Cited by 415Cervical Cancer and HPV ResearchEndometrial and Cervical Cancer TreatmentsWomen's cancer prevention and management

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Surgery for cervical intraepithelial neoplasia

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Martin-Hirsch, Pierre PL, Paraskevaidis, Evangelos, Bryant, Andrew, Dickinson, Heather O·2013·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd001318.pub3PMC PMC8958508

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Abstract

BACKGROUND: Cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion. Atypical squamous changes occur in the transformation zone of the cervix with mild, moderate or severe changes described by their depth (CIN 1, 2 or 3). Cervical intraepithelial neoplasia is treated by local ablation or lower morbidity excision techniques. Choice of treatment depends on the grade and extent of the disease. OBJECTIVES: To assess the effectiveness and safety of alternative surgical treatments for CIN. SEARCH METHODS: We searched the Cochrane Gynaecological Cancer Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE and EMBASE (up to November 2012). We also searched registers of clinical trials, abstracts of scientific meetings and reference lists of included studies. SELECTION CRITERIA: Randomised controlled trials (RCTs) of alternative surgical treatments in women with cervical intraepithelial neoplasia. DATA COLLECTION AND ANALYSIS: Two review authors independently abstracted data and assessed risks of bias. Risk ratios that compared residual disease after the follow-up examination and adverse events in women who received one of either laser ablation, laser conisation, large loop excision of the transformation zone (LLETZ), knife conisation or cryotherapy were pooled in random-effects model meta-analyses. MAIN RESULTS: Twenty-nine trials were included. Seven surgical techniques were tested in various comparisons. No significant differences in treatment failures were demonstrated in terms of persistent disease after treatment. Large loop excision of the transformation zone appeared to provide the most reliable specimens for histology with the least morbidity. Morbidity was lower than with laser conisation, although the trials did not provide data for every outcome measure. There were not enough data to assess the effect on morbidity when compared with laser ablation. AUTHORS' CONCLUSIONS: The evidence suggests that there is no obvious superior surgical technique for treating cervical intraepithelial neoplasia in terms of treatment failures or operative morbidity.

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Authors: Martin-Hirsch, P. P., Paraskevaidis, E., Bryant, A., & Dickinson, H. O.
Affiliations: Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust; Gynaecological Oncology Unit; Sharoe Green Lane Fullwood Preston Lancashire UK PR2 9HT
University Hospital of Ioannina (GR)
Newcastle University (GB)
ORCID: Paraskevaidis, Evangelos
Bryant, Andrew
Venue: Cochrane Database of Systematic Reviews
Publisher: Wiley
Published: 2013-12-04
Volume: 2014
Issue: 2
Pages: CD001318-CD001318
ISSN: 1361-6137 (ISSN-L)
1465-1858
DOI: 10.1002/14651858.cd001318.pub3
PMC: PMC8958508
OpenAlex: W1528230525
Cited by: 415
References: 82
Citations by year: 2026: 4 · 2025: 10 · 2024: 23 · 2023: 21 · 2022: 29 · 2021: 25 · 2020: 25 · 2019: 20 · 2018: 22 · 2017: 19 · 2016: 26 · 2015: 17 · 2014: 24 · 2013: 29
FWCI: 3.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: National Institute for Health and Care Research
Topics: Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords: cervical intraepithelial neoplasia, cervical cancer surgery, LLETZ, laser ablation, cryotherapy, treatment failure, surgical morbidity
MeSH terms: Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Cryosurgery, Female, Humans, Conization, Laser Therapy

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