Antioxidants for male subfertility

Free radicals, metals and antioxidants in oxidative stress-induced cancer

Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680 · see citing works

International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care

Boivin, J., Bunting, L., Collins, J. A., & Nygren, K. G. (2007) · Human Reproduction · doi:10.1093/humrep/dem046 · Cited by 2,437 · see citing works

National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys

Mascarenhas, M., Flaxman, S. R., Boerma, T., Vanderpoel, S., & Stevens, G. A. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001356 · Cited by 2,357 · see citing works

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

Compounds, P. O. D. A. A. R., Nutrients, S. O. U. R. L. O., Intakes, S. O. I. A. U. O. D. R., Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, & Institute of Medicine (2000) · doi:10.17226/9810 · Cited by 2,034 · see citing works

Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention

Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949 · see citing works

Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century

Inhorn, M. C., & Patrizio, P. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv016 · Cited by 1,926 · see citing works

Oxidative stress and male infertility--a clinical perspective.

Tremellen, K. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn004 · Cited by 1,540 · see citing works

Vitamin E, antioxidant and nothing more

Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,501 · see citing works

Modern Nutrition in Health and Disease

FELDMAN, E. B. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.948 · Cited by 1,426 · see citing works

The international glossary on infertility and fertility care, 2017

Zegers-Hochschild, F., Adamson, G. D., Dyer, S., Racowsky, C., de Mouzon, J., Sokol, R., Rienzi, L., Sunde, A., Schmidt, L., Cooke, I. D., et al. (2017) · Human Reproduction · doi:10.1093/humrep/dex234 · Cited by 1,320 · see citing works

Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic

Evenson, D. P. (1999) · Human Reproduction · doi:10.1093/humrep/14.4.1039 · Cited by 1,125 · see citing works

Homocysteine and vascular disease

Hankey, G. J., & Eikelboom, J. W. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11058-9 · Cited by 1,070 · see citing works

Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa

Aitken, R. J., & Clarkson, J. S. (1987) · Reproduction · doi:10.1530/jrf.0.0810459 · Cited by 1,020 · see citing works

Incidence and main causes of infertility in a resident population (1 850 000) of three French regions (1988–1989)*

Thonneau, P. F., Marchand, S., Tallec, A., Ml, F., Ducot, B., Lansac, J., Lopès, P., Tabaste, J.-M., & Spira, A. (1991) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137433 · Cited by 919 · see citing works

Role of sperm chromatin abnormalities and DNA damage in male infertility.

Agarwal, A., & Said, T. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg027 · Cited by 889 · see citing works

Selenium in food and the human body: A review

Navarro‐Alarcón, M., & Cabrera–Vique, C. (2008) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2008.06.024 · Cited by 870 · see citing works

Polyunsaturated Fatty Acids in Male and Female Reproduction1

Wathes, D. C., Abayasekara, D. R. E., & Aitken, R. J. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.060558 · Cited by 794 · see citing works

N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency

Atkuri, K. R., Mantovani, J. J., Herzenberg, L. A., & Herzenberg, L. A. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.04.005 · Cited by 721 · see citing works

Sperm chromatin damage impairs human fertility

Spanò, M., Bonde, J. ­., Hjøllund, N. H., Kolstad, H. A., Cordelli, E., & Leter, G. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00462-8 · Cited by 719 · see citing works

Formation of reactive oxygen species in spermatozoa of infertile patients

Iwasaki, A., & Gagnon, C. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54855-9 · Cited by 670 · see citing works

Lipid Peroxidation and Human Sperm Motility: Protective Role of Vitamin E

SULEIMAN, S. A., Ali, M., Zaki, Z. M. S., Elmalik, E. M. A., & NASR, M. A. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb01830.x · Cited by 662 · see citing works

The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis

Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., Kirkman-Brown, J., & Coomarasamy, A. (2012) · Human Reproduction · doi:10.1093/humrep/des261 · Cited by 629 · see citing works

Endogenous non-enzymatic antioxidants in the human body

Mirończuk-Chodakowska, I., Witkowska, A. M., & Zujko, M. E. (2017) · Advances in Medical Sciences · doi:10.1016/j.advms.2017.05.005 · Cited by 620 · see citing works

Definition and prevalence of subfertility and infertility

Gnoth, C., Godehardt, E., Frank-Herrmann, P., Friol, K., Tigges, J., & Freundl, G. (2005) · Human Reproduction · doi:10.1093/humrep/deh870 · Cited by 603 · see citing works

Female subfertility

Evers, J. L. H. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09417-5 · Cited by 598 · see citing works

Antioxidants for male subfertility

Showell, M. G., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub2 · Cited by 587 · see citing works

β-Carotene Is an Important Vitamin A Source for Humans

Grune, T., Lietz, G., Palou, A., Ross, A. C., Stahl, W., Tang, G., Thurnham, D., Yin, S.-A., & Biesalski, H. K. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.119024 · Cited by 587 · see citing works

Reactive oxygen species generation and human spermatozoa: The balance of benefit and risk

Aitken, R. J., & Fisher, H. M. (1994) · BioEssays · doi:10.1002/bies.950160409 · Cited by 582 · see citing works

Biological actions of carotenoids 1

Bendich, A., & Olson, J. A. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.8.2656356 · Cited by 564 · see citing works

Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics

Bhagavan, H. N., & Chopra, R. K. (2006) · Free Radical Research · doi:10.1080/10715760600617843 · Cited by 550 · see citing works

Role of antioxidants in treatment of male infertility: an overview of the literature.

Agarwal, A., Nallella, K. P., Allamaneni, S., & Said, T. (2004) · Reproductive Biomedicine Online · doi:10.1016/s1472-6483(10)61641-0 · Cited by 538 · see citing works

Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients

Kodama, H., Yamaguchi, R., Fukuda, J., Kasai, H., & Tanaka, T. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00236-7 · Cited by 528 · see citing works

Polyunsaturated fatty acids as antioxidants

Richard, D., Kefi, K., Barbe, U., Bausero, P., & Visioli, F. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.05.002 · Cited by 524 · see citing works

Reduction of the Incidence of Sperm DNA Fragmentation by Oral Antioxidant Treatment

Greco, E., Iacobelli, M., Rienzi, L. F., Ubaldi, F. M., Ferrero, S., & Tesařík, J. (2005) · Journal of Andrology · doi:10.2164/jandrol.04146 · Cited by 511 · see citing works

The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility

Ebisch, I. M. W., Thomas, C. M. G., Peters, W. H. M., Braat, D. D. M., & Steegers‐Theunissen, R. P. M. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml054 · Cited by 505 · see citing works

The diagnosis of male infertility: An analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities

Barratt, C. L. R., Björndahl, L., De Jonge, C. J., Lamb, D. J., Osorio Martini, F., McLachlan, R., Oates, R. D., van der Poel, S., St John, B., Sigman, M., et al. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx021 · Cited by 505 · see citing works

Dietary patterns, foods and nutrients in male fertility parameters and fecundability: A systematic review of observational studies

Salas-Huetos, A., Bulló, M., & Salas-Salvadó, J. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx006 · Cited by 491 · see citing works

The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI.

Bungum, M., Humaidan, P., Spanô, M., Jepson, K., Bungum, L., & Giwercman, A. (2004) · Human Reproduction · doi:10.1093/humrep/deh280 · Cited by 472 · see citing works

Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments

Littarru, G. P., & Tiano, L. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0052-y · Cited by 465 · see citing works

Epidemiology and aetiology of male infertility

Irvine, D. S. (1998) · Human Reproduction · doi:10.1093/humrep/13.suppl_1.33 · Cited by 459 · see citing works

Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity

Joshi, R. K., Adhikari, S., Patro, B. S., Chattopadhyay, S., & Mukherjee, T. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00543-3 · Cited by 432 · see citing works

Acute Selenium Toxicity Associated With a Dietary Supplement

MacFarquhar, J. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.495 · Cited by 421 · see citing works

Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial

Wong, W. Y., Merkus, H. M. W. M., Thomas, C. M. G., Menkveld, R., Zielhuis, G. A., & Steegers‐Theunissen, R. P. M. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03229-0 · Cited by 402 · see citing works

Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase‐ and catalase‐like activities in seminal plasma and spermatozoa

Zini, A. S., de Lamirande, E., & Gagnon, C. (1993) · International Journal of Andrology · doi:10.1111/j.1365-2605.1993.tb01177.x · Cited by 398 · see citing works

Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria

Aitken, R. J., Iuliis, G. N. D., Finnie, J. M., Hedges, A., & McLachlan, R. I. (2010) · Human Reproduction · doi:10.1093/humrep/deq214 · Cited by 395 · see citing works

A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay

Hughes, C., Lewis, S. E. M., McKelvey‐Martin, V. J., & Thompson, W. (1996) · Molecular Human Reproduction · doi:10.1093/molehr/2.8.613 · Cited by 394 · see citing works

SPERM OXIDATIVE STRESS AND THE EFFECT OF AN ORAL VITAMIN E AND SELENIUM SUPPLEMENT ON SEMEN QUALITY IN INFERTILE MEN

Keskes, L., Chakroun, N. F., Rebaï, T., Sahnoun, Z., Ghozzi, H., Hammami, S., Zghal, K., Fki, H., Dammak, J., & Bahloul, A. (2003) · Archives of Andrology · doi:10.1080/01485010390129269 · Cited by 385 · see citing works

Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

Agarwal, A. K., Majzoub, A. A., Esteves, S. C., Ko, E., Ramasamy, R., & Zini, A. S. (2016) · Translational Andrology and Urology · doi:10.21037/tau.2016.10.03 · Cited by 385 · see citing works

Do sperm DNA integrity tests predict pregnancy with in vitro fertilization?

Collins, J. A., Barnhart, K. T., & Schlegel, P. N. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.04.055 · Cited by 373 · see citing works

Role of Oxidative Stress and Antioxidants in Male Infertility

Sikka, S. C., Rajasekaran, M. R., & Hellstrom, W. J. G. (1995) · Journal of Andrology · doi:10.1002/j.1939-4640.1995.tb00566.x · Cited by 355 · see citing works

A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility

Kessopoulou, E., Powers, H. J., Sharma, K. K., Pearson, M. J., Russell, J., Cooke, I. D., & Barratt, C. L. R. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57861-3 · Cited by 336 · see citing works

Analysis of the Relationship Between Defective Sperm Function and the Generation of Reactive Oxygen Species in Cases of Oligozoospermia

Aitken, R. J., Clarkson, J. S., Hargreave, T. B., Irvine, D. S., & Wu, F. C. W. (1989) · Journal of Andrology · doi:10.1002/j.1939-4640.1989.tb00091.x · Cited by 331 · see citing works

Comparison of individual antioxidants of sperm and seminal plasma in fertile and infertile men

Lewis, S. E. M., Sterling, E. S. L., Young, I. S., & Thompson, W. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81871-7 · Cited by 331 · see citing works

Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis

Cissen, M., van Wely, M., Scholten, I., Mansell, S. A., de Bruin, J. P., Mol, B. W., Braat, D. D. M., Repping, S., & Hamer, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165125 · Cited by 329 · see citing works

Selenium, an Antioxidant Nutrient

Burk, R. F. (2002) · Nutrition in Clinical Care · doi:10.1046/j.1523-5408.2002.00006.x · Cited by 326 · see citing works

Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men

Colagar, A. H., Tahmasbpour, E., & Chaichi, M. J. (2009) · Nutrition Research · doi:10.1016/j.nutres.2008.11.007 · Cited by 325 · see citing works

The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta-analysis

Osman, A., Alsomait, H., Seshadri, S., El‐Toukhy, T., & Khalaf, Y. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.10.018 · Cited by 318 · see citing works

Antioxidant intake is associated with semen quality in healthy men

Eskenazi, B., Kidd, S. A., Marks, A. R., Sloter, E. D., Block, G., & Wyrobek, A. J. (2005) · Human Reproduction · doi:10.1093/humrep/deh725 · Cited by 306 · see citing works

Meta-analysis of sperm DNA fragmentation using the sperm chromatin structure assay

Evenson, D. P., & Wixon, R. L. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62000-7 · Cited by 303 · see citing works

Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study

Rolf, C. (1999) · Human Reproduction · doi:10.1093/humrep/14.4.1028 · Cited by 297 · see citing works

Paternal influence of sperm DNA integrity on early embryonic development

Simon, L., Murphy, K. E., Shamsi, M. B., Liu, L., Emery, B. R., Aston, K. I., Hotaling, J. M., & Carrell, D. T. (2014) · Human Reproduction · doi:10.1093/humrep/deu228 · Cited by 296 · see citing works

A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia

Lenzi, A., Sgrò, P., Salacone, P., Paoli, D., Gilio, B., Lombardo, F. P., Santulli, M., Agarwal, A. K., & Gandini, L. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.034 · Cited by 286 · see citing works

Grapes, Wines, Resveratrol, and Heart Health

Bertelli, A. A. A., & Das, D. K. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181bfaff3 · Cited by 285 · see citing works

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

Lewis, S. E. M., Aitken, R. J., Conner, S. J., Iuliis, G. N. D., Evenson, D. P., Henkel, R., Giwercman, A., & Gharagozloo, P. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.06.014 · Cited by 285 · see citing works

Antioxidants for male subfertility

Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub3 · Cited by 285 · see citing works

Molecular Mechanisms in Spermatogenesis

Cheng, C.-Y. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09597-4 · Cited by 278 · see citing works

The Epidemiology of Male Infertility

Winters, B. R., & Walsh, T. J. (2013) · Urologic Clinics of North America · doi:10.1016/j.ucl.2013.08.006 · Cited by 278 · see citing works

Analysis of the relationship between reactive oxygen species production and leucocyte infiltration in fractions of human semen separated on Percoll gradients

Aitken, R. J., & WEST, K. M. (1990) · International Journal of Andrology · doi:10.1111/j.1365-2605.1990.tb01051.x · Cited by 276 · see citing works

The effect of oral selenium supplementation on human sperm motility

Scott, Macpherson, Yates, Hussain, & Dixon (1998) · British Journal of Urology · doi:10.1046/j.1464-410x.1998.00683.x · Cited by 274 · see citing works

Differential contribution of leucocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors

Aitken, R. J., Buckingham, D., West, K., Wu, F. C. W., Zikopoulos, K., & Richardson, D. C. (1992) · Reproduction · doi:10.1530/jrf.0.0940451 · Cited by 268 · see citing works

Efficacy of Selenium and/or N-Acetyl-Cysteine for Improving Semen Parameters in Infertile Men: A Double-Blind, Placebo Controlled, Randomized Study

Safarinejad, M. R., & Safarinejad, S. (2008) · The Journal of Urology · doi:10.1016/j.juro.2008.10.015 · Cited by 263 · see citing works

A systematic review of the effect of oral antioxidants on male infertility

Ross, C., Morriss, A. K., Khairy, M., Khalaf, Y., Braude, P., Coomarasamy, A., & El‐Toukhy, T. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.03.008 · Cited by 262 · see citing works

Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial

Lenzi, A., Lombardo, F. P., Sgrò, P., Salacone, P., Caponecchia, L., Dondero, F., & Gandini, L. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04679-4 · Cited by 257 · see citing works

Andrology: Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility

Lenzi, A., Culasso, F., Gandini, L., Lombardo, F. P., & Dondero, F. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137909 · Cited by 249 · see citing works

Placebo-controlled double-blind randomized trial on the use of l-carnitine, l-acetylcarnitine, or combined l-carnitine and l-acetylcarnitine in men with idiopathic asthenozoospermia

Balercia, G., Regoli, F., Armeni, T., Koverech, A., Mantero, F., & Boscaro, M. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.03.064 · Cited by 234 · see citing works

Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate

Majzoub, A. A., & Agarwal, A. K. (2018) · Arab Journal of Urology · doi:10.1016/j.aju.2017.11.013 · Cited by 232 · see citing works

Efficacy of Coenzyme Q10 on Semen Parameters, Sperm Function and Reproductive Hormones in Infertile Men

Safarinejad, M. R. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.02.121 · Cited by 231 · see citing works

Coenzyme Q10 Contents in Foods and Fortification Strategies

Pravst, I., Žmitek, K., & Žmitek, J. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390902773037 · Cited by 224 · see citing works

Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial

Balercia, G., Buldreghini, E., Vignini, A., Tiano, L., Paggi, F., Amoroso, S., Lamonica, G. R., Boscaro, M., Lenzi, A., & Littarru, G. P. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.119 · Cited by 211 · see citing works

Carnitines and male infertility

Agarwal, A. K., & Said, T. M. (2004) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60920-0 · Cited by 208 · see citing works

A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF‐ICSI treatment

Tremellen, K. P., MIARI, G., Froiland, D. A., & Thompson, J. G. (2007) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2007.00723.x · Cited by 201 · see citing works

A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics

Mendiola, J., Torres-Cantero, A. M., Vioqué, J., Moreno, J., Ten, J., Roca, M., Moreno‐Grau, S., & Bernabéu, R. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.10.075 · Cited by 199 · see citing works

Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial

Comhaire, F., Garem, Y. F. E., Mahmoud, A., Eertmans, F., & Schoonjans, F. (2005) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2005.00047.x · Cited by 197 · see citing works

Indications of the Mechanisms Involved in Improved Sperm Parameters by Zinc Therapy

Omu, A. E., Al‐Azemi, M., Kehinde, E. O., Anim, J. T., Oriowo, M. A., & Mathew, T. C. (2008) · Medical Principles and Practice · doi:10.1159/000112963 · Cited by 191 · see citing works

The sperm chromatin structure assay as a diagnostic tool in the human fertility clinic.

Boe-Hansen, G., Fedder, J., Ersbøll, A., & Christensen, P. (2006) · Human Reproduction · doi:10.1093/humrep/del019 · Cited by 190 · see citing works

Antioxidants for female subfertility

Showell, M. G., Brown, J., Clarke, J., & Hart, R. J. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007807.pub2 · Cited by 188 · see citing works

Correlation of sperm DNA damage with IVF and ICSI outcomes: A systematic review and meta-analysis

Li, Z., Wang, L., Cai, J., & Huang, H. (2006) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-006-9066-9 · Cited by 183 · see citing works

Andrology: Total antioxidant capacity of human seminal plasma

Smith, R., Vantman, D., Ponce, J., Escobar, J., & Lissi, E. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019465 · Cited by 181 · see citing works

Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis

Vicari, E. S. D., & Calogero, A. E. (2001) · Human Reproduction · doi:10.1093/humrep/16.11.2338 · Cited by 180 · see citing works

Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus—systematic review and meta‐analysis

Hausenblas, H. A., Schoulda, J. A., & Smoliga, J. M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400173 · Cited by 176 · see citing works

Are varicoceles associated with increased deoxyribonucleic acid fragmentation?

Zini, A. S., & Dohle, G. R. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.10.016 · Cited by 175 · see citing works

Effects of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status

Çiftçi, H., Verit, A., Savaş, M., Yeni, E., & Erel, Ö. (2009) · Urology · doi:10.1016/j.urology.2009.02.034 · Cited by 167 · see citing works

Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males

Conquer, J. A., Martin, J. B., Tummon, I. S., Watson, L., & Tekpetey, F. R. (2000) · Lipids · doi:10.1007/bf02664764 · Cited by 167 · see citing works

Oxidative Stress in Normospermic Men Undergoing Infertility Evaluation

Pasqualotto, F. F., Sharma, R. K., Kobayashi, H., Nelson, D. R., Thomas, A. J., & Agarwal, A. K. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02185.x · Cited by 167 · see citing works

Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial

Sigman, M., Glass, S. L., Campagnone, J., & Pryor, J. L. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.055 · Cited by 164 · see citing works

Role of oxidative stress and antioxidants in male infertility.

Sikka, S. C., Rajasekaran, M. R., & Hellstrom, W. J. G. (1997) · PubMed · Cited by 159 · see citing works

Coenzyme Q10 and male infertility: a meta-analysis

Lafuente, R., González-Comadran, M., Solà, I., López, G., Brassesco, M., Carreras, R., & Checa, M. Á. (2013) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-0047-5 · Cited by 159 · see citing works

Superoxide anion in human semen related to seminal parameters and clinical aspects

Mazzilli, F., Rossi, T., Marchesini, M., Ronconi, C., & Dondero, F. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57017-4 · Cited by 154 · see citing works

Cinnoxicam and l ‐Carnitine/Acetyl‐ l ‐Carnitine Treatment for Idiopathic and Varicocele‐Associated Oligoasthenospermia

Cavallini, G., Ferraretti, A. P., Gianaroli, L., Biagiotti, G., & Vitali, G. (2004) · Journal of Andrology · doi:10.1002/j.1939-4640.2004.tb02853.x · Cited by 152 · see citing works

Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men?

Ebisch, I. M. W., Pierik, F. H., de Jong, F. H., Thomas, C. M. G., & Steegers‐Theunissen, R. P. M. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00598.x · Cited by 145 · see citing works

Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds

Vicari, E. S. D., Vignera, S. L., & Calogero, A. E. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04350-9 · Cited by 143 · see citing works

Resveratrol and ascorbic acid prevent DNA damage induced by cryopreservation in human semen

Branco, C. S., Garcez, M. E., Pasqualotto, F. F., Erdtmann, B., & Salvador, M. M. (2009) · Cryobiology · doi:10.1016/j.cryobiol.2009.10.012 · Cited by 143 · see citing works

Ascorbic Acid in Human Seminal Plasma: Determination and Its Relationship to Sperm Quality

Colagar, A. H., & Tahmasbpour, E. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.08-251 · Cited by 143 · see citing works

Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome

Omu, A. E., Dashti, H. M., & Al‐Othman, S. (1998) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(97)00262-5 · Cited by 142 · see citing works

Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial

Ghanem, H. M., Shaeer, O. K. Z., & El-Segini, A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.117 · Cited by 140 · see citing works

Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial

Nadjarzadeh, A., Shidfar, F., Amirjannati, N., Vafa, M., Motevalian, S. A., Gohari, M. R., Kakhki, S. A. N., Akhondi, M. M., & Sadeghi, M. R. (2013) · Andrologia · doi:10.1111/and.12062 · Cited by 138 · see citing works

Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial

Alizadeh, F., Javadi, M., Karami, A. A., Gholaminejad, F., Kavianpour, M., & Haghighian, H. K. (2017) · Phytotherapy Research · doi:10.1002/ptr.5998 · Cited by 138 · see citing works

Effects of the Reduced Form of Coenzyme Q 10 (Ubiquinol) on Semen Parameters in Men with Idiopathic Infertility: a Double-Blind, Placebo Controlled, Randomized Study

Safarinejad, M. R., Safarinejad, S., Shafiei, N., & Safarinejad, S. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.03.131 · Cited by 134 · see citing works

Lipid peroxidation in spermatozoa

Jones, R., & Mann, T. R. R. (1973) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1973.0035 · Cited by 132 · see citing works

Comparison of the effectiveness of placebo, clomiphene citrate, mesterolone, pentoxifylline, and testosterone rebound therapy for the treatment of idiopathic oligospermia

Wang, C., Chan, C.-W., Wong, K.-K., & Yeung, K.-K. (1983) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47300-0 · Cited by 131 · see citing works

Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation

Martínez-Soto, J. C., Domingo, J. C., Cordobilla, B., Nicolás, M., Fernández, L., Albero, P., Gadea, J., & Landeras, J. (2016) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2016.1246623 · Cited by 129 · see citing works

Effects of vitamin D supplementation on semen quality, reproductive hormones, and live birth rate: a randomized clinical trial

Blomberg Jensen, M., Lawaetz, J. G., Petersen, J. H., Juul, A., & Jørgensen, N. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01656 · Cited by 129 · see citing works

Effect of trans-resveratrol on induced oxidative stress in human sperm and in rat germinal cells

Collodel, G., Federico, M. G., Geminiani, M., Martini, S., Bonechi, C., Rossi, C., Figura, N., & Moretti, E. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.11.010 · Cited by 128 · see citing works

C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration

Ebisch, I. M. W., van Heerde, W. L., Thomas, C. M. G., van der Put, N., Wong, W. Y., & Steegers‐Theunissen, R. P. M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)02157-5 · Cited by 127 · see citing works

Selenium, a Key Element in Spermatogenesis and Male Fertility

Boitani, C., & Puglisi, R. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09597-4_4 · Cited by 124 · see citing works

Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men

Jensen, M. B., Lawaetz, J. G., Andersson, A., Petersen, J. H., Nordkap, L., Bang, A. K., Ekbom, P., Joensen, U. N., Prætorius, L., Lundstrøm, P., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew152 · Cited by 122 · see citing works

Long-chain omega 3 fatty acids: Molecular bases of potential antioxidant actions

Giordano, E., & Visioli, F. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.11.002 · Cited by 121 · see citing works

Arginine: Clinical potential of a semi-essential amino acid..

Appleton, J. (2002) · PubMed · Cited by 120 · see citing works

The role of vitamin D in male fertility: A focus on the testis

de Angelis, C., Galdiero, M., Pivonello, C., Garifalos, F., Menafra, D., Cariati, F., Salzano, C., Galdiero, G., Piscopo, M., Vece, A., et al. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9425-0 · Cited by 115 · see citing works

Mystery of idiopathic male infertility: is oxidative stress an actual risk?

Aktan, G., Doğru‐Abbasoğlu, S., Küçükgergin, C., Kadıoğlu, A., Özdemirler, G., & Koçak‐Toker, N. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.11.045 · Cited by 114 · see citing works

Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: A double-blind placebo-controlled study

Busetto, G. M., Agarwal, A. K., Virmani, A., Antonini, G., Ragonesi, G., Giudice, F. D., Mičić, S., Gentile, V., & BERARDINIS, E. D. (2018) · Andrologia · doi:10.1111/and.12927 · Cited by 114 · see citing works

Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.

Xin Min, Z. H. O. U., Liu, F., & Zhai, S. (2007) · PubMed · Cited by 113 · see citing works

Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial.

Nadjarzadeh, A., Sadeghi, M. R., Amirjannati, N., Vafa, M., Motevalian, S. A., Gohari, M. R., Akhondi, M. M., Yavari, P., & Shidfar, F. (2011) · PubMed · doi:10.3275/7572 · Cited by 109 · see citing works

May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele?

Galatioto, G. P., Gravina, G., Angelozzi, G., Sacchetti, A., Innominato, P. F., Pace, G., Ranieri, G., & Vicentini, C. (2008) · World journal of urology · doi:10.1007/s00345-007-0218-z · Cited by 106 · see citing works

Sperm DNA fragmentation index and pregnancy outcome after IVF or ICSI: a meta-analysis

Zhang, Z., Zhu, L., Jiang, H., Chen, H., Chen, Y., & Dai, Y. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0374-1 · Cited by 105 · see citing works

The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial

Cyrus, A., Kabir, A., Goodarzi, D., & Moghimi, M. (2015) · International braz j urol · doi:10.1590/s1677-5538.ibju.2015.02.07 · Cited by 103 · see citing works

Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men

Haghighian, H. K., Haidari, F., Asl, J. M., & Dadfar, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.05.014 · Cited by 98 · see citing works

Relationship between ascorbic acid and male fertility.

Dawson, E. B., Harris, W. A., & Powell, L. C. (1990) · World Review of Nutrition and Dietetics · doi:10.1159/000417532 · Cited by 98 · see citing works

Semen quality in relation to antioxidant intake in a healthy male population

Zareba, P., Colaci, D., Afeiche, M. C., Gaskins, A. J., Jørgensen, N., Mendiola, J., Swan, S. H., & Chavarro, J. E. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.032 · Cited by 94 · see citing works

The micronutrient supplements, zinc sulphate and folic acid, did not ameliorate sperm functional parameters in oligoasthenoteratozoospermic men

Raigani, M., Yaghmaei, B., Amirjannti, N., Lakpour, N., Akhondi, M. M., Zeraati, H., Hajihosseinal, M., & Sadeghi, M. R. (2013) · Andrologia · doi:10.1111/and.12180 · Cited by 93 · see citing works

Incidence and level of seminal reactive oxygen species in normal men

Shekarriz, M., Thomas, A. J., & Agarwal, A. K. (1995) · Urology · doi:10.1016/s0090-4295(95)97088-6 · Cited by 90 · see citing works

Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology

Bevilacqua, A., Carlomagno, G., Gerli, S., Oliva, M. M., Devroey, P., Lanzone, A., Soulage, C. O., Facchinetti, F., Renzo, G. C. D., Bizzarri, M., et al. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1006616 · Cited by 83 · see citing works

Antioxidants for female subfertility

Showell, M. G., Mackenzie-Proctor, R., Jordan, V., & Hart, R. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007807.pub3 · Cited by 83 · see citing works

Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study

Calogero, A. E., Gullo, G., Vignera, S. L., Condorelli, R. A., & Vaiarelli, A. (2015) · Andrology · doi:10.1111/andr.12025 · Cited by 81 · see citing works

Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis

Zhao, J., Huang, X., Xu, B., Yi, Y., Zhang, Q., & Li, Y. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0324-3 · Cited by 81 · see citing works

Resveratrol improves sperm motility, prevents lipid peroxidation and enhances antioxidant defences in the testes of hyperthyroid rats

Ourique, G. M., Finamor, I., Saccol, E. M. H., Riffel, A. P. K., Pês, T. S., Gutierrez, K., Gonçalves, P. B. D., Baldisserotto, B., Pavanato, M. A., & Barreto, K. P. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.01.006 · Cited by 75 · see citing works

Electrophilic methyl groups present in the diet ameliorate pathological states induced by reductive and oxidative stress: a hypothesis

Ghyczy, M., & Boros, M. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000274 · Cited by 75 · see citing works

Differences in the seminal plasma proteome are associated with oxidative stress levels in men with normal semen parameters

Intasqui, P., Antoniassi, M. P., Camargo, M., Nichi, M., Carvalho, V. M., Cardozo, K. H. M., Zylbersztejn, D. S., & Bertolla, R. P. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.04.037 · Cited by 75 · see citing works

Oxidative stress and epididymal sperm transport, motility and morphological defects

Taieb, M. A. E., Herwig, R., Nada, E., Greilberger, J., & Marberger, M. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.02.018 · Cited by 74 · see citing works

IN VIVO SCAVENGING EFFECT OF ETHYLCYSTEINE ON REACTIVE OXYGEN SPECIES IN HUMAN SEMEN

Akiyama, M. (1999) · The Japanese Journal of Urology · doi:10.5980/jpnjurol1989.90.421 · Cited by 71 · see citing works

An update on the role of medical treatment including antioxidant therapy in varicocele

Kumar, R., & Garg, H. (2015) · Asian Journal of Andrology · doi:10.4103/1008-682x.171657 · Cited by 70 · see citing works

Antioxidant therapy in idiopathic oligoasthenoteratozoospermia

Agarwal, A., & Majzoub, A. A. (2017) · Indian Journal of Urology · doi:10.4103/iju.iju_15_17 · Cited by 70 · see citing works

Studies on the metabolic role of myo -inositol. Distribution of radioactive myo -inositol in the male rat

Lewin, L. M., Yannai, Y., Sulimovici, S., & Kraicer, P. F. (1976) · Biochemical Journal · doi:10.1042/bj1560375 · Cited by 68 · see citing works

Effect of pentoxifylline on semen parameters, reproductive hormones, and seminal plasma antioxidant capacity in men with idiopathic infertility: a randomized double-blind placebo-controlled study

Safarinejad, M. R. (2010) · International Urology and Nephrology · doi:10.1007/s11255-010-9826-4 · Cited by 68 · see citing works

Laboratory tests for oxidative stress

Agarwal, A. K., & Majzoub, A. A. (2017) · Indian Journal of Urology · doi:10.4103/iju.iju_9_17 · Cited by 67 · see citing works

A prospective double‐blind randomized placebo‐controlled study of the effect of saffron (Crocus sativusLinn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia

Safarinejad, M. R., Shafiei, N., & Safarinejad, S. (2010) · Phytotherapy Research · doi:10.1002/ptr.3294 · Cited by 65 · see citing works

Safety Considerations and Potential Interactions of Vitamins: Should Vitamins Be Considered Drugs?

Rogovik, A. L., Vohra, S., & Goldman, R. D. (2009) · Annals of Pharmacotherapy · doi:10.1345/aph.1m238 · Cited by 65 · see citing works

Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet

Dattilo, M., Giuseppe, D., Caroppo, E., & Menezo, Y. J. R. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0767-4 · Cited by 65 · see citing works

Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects

Azizollahi, G., Azizollahi, S., Babaei, H., Kianinejad, M., Baneshi, M. R., & Nematollahi‐Mahani, S. N. (2013) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-9961-9 · Cited by 62 · see citing works

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3

Halicka, H. D., Zhao, H. L., Li, J., Traganos, F., Studzinski, G. P., & Darżynkiewicz, Z. (2012) · Aging · doi:10.18632/aging.100450 · Cited by 61 · see citing works

A Preliminary Study: N-acetyl-L-cysteine Improves Semen Quality following Varicocelectomy.

Barekat, F., Tavalaee, M., Deemeh, M. R., Bahreinian, M., Azadi, L., Abbasi, H., Rozbahani, S., & Nasr‐Esfahani, M. H. (2016) · PubMed Central · doi:10.22074/ijfs.2016.4777 · Cited by 60 · see citing works

Effect of in vitro selenium supplementation on sperm quality in asthenoteratozoospermic men

Ghafarizadeh, A. A., Vaezi, G., Shariatzadeh, S. M. A., & Malekirad, A. A. (2017) · Andrologia · doi:10.1111/and.12869 · Cited by 60 · see citing works

No increase in sperm DNA damage and seminal oxidative stress in patients with idiopathic infertility

Verit, F. F., Verit, A., Koçyiğit, A., Çiftçi, H., Çelık, H., & Köksal, M. (2006) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-006-0172-9 · Cited by 59 · see citing works

The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis.

Irani, M., Amirian, M., Sadeghi, R., Lez, J. L., & Roudsari, R. L. (2017) · Urology journal./Urology jornal. · Cited by 58 · see citing works

Effects of phosphodiesterase‐5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial

Dimitriadis, F., Tsambalas, S., Tsounapi, P., Kawamura, H., Vlachopoulou, E., Haliasos, N., Gratsias, S., Watanabe, T., Saito, M., Miyagawa, I., et al. (2010) · British Journal of Urology · doi:10.1111/j.1464-410x.2010.09243.x · Cited by 57 · see citing works

Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy

Nematollahi‐Mahani, S. N., Azizollahi, G., Baneshi, M. R., Safari, Z., & Azizollahi, S. (2013) · Andrologia · doi:10.1111/and.12067 · Cited by 55 · see citing works

The impact of vitamin E supplementation on semen parameters and pregnancy rates after varicocelectomy: a randomised controlled study

Ener, K., Aldemir, M., Işık, E., Okulu, E., Özcan, M. F., Uğurlu, M., Tangal, S., & Özayar, A. (2016) · Andrologia · doi:10.1111/and.12521 · Cited by 54 · see citing works

Inositol activity in oligoasthenoteratospermia--an in vitro study.

Colone, M., Marelli, G., Unfer, V., Bozzuto, G., Molinari, A., & Stringaro, A. (2010) · PubMed · Cited by 52 · see citing works

Evaluation of correlation between NF-κB mediated PAI-1 gene and sepsis.

Condorelli, R. A., Vignera, S. L., Mongioì, L. M., Vitale, S. G., Laganà, A. S., Cimino, L., & Calogero, A. E. (2017) · PubMed · Cited by 49 · see citing works

Effect of treatment with myo-inositol on semen parameters of patients undergoing an IVF cycle: in vivo study

Gulino, F. A., Leonardi, E., Marilli, I., Musmeci, G., Vitale, S. G., Leanza, V., & Palumbo, M. A. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1080680 · Cited by 47 · see citing works

ESHRE: Guidelines to the prevalence, diagnosis, treatment and management of infertility, 1996

Workshop, T. E. C. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019484 · Cited by 47 · see citing works

Antioxidant Therapy in Male Infertility

Patel, S. R., & Sigman, M. (2008) · Urologic Clinics of North America · doi:10.1016/j.ucl.2008.01.009 · Cited by 44 · see citing works

Evidence of improving quality of reporting of randomized controlled trials in subfertility

Dias, S., McNamee, R., & Vail, A. (2006) · Human Reproduction · doi:10.1093/humrep/del236 · Cited by 44 · see citing works

Controlled Clinical Trial of Arginine for Infertile Men with Oligozoospermia

PRYOR, J. P., Blandy, J. P., EVANS, P., de Saintonge, D. M. C., & Usherwood, M. M. (1978) · British Journal of Urology · doi:10.1111/j.1464-410x.1978.tb02765.x · Cited by 44 · see citing works

Improvement of seminal parameters with Prelox®: a randomized, double‐blind, placebo‐controlled, cross‐over trial

Stanislavov, R., Nikolova, V. P., & Rohdewald, P. J. (2009) · Phytotherapy Research · doi:10.1002/ptr.2592 · Cited by 43 · see citing works

The Novel Surveillance Mechanism of the Trp53-Dependent S-Phase Checkpoint Ensures Chromosome Damage Repair and Preimplantation-Stage Development of Mouse Embryos Fertilized with X-Irradiated Sperm

Shimura, T., Toyoshima, M., Taga, M., Shiraishi, K., Uematsu, N., Inoue, M., & Niwa, O. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)158[0735:tnsmot]2.0.co;2 · Cited by 41 · see citing works

Myo-inositol as a male fertility molecule: speed them up!

Condorelli, R., Vignera, S. L., Mongioì, L. M., Vitale, S. G., Laganà, A. S., Cimino, L., & Calogero, A. E. (2017) · UNICA IRIS Institutional Research Information System (University of Cagliari) · Cited by 39 · see citing works

Magnesium-orotate supplementation for idiopathic infertile male patients: a randomized, placebo-controlled clinical pilot study.

Závaczki, Z., Szöllõsi, J., Kiss, S. A., Koloszár, S., Fejes, I., Kovács, L., & Pál, A. (2003) · PubMed · Cited by 35 · see citing works

Therapeutic effect of magnesium sulphate on carbon monoxide toxicity-mediated brain lipid peroxidation.

Yavuz, Y., Mollaoğlu, H., Yürümez, Y., Üçok, K., Duran, L., Tünay, K., & Akgün, L. (2013) · PubMed · Cited by 34 · see citing works

Combination effect of Pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermia.

Mehni, N. M., Ketabchi, A. A., & Hosseini, S. E. (2014) · Europe PMC (PubMed Central) · Cited by 33 · see citing works

Effect of micronutrient supplementation on IVF outcomes: a systematic review of the literature

Arhin, S. K., Yu, Z., Lu, X., Chetry, M., & Lü, J.-Q. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.08.018 · Cited by 31 · see citing works

Effect of Oral Zinc Supplementation on the Thiol Oxido-Reductive Index and Thiol-Related Enzymes in Seminal Plasma and Spermatozoa of Iraqi Asthenospermic Patients

Alsalman, A. R. S., Almashhedy, L. A., & Hadwan, M. H. (2017) · Biological Trace Element Research · doi:10.1007/s12011-017-1215-8 · Cited by 31 · see citing works

Semen Quality in Patients With Chlamydia trachomatis Genital Infection Treated Concurrently With Prulifloxacin and a Phytotherapeutic Agent

Cai, T., Wagenlehner, F. R. A., Mazzoli, S., Meacci, F., Mondaini, N., Nesi, G., TISCIONE, D., MALOSSINI, G., & Bartoletti, R. (2012) · Journal of Andrology · doi:10.2164/jandrol.111.013961 · Cited by 30 · see citing works

Does l-carnitine Therapy Add any Extra Benefit to Standard Inguinal Varicocelectomy in Terms of Deoxyribonucleic Acid Damage or Sperm Quality Factor Indices: A Randomized Study

Pourmand, G., Movahedin, M., Dehghani, S., Mehrsai, A., Ahmadi, A., Pourhosein, M., Hoseini, M., Ziloochi, M., Heidari, F., Beladi, L., et al. (2014) · Urology · doi:10.1016/j.urology.2014.07.006 · Cited by 29 · see citing works

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Alahmar, A. T. (2017) · International Journal of Infertility & Fetal Medicine · doi:10.5005/jp-journals-10016-1147 · Cited by 29 · see citing works

Carnitine Levels in Human Accessory Sex Organs

Bøhmer, T., Hoel, P. S., Purvis, K., & Hansson, V. (1978) · Archives of Andrology · doi:10.3109/01485017808988318 · Cited by 28 · see citing works

[A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia].

Li, Z., Chen, G., Shang, X., Bai, W.-J., Han, Y.-F., Chen, B., Teng, X., Meng, F.-H., Zhang, B., Chen, D.-N., et al. (2005) · PubMed · Cited by 28 · see citing works

Effects of Pentoxifylline on Sperm Motility in Normogonadotropic Asthenozoospermic Men

Merino, G., Chequer, J., Barahona, E., BERMUDEZ, J. A., Morán, C., & Carranza‐Lira, S. (1997) · Archives of Andrology · doi:10.3109/01485019708987903 · Cited by 27 · see citing works

[L-carnitine: safe and effective for asthenozoospermia].

Wang, Y., Yang, S., Qu, C., Huo, H.-X., Li, W., Li, J., Chang, X.-L., & Cai, G.-Z. (2010) · PubMed · Cited by 26 · see citing works

[Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia].

Deng, X., Li, Y., Yang, X., Huang, J.-R., Guo, S.-L., & Song, L. (2014) · PubMed · Cited by 26 · see citing works

[Antioxidant therapeutic efficiency after the use of carnitine in infertile patients with bacterial or non bacterial prostato-vesiculo-epididymitis].

Vicari, E. S. D., Rubino, C., Palma, A. D., Longo, G., Lauretta, M. P., Consoli, S., & Arancio, A. (2001) · PubMed · Cited by 26 · see citing works

[Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia].

Morgante, G., Scolaro, V., Tosti, C., Sabatino, A. D., Piomboni, P., & Leo, V. D. (2010) · PubMed · Cited by 25 · see citing works

Effects of micronised purified flavonoid fraction on pain, semen analysis and scrotal color Doppler parameters in patients with painful varicocele; results of a randomized placebo-controlled study

Söylemez, H., Kılıç, S., Atar, M., Penbegül, N., Sancaktutar, A. A., & Bozkurt, Y. (2011) · International Urology and Nephrology · doi:10.1007/s11255-011-0038-3 · Cited by 25 · see citing works

[Clinical efficacy of mecobalamin in the treatment of oligozoospermia--results of double-blind comparative clinical study].

Kumamoto, Y., Maruta, H., Ishigami, J., Kamidono, S., Orikasa, S., Kimura, M., Yamanaka, H., Kurihara, H., Koiso, K., & Okada, K. (1988) · PubMed · Cited by 24 · see citing works

Herbo-mineral supplementation in men with idiopathic oligoasthenoteratospermia : A double blind randomized placebo-controlled trial

Kumar, R., Saxena, V., Shamsi, M. B., Venkatesh, S., & Dada, R. (2011) · Indian Journal of Urology · doi:10.4103/0970-1591.85440 · Cited by 23 · see citing works

Fixed Dose Combination Therapy of Antioxidants in Treatment of Idiopathic Oligoasthenozoospermia: Results of a Randomized, Double-blind, Placebo-controlled Clinical Trial

Malik, S., Kalra, S., Gopinath, P., Saxena, A. K., Kalra, B., Kochhar, K., & Zaveri, H. (2013) · International Journal of Infertility & Fetal Medicine · doi:10.5005/jp-journals-10016-1053 · Cited by 23 · see citing works

Physiological Intra-Cytoplasmic Sperm Injection (PICSI) outcomes after oral pretreatment and semen incubation with myo-inositol in oligoasthenoteratozoospermic men: results from a prospective, randomized controlled trial.

Kórösi, T., Barta, C., Rokob, K., & Torok, T. (2017) · PubMed · Cited by 23 · see citing works

Sperm quality in men is improved by supplementation with a combination of L-arginine, L-citrullin, roburins and Pycnogenol®.

Stanislavov, R., & Rohdewald, P. J. (2014) · PubMed · Cited by 21 · see citing works

Andrology Lab Corner*: Nurture vs Nature: How Can We Optimize Sperm Quality?

Álvarez, J. G. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02719.x · Cited by 20 · see citing works

Comparative Study of the Effects of Tamoxifen Citrate and Folate on Semen Quality of the Infertile Male with Semen Abnormality.

Boonyarangkul, A., Vinayanuvattikhun, N., Chiamchanya, C., & Visutakul, P. (2015) · PubMed · Cited by 20 · see citing works

[Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospective multi-centered randomized controlled study of 106 cases].

Chen, X., Li, Z., Ping, P., Dai, J., Zhang, F., & Shang, X. (2012) · PubMed · Cited by 20 · see citing works

A randomized clinical study assessing the effects of the antioxidants, resveratrol or SG1002, a hydrogen sulfide prodrug, on idiopathic oligoasthenozoospermia

Martinez, A. M., Sordia-Hernández, L. H., Morales, J. A., Merino, M., Vidal, O., Garza, M. R. G., & Valdés‐Martínez, O. H. (2015) · Asian Pacific Journal of Reproduction · doi:10.1016/s2305-0500(15)30005-1 · Cited by 19 · see citing works

Combined Tamoxifen and L-Carnitine Therapies for the Treatment of Idiopathic Male Infertility Attending Intracytoplasmic Sperm Injection: A Randomized Controlled Trial

Haje, M. I., & Naoom, K. (2015) · International Journal of Infertility & Fetal Medicine · doi:10.5005/jp-journals-10016-1096 · Cited by 18 · see citing works

A Phytotherapic Approach to Reduce Sperm DNA Fragmentation in Patients with Male Infertility

Capece, M., Romeo, G., Ruffo, A., Romis, L., Mordente, S., & Lauro, G. D. (2016) · Urologia Journal · doi:10.5301/uro.5000210 · Cited by 17 · see citing works

Mineral analyses of vegetarian, health, and conventional foods: Magnesium, zinc, copper, and manganese content

McNeill, D. A., Ali, P. S., & Song, Y. S. (1985) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)03654-3 · Cited by 16 · see citing works

A placebo-controlled double-blind randomized trial of the effect of oral supplementation with spermotrend, maca extract (lepidium meyenii) or L-carnitine in semen parameters of infertile men

Poveda, C., Rodriguez, R., Chu, E., Aparicio, L. E., Gonzales, I., & Moreno, C. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.560 · Cited by 16 · see citing works

[Administration of natural anthocyanins derived from chokeberry (aronia melanocarpa) extract in the treatment of oligospermia in males with enhanced autoantibodies to oxidized low density lipoproteins (oLAB). The impact on fructose levels].

Pawłowicz, P., Stachowiak, G., Bielak, A., & Wilczyński, J. (2001) · PubMed · Cited by 16 · see citing works

Defining the reference value of seminal reactive oxygen species in a population of infertile men and normal healthy volunteers

Bykova, M., Athayde, K. S., Sharma, R. K., Jha, R. K., Sabanegh, E., & Agarwal, A. K. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.07.1025 · Cited by 15 · see citing works

Male infertility

Agarwal, A. K., Baskaran, S., Parekh, N. V., Cho, C., Henkel, R., Vij, S. C., Arafa, M. M., Selvam, M. K. P., & Shah, R. S. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32667-2 · Cited by 1,329 · see citing works

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility

Minhas, S., Bettocchi, C., Boeri, L., Capogrosso, P., Carvalho, J., Çilesiz, N. C., Cocci, A., Corona, G., Dimitropoulos, K., Gül, M., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.08.014 · Cited by 643 · see citing works

Sperm DNA Fragmentation: A New Guideline for Clinicians

Agarwal, A. K., Majzoub, A. A., Baskaran, S., Selvam, M. K. P., Cho, C., Henkel, R., Finelli, R., Leisegang, K., Sengupta, P., Zenoaga-Barbăroşie, C., et al. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.200128 · Cited by 341 · see citing works

Male infertility due to testicular disorders

Sharma, A., Minhas, S., Dhillo, W. S., & Jayasena, C. N. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa781 · Cited by 268 · see citing works

Oxidative stress and male infertility

Takeshima, T., Usui, K., Mori, K., Asai, T., Yasuda, K., Kuroda, S., & Yumura, Y. (2020) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12353 · Cited by 234 · see citing works

The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial

Steiner, A. Z., Hansen, K. R., Barnhart, K. T., Cedars, M. I., Legro, R. S., Diamond, M. P., Krawetz, S. A., Usadi, R., Baker, V. L., Coward, R. M., et al. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.11.008 · Cited by 213 · see citing works

Oxidative Stress and Male Infertility: The Protective Role of Antioxidants

Kaltsas, A. (2023) · Medicina · doi:10.3390/medicina59101769 · Cited by 221 · see citing works

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

Qazi, I. H., Angel, C., Yang, H., Zoidis, E., Pan, B., Wu, Z., Ming, Z., Zeng, C., Meng, Q., Han, H., et al. (2019) · Antioxidants · doi:10.3390/antiox8080268 · Cited by 189 · see citing works

Diet and Nutritional Factors in Male (In)fertility—Underestimated Factors

Skoracka, K., Eder, P., Łykowska‐Szuber, L., Dobrowolska, A., & Krela‐Kaźmierczak, I. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051400 · Cited by 188 · see citing works

Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment

Schisterman, E. F., Sjaarda, L. A., Clemons, T., Carrell, D. T., Perkins, N. J., Johnstone, E., Lamb, D., Chaney, K., Van Voorhis, B. J., Ryan, G., et al. (2020) · JAMA · doi:10.1001/jama.2019.18714 · Cited by 179 · see citing works

Impact of environmental toxin exposure on male fertility potential

Krzastek, S. C., Farhi, J., Gray, M. C., & Smith, R. P. (2020) · Translational Andrology and Urology · doi:10.21037/tau-20-685 · Cited by 176 · see citing works

Clinical implications of sperm DNA damage in IVF and ICSI : updated systematic review and meta‐analysis

Ribas‐Maynou, J., Yeste, M., Becerra‐Tomás, N., Aston, K. I., James, E. R., & Salas‐Huetos, A. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12700 · Cited by 149 · see citing works

Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment

Agarwal, A. K., Rosas, I. M., Anagnostopoulou, C., Cannarella, R., Boitrelle, F., Villar, L., Finelli, R., Durairajanayagam, D., Henkel, R., & Saleh, R. A. (2022) · Antioxidants · doi:10.3390/antiox11030477 · Cited by 148 · see citing works

Diet and sperm quality: Nutrients, foods and dietary patterns

Salas‐Huetos, A., James, E. R., Aston, K. I., Jenkins, T. G., & Carrell, D. T. (2019) · Reproductive Biology · doi:10.1016/j.repbio.2019.07.005 · Cited by 137 · see citing works

An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men

Esteves, S. C., Santi, D., & Simoni, M. (2019) · Andrology · doi:10.1111/andr.12724 · Cited by 132 · see citing works

Antioxidants for male subfertility.

de Ligny, W. D., Smits, R., Mackenzie-Proctor, R., Jordan, V., Fleischer, K., de Bruin, J., & Showell, M. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub5 · Cited by 10 · see citing works

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2025 Update on Male Infertility

Minhas, S., Boeri, L., Capogrosso, P., Cocci, A., Corona, G., Dinkelman‐Smit, M., Falcone, M., Jensen, C. F. S., Gül, M., Kalkanlı, A., et al. (2025) · European Urology · doi:10.1016/j.eururo.2025.02.026 · Cited by 135 · see citing works

Antioxidants for female subfertility

Showell, M. G., Mackenzie-Proctor, R., Jordan, V., & Hart, R. J. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007807.pub4 · Cited by 119 · see citing works

OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Reactive oxygen species in the mammalian pre-implantation embryo

Deluao, J. C., Winstanley, Y. E., Robker, R. L., Pacella‐Ince, L., Gonzalez, M. B., & McPherson, N. O. (2022) · Reproduction · doi:10.1530/rep-22-0121 · Cited by 112 · see citing works

Oxidative Stress in Male Infertility: Causes, Effects in Assisted Reproductive Techniques, and Protective Support of Antioxidants

Ribas-Maynou, J., & Yeste, M. (2020) · Biology · doi:10.3390/biology9040077 · Cited by 88 · see citing works

Management of male factor infertility: position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS)

Ferlin, A., Calogero, A. E., Krausz, C. G., Lombardo, F. P., Paoli, D., Rago, R., Scarica, C., Simoni, M., Foresta, C., Rochira, V., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01741-6 · Cited by 96 · see citing works

The Influence of Metabolic Factors and Diet on Fertility

Łakoma, K., Kukharuk, O., & Śliż, D. (2023) · Nutrients · doi:10.3390/nu15051180 · Cited by 97 · see citing works

Zinc Intakes and Health Outcomes: An Umbrella Review

Li, J. H., Cao, D., Huang, Y. C., Chen, B., Chen, Z., Wang, R., Dong, Q. G., Wei, Q., & Liu, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.798078 · Cited by 91 · see citing works

Coenzyme Q10, oxidative stress, and male infertility: A review

Alahmar, A. T., Calogero, A. E., Rajender, S., Cannarella, R., Sengupta, P., & Dutta, S. (2021) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2020.04175 · Cited by 76 · see citing works

The Effect of Antioxidants on Sperm Quality Parameters and Pregnancy Rates for Idiopathic Male Infertility: A Network Meta-Analysis of Randomized Controlled Trials

Li, K.-P., Yang, X.-S., & Wu, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.810242 · Cited by 79 · see citing works

Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men with Idiopathic Infertility

Alahmar, A. T., & Sengupta, P. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02251-3 · Cited by 73 · see citing works

Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials

Florou, P., Anagnostis, P. G., Theocharis, P., Chourdakis, M., & Goulis, D. G. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01906-3 · Cited by 71 · see citing works

Frequency, morbidity and equity — the case for increased research on male fertility

Kimmins, S., Anderson, R. A., Barratt, C. L. R., Behre, H. M., Catford, S. R., Jonge, C. J. D., Delbès, G., Eisenberg, M. L., Garrido, N., Houston, B. J., et al. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00820-4 · Cited by 70 · see citing works

European Association of Urology Guidelines Panel on Male Sexual and Reproductive Health: A Clinical Consultation Guide on the Indications for Performing Sperm DNA Fragmentation Testing in Men with Infertility and Testicular Sperm Extraction in Nonazoospermic Men

Tharakan, T., Bettocchi, C., Carvalho, J., Corona, G., Jones, T. H., Kadıoğlu, A., Martínez‐Salamanca, J. I., Şerefoğlu, E. C., Verze, P., Salonia, A., et al. (2021) · European Urology Focus · doi:10.1016/j.euf.2020.12.017 · Cited by 70 · see citing works

Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress

Torres-Arce, E., Vizmanos-Lamotte, B., Babió, N., Márquez‐Sandoval, F., & Salas‐Huetos, A. (2021) · Biology · doi:10.3390/biology10030241 · Cited by 74 · see citing works

The mutagenic effect of tobacco smoke on male fertility

Omolaoye, T. S., Shahawy, O. E., Skosana, B. T., Boillat, T., Loney, T., & du Plessis, S. S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16331-x · Cited by 70 · see citing works

Measuring Reactive Oxygen Species in Semen for Male Preconception Care: A Scientist Perspective

Castleton, P., Deluao, J. C., Sharkey, D. J., & McPherson, N. O. (2022) · Antioxidants · doi:10.3390/antiox11020264 · Cited by 67 · see citing works

Preconception lifestyle advice for people with infertility

Boedt, T., Vanhove, A.-C., Vercoe, M. A., Matthys, C., Dancet, E., & Lie Fong, S. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008189.pub3 · Cited by 66 · see citing works

Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele

Finelli, R., Leisegang, K., Kandil, H., & Agarwal, A. K. (2021) · The World Journal of Men s Health · doi:10.5534/wjmh.210153 · Cited by 67 · see citing works

Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines

Marinaro, J., & Schlegel, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021446 · Cited by 57 · see citing works

Extended semen examinations in the sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen: contributing to the understanding of the function of the male reproductive system

Baldi, E., Gallagher, M. T., Сергеевич, К. С., Kirkman‐Brown, J., Apolikhin, O. I., Barratt, C. L. R., Festin, M., Kiarie, J. N., Lamb, D. J., Mbizvo, M. T., et al. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.11.034 · Cited by 61 · see citing works

Clinical adjuncts in in vitro fertilization: a growing list

Kamath, M. S., Mascarenhas, M., Franik, S., Liu, E., & Sunkara, S. K. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.09.019 · Cited by 60 · see citing works

The effect of oxidative and reductive stress on semen parameters and functions of physiologically normal human spermatozoa

Selvam, M. K. P., Agarwal, A. K., Henkel, R., Finelli, R., Robert, K. A., Iovine, C., & Baskaran, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.008 · Cited by 60 · see citing works

Impact of Antioxidant Therapy on Natural Pregnancy Outcomes and Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Agarwal, A., Cannarella, R., Saleh, R., Harraz, A., Kandil, H., Salvio, G., Boitrelle, F., Kuroda, S., Farkouh, A., Rambhatla, A., et al. (2022) · The World Journal of Men's Health · doi:10.5534/wjmh.220067 · Cited by 49 · see citing works

SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

Gojon, G., & Morales, G. A. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8060 · Cited by 55 · see citing works

Male fertility as a marker for health

Chen, T., Belladelli, F., Giudice, F. D., & Eisenberg, M. L. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.09.023 · Cited by 53 · see citing works

Impacts of Immunometabolism on Male Reproduction

Ye, L., Huang, W., Liu, S., Cai, S., Hong, L., Xiao, W., Thiele, K., Zeng, Y., Song, M., & Diao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658432 · Cited by 51 · see citing works

The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study

Humaidan, P., Haahr, T., Povlsen, B. B., Kofod, L., Laursen, R., Alsbjerg, B., Elbæk, H. O., & Esteves, S. C. (2022) · International braz j urol · doi:10.1590/s1677-5538.ibju.2021.0604 · Cited by 50 · see citing works

Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions

Wang, J., Wang, S.-X., Tehmina, Feng, Y., Zhang, R., Li, X., Sun, Q., & Ding, J. (2022) · Pharmaceuticals · doi:10.3390/ph15050519 · Cited by 50 · see citing works

Association of Dietary Patterns With Testicular Function in Young Danish Men

Nassan, F. L., Jensen, T. K., Priskorn, L., Halldorsson, T. I., Chavarro, J. E., & Jørgensen, N. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.21610 · Cited by 50 · see citing works

l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility

Khaw, S. C., Wong, Z. Z., Anderson, R. A., & da Silva, S. M. (2020) · Reproduction and Fertility · doi:10.1530/raf-20-0037 · Cited by 46 · see citing works

Effect of Paternal Diet on Spermatogenesis and Offspring Health: Focus on Epigenetics and Interventions with Food Bioactive Compounds

Pascoal, G. D. F. L., Geraldi, M. V., Maróstica, M. R., & Ong, T. P. (2022) · Nutrients · doi:10.3390/nu14102150 · Cited by 46 · see citing works

Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility

Cannarella, R., Barbagallo, F., Crafa, A., Vignera, S. L., Condorelli, R. A., & Calogero, A. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197308 · Cited by 46 · see citing works

Dietary supplementation with a novel l ‐carnitine multi‐micronutrient in idiopathic male subfertility involving oligo‐, astheno‐, teratozoospermia: A randomized clinical study

Kopets, R., Kuibida, I. S., Chernyavska, I., Cherepanyn, V., Mazo, R., Fedevych, V. S., & Gerasymov, S. (2020) · Andrology · doi:10.1111/andr.12805 · Cited by 45 · see citing works

Management of recurrent implantation failure: British Fertility Society policy and practice guideline

Mascarenhas, M., Jeve, Y. B., Polański, Ł., Sharpe, A., Yasmin, E., & Bhandari, H. M. (2021) · Human Fertility · doi:10.1080/14647273.2021.1905886 · Cited by 43 · see citing works

The current status and future of andrology: A consensus report from the Cairo workshop group

Cairo Consensus Workshop Group (2019) · Andrology · doi:10.1111/andr.12720 · Cited by 43 · see citing works

Redox Balance in Male Infertility: Excellence through Moderation—“Μέτρον ἄριστον”

Symeonidis, E. N., Evgeni, E., Palapelas, V., Koumasi, D., Pyrgidis, N., Sokolakis, I., Hatzichristodoulou, G., Tsiampali, C., Mykoniatis, I., Zachariou, A., et al. (2021) · Antioxidants · doi:10.3390/antiox10101534 · Cited by 42 · see citing works

Are antioxidants a viable treatment option for male infertility?

Ali, M., Martinez, M. P., & Parekh, N. V. (2020) · Andrologia · doi:10.1111/and.13644 · Cited by 41 · see citing works

Mediterranean diet and infertility: a systematic review with meta-analysis of cohort studies

Muffone, A. R. M. C., Lübke, P. D. P. D. O., & Rabito, E. I. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac087 · Cited by 41 · see citing works

Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy

Salvio, G., Ciarloni, A., Cutini, M., Muti, N. D., Finocchi, F., Perrone, M., Rossi, S., & Balercia, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105497 · Cited by 41 · see citing works

Effects of vitamin E and vitamin C on male infertility: a meta-analysis

Zhou, X., Shi, H., Zhu, S., Wang, H., & Sun, S. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03237-x · Cited by 38 · see citing works

The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications

Bouhadana, D., Pagé, M.-H. G., Montjean, D., Bélanger, M., Benkhalifa, M., Miron, P., & Petrella, F. (2025) · Antioxidants · doi:10.3390/antiox14081013 · Cited by 38 · see citing works

Food & Fertility Study: study protocol for a Danish multicentre prospective cohort study investigating the association between food intake and semen quality, pregnancy and birth outcomes in infertile women and men

Borgstrøm, M. B., Bjerregaard, A. A., Olsen, S. F., Gabrielsen, A., Humaidan, P., & Kesmodel, U. S. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-068354 · Cited by 37 · see citing works

Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition

Garolla, A., Petre, G. C., Francini‐Pesenti, F., Toni, L. D., Vitagliano, A., Nisio, A. D., & Foresta, C. (2020) · Nutrients · doi:10.3390/nu12051472 · Cited by 36 · see citing works

Effects of coadministration of DHA and vitamin E on spermatogram, seminal oxidative stress, and sperm phospholipids in asthenozoospermic men: a randomized controlled trial

Eslamian, G., Amirjannati, N., Noori, N., Sadeghi, M. R., & Hekmatdoost, A. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa124 · Cited by 36 · see citing works

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Amorini, A. M., Listorti, I., Bilotta, G., Pallisco, R., Saab, M. W., Mangione, R., Manca, B., Lazzarino, G., Tavazzi, B., Lazzarino, G., et al. (2021) · Antioxidants · doi:10.3390/antiox10020220 · Cited by 35 · see citing works

The effect of healthy dietary patterns on male semen quality: a systematic review and meta-analysis

Cao, L., Chang, J.-J., Wang, S.-J., Li, Y., Yuan, M., Wang, G., & Su, P. (2022) · Asian Journal of Andrology · doi:10.4103/aja202252 · Cited by 35 · see citing works

Leukocytospermia and/or Bacteriospermia: Impact on Male Infertility

Henkel, R. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102841 · Cited by 34 · see citing works

The Effect of Antioxidant Supplementation on Operated or Non-Operated Varicocele-Associated Infertility: A Systematic Review and Meta-Analysis

Pyrgidis, N., Sokolakis, I., Palapelas, V., Tishukov, M., Mykoniatis, I., Symeonidis, E., Zachariou, A., Kaltsas, A., Sofikitis, N., Hatzichristodoulou, G., et al. (2021) · Antioxidants · doi:10.3390/antiox10071067 · Cited by 33 · see citing works

Evaluating interventions and adjuncts to optimize pregnancy outcomes in subfertile women: an overview review

Holt-Kentwell, A., Ghosh, J., Devall, A., Coomarasamy, A., & Dhillon‐Smith, R. K. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmac001 · Cited by 36 · see citing works

The Effect of Dietary Patterns on Clinical Pregnancy and Live Birth Outcomes in Men and Women Receiving Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

Kellow, N. J., Cerf, J. L., Horta, F., Dordevic, A. L., & Bennett, C. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac023 · Cited by 33 · see citing works

Coenzyme Q10 and Melatonin for the Treatment of Male Infertility: A Narrative Review

Lucignani, G., Jannello, L. M. I., Fulgheri, I., Silvani, C., Turetti, M., Gadda, F., Viganò, P., Somigliana, E., Montanari, E., & Boeri, L. (2022) · Nutrients · doi:10.3390/nu14214585 · Cited by 33 · see citing works

A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males

Williams, E. A., Parker, M., Robinson, A. A., Pitt, S., & Pacey, A. A. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02091-5 · Cited by 33 · see citing works

Add-ons in the laboratory: hopeful, but not always helpful

Armstrong, S., Atkinson, M., MacKenzie, J., Pacey, A. A., & Farquhar, C. M. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.10.031 · Cited by 31 · see citing works

Who cares about oligozoospermia when we have ICSI

Esteves, S. C. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.11.026 · Cited by 31 · see citing works

Botanicals in health and disease of the testis and male fertility: A scoping review

Shepherd, A., Brunckhorst, O., Ahmed, K., & Xu, Q. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154398 · Cited by 30 · see citing works

Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines

Kaltsas, A., Zachariou, A., Dimitriadis, F., Chrisofos, M., & Sofikitis, N. (2024) · Diseases · doi:10.3390/diseases12090209 · Cited by 34 · see citing works

Novel methods to detect ROS in viable spermatozoa of native semen samples

Riley, L., Ammar, O., Mello, T., Giovannelli, L., Vignozzi, L., & Muratori, M. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.10.004 · Cited by 30 · see citing works

Idiopathic male infertility – what are we missing?

Boeri, L., Kandil, H., & Ramsay, J. W. A. (2024) · Arab Journal of Urology · doi:10.1080/20905998.2024.2381972 · Cited by 29 · see citing works

Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects

Saleh, R., Sallam, H., Elsuity, M. A., Dutta, S., Sengupta, P., & Nasr, A. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1503905 · Cited by 33 · see citing works

Assessing the influence of preconception diet on male fertility: a systematic scoping review

Tully, C. A., Alesi, S., McPherson, N. O., Sharkey, D. J., Teong, X. T., Tay, C. T., Silva, T. R., Puglisi, C. J., Barsby, J. P., Moran, L., et al. (2023) · Human Reproduction Update · doi:10.1093/humupd/dmad035 · Cited by 28 · see citing works

A Prospective Cohort Study to Evaluate the Impact of Diet, Exercise, and Lifestyle on Fertility: Design and Baseline Characteristics

Mumford, S. L., Johnstone, E. B., Kim, K., Ahmad, M., Salmon, S., Summers, K. M., Chaney, K., Ryan, G. L., Hotaling, J. M., Purdue‐Smithe, A., et al. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa073 · Cited by 27 · see citing works

Comparison of the Effect of Ceratonia siliqua L. (Carob) Syrup and Vitamin E on Sperm Parameters, Oxidative Stress Index, and Sex Hormones in Infertile Men: a Randomized Controlled Trial

Aghajani, M. M. R., Mahjoub, S., Mojab, F., Namdari, M., Gorji, N. M., Dashtaki, A., & Mirabi, P. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00314-3 · Cited by 26 · see citing works

Effect of Antioxidants on Sperm Quality Parameters in Subfertile Men: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Su, L., Qu, H., Cao, Y., Zhu, J., Zhang, S., Wu, J., & Jiao, Y. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab127 · Cited by 28 · see citing works

Epimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16

Zhao, H., Zhao, T., Yang, J., Huang, Q., Wu, H., Pan, Y., Wang, H., & Qian, Y. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04435-8 · Cited by 27 · see citing works

Current management of recurrent pregnancy loss

Chester, M. R., Tirlapur, A. S., & Jayaprakasan, K. M. (2022) · The Obstetrician & Gynaecologist · doi:10.1111/tog.12832 · Cited by 31 · see citing works

Effectiveness of Nutritional Therapies in Male Factor Infertility Treatment: A Systematic Review and Network Meta-analysis

Zafar, M. I., Mills, K. E., Baird, C. D., Jiang, H.-H., & Li, H.-G. (2023) · Drugs · doi:10.1007/s40265-023-01853-0 · Cited by 23 · see citing works

The effects of boar seminal plasma extracellular vesicles on sperm fertility

Xu, Z., Xie, Y., Wu, C., Gu, T., Zhang, X., Yang, J., Yang, J., Zheng, E., Huang, S., Xu, Z., et al. (2023) · Theriogenology · doi:10.1016/j.theriogenology.2023.09.026 · Cited by 26 · see citing works

From Diagnosis to Treatment: Comprehensive Care by Reproductive Urologists in Assisted Reproductive Technology

Kaltsas, A., Dimitriadis, F., Zachariou, D., Zikopoulos, A., Symeonidis, E. N., Markou, E., Tien, D. M. B., Takenaka, A., Sofikitis, N., & Zachariou, A. (2023) · Medicina · doi:10.3390/medicina59101835 · Cited by 32 · see citing works

Oral Antioxidant Treatment of Men Significantly Improves the Reproductive Outcome of IVF Cycles

Scaruffi, P., Licata, E., Maccarini, E., Massarotti, C., Bovis, F., SOZZI, F., Stigliani, S., Lago, A. D., Casciano, I., Rago, R., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153254 · Cited by 25 · see citing works

Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of <i>Musa sinensis</i> L. and <i>Musa paradisiaca</i> L. Fruit Compartments (Musaceae)

Oyeyinka, B. O., & Afolayan, A. J. (2020) · The Scientific World JOURNAL · doi:10.1155/2020/4503824 · Cited by 25 · see citing works

Paternal adherence to healthy dietary patterns in relation to sperm parameters and outcomes of assisted reproductive technologies

Salas‐Huetos, A., Mínguez‐Alarcón, L., Mitsunami, M., Arvizu, M., Ford, J. B., Souter, I. C., Yeste, M., & Chavarro, J. E. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.10.021 · Cited by 24 · see citing works

Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Infertility

Sharma, A. J., Sharma, G., & Kumar, R. (2021) · Urology · doi:10.1016/j.urology.2021.10.041 · Cited by 24 · see citing works

Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta‐Analysis and Systematic Review

Wang, J., Liao, B., Wang, C., Zhong, O., Lei, X., & Yang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7255413 · Cited by 24 · see citing works

The association between dietary patterns and risk of miscarriage: a systematic review and meta-analysis

Chung, Y., Melo, P. M. D. A., Pickering, O., Dhillon‐Smith, R. K., Coomarasamy, A., & Devall, A. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.04.011 · Cited by 24 · see citing works

Research progress on the role and mechanism of DNA damage repair in germ cell development

Wang, Y., Su, M., Chen, Y.-J., Huang, X., Ruan, L.-G., Lv, Q.-Z., & Li, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1234280 · Cited by 19 · see citing works

Male infertility and antioxidants: one small step for man, no giant leap for andrology?

da Silva, S. M. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2019.08.008 · Cited by 24 · see citing works

Micronutrient supplements as antioxidants in improving sperm quality and reducing DNA fragmentation

Nguyễn, Đ. N., Lê, M. T., Tran, N. Q. T., Nguyễn, V. Q. H., & Cao, N. T. (2023) · Basic and Clinical Andrology · doi:10.1186/s12610-023-00197-9 · Cited by 23 · see citing works

High sperm DNA fragmentation: do we have robust evidence to support antioxidants and testicular sperm extraction to improve fertility outcomes? a narrative review

Romanò, M., Cirillo, F., Spadaro, D., Busnelli, A., Castellano, S., Albani, E., & Levi-Setti, P. E. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150951 · Cited by 23 · see citing works

The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives

Pallotti, F., Barbonetti, A., Rastrelli, G., Santi, D., Corona, G., & Lombardo, F. P. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01778-7 · Cited by 24 · see citing works

Association of the Dietary Approaches to Stop Hypertension, Physical Activity, and Their Combination with Semen Quality: A Cross-Sectional Study

Danielewicz, A., Morze, J., Przybyłowicz, M., & Przybyłowicz, K. E. (2019) · Nutrients · doi:10.3390/nu12010039 · Cited by 23 · see citing works

Astaxanthin Ameliorates the Lipopolysaccharides-Induced Subfertility in Mouse via Nrf2/HO-1 Antioxidant Pathway

Wang, L., & Zhuang, L. (2019) · Dose-Response · doi:10.1177/1559325819878537 · Cited by 22 · see citing works

Effect of vitamin E administered to men in infertile couples on sperm and assisted reproduction outcomes: a double-blind randomized study

Matorras, R., Pérez‐Sanz, J., Corcóstegui, B., Pérez-Ruiz, I., Malaina, I., Quevedo, S., Aspichueta, F., Crisol, L., Martínez‐Indart, L., Prieto, B., et al. (2020) · F&S Reports · doi:10.1016/j.xfre.2020.09.006 · Cited by 22 · see citing works

Sperm redox biology challenges the role of antioxidants as a treatment for male factor infertility

Caroppo, E., & Dattilo, M. (2021) · F&S Reviews · doi:10.1016/j.xfnr.2021.12.001 · Cited by 22 · see citing works

Effect of Antioxidants Supplementation on Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Su, L., Yang, Z.-T., Qu, H., Luo, C.-L., Yuan, G.-X., Wu, J., & Jiao, Y. (2022) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2022.01.002 · Cited by 24 · see citing works

Antioxidants for male subfertility: A systematic review and meta-analysis

Smits, R. M., Mackenzie-Proctor, R., Yazdani, A., Stankiewicz, M., Hart, R. J., Jordan, V., & Showell, M. G. (2019) · Keele Research Repository (Keele University) · doi:10.1093/humrep/34.supplement_1.1

Antioxidants for female subfertility

Showell, M. G., Mackenzie-Proctor, R., Jordan, V., & Hart, R. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007807.pub3 · Cited by 83 · see citing works

What are the effects of antioxidants for male subfertility?

Siristatidis, C. S. (2022) · Cochrane Clinical Answers · doi:10.1002/cca.4087

Efficacy of combined antioxidant therapy in male subfertility-A systematic review and meta-analysis

Arhin, S. K., Ocansey, S., Barnes, P., Botchey, C. P. K., & Taylor-Adbulai, H. B. (2022) · Cellular and Molecular Biology · doi:10.14715/cmb/2021.67.4.27 · Cited by 4 · see citing works

OXIDATIVE STRESS AND MALE FERTILITY: THE IMPACT OF ANTIOXIDANT BLENDS IN TREATMENT

Whitmore, C. A., & Diarra, A. F. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.19604450