The DOI matches its Crossref record; 238 of the 240 references it cites were found in a registry or an index.
Antioxidants for male subfertility
Open accessAbstract
versus placebo or no treatment, Outcome 2 Live birth; placebo or no treatment........ Analysis 1.3.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 3 Live birth; IVF/ICSI.................................. Analysis 1.4.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 4 Live birth; as-treated analysis................ Analysis 1.5.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 5 Clinical pregnancy; type of antioxidant.... Analysis 1.6.Comparison 1 Antioxidant(s) versus placebo or no treatment, Outcome 6 Clinical pregnancy; placebo or no treatment.....................................
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Taken together with previous findings, our results indicate that while antioxidants may reduce ROS, this does not appear to translate into reduced sperm DNA fragmentation.”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The recent Cochrane meta-analysis, which included 5 trials with a variety of antioxidants with a total of 254 subjects, found that men treated with antioxidants had on average 5% lower DNA fragmentation, but the confidence interval was broad and crossed 0. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The recent Cochrane Review found that antioxidant use increased the odds of pregnancy by 2.97 fold and the odd of live birth by 1.8 fold. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
The cited source says what the claim attributes to it.
In the citing paper
“The recent Cochrane Review found that antioxidant use increased the odds of pregnancy by 2.97 fold and the odd of live birth by 1.8 fold. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
The cited source says what the claim attributes to it.
In the citing paper
“However, the Cochrane meta-analysis did find a 12% absolute increase in motility in men treated with combination antioxidants for 3 months compared to controls. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
The cited source says what the claim attributes to it.
In the citing paper
“A recent meta-analysis concluded that antioxidant supplementation taken by subfertile males may increase the chance of live birth; however, large randomized, well-designed, placebo-controlled trials were needed. (7)”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
The cited source says what the claim attributes to it.
In the citing paper
“Our negative findings contradict the overall conclusions from the Cochrane Review and meta-analysis.”
From The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial (2020) · cites this paper as [7]
In the citing paper
“Low-quality evidence suggests that antioxidant supplementation for men with infertility may improve live birth rates (Smits 2019).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Smits 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Hsia, T., & Yin, M.-C. (2016) · Nutrients · doi:10.3390/nu8080507 · Cited by 6
RetractedHsia, T., Yin, M., & Nutrients Editorial Office (2017) · Nutrients · doi:10.3390/nu9060528 · Cited by 2
RetractedFree radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Boivin, J., Bunting, L., Collins, J. A., & Nygren, K. G. (2007) · Human Reproduction · doi:10.1093/humrep/dem046 · Cited by 2,437
Mascarenhas, M., Flaxman, S. R., Boerma, T., Vanderpoel, S., & Stevens, G. A. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001356 · Cited by 2,357
Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids
Compounds, P. O. D. A. A. R., Nutrients, S. O. U. R. L. O., Intakes, S. O. I. A. U. O. D. R., Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, & Institute of Medicine (2000) · doi:10.17226/9810 · Cited by 2,034
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
Inhorn, M. C., & Patrizio, P. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv016 · Cited by 1,926
Vitamin E, antioxidant and nothing more
Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,547
Oxidative stress and male infertility—a clinical perspective
Tremellen, K. P. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn004 · Cited by 1,544
Research works printed but not linked: 25
- Azizollahi, 2013, Effects of zinc sulfate and folic acid coadministration on sperm parameters, protamine content and acrosomal integrity of varicocelectomized patients, Iranian Journal of Reproductive Medicine, 1), 37
- Azizollahi, 2011, The effect of folic acid administration on protamine deficiency, acrosomal activity and semen parameters in varicocelectomized patients, Human Reproduction, 26 Suppl 1 Abst, i340
- Azizollahi, 2013, The effect of folic acid and zinc sulfate on endocrine parameters and seminal antioxidant level, after variocelectomy, Iranian Journal of Reproductive Medicine, 1), 36
- Biagiotti, 2003, Prostaglanadins pulsed down-regulation enhances carnitine therapy performance in severe idiopathic oligoasthenospermia, Human Reproduction, 18 Suppl 1, 202
- Li Z Gu R Liu Y Xiang Z Cao X Han Y Curative effect of L-carnitine supplementation in the treatment of male infertility Academic Journal of Shanghai Second Medical University 2005 292 4
- Peivandi, 2010, Effects of L-carnitine on infertile men's spermogram; a randomised clinical trial, Journal of Reproduction and Infertility, 10, 331
- Pourmand GH Movahedin M Dehghan S Mehrsai A Ahmadi A Pourhosein M Does L-carnitine therapy add any extra benefit to standard inguinal varicocelectomy in terms of deoxyribonucleic acid damage or sperm quality factor indices: a randomized study Iranian Journal of Reproductive Medicine. 2015 67 · DOI
- Rolf, 1999, Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study [see comment], Human Reproduction, 14, 1028, 10.1093/humrep/14.4.1028 · DOI
- Tremellen, 2006, A randomised control trial examining the effect of an antioxidant on sperm function pregnancy outcome during IVF treatment. The Fertility Society of Australia 25th Annual scientific meeting, Australian & New Zealand Journal of Obstetrics & Gynaecology, 46 Suppl 2, A.2
- Zalata, 1998, Protection of sperm function and DNA by essential fatty acids and antioxidants dietary supplementation, Fertility and Sterility, 70, 287
- Adel, 2015, Vitamin e and berberine counteract the adverse effects of ros on sperm and seminal parameters, Human Reproduction, 30 Suppl 1, i171 Abstract n
- Azizollahi, 2013, The effect of folic acid and zinc sulfate on endocrine parameters and seminal antioxidant level, after variocelectomy, Iranian Journal of Reproductive Medicine, 1), 36
- Capece, 2015, Alga Ecklonia Bicyclis, tribulus terrestris, myoinositol and biovistm reduce sperm DNA fragmentation in patients with oligo-asthenoterato-zoospermia (OAT) syndrome, Journal of Sexual Medicine, 12 (Supplement, 365
- Iacono, 2014, Combination therapy with antiestrogen and a natural composite containing tribulus terrestris, alga ecklonia bicyclis, biovis and myo-inositol in the treatment of male idiopathic infertility, Journal of Sexual Medicine, 1, 92
- Movahedin, 2014, Does anti-oxidant therapy add any extra benefit to standard inguinal varicocelectomy in terms of DNA damage or sperm quality factor indices: a randomized study, Urology, 4, S252
- Raigani, 2010, Impacts of MTHFR polymorphism on the effects of folic acid and zinc sulfate supplementations in OAT men, Iranian Journal of Reproductive Medicine, 1), 46
- Singh, 2016, Role of nutraceuticals in treatment of azoospermia due to maturation arrest, Indian Journal of Physiology and Pharmacology, 60 (5 Supplemen, 6
- Stanislavov, 2014, Sperm quality in men is improved by supplementation with a combination of L-arginine, L-citrulline, roburins and Pycnogenol, Minerva Urologica e Nefrologica, 66, 217
- Stanislavov, 2014, Sperm quality in men is improved by supplementation with a combination of L-arginine, L-citrulline, roburins and Pycnogenol, Minerva Urologica e Nefrologica, 66, 217
- Wang, 2010, [Clinical efficacy of L-carnitine combined with tamoxifen in treatment of oligoasthenozoospermia] LA: Chi, Zhonghua nan ke xue - National Journal of Andrology, 16, 420
- Annals of the New York Academy of Science Preface: Carnitine: Lessons from One Hundred Years of Research Annals of the New York Academy of Science 2004 ix xi
- Comhaire FH Towards more objectivity in diagnosis and management of male infertility International Journal of Andrology. Supplement 1987
- Institute of Medicine, 2000, Vitamin E
- Nordic Cochrane Centre, The Cochrane Collaboration Review Manager 5 (RevMan 5) 2014
- Ross, 2006, Vitamin A and Carotenoids, 10th edition, 351
Cited by
Sorted by citations
Agarwal, A. K., Baskaran, S., Parekh, N. V., Cho, C., Henkel, R., Vij, S. C., Arafa, M. M., Selvam, M. K. P., & Shah, R. S. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32667-2 · Cited by 1,497
Minhas, S., Bettocchi, C., Boeri, L., Capogrosso, P., Carvalho, J., Çilesiz, N. C., Cocci, A., Corona, G., Dimitropoulos, K., Gül, M., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.08.014 · Cited by 643
Sperm DNA Fragmentation: A New Guideline for Clinicians
Agarwal, A. K., Majzoub, A. A., Baskaran, S., Selvam, M. K. P., Cho, C., Henkel, R., Finelli, R., Leisegang, K., Sengupta, P., Zenoaga-Barbăroşie, C., et al. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.200128 · Cited by 341
Male infertility due to testicular disorders
Sharma, A., Minhas, S., Dhillo, W. S., & Jayasena, C. N. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa781 · Cited by 285
Oxidative stress and male infertility
Takeshima, T., Usui, K., Mori, K., Asai, T., Yasuda, K., Kuroda, S., & Yumura, Y. (2020) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12353 · Cited by 234
Metadata
- Authors
- Smits, R. M., Mackenzie-Proctor, R., Yazdani, A., Stankiewicz, M. T., Jordan, V., & Showell, M. G.
- Affiliations
- Radboud University Medical Center (NL)
- Auckland City Hospital (NZ)
- Queensland Fertility Group Research Foundation; 55 Little Edward St, Level 2 Boundary Court Spring Hill Brisbane Queensland Australia 4000
- Ashford Specialist Centre Suite 22; 57-59 Anzac Highway Ashford Adelaide SA Australia
- University of Auckland (NZ)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2019-03-14
- Volume
- 2019
- Issue
- 3
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W3049686564
- Cited by
- 277
- References
- 240
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 28 · 2023: 47 · 2022: 52 · 2021: 52 · 2020: 52 · 2019: 15
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Update notices
- new_version (2022-05-04)
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- antioxidants, male subfertility, male infertility, live birth, clinical pregnancy, in vitro fertilization, intracytoplasmic sperm injection, antioxidant supplementation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
