tilson, S. G., Haley, E. M., Triantafillu, U. L., Dozier, D. A., Langford, C. P., Gillespie, G. Y., & Kim, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132823 · Cited by 40

Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma

Lei, F., Chiang, J., Chang, H.-J., Chen, D.-C., Wang, H.-L., Yang, H.-A., Wei, K.-Y., Huang, Y., Wang, C.-C., Wei, S., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102831 · Cited by 45

IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling

Oliva, C. R., Halloran, B., Hjelmeland, A. B., Vazquez, A. I., Bailey, S. M., Sarkaria, J. N., & Griguer, C. E. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0273-7 · Cited by 39

Carbenoxolone Enhances TRAIL -Induced Apoptosis Through the Upregulation of Death Receptor 5 and Inhibition of Gap Junction Intercellular Communication in Human Glioma

Yulyana, Y., Endaya, B., Ng, W. H., Guo, C. M., Hui, K. M., Lam, P. Y. P., & Ho, I. A. W. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0529 · Cited by 39

Antiproliferative and apoptosis-inducing activity of schisandrin B against human glioma cells

Li, Q., Lu, X., Wang, C., Cai, L., Lu, J., Wu, J., Zhuge, Q., Zheng, W., & Su, Z. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0160-x · Cited by 38

Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma

Lescarbeau, R. S., Lei, L., Bakken, K. K., Sims, P. A., Sarkaria, J. N., Canoll, P., & White, F. M. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0692 · Cited by 38

Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma

Guo, G., Gong, K., Puliyappadamba, V. T., Panchani, N., Pan, E., Mukherjee, B., Damanwalla, Z., Bharia, S., Hatanpaa, K. J., Gerber, D. E., et al. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz127 · Cited by 37

Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models

Jain, S., Griffith, J. I. G., Porath, K. A., Rathi, S., Le, J., Pasa, T. I., Decker, P. A., Gupta, S. K., Hu, Z., Carlson, B. L., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-0426 · Cited by 36

Patient-Derived Xenografts as a Model System for Radiation Research

Willey, C. D., Gilbert, A. N., Anderson, J. C., & Gillespie, G. Y. (2015) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2015.05.008 · Cited by 36

Microtubule actin cross-linking factor 1, a novel target in glioblastoma

Afghani, N., Mehta, T. R., Wang, J., Tang, N., Skalli, O., & Quick, Q. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3798 · Cited by 36

A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells

Quereda, V., Hou, S., Madoux, F., Scampavia, L. D., Spicer, T., & Duckett, D. R. (2018) · SLAS DISCOVERY · doi:10.1177/2472555218775055 · Cited by 36

Dominant Effects of Δ40p53 on p53 Function and Melanoma Cell Fate

Takahashi, R., Markovic, S. N., & Scrable, H. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.391 · Cited by 36

Perivascular Stromal Cells Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model

Ngo, M. T., Sarkaria, J. N., & Harley, B. A. C. (2022) · Advanced Science · doi:10.1002/advs.202201888 · Cited by 36

Integrating in vitro experiments with in silico approaches for Glioblastoma invasion: the role of cell-to-cell adhesion heterogeneity

Oraiopoulou, M., Tzamali, E., Tzedakis, G., Liapis, E., Zacharakis, G., Vakis, A. F., Papamatheakis, J. D., & Sakkalis, V. (2018) · Scientific Reports · doi:10.1038/s41598-018-34521-5 · Cited by 34

Critical functions of RhoB in support of glioblastoma tumorigenesis

Ma, Y., Gong, Y., Cheng, Z., Loganathan, S. N., Kao, C., Sarkaria, J. N., Abel, T. W., & Wang, J. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou228 · Cited by 33

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma

Hover, L. D., Owens, P., Munden, A. L., Wang, J., Chambless, L. B., Hopkins, C. R., Hong, C. C., Moses, H. L., & Abel, T. W. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov310 · Cited by 33

Crizotinib and erlotinib inhibits growth of c-Met+/EGFRvIII+ primary human glioblastoma xenografts

Goodwin, C. R., Rath, P., Oyinlade, O., López-Bertoni, H., Mughal, S., Xia, S., Li, Y.-Q., Kaur, H., Zhou, X., Ahmed, A. K., et al. (2018) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2018.02.041 · Cited by 32

Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

Kurokawa, C., Geekiyanage, H., Allen, C., Iankov, I. D., Schroeder, M. A., Carlson, B. L., Bakken, K., Sarkaria, J. N., Ecsedy, J., D’Assoro, A. B., et al. (2016) · Journal of Neuro-Oncology · doi:10.1007/s11060-016-2285-8 · Cited by 32

Network Modeling Identifies Patient-specific Pathways in Glioblastoma

Tunçbağ, N., Milani, P., Pokorny, J. L., Johnson, H., Sio, T. T.-W., Dalin, S., Iyekegbe, D. O., White, F. M., Sarkaria, J. N., & Fraenkel, E. (2016) · Scientific Reports · doi:10.1038/srep28668 · Cited by 33

A reproducible brain tumour model established from human glioblastoma biopsies

Wang, J., Miletić, H., Sakariassen, P. Ø., Huszthy, P. C., Jacobsen, H. K., Brekkå, N., Li, X., Zhao, P., Mørk, S. J., Chekenya, M., et al. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-465 · Cited by 105

Establishment of Stereotactic Orthotopic Brain Tumor Xenografts in Mice: Technical Report

Gholamin, S., Feroze, A. H., Mitra, S. S., Kahn, S. A., & Cheshier, S. H. (2013) · Cureus · doi:10.7759/cureus.150 · Cited by 9

The development of xenograft glioblastoma implants in nude mice brain.

Brehar, F. M., Ciurea, A. V., Chivu‐Economescu, M., Zărnescu, O., Rădulescu, R., & Dragu, D. (2008) · PubMed Central · Cited by 12

Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development

Basso, J., Sereno, J., Fortuna, A. C., Castelo-Branco, M. S., & Vitorino, C. (2020) · Neuromethods · doi:10.1007/978-1-0716-1052-7_12 · Cited by 5

Orthotopic Patient-Derived Glioblastoma Xenografts in Mice

Xu, Z., Kader, M. E., Sen, R., & Placantonakis, D. G. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7659-1_14 · Cited by 24