The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Toll‐Like Receptors
Abstract
The mammalian Toll‐like receptor (TLR) family consists of 13 members, and recognizes specific patterns of microbial components, called pathogen‐associated molecular patterns (PAMPs). TLR‐dependent recognition of PAMPs leads to activation of the innate immune system, which subsequently leads to activation of antigen‐specific adaptive immunity. The TLR‐mediated signaling pathways consist of the MyD88‐dependent pathway and TRIF‐dependent pathway, both of which induce gene expression. This unit discusses mammalian TLRs (TLR1 to 13) that have an essential role in the innate immune recognition of microorganisms. Also discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs. © 2015 by John Wiley & Sons, Inc.
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Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Self-citationA Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 8×
“B cell receptor or Fc receptor–mediated internalization of the immune complex is thought to result in TLR9-mediated recognition of hostderived CpG DNA within chromatins.”
BackgroundInfluentialSelf-citationRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., & Simon, J. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20001858 · Cited by 1,378
TLR13 Recognizes Bacterial 23 S rRNA Devoid of Erythromycin Resistance–Forming Modification
Oldenburg, M., Krüger, A., Ferstl, R., Kaufmann, A., Nees, G., Sigmund, A., Bathke, B., Lauterbach, H., Suter, M., Dreher, S., et al. (2012) · Science · doi:10.1126/science.1220363 · Cited by 405 · cited 1×
“The introduction of a dominant negative form of TLR6 into macrophage cell lines inhibited TNF-α production in response to peptidoglycan, but not to bacterial lipopeptides, both of which are recognized by TLR2 (Ozinsky et al., 2000).”
Background
Cited by
Akkermansia muciniphila phospholipid induces homeostatic immune responses
Bae, M., Cassilly, C. D., Liu, X., Park, S.-M., Tusi, B. K., Chen, X., Kwon, J., Filipčík, P., Bolze, A. S., Liu, Z., et al. (2022) · Nature · doi:10.1038/s41586-022-04985-7 · Cited by 413
Immunogenicity and toxicity of AAV gene therapy
Ertl, H. C. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.975803 · Cited by 402
Microglia: Agents of the CNS Pro-Inflammatory Response
Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365
Role of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352
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Metadata
- Authors
- Takeda, K., & Akira, S.
- Venue
- Current Protocols in Immunology
- Publisher
- Wiley
- Published
- 2015-04
- Volume
- 109
- Issue
- 1
- ISSN
- 1934-3671 (ISSN-L)
- 1934-368X
- OpenAlex
- W3214706838
- Cited by
- 421
- References
- 6
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- closed
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