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Antioxidants for male subfertility
Open accessAbstract
versus placebo or no treatment, Outcome 2 Live birth; placebo or no treatment........ Analysis 1.3.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 3 Live birth; IVF/ICSI.................................. Analysis 1.4.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 4 Live birth; as-treated analysis................ Analysis 1.5.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 5 Clinical pregnancy; type of antioxidant.... Analysis 1.6.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 6 Clinical pregnancy; placebo or no treatment.....................................
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“Taken together with previous findings, our results indicate that while antioxidants may reduce ROS, this does not appear to translate into reduced sperm DNA fragmentation.”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
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“The recent Cochrane meta-analysis, which included 5 trials with a variety of antioxidants with a total of 254 subjects, found that men treated with antioxidants had on average 5% lower DNA fragmentation, but the confidence interval was broad and crossed 0. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
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“The recent Cochrane Review found that antioxidant use increased the odds of pregnancy by 2.97 fold and the odd of live birth by 1.8 fold. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
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“The recent Cochrane Review found that antioxidant use increased the odds of pregnancy by 2.97 fold and the odd of live birth by 1.8 fold. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
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“However, the Cochrane meta-analysis did find a 12% absolute increase in motility in men treated with combination antioxidants for 3 months compared to controls. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
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“A recent meta-analysis concluded that antioxidant supplementation taken by subfertile males may increase the chance of live birth; however, large randomized, well-designed, placebo-controlled trials were needed. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
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“Our negative findings contradict the overall conclusions from the Cochrane Review and meta-analysis.”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
In the citing paper
“Low-quality evidence suggests that antioxidant supplementation for men with infertility may improve live birth rates (Smits 2019).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Smits 2019
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Coenzyme Q10 and Melatonin for the Treatment of Male Infertility: A Narrative Review
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Idiopathic male infertility – what are we missing?
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Assessing the influence of preconception diet on male fertility: a systematic scoping review
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Current management of recurrent pregnancy loss
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Oral Antioxidant Treatment of Men Significantly Improves the Reproductive Outcome of IVF Cycles
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Micronutrient supplements as antioxidants in improving sperm quality and reducing DNA fragmentation
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Sperm redox biology challenges the role of antioxidants as a treatment for male factor infertility
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Metadata
- Authors
- Smits, R. M., Mackenzie-Proctor, R., Yazdani, A., Stankiewicz, M. T., Jordan, V., & Showell, M. G.
- Affiliations
- Radboud University Medical Center (NL)
- Auckland City Hospital (NZ)
- Queensland Fertility Group Research Foundation; 55 Little Edward St, Level 2 Boundary Court Spring Hill Brisbane Queensland Australia 4000
- Ashford Specialist Centre Suite 22; 57-59 Anzac Highway Ashford Adelaide SA Australia
- University of Auckland (NZ)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2019-03-14
- Volume
- 2019
- Issue
- 3
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W3049686564
- Cited by
- 277
- References
- 240
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 28 · 2023: 47 · 2022: 52 · 2021: 52 · 2020: 52 · 2019: 15
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Update notices
- new_version (2022-05-04)
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- antioxidants, male subfertility, male infertility, live birth, clinical pregnancy, in vitro fertilization, intracytoplasmic sperm injection, antioxidant supplementation
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