Interventions for paracetamol (acetaminophen) overdose

Bias in meta-analysis detected by a simple, graphical test

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Meta-analysis in clinical trials

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Quantifying heterogeneity in a meta‐analysis

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GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305 · see citing works

Operating characteristics of a rank correlation test for publication bias

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Untitled work

Schulz (1995) · doi:10.1001/jama.1995.03520290060030 · Cited by 5,634 · see citing works

Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?

Moher, D., Pham, B., Jones, A., Cook, D. J., Jadad, A. R., Moher, M., Tugwell, P., & Klassen, T. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01085-x · Cited by 3,560 · see citing works

Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

Wood, L., Egger, M., Gluud, L. L., Schulz, K. F., Jüni, P., Altman, D. G., Gluud, C., Martin, R. M., Wood, A. J. G., & Sterne, J. A. C. (2008) · BMJ · doi:10.1136/bmj.39465.451748.ad · Cited by 2,538 · see citing works

A modified test for small‐study effects in meta‐analyses of controlled trials with binary endpoints

Harbord, R. M., Egger, M., & Sterne, J. A. C. (2006) · Statistics in Medicine · doi:10.1002/sim.2380 · Cited by 2,267 · see citing works

Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses

Gluud, L. L., Villumsen, J., & Gluud, C. N. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-11-200112040-00010 · Cited by 2,262 · see citing works

Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis

Wetterslev, J., Thorlund, K., Brok, J., & Gluud, C. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.03.013 · Cited by 1,881 · see citing works

Industry sponsorship and research outcome

Lundh, A., Lexchin, J., Mintzes, B., Schroll, J. B., & Bero, L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000033.pub3 · Cited by 1,697 · see citing works

Trial Sequential Analysis in systematic reviews with meta-analysis

Wetterslev, J., Jakobsen, J. C., & Gluud, C. N. (2017) · BMC Medical Research Methodology · doi:10.1186/s12874-017-0315-7 · Cited by 1,207 · see citing works

Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses

Brok, J. S., Thorlund, K., Gluud, C. N., & Wetterslev, J. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.10.007 · Cited by 1,116 · see citing works

Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose

Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102 · see citing works

Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials

Savović, J., Jones, H. E., Altman, D. G., Harris, R. J., Jüni, P., Pildal, J., Als-Nielsen, B., Balk, E. M., Gluud, C., Gluud, L. L., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-6-201209180-00537 · Cited by 1,049 · see citing works

Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events

Bradburn, M. J., Deeks, J. J., Berlin, J. A., & Russell Localio, A. (2007) · Statistics in Medicine · doi:10.1002/sim.2528 · Cited by 938 · see citing works

Estimating required information size by quantifying diversity in random-effects model meta-analyses

Wetterslev, J., Thorlund, K., Brok, J. S., & Gluud, C. N. (2009) · BMC Medical Research Methodology · doi:10.1186/1471-2288-9-86 · Cited by 934 · see citing works

Apparently conclusive meta-analyses may be inconclusive—Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses

Brok, J. S., Thorlund, K., Wetterslev, J., & Gluud, C. N. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn188 · Cited by 918 · see citing works

Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?

Thorlund, K., Devereaux, P. J., Wetterslev, J., Guyatt, G. H., Ioannidis, J. P. A., Thabane, L., Gluud, L. L., Als-Nielsen, B. E. T., & Gluud, C. N. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn179 · Cited by 835 · see citing works

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

(2016) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2015.00052 · Cited by 744 · see citing works

Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods

Jakobsen, J. C., Wetterslev, J., Winkel, P., Lange, T., & Gluud, C. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-120 · Cited by 704 · see citing works

LITERATURE SEARCHING FOR RANDOMIZED CONTROLLED TRIALS USED IN COCHRANE REVIEWS: RAPID VERSUS EXHAUSTIVE SEARCHES

Royle, P., & Milne, R. (2003) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462303000552 · Cited by 693 · see citing works

Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies

Savović, J., Jones, H., Altman, D., Harris, R., Jűni, P., Pildal, J., Als-Nielsen, B., Balk, E., Gluud, C., Gluud, L., et al. (2012) · Health Technology Assessment · doi:10.3310/hta16350 · Cited by 668 · see citing works

Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.

Prescott, L. F., Illingworth, R. N., Critchley, J. A., Stewart, M. J., Adam, R. D., & Proudfoot, A. T. (1979) · BMJ · doi:10.1136/bmj.2.6198.1097 · Cited by 667 · see citing works

Acetaminophen Poisoning and Toxicity

Rumack, B. H., & Matthew, H. (1975) · Pediatrics · doi:10.1542/peds.55.6.871 · Cited by 640 · see citing works

Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.

Prescott, L. F., Illingworth, R. N., Critchley, J., & Proudfoot, A. T. (1980) · BMJ · doi:10.1136/bmj.280.6206.46-b · Cited by 625 · see citing works

Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure

O’Grady, J. G., Gimson, A. E., O’Brien, C., Pucknell, A., Hughes, R. D., & Williams, R. L. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90011-x · Cited by 534 · see citing works

Acetaminophen‐induced hepatic injury: Protective role of glutathione in man and rationale for therapy

Mitchell, J. R., Thorgeirsson, S. S., Potter, W. Z., Jollow, D. J., & Keiser, H. R. (1974) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1974164676 · Cited by 529 · see citing works

Acute liver necrosis following overdose of paracetamol

Davidson, D. G., & Eastham, W. N. (1966) · BMJ · doi:10.1136/bmj.2.5512.497 · Cited by 528 · see citing works

Acetaminophen and the U.S. acute liver failure study group: Lowering the risks of hepatic failure

Lee, W. M. (2004) · Hepatology · doi:10.1002/hep.20293 · Cited by 498 · see citing works

Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.

Keays, R. T., Harrison, P. M., Wendon, J. A., Forbes, A., Gove, C. D., Alexander, G., & Williams, R. L. (1991) · BMJ · doi:10.1136/bmj.303.6809.1026 · Cited by 480 · see citing works

Kinetics and metabolism of paracetamol and phenacetin.

Prescott, L. (1980) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1980.tb01812.x · Cited by 454 · see citing works

Lessons from look-back in acute liver failure? A single centre experience of 3300 patients

Bernal, W. E., Hyyrylainen, A., Gera, A., Audimoolam, V. K., McPhail, M. J. W., Auzinger, G. M., Rela, M., Heaton, N. D., O’Grady, J. G., Wendon, J. A., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.010 · Cited by 435 · see citing works

Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study

Reuben, A., Tillman, H., Fontana, R. J., Davern, T., McGuire, B., Stravitz, R. T., Durkalski, V., Larson, A. M., Liou, I., Fix, O., et al. (2016) · Annals of Internal Medicine · doi:10.7326/m15-2211 · Cited by 390 · see citing works

Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine

Harrison, P. M., Keays, R., Bray, G. P., Alexander, G., & Williams, R. L. (1990) · The Lancet · doi:10.1016/0140-6736(90)91388-q · Cited by 389 · see citing works

Position Paper: Single-Dose Activated Charcoal

American Academy of Clinical Toxico, & European Association of Poisons Cen (2005) · Clinical Toxicology · doi:10.1081/clt-51867 · Cited by 372 · see citing works

Position Paper: Single-Dose Activated Charcoal

Toxicology, A. A. O. C., Centres, E. A. O. P., & Toxicologists, C. (2005) · Clinical Toxicology · doi:10.1081/clt-200051867 · Cited by 366 · see citing works

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

Olsson, B., Johansson, M., Gabrielsson, J., & Bolme, P. (1988) · European Journal of Clinical Pharmacology · doi:10.1007/bf01061422 · Cited by 352 · see citing works

Management of acutely poisoned patients without gastric emptying

Kulig, K. W., Bar‐Or, D., Cantrill, S. V., Rosen, P. L., & Rumack, B. H. (1985) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(85)80780-0 · Cited by 294 · see citing works

Albumin Dialysis With a Noncell Artificial Liver Support Device in Patients With Acute Liver Failure

Saliba, F., Camus, C., Durand, F., Mathurin, P., Letierce, A., Delafosse, B. X., Barange, K., Perrigault, P. F., Belnard, M., Ichaı̈, P., et al. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-8-201310150-00005 · Cited by 289 · see citing works

Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals

Mills (2010) · Clinical Epidemiology · doi:10.2147/clep.s9242 · Cited by 281 · see citing works

Acetaminophen overdose: A 48-hour intravenous N-acetylcysteine treatment protocol

Smilkstein, M. J., Bronstein, A. C., Linden, C. H., Augenstein, W. L., Kulig, K. W., & Rumack, B. H. (1991) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(05)81352-6 · Cited by 259 · see citing works

Position Paper: Gastric Lavage

American Academy of Clinical Toxicology, & European Association of Poisons Centres and Clinical Toxicologists (2004) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-200045006 · Cited by 249 · see citing works

HEPATIC DAMAGE AND DEATH FROM OVERDOSE OF PARACETAMOL

Clark, R., Borirakchanyavat, V., Davidson, A. R., Williams, R., Thompson, R. P. H., Widdop, B., & Goulding, R. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90466-2 · Cited by 248 · see citing works

Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial

Bateman, D. N., Dear, J. W., Thanacoody, R. H. K., Thomas, S. H. L., Eddleston, M., Sandilands, E. A., Coyle, J., Cooper, J. G., Rodríguez, A., Butcher, I., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)62062-0 · Cited by 239 · see citing works

Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial

Eddleston, M., Juszczak, E., Buckley, N. A., Senarathna, L., Mohamed, F., Dissanayake, W., Hittarage, A., Azher, S., Jeganathan, K., Jayamanne, S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60270-6 · Cited by 227 · see citing works

Interventions for paracetamol (acetaminophen) overdose

Brok, J. S., Buckley, N., & Gluud, C. N. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003328.pub2 · Cited by 227 · see citing works

Guidelines for the management of paracetamol poisoning in Australia and New Zealand — explanation and elaboration

Daly, F. F. S., Fountain, J. S., Murray, L., Graudins, A., & Buckley, N. A. (2008) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb01625.x · Cited by 224 · see citing works

CYSTEAMINE, METHIONINE, AND PENICILLAMINE IN THE TREATMENT OF PARACETAMOL POISONING

Prescott, L. F., Sutherland, G. R., Park, J., Smith, I. J., & Proudfoot, A. T. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92842-7 · Cited by 210 · see citing works

Acetaminophen and acetylcysteine dose and duration: Past, present and future

Rumack, B. H., & Bateman, D. N. (2012) · Clinical Toxicology · doi:10.3109/15563650.2012.659252 · Cited by 205 · see citing works

Adverse reactions associated with acetylcysteine

Sandilands, E. A., & Bateman, D. N. (2009) · Clinical Toxicology · doi:10.1080/15563650802665587 · Cited by 204 · see citing works

Acetaminophen Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital Management

Dart, R. C., Erdman, A. R., Olson, K. R., Christianson, G., Manoguerra, A. S., Chyka, P. A., Caravati, E. M., Wax, P. M., Keyes, D. C., Woolf, A. D., et al. (2006) · Clinical Toxicology · doi:10.1080/15563650500394571 · Cited by 196 · see citing works

Adverse reactions to acetylcysteine and effects of overdose.

Mant, T., Tempowski, J. H., Volans, G. N., & Talbot, J. C. C. (1984) · BMJ · doi:10.1136/bmj.289.6439.217 · Cited by 194 · see citing works

Paracetamol (acetaminophen) poisoning

Vale, J. A., & Proudfoot, A. T. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91385-8 · Cited by 175 · see citing works

Use of paracetamol for suicide and non-fatal poisoning in the UK and France: are restrictions on availability justified?

Gunnell, D., Hawton, K. E., Murray, V. S. G., Garnier, R., Bismuth, C., Fagg, J., & Simkin, S. (1997) · Journal of Epidemiology & Community Health · doi:10.1136/jech.51.2.175 · Cited by 163 · see citing works

The Australasian Clinical Toxicology Investigators Collaboration Randomized Trial of Different Loading Infusion Rates of N-Acetylcysteine

Kerr, F., Dawson, A. H., Whyte, I. M., Buckley, N. A., Murray, L., Graudins, A., Chan, B. S. H., & Trudinger, B. (2005) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2004.08.040 · Cited by 162 · see citing works

Position Paper: Ipecac Syrup

American Academy of Clinical Toxico, & European Association of Poisons Centres and Clinical Toxicologists (2004) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-120037421 · Cited by 155 · see citing works

Mechanism of Action and Value of N-Acetylcysteine in the Treatment of Early and Late Acetaminophen Poisoning: A Critical Review

Jones, A. L. (1998) · Journal of Toxicology Clinical Toxicology · doi:10.3109/15563659809028022 · Cited by 152 · see citing works

Management of Anaphylactoid Reactions to Intravenous N-Acetylcysteine

Bailey, B., & McGuigan, M. A. (1998) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(98)70229-x · Cited by 135 · see citing works

Oral and Intravenous Acetylcysteine for Treatment of Acetaminophen Toxicity: A Systematic Review and Meta-analysis

Green, J., Heard, K., Reynolds, K., & Albert, D. (2013) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2012.4.6885 · Cited by 135 · see citing works

Extracorporeal treatment for acetaminophen poisoning: Recommendations from the EXTRIP workgroup

Gosselin, S., Juurlink, D. N., Kielstein, J. T., Ghannoum, M., Lavergne, V., Nolin, T. D., Hoffman, R. S., & workgroup, O. B. O. T. E. (2014) · Clinical Toxicology · doi:10.3109/15563650.2014.946994 · Cited by 130 · see citing works

Risk factors in the development of adverse reactions to <i>N</i>‐acetylcysteine in patients with paracetamol poisoning

Schmidt, L. E., & Dalhoff, K. (2001) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2001.01305.x · Cited by 127 · see citing works

Acetaminophen‐Related Acute Renal Failure without Fulminant Liver Failure

Eguia, L., & Materson, B. J. (1997) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1997.tb03721.x · Cited by 126 · see citing works

Oral or IntravenousN-Acetylcysteine: Which Is the Treatment of Choice for Acetaminophen (Paracetamol) Poisoning?

Buckley, N. A., Buckley, N. A., Whyte, I. M., O’Connell, D. L., & Dawson, A. H. (1999) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-100102453 · Cited by 126 · see citing works

Early changes in coagulation following a paracetamol overdose and a controlled trial of fresh frozen plasma therapy.

Gazzard, B., Henderson, J. M., & Williams, R. L. (1975) · Gut · doi:10.1136/gut.16.8.617 · Cited by 117 · see citing works

Detailed analyses of self‐poisoning episodes presenting to a large regional teaching hospital in the UK

Prescott, K., Stratton, R., Freyer, A. M., Hall, I. P., & Jeune, I. L. (2009) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2009.03458.x · Cited by 116 · see citing works

Reduction of Absorption of Paracetamol by Activated Charcoal and Cholestyramine: A Possible Therapeutic Measure

Dordoni, B., Willson, R. A., Thompson, R. P. H., & Williams, R. L. (1973) · BMJ · doi:10.1136/bmj.3.5871.86 · Cited by 116 · see citing works

The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage.: A pharmacokinetic study

Prescott, L. F., & Wright, N. (1973) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1973.tb08536.x · Cited by 114 · see citing works

Activated Charcoal Reduces the Need for<i>N</i>-Acetylcysteine Treatment After Acetaminophen (Paracetamol) Overdose

Buckley, N. A., Buckley, N., Whyte, I. M., O'Connell, D. L., & Dawson, A. H. (1999) · Journal of Toxicology: Clinical Toxicology · doi:10.1081/clt-100102452 · Cited by 112 · see citing works

Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2)

Chiew, A. L., Isbister, G. K., Kirby, K. A., Page, C. B., Chan, B. S. H., & Buckley, N. A. (2017) · Clinical Toxicology · doi:10.1080/15563650.2017.1334915 · Cited by 107 · see citing works

Shorter duration of oral N -Acetylcysteine therapy for acute acetaminophen overdose

Woo, O. F., Mueller, P. D., Olson, K. R., Anderson, I. B., & Kim, S. Y. (2000) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(00)70055-2 · Cited by 104 · see citing works

Acetaminophen

Koch‐Weser, J. (1976) · New England Journal of Medicine · doi:10.1056/nejm197612022952306 · Cited by 103 · see citing works

What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?

Kao, L. W., Kirk, M. A., Furbee, R. B., Mehta, N. H., Skinner, J. R., & Brizendine, E. J. (2003) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(03)00508-0 · Cited by 100 · see citing works

Acetaminophen Causes an Increased International Normalized Ratio by Reducing Functional Factor VII

Whyte, I. M., Buckley, N. A., Reith, D. M., Goodhew, I., Seldon, M., & Dawson, A. H. (2000) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200012000-00015 · Cited by 91 · see citing works

Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine

Cairney, D. G., Beckwith, H., Al-Hourani, K., Eddleston, M., Bateman, D. N., & Dear, J. W. (2016) · Clinical Toxicology · doi:10.3109/15563650.2016.1159309 · Cited by 90 · see citing works

Practical aspects in data monitoring: A brief review

DeMets, D. L. (1987) · Statistics in Medicine · doi:10.1002/sim.4780060706 · Cited by 89 · see citing works

Frequency of Medication Errors with Intravenous Acetylcysteine for Acetaminophen Overdose

Hayes, B. D., Klein‐Schwartz, W., & Doyon, S. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1k685 · Cited by 88 · see citing works

CONTROLLED TRIAL OF CYSTEAMINE IN TREATMENT OF ACUTE PARACETAMOL (ACETAMINOPHEN) POISONING

Douglas, A., Hamlyn, A. N., & James, O. (1976) · The Lancet · doi:10.1016/s0140-6736(76)93154-8 · Cited by 85 · see citing works

Hepatotoxicity Despite Early Administration of Intravenous N‐Acetylcysteine for Acute Acetaminophen Overdose

Doyon, S., & Klein‐Schwartz, W. (2008) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2008.00296.x · Cited by 83 · see citing works

Outcomes from massive paracetamol overdose: a retrospective observational study

Marks, D. J., Dargan, P. I., Archer, J. R. H., Davies, C. L., Dines, A. M., Wood, D. M., & Greene, S. L. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13214 · Cited by 82 · see citing works

A comparison of the efficacy of gastric lavage, ipecacuanha and activated charcoal in the emergency management of paracetamol overdose.

Underhill, T. J., Greene, M. K., & Dove, A. F. (1990) · Emergency Medicine Journal · doi:10.1136/emj.7.3.148 · Cited by 80 · see citing works

Paracetamol: are therapeutic doses entirely safe?

Jalan, R., Williams, R., & Bernuau, J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69874-7 · Cited by 80 · see citing works

Paracetamol overdose in pregnancy analysis of the outcomes of 300 cases referred to the teratology information service

McElhatton, P. R., Sullivan, F., & Volans, G. N. (1997) · Reproductive Toxicology · doi:10.1016/s0890-6238(96)00200-6 · Cited by 76 · see citing works

A randomized clinical trial of activated charcoal for the routine management of oral drug overdose

Cooper, G. M., Couteur, D. G. L., Richardson, D., & Buckley, N. A. (2005) · QJM · doi:10.1093/qjmed/hci102 · Cited by 72 · see citing works

Reviews

Routledge, P. A., Vale, A., Bateman, D. N., Johnston, G. D., Jones, A., Judd, A. M., Thomas, S. H. L., Volans, G. N., Prescott, L. F., & Proudfoot, A. T. (1998) · BMJ · doi:10.1136/bmj.317.7173.1609 · Cited by 71 · see citing works

Evidence for the changing regimens of acetylcysteine

Chiew, A. L., Isbister, G. K., Duffull, S. B., & Buckley, N. A. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12789 · Cited by 67 · see citing works

IS THERE A PLACE FOR CIMETIDINE OR ETHANOL IN THE TREATMENT OF PARACETAMOL POISONING?

Critchley, J., Scott, A., Dyson, E. H., Jarvie, D. R., & Prescott, L. F. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92150-5 · Cited by 67 · see citing works

How Long After Drug Ingestion Is Activated Charcoal Still Effective?

Green, R. S., Grierson, R., SITAR, D. S., & Tenenbein, M. (2001) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-100108492 · Cited by 66 · see citing works

Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man.

Mitchell, M. C., Schenker, S., & Speeg, K. V. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111223 · Cited by 64 · see citing works

Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury

Schmidt, L. E., Knudsen, T. T., Dalhoff, K., & Bendtsen, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11194-9 · Cited by 64 · see citing works

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Wang, J., Zhang, L., Shi, Q. W., Yang, B., He, Q., Wang, J., & Weng, Q. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115142 · Cited by 14 · see citing works

Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroids

Rowan‐Carroll, A., Meier, M. J., Yauk, C. L., Williams, A., Leingartner, K., Bradford, L. M., Lorusso, L., & Atlas, E. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf023 · Cited by 12 · see citing works

Zinc oxide-coated carboxyl-riched graphene oxide efficiently degrades microcystin-leucine arginine and antibiotics under visible light

He, Y., Han, S., Zhao, G., Luo, J., Jia, C., Chen, Y., Liu, Q., Gao, J., Wang, C., & Wang, J. (2022) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2022.107829 · Cited by 11 · see citing works

Association of regular use of ibuprofen and paracetamol, genetic susceptibility, and new-onset dementia in the older population

Zhang, Y., Zhou, C., Yang, S., Zhang, Y., Ye, Z., He, P., Liu, M., Wu, Q., & Qin, X. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.08.006 · Cited by 11 · see citing works

Massive Acetaminophen Overdose Treated Successfully with N-Acetylcysteine, Fomepizole, and Hemodialysis

Chiu, M. H., Jaworska, N., Li, N. L., & Yarema, M. C. (2021) · Case Reports in Critical Care · doi:10.1155/2021/6695967 · Cited by 14 · see citing works

Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila

Saeedi, B. J., Hunter-Chang, S., Luo, L., Li, K., Liu, K., & Robinson, B. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-21156-w · Cited by 10 · see citing works

UegWeek 2020 Poster Presentations

de Pierola, L. B. F., Nyssen, O. P., Cosme, Á., Bordin, D. S., Tepeš, B., Aísa, Á. P., Vaira, D., Álvarez, M. C., Fernández, M. C., Lerang, F., et al. (2020) · United European Gastroenterology Journal · doi:10.1177/2050640620927345 · Cited by 10 · see citing works

Effects of Prenatal Paracetamol Exposure on the Development of Asthma and Wheezing in Childhood: A Systematic Review and Meta-Analysis

Barańska, A., Kanadys, W. M., Wdowiak, A., Malm, M., Błaszczuk, A., Religioni, U., Wdowiak-Filip, A., & Polz‐Dacewicz, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051832 · Cited by 9 · see citing works

Comparison of two-bag and three-bag acetylcysteine regimens in the treatment of paracetamol poisoning: a systematic review and meta-analysis

Nakatsu, L., Lopez, J. R., Garcia, C. M., Cherian, M., Nash, J. L., Tofighi, D., Seifert, S. A., Smolinske, S. C., & Warrick, B. J. (2025) · Clinical Toxicology · doi:10.1080/15563650.2025.2456116 · Cited by 9 · see citing works

Delayed Acetaminophen Absorption Resulting in Acute Liver Failure

Tan, H., Stathakis, P., Varghese, B., Buckley, N. A., & Chiew, A. L. (2022) · Case Reports in Critical Care · doi:10.1155/2022/3672248 · Cited by 9 · see citing works

Emerging Roles of High-mobility Group Box-1 in Liver Disease

Wang, L., Dong, Z., Zhang, Y., & Peng, L. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2024.00317 · Cited by 8 · see citing works

Smartphone Biosensors for Non-Invasive Drug Monitoring in Saliva

Awad, A., Rodríguez‐Pombo, L., Simón, P. E., Álvarez, A. C., Alvarez‐Lorenzo, C., Basit, A. W., & Goyanes, Á. (2025) · Biosensors · doi:10.3390/bios15030163 · Cited by 8 · see citing works

HiSNAP trial—a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 600 mg/kg) in patients with paracetamol overdose in the UK: study protocol

Humphries, C., Clarke, E., Eddleston, M., Gillings, M., Irvine, S., Keating, L., Miell, A., Milne, L., Muir, L., O’Brien, R., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-097432 · Cited by 8 · see citing works

Has the time come to stop routine N‐acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0–6 years

Gade, C., Bøgevig, S., Daoud, A., Mathiesen, P. R., Christensen, M., Dalhoff, K., & Petersen, T. S. (2021) · Acta Paediatrica · doi:10.1111/apa.16185 · Cited by 8 · see citing works

Exploring the Updated Roles of Ferroptosis in Liver Diseases: Mechanisms, Regulators, and Therapeutic Implications

Ge, T., Wang, Y., Han, Y., Bao, X., & Chunfeng, L. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01611-3 · Cited by 7 · see citing works

The Role of Activated Charcoal in Prehospital Care

Aljumaan, M. A. (2023) · Medical Archives · doi:10.5455/medarh.2023.77.64-69 · Cited by 7 · see citing works

Neurologic Complications of Critical Medical Illness

Morris, N. A., & Sarwal, A. (2023) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001278 · Cited by 7 · see citing works

Adverse events associated with analgesics: A focus on paracetamol use

Popiołek, I., & Porębski, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820237-1.00028-4 · Cited by 6 · see citing works

Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine

Taş, N., Altınbaş, A., Noyan, T., Köktürk, S., Ayhan, S., & Canakci, E. (2019) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2019_047 · Cited by 6 · see citing works

Analgesics and anti-inflammatory drugs

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Acetaminophen syn. Paracetamol: Acute Liver Injury and Acute on Chronic Liver Failure with Case Analysis and Causality Assessment Using RUCAM

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Nonsteroidal Anti-inflammatory Drugs

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A Stepwise Approach for Preventing Suicide by Lethal Poisoning.

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Efficacy of erector spinae plane block in pain management for patients with herpes zoster: a systematic review and meta-analysis

Fujimura, A. Y., Moura, C. B., & dos Santos, A. B. (2025) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2025.844598 · Cited by 5 · see citing works

SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress

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Risk factors for the need for advanced care among prescription and over‐the‐counter drug overdose patients

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Sodium taurocholate co-transporting polypeptide deficiency attenuates acetaminophen-induced hepatotoxicity via regulating expression of drug metabolism enzymes in mice

Yang, F., Wu, L., Xu, W., Wu, Y., Zhu, S., Zhang, Y., Chong, Y., & Peng, L. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117266 · Cited by 4 · see citing works

Paracetamol Poisoning: Epidemiology, Diagnosis, Treatment (Status of the Issue)

Геннадьевич, С. В., Gusev, K. Y., Davydova, N. S., & Чекмарев, А. В. (2024) · Ural Medical Journal · doi:10.52420/umj.23.6.108 · Cited by 4 · see citing works

The effect of acetylcysteine on the prothrombin time and international normalized ratio: a narrative review

Nazar, M., Kootstra‐Ros, J. E., Mian, P., Touw, D. J., & Sturkenboom, M. G. G. (2025) · Clinical Toxicology · doi:10.1080/15563650.2025.2451642 · Cited by 4 · see citing works

HEPATOTOXICIDADE DO PARACETAMOL E FATORES PREDISPONENTES

Torres, L. V., Oliveira, P. D. S., Macêdo, C. L., & Wanderley, T. L. R. (2019) · Revista de Ciências da Saúde Nova Esperança · doi:10.17695/revnevol17n1p93-99 · Cited by 4 · see citing works

On the Treatment of Acute Poisoning With Paracetamol

Simonova, A. Y., Potskhveriya, М. М., Belova, M. V., Ilyashenko, K. K., Кулабухов, В. В., Stolbova, N. E., & Kliuev, A. E. (2022) · Russian Sklifosovsky Journal Emergency Medical Care · doi:10.23934/2223-9022-2022-11-2-249-257 · Cited by 4 · see citing works

Massive Acetaminophen Overdose

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Electrochemical study of amino acids’ detoxification potential in acetaminophen overdose

Moeinifar, S., Shayani‐Jam, H., Yaftian, M. R., & Moeini, M. H. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.116181 · Cited by 3 · see citing works

Macrophage manufacturing and engineering with 5′-Cap1 and N1-methylpseudouridine-modified mRNA

Zhang, P., Wang, Y., Jiang, J., Yang, C., Liu, X., Lei, T., Meng, X., Yang, J., Ding, P. X., Chen, J., et al. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101307 · Cited by 3 · see citing works

Il était une fois l’hépatotoxicité…

Daré, B. L., Ferron, P., & Gicquel, T. (2021) · médecine/sciences · doi:10.1051/medsci/2021009 · Cited by 3 · see citing works

Successful management of delayed presentation of massive paracetamol overdose in a resource‐limited setting: A case report from Nepal

Lamichhane, P., Pokhrel, K. M., Bhandari, B., Agrawal, A., Ghimire, B., & Shilpakar, O. (2022) · Clinical Case Reports · doi:10.1002/ccr3.6733 · Cited by 2 · see citing works

Comparative evaluation of the effectiveness and safety of 12-hour and 21-hour protocols for the administration of acetylcysteine in paracetamol poisoning

Simonova, A. Y., Potskhveriya, М. М., Belova, M. V., Ilyashenko, K. K., Кулабухов, В. В., & Рустамовна, А. Л. (2023) · Messenger of Anesthesiology and Resuscitation · doi:10.24884/2078-5658-2022-20-4-46-53 · Cited by 3 · see citing works

Patterns and outcomes of paracetamol poisoning management in Hamad Medical Corporation, Qatar: A retrospective cohort study

Abushanab, D., Gasim, M., Devi, D., Elbdairy, M., Elqasass, H., Ahmed, N., Vincent, M., Pallivalapila, A., Mohammed, H. R., Hail, M. A., et al. (2023) · Medicine · doi:10.1097/md.0000000000034872 · Cited by 3 · see citing works

Mesenchymal Stem Cells with Simultaneous Overexpression of GPX3 and CD47 for the Treatment of Drug-Induced Acute Liver Injury

Jing, Y., Li, B., Aierken, A., Zhang, Z., Han, D., Lin, Z., Gao, J., Tian, H., & Hua, J. (2025) · Veterinary Sciences · doi:10.3390/vetsci12020149 · Cited by 3 · see citing works

Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice

Shi, J.-L., Sun, T., Li, Q., Li, C., Jin, J., & Zhang, C. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i3.104520 · Cited by 3 · see citing works

Cost of inappropriate use of intravenous N-acetylcysteine for acetaminophen toxicity

Dalabih, A. R., Cox, C. L., & Anderson, J. (2021) · Journal of Hospital Management and Health Policy · doi:10.21037/jhmhp-20-87 · Cited by 3 · see citing works

HEPATOTOXICIDADE DO PARACETAMOL E FATORES PREDISPONENTES

Torres, L. V., Oliveira, P. D. S., Macêdo, C. L., & Wanderley, T. L. R. (2019) · Revista de Ciências da Saúde Nova Esperança · doi:10.17695/revcsnevol17n1p93-99 · Cited by 3 · see citing works

Intoxicación aguda por acetaminofén en atención primaria

Herrera, J. M. D., Avendaño, L. P. C., & Buitrago, J. R. R. (2022) · Revista Med · doi:10.18359/rmed.5770 · Cited by 2 · see citing works

Intoxicación por paracetamol en adolescentes

Mena, Y., Casuriaga, A. L., Notejane, M., & Giachetto, G. (2024) · Revista Médica del Uruguay · doi:10.29193/rmu.40.2.4 · Cited by 2 · see citing works

A Macrophage-Specific PET Tracer for Grading Acute Liver Injury

Zhang, X., Wang, G., Wang, T., Li, J., Liu, N., & Su, X. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03042 · Cited by 2 · see citing works

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Ivashkin, V. T., Drapkina, О. M., Raikhelson, K. L., Okovityi, S. V., Maevskaya, M. V., Grechishnikova, V. R., Жаркова, М. С., Khlynova, O. V., Gladkov, O. A., Deeva, Т. A., et al. (2026) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2026-36-1-70-146 · Cited by 2 · see citing works

Management of paracetamol (acetaminophen) toxicity

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N-Acetylcysteine

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Drug Interactions Pharmacology: A Narrative Review

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The Insidious Enemy of the Liver

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Treatment of Acute Paracetamol Overdose: A Comprehensive Overview

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Treatment of paracetamol overdose: room for improvement?

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