Self‐nonself discrimination by the complement system

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · see citing works

Complement

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Complement factor H polymorphism and age-related macular degeneration

Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works

A common haplotype in the complement regulatory gene factor H ( <i>HF1/CFH</i> ) predisposes individuals to age-related macular degeneration

Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961 · see citing works

ANTIGENIC SIMILARITIES BETWEEN BRAIN COMPONENTS AND BACTERIA CAUSING MENINGITIS

Finne, J., Leinonen, M., & Mäkelä, P. H. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90340-9 · Cited by 798 · see citing works

Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense

Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762 · see citing works

A universal vaccine for serogroup B meningococcus

Giuliani, M. M., Adu‐Bobie, J., Comanducci, M., Aricò, B., Savino, S., Santini, L., Brunelli, B., Bambini, S., Biolchi, A., Capecchi, B., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603940103 · Cited by 733 · see citing works

Multifarious roles of sialic acids in immunity

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Structures of complement component C3 provide insights into the function and evolution of immunity

Janssen, B. J. C., Huizinga, E. G., Raaijmakers, H. C. A., Roos, A., Daha, M. R., Nilsson‐Ekdahl, K., Nilsson, B., & Gros, P. (2005) · Nature · doi:10.1038/nature04005 · Cited by 542 · see citing works

Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.

Meri, S., Morgan, B. P., Davies, A., Daniels, R. H., Olavesen, M. G., Waldmann, H., & Lachmann, P. J. (1990) · PubMed Central · Cited by 533 · see citing works

Thrombosis in paroxysmal nocturnal hemoglobinuria

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Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Girardi, G., Yarilin, D. A., Thurman, J. M., Holers, V. M., & Salmon, J. E. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061022 · Cited by 507 · see citing works

The Regulators of Complement Activation (RCA) Gene Cluster

Hourcade, D. E., Holers, V. M., & Atkinson, J. P. (1989) · Advances in immunology · doi:10.1016/s0065-2776(08)60697-5 · Cited by 443 · see citing works

Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

Nicholson-Weller, A., March, J., ROSENFELD, S. I., & Austen, K. F. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.16.5066 · Cited by 427 · see citing works

Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.

Meri, S., & Pangburn, M. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3982 · Cited by 413 · see citing works

The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9.

Rollins, S. A., & Sims, P. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3478 · Cited by 408 · see citing works

A Novel Sialic Acid Binding Site on Factor H Mediates Serum Resistance of Sialylated Neisseria gonorrhoeae

Ram, S., Sharma, A. K., Simpson, S. D., Gulati, S., McQuillen, D. P., Pangburn, M. K., & Rice, P. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.5.743 · Cited by 400 · see citing works

The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance

Madico, G. E., Welsch, J. A., Lewis, L. A., McNaughton, A., Perlman, D. H., Costello, C. E., Ngampasutadol, J., Vogel, U. F., Granoff, D. M., & Ram, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.501 · Cited by 390 · see citing works

Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG‐A gene.

Bessler, M., Mason, P. J., Hillmen, P., Miyata, T., Yamada, N., Takeda, J., Luzzatto, L., & Kinoshita, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06240.x · Cited by 387 · see citing works

STEC-HUS, atypical HUS and TTP are all diseases of complement activation

Noris, M., Mescia, F., & Remuzzi, G. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.195 · Cited by 384 · see citing works

Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease)

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Structure of C3b reveals conformational changes that underlie complement activity

Janssen, B. J. C., Christodoulidou, A., McCarthy, A. A., Lambris, J. D., & Gros, P. (2006) · Nature · doi:10.1038/nature05172 · Cited by 369 · see citing works

The Complement Regulator Factor H Binds to the Surface Protein OspE of Borrelia burgdorferi

Hellwage, J., Meri, T., Heikkilä, T., Alitalo, A., Panelius, J., Lahdenne, P., Seppälä, J. T. I., & Meri, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007994200 · Cited by 365 · see citing works

Identification of committed NK cell progenitors in adult murine bone marrow

Rosmaraki, E. E., Douagi, I., Roth, C., Colucci, F., Cumano, A., & Santo, J. P. D. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200106)31:6 · Cited by 361 · see citing works

Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.

Kazatchkine, M. D., Fearon, D. T., & Kf, A. (1979) · PubMed · Cited by 350 · see citing works

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

Manuelian, T., Hellwage, J., Meri, S., Caprioli, J., Noris, M., Heinen, S., Józsi, M., Neumann, H. P. H., Remuzzi, G., & Zipfel, P. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16651 · Cited by 350 · see citing works

Mannose‐binding lectin: targeting the microbial world for complement attack and opsonophagocytosis

Jack, D. L., Klein, N. J., & TURNER, M. W. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1800108.x · Cited by 347 · see citing works

Complement C3 convertase: Cell surface restriction of β1H control and generation of restriction on neuraminidase-treated cells

Pangburn, M. K., & Müller‐Eberhard, H. J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2416 · Cited by 346 · see citing works

Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement.

Pangburn, M. K., & Müller‐Eberhard, H. J. (1980) · The Journal of Experimental Medicine · doi:10.1084/jem.152.4.1102 · Cited by 336 · see citing works

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis

Gale, D. P., de Jorge, E. G., Cook, H. T., Martínez‐Barricarte, R., Hadjisavvas, A., McLean, A. G., Pusey, C. D., Pierides, A., Kyriacou, K. C., Athanasiou, Y., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60670-8 · Cited by 326 · see citing works

Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

Zipfel, P. F., Edey, M. M., Heinen, S., Józsi, M., Richter, H., Misselwitz, J., Höppe, B., Routledge, D., Strain, L., Hughes, A. E., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030041 · Cited by 325 · see citing works

Factor H Mutations in Hemolytic Uremic Syndrome Cluster in Exons 18–20, a Domain Important for Host Cell Recognition

Richards, A., Buddles, M., Donne, R. L., Kaplan, B. S., Kirk, E. P., Venning, M. C., Tielemans, C. L., Goodship, J. A., & Goodship, T. H. J. (2001) · The American Journal of Human Genetics · doi:10.1086/318203 · Cited by 310 · see citing works

Natural killer cell recognition of missing self

Kärre, K. (2008) · Nature Immunology · doi:10.1038/ni0508-477 · Cited by 296 · see citing works

CTRP family: linking immunity to metabolism

Schäffler, A., & Buechler, C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.12.003 · Cited by 293 · see citing works

The alternative pathway of complement

Pangburn, M. K., & Müller‐Eberhard, H. J. (1984) · Springer Seminars in Immunopathology · doi:10.1007/bf01893019 · Cited by 292 · see citing works

Dimerization of complement factor H-related proteins modulates complement activation in vivo

de Jorge, E. G., Caesar, J. J. E., Malik, T. H., Patel, M., Colledge, M., Johnson, S., Hakobyan, S., Morgan, B. P., Harris, C. L., Pickering, M. C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219260110 · Cited by 290 · see citing works

Human Alternative Complement Pathway: Membrane-Associated Sialic Acid Regulates the Competition between B and β1H for Cell-Bound C3b

Kazatchkine, M. D., Fearon, D. T., & Austen, K. F. (1979) · The Journal of Immunology · doi:10.4049/jimmunol.122.1.75 · Cited by 290 · see citing works

Structural basis for sialic acid–mediated self-recognition by complement factor H

Blaum, B. S., Hannan, J. P., Herbert, A. P., Kavanagh, D., Uhrín, D., & Stehle, T. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1696 · Cited by 278 · see citing works

Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome

Rooryck, C., Dı́az-Font, A., Osborn, D. P. S., Chabchoub, E., Hernández-Hernández, V., Shamseldin, H. E., Kenny, J., Waters, A. M., Jenkins, D., Kaissi, A. A., et al. (2011) · Nature Genetics · doi:10.1038/ng.757 · Cited by 265 · see citing works

Membrane proteins that protect against complement lysis

Morgan, B. P., & Meri, S. (1994) · Springer Seminars in Immunopathology · doi:10.1007/bf01837366 · Cited by 264 · see citing works

Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1

Kühn, S., Skerka, C., & Zipfel, P. F. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.12.5663 · Cited by 260 · see citing works

C3 Nephritic Factor (C3NeF): Stabilization of Fluid Phase and Cell-Bound Alternative Pathway Convertase

Daha, M. R., Fearon, D. T., & Austen, K. F. (1976) · The Journal of Immunology · doi:10.4049/jimmunol.116.1.1 · Cited by 258 · see citing works

Factor H family proteins: on complement, microbes and human diseases

Zipfel, P. F., Skerka, C., Hellwage, J., Jokiranta, S. T., Meri, S., Brade, V., Kraiczy, P., Noris, M., & Remuzzi, G. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300971 · Cited by 252 · see citing works

Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein

Laine, M., Jarva, H., Seitsonen, S., Haapasalo, K., Lehtinen, M. J., Lindeman, N., Anderson, D. H., Johnson, P. T., Järvelä, I., Jokiranta, T. S., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3831 · Cited by 246 · see citing works

Metabolic function of the CTRP family of hormones

Seldin, M. M., Tan, S. Y., & Wong, G. W. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9255-7 · Cited by 244 · see citing works

Structural basis for engagement by complement factor H of C3b on a self surface

Morgan, H. P., Schmidt, C. Q., Guariento, M., Blaum, B. S., Gillespie, D., Herbert, A. P., Kavanagh, D., Mertens, H. D. T., Svergun, D. I., Johansson, C. M., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2018 · Cited by 239 · see citing works

Each of the Three Binding Sites on Complement Factor H Interacts with a Distinct Site on C3b

Jokiranta, T. S., Hellwage, J., Koistinen, V., Zipfel, P. F., & Meri, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002903200 · Cited by 226 · see citing works

Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis.

Meri, S., Koistinen, V., Miettinen, A., Törnroth, T., & Seppälä, I. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.4.939 · Cited by 223 · see citing works

Identification of the Second Heparin-Binding Domain in Human Complement Factor H

Blackmore, T., Hellwage, J., Sadlon, T. A., Higgs, N., Zipfel, P. F., Ward, H. M., & Gordon, D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3342 · Cited by 222 · see citing works

The Amplification Loop of the Complement Pathways

Lachmann, P. J. (2009) · Advances in immunology · doi:10.1016/s0065-2776(08)04004-2 · Cited by 220 · see citing works

Dual interaction of factor H with C3d and glycosaminoglycans in host–nonhost discrimination by complement

Kajander, T., Lehtinen, M. J., Hyvärinen, S., Bhattacharjee, A., Leung, E., Isenman, D. E., Meri, S., Goldman, A., & Jokiranta, T. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017087108 · Cited by 220 · see citing works

Differential Binding of Host Complement Inhibitor Factor H byBorrelia burgdorferiErp Surface Proteins: a Possible Mechanism Underlying the Expansive Host Range of Lyme Disease Spirochetes

Stevenson, B., El‐Hage, N., Hines, M. A., Miller, J. C., & Babb, K. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.491-497.2002 · Cited by 219 · see citing works

Regulation of the Adhesion versus Cytotoxic Functions of the Mac-1/CR3/αMβ2 - lntegrin Glycoprotein

Ross, G. D. (2000) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v20.i3.20 · Cited by 218 · see citing works

Hypocomplementaemia due to a genetic deficiency of beta 1H globulin.

Thompson, R. A., & Winterborn, M. H. (1981) · PubMed · Cited by 207 · see citing works

Immune evasion of tumor cells using membrane-bound complement regulatory proteins

Gorter, A., Gorter, A., & Meri, S. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01537-6 · Cited by 207 · see citing works

The mechanism of action of decay-accelerating factor (DAF). DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb.

Fujita, T., Inoue, T., Ogawa, K., Iida, K.-I., & Tamura, N. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.5.1221 · Cited by 204 · see citing works

Complement resistance of tumor cells: basal and induced mechanisms

Jurianz, K., Ziegler, S., Schüler, H. I. G., Kraus, S. R., Bohana‐Kashtan, O., Fishelson, Z., & Kirschfink, M. (1999) · Molecular Immunology · doi:10.1016/s0161-5890(99)00115-7 · Cited by 199 · see citing works

Regulation of Complement Activation by C-Reactive Protein: Targeting the Complement Inhibitory Activity of Factor H by an Interaction with Short Consensus Repeat Domains 7 and 8–11

Jarva, H., Jokiranta, T. S., Hellwage, J., Zipfel, P. F., & Meri, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3957 · Cited by 197 · see citing works

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

Tortajada, A., Yébenes, H., Abarrategui-Garrido, C., Anter, J., García-Fernández, J., Martínez‐Barricarte, R., Alba‐Domínguez, M., Malik, T. H., Bedoya, R., Pérez, R. C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68280 · Cited by 197 · see citing works

Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H

Blackmore, T., Sadlon, T. A., Ward, H. M., Lublin, D. M., & Gordon, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.12.5422 · Cited by 195 · see citing works

Streptococcus pneumoniae Evades Complement Attack and Opsonophagocytosis by Expressing the pspC Locus-Encoded Hic Protein That Binds to Short Consensus Repeats 8–11 of Factor H

Jarva, H., Janulczyk, R., Hellwage, J., Zipfel, P. F., Björck, L., & Meri, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1886 · Cited by 192 · see citing works

Localization of the heparin-binding site on complement factor H.

Pangburn, M. K., Atkinson, M. A., & Meri, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55379-5 · Cited by 190 · see citing works

Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina

Clark, S. J., Perveen, R., Hakobyan, S., Morgan, B. P., Sim, R. B., Bishop, P. N., & Day, A. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103986 · Cited by 188 · see citing works

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

Deban, L., Jarva, H., Lehtinen, M. J., Bottazzi, B., Bastone, A., Doni, A., Jokiranta, T. S., Mantovani, A., & Meri, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8433 · Cited by 185 · see citing works

The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular proteinase

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The physiological role of DC-SIGN: A tale of mice and men

García-Vallejo, J. J., & van Kooyk, Y. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.001 · Cited by 183 · see citing works

H deficiency in two brothers with atypical dense intramembranous deposit disease

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Complement Evasion byBorrelia burgdorferi: Serum-Resistant Strains Promote C3b Inactivation

Alitalo, A., Meri, T., Rämö, L., Jokiranta, T. S., Heikkilä, T., Seppälä, I., Oksi, J., Viljanen, M. K., & Meri, S. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.3685-3691.2001 · Cited by 166 · see citing works

MBL2, FCN1, FCN2 and FCN3—The genes behind the initiation of the lectin pathway of complement

Garred, P., Honoré, C., Ma, Y. J., Munthe‐Fog, L., & Hummelshøj, T. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.05.005 · Cited by 161 · see citing works

Complement Inhibitor Factor H Binding to Lyme Disease Spirochetes Is Mediated by Inducible Expression of Multiple Plasmid-Encoded Outer Surface Protein E Paralogs

Alitalo, A., Meri, T., Lankinen, H., Seppälä, I., Lahdenne, P., Hefty, P. S., Akins, D. R., & Meri, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3847 · Cited by 161 · see citing works

Structure of complement factor H carboxyl‐terminus reveals molecular basis of atypical haemolytic uremic syndrome

Jokiranta, T. S., Jaakola, V., Lehtinen, M. J., Pärepalo, M., Meri, S., & Goldman, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601052 · Cited by 156 · see citing works

Review: Gp-340/DMBT1 in mucosal innate immunity

Madsen, J., Mollenhauer, J., & Holmskov, U. (2010) · Innate Immunity · doi:10.1177/1753425910368447 · Cited by 154 · see citing works

Metabolic Studies of the Third Component of Complement and the Glycine-Rich Beta Glycoprotein in Patients with Hypocomplementemia

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Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo.

Rossen, R. D., Michael, L. H., Kagiyama, A., Savage, H., Hanson, G., Reisberg, M. A., Moake, J. L., Kim, S. H., Self, D. J., & Weakley, S. (1988) · Circulation Research · doi:10.1161/01.res.62.3.572 · Cited by 149 · see citing works

Genetics of Atypical Hemolytic Uremic Syndrome (aHUS)

Hidalgo, M., Pinto, S., Tortajada, A., & de Córdoba, S. R. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1375296 · Cited by 148 · see citing works

Antimalarial Responses in Anopheles gambiae: From a Complement-like Protein to a Complement-like Pathway

Blandin, S. A., Marois, É., & Levashina, E. A. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.007 · Cited by 144 · see citing works

The Factor H Variant Associated with Age-related Macular Degeneration (His-384) and the Non-disease-associated Form Bind Differentially to C-reactive Protein, Fibromodulin, DNA, and Necrotic Cells

Sjöberg, A. P., Trouw, L. A., Clark, S. J., Sjölander, J., Heinegård, D. K., Sim, R. B., Day, A. J., & Blom, A. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610256200 · Cited by 142 · see citing works

Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity

Scarselli, M., Aricò, B., Brunelli, B., Savino, S., Marcello, F. D., Palumbo, E., Veggi, D., Ciucchi, L., Cartocci, E., Bottomley, M. J., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002234 · Cited by 140 · see citing works

Exceptional Resistance of Human H2 Glioblastoma Cells to Complement-Mediated Killing by Expression and Utilization of Factor H and Factor H-Like Protein 1

Junnikkala, S., Jokiranta, T. S., Friese, M. A., Jarva, H., Zipfel, P. F., & Meri, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.6075 · Cited by 139 · see citing works

The pathobiology of pig‐to‐primate xenotransplantation: a historical review

Cooper, D. K. C., Ezzelarab, M., Hara, H., Iwase, H., Lee, W., Wijkstrom, M., & Bottino, R. (2016) · Xenotransplantation · doi:10.1111/xen.12219 · Cited by 139 · see citing works

Regulation of Alternative Pathway Complement Activation by Glycosaminoglycans: Specificity of the Polyanion Binding Site on Factor H

Meri, S., & Pangburn, M. K. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1008 · Cited by 131 · see citing works

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci

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Complement C3b/C3d and Cell Surface Polyanions Are Recognized by Overlapping Binding Sites on the Most Carboxyl-Terminal Domain of Complement Factor H

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Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations*

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Molecular Mechanisms of Target Recognition in an Innate Immune System: Interactions Among Factor H, C3b, and Target in the Alternative Pathway of Human Complement

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Binding of Complement Factor H to Endothelial Cells Is Mediated by the Carboxy-Terminal Glycosaminoglycan Binding Site

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Complement Regulator-Acquiring Surface Protein 1 Imparts Resistance to Human Serum in Borrelia burgdorferi

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Comprehensive Analysis of the Factor H Binding Capabilities of Borrelia Species Associated with Lyme Disease: Delineation of Two Distinct Classes of Factor H Binding Proteins

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Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells

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Microbes Bind Complement Inhibitor Factor H via a Common Site

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Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer

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FHL-1/reconectin and factor H: two human complement regulators which are encoded by the same gene are differently expressed and regulated

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Complement Activation and Regulation in Preeclamptic Placenta

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Binding of the Complement Inhibitor C4bp to Serogroup B Neisseria meningitidis

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Identification and Functional Characterization of Complement Regulator-Acquiring Surface Protein 1 of the Lyme Disease SpirochetesBorrelia afzeliiandBorrelia garinii

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Complement Factor H: A Biomarker for Progression of Cutaneous Squamous Cell Carcinoma

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Self, Non-Self, and Danger: A Complementary View

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The evolution of natural killer cell receptors

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Complement activation in diseases presenting with thrombotic microangiopathy

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Primitive complement system of invertebrates

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Analysis of the recognition mechanism of the alternative pathway of complement by monoclonal anti‐factor H antibodies: evidence for multiple interactions between H and surface bound C3b

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Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

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Paroxysmal nocturnal hemoglobinuria: deficiency in factor H-like functions of the abnormal erythrocytes.

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Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1

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New Insights into the Role of Ficolins in the Lectin Pathway of Innate Immunity

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Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. II. The role of complement components in the increased sensitivity of PNH red cells to immune lysis.

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Humoral Pattern Recognition Molecules: Mannan-Binding Lectin and Ficolins

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Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome

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The Group B Streptococcal β and Pneumococcal Hic Proteins Are Structurally Related Immune Evasion Molecules That Bind the Complement Inhibitor Factor H in an Analogous Fashion

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Complement Factor H as a Marker for Detection of Bladder Cancer

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iC3b‐opsonized apoptotic cells mediate a distinct anti‐inflammatory response and transcriptional NF‐κB‐dependent blockade

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The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease

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Anti-Factor H Autoantibody–Associated Hemolytic Uremic Syndrome: Review of Literature of the Autoimmune Form of HUS

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Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

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Role of Complement in Enterohemorrhagic Escherichia coli–Induced Hemolytic Uremic Syndrome

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Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility

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A mechanism of activation of the alternative complement pathway by the classical pathway: protection of C3b from inactivation by covalent attachment to C4b

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Alternative complement pathway activation by Salmonella O polysaccharide as a virulence determinant in the mouse

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Complement-Regulator Factor H and Related Proteins in Otitis Media with Effusion

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The bacteria binding glycoprotein salivary agglutinin (SAG/gp340) activates complement via the lectin pathway

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Microbial complement inhibitors as vaccines

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Loss of Self‐Control in the Complement System and Innate Autoreactivity

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Atypical Hemolytic Uremic Syndrome Associated with Mutations in Complement Regulator Genes

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Interactions of C-reactive protein and complement with liposomes

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Monocyte Expressed Macromolecular C1 and C1q Receptors as Molecular Sensors of Danger: Implications in SLE

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SALSA: A Regulator of the Early Steps of Complement Activation on Mucosal Surfaces

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The salivary scavenger and agglutinin binds MBL and regulates the lectin pathway of complement in solution and on surfaces

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The Salivary Scavenger and Agglutinin in Early Life: Diverse Roles in Amniotic Fluid and in the Infant Intestine

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The Role of the Classical Pathway for the Bactericidal Effect of Normal Sera Against Gram-Negative Bacteria

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Catalysed hydrolysis — the complement quickstep

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Approach to the Discovery, Development, and Evaluation of a Novel Neisseria meningitidis Serogroup B Vaccine

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Purification, Measurement of Concentration, and Functional Complement Assay of Human Ficolins

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New Insights Into CRASP-Mediated Complement Evasion in the Lyme Disease Enzootic Cycle

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Complement factor H in host defense and immune evasion

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The conceptual foundations of innate immunity: Taking stock 30 years later.

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Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology

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Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

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Regulation of regulators: Role of the complement factor H-related proteins

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Heparan sulfate as a regulator of inflammation and immunity

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Pentraxins in the activation and regulation of innate immunity

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Regulation of the Complement System by Pentraxins

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Regulation of the complement system and immunological tolerance in pregnancy

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Intracellular complement activation—An alarm raising mechanism?

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Factor H Family Proteins in Complement Evasion of Microorganisms

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Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

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Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

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Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

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Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity

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Innate immune sensing of adeno-associated virus vectors

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Human granulosa cells function as innate immune cells executing an inflammatory reaction during ovulation: a microarray analysis

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Initiation of the alternative pathway of complement and the history of “tickover”

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Dengue Virus Induces Increased Activity of the Complement Alternative Pathway in Infected Cells

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Blood treatment of Lyme borreliae demonstrates the mechanism of CspZ ‐mediated complement evasion to promote systemic infection in vertebrate hosts

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SALSA—A dance on a slippery floor with changing partners

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Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

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Anaphylatoxin C5a induces inflammation and reduces insulin sensitivity by activating TLR4/NF-kB/PI3K signaling pathway in 3T3-L1 adipocytes

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Complement in trauma—Traumatised complement?

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Wandering pathways in the regulation of innate immunity and inflammation

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High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B

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Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits

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Strategies to improve safety profile of AAV vectors

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The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease

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Factor H–IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes

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Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features

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Complement evasion by the human respiratory tract pathogens Haemophilus influenzae and Moraxella catarrhalis

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Complement in Human Pre-implantation Embryos: Attack and Defense

Reichhardt, M. P., Lundin, K., Lokki, A. I., Recher, G., Vuoristo, S., Katayama, S., Tapanainen, J. S., Kere, J., Meri, S., & Tuuri, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02234 · Cited by 25 · see citing works

Perforin-Like Proteins of Apicomplexan Parasites

Sassmannshausen, J., Pradel, G., & Bennink, S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.578883 · Cited by 23 · see citing works

Molecular Aspects of Resistance to Immunotherapies—Advances in Understanding and Management of Diffuse Large B-Cell Lymphoma

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Advances in our understanding of the pathogenesis of hemolytic uremic syndromes

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Roles of Siglecs in neurodegenerative diseases

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Autoantibodies Against the Complement Regulator Factor H in the Serum of Patients With Neuromyelitis Optica Spectrum Disorder

Uzonyi, B., Szabó, Z., Trojnár, E., Hyvärinen, S., Uray, K., Nielsen, H. H., Erdei, A., Jokiranta, T. S., Prohászka, Z., Illés, Z., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660382 · Cited by 19 · see citing works

Alternative pathway activation: Ever ancient and ever new

Liszewski, M. K., & Atkinson, J. P. (2022) · Immunological Reviews · doi:10.1111/imr.13132 · Cited by 19 · see citing works

Complement Immune Evasion by Spirochetes

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Anti-complement factor H autoantibodies may be protective in lupus nephritis

Li, L., Tan, Y. C. R. S., Song, D., Li, Y., Yu, F., Chen, M., & Zhao, M. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.05.005 · Cited by 18 · see citing works

Resilience and Sovereignty in the Context of Contemporary Biopolitics

Fabián, R. D. L. (2020) · Critical Times · doi:10.1215/26410478-8662272 · Cited by 15 · see citing works

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

Cserhalmi, M., Csincsi, Á. I., Mezei, Z. A., Kopp, A., Hebecker, M., Uzonyi, B., & Józsi, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01145 · Cited by 15 · see citing works

Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases

Lacroix, M., Tessier, A., Dumestre‐Pérard, C., Goff, S. V., Gout, E., Bruckner‐Tuderman, L., Kiritsi, D., Nyström, A., Ricard‐Blum, S., Moali, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17318-w · Cited by 14 · see citing works

Bioinformatics-based identification of miRNA-, lncRNA-, and mRNA-associated ceRNA networks and potential biomarkers for preeclampsia

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Severe hemolysis after plasma transfusion in a neonate with necrotizing enterocolitis,Clostridium perfringensinfection, and red blood cell T‐polyagglutination

Klaren, J. M., Bodivit, G., Jugie, M., Chadebech, P., Chevret, L., Mokhtari, M., Chamillard, X., Gallon, P., Tissières, P., Bierling, P., et al. (2017) · Transfusion · doi:10.1111/trf.14196 · Cited by 12 · see citing works

Cervicovaginal Complement Activation and Microbiota During Pregnancy and in Parturition

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A soft tick Ornithodoros moubata salivary protein OmCI is a potent inhibitor to prevent avian complement activation

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Understanding rare genetic variants within the terminal pathway of complement system in preeclampsia

Lokki, A. I., Triebwasser, M. P., Daly, E., The FINNPEC Core Investigator Group, Heinonen, S. T., Kajantie, E., Kere, J., Kivinen, K., Pouta, A., Kurki, M., et al. (2024) · Genes and Immunity · doi:10.1038/s41435-024-00310-6 · Cited by 12 · see citing works

How Lutzomyia longipalpis deals with the complement system present in the ingested blood: The role of soluble inhibitors and the adsorption of factor H by midgut

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Bioactive Carbohydrates, Biological Activities, and Sources

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Genetic analysis of CFH and MCP in Egyptian patients with immune-complex proliferative glomerulonephritis

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Loss of CFHR5 function reduces the risk for age-related macular degeneration

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Quantification of Factor H Mediated Self vs. Non-self Discrimination by Mathematical Modeling

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The bittersweet taste of tubulo-interstitial glycans

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Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration

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The 4 functional segments of Factor H: Role in physiological target recognition and contribution to disease

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Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton

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Chemical-mediated virulence: the effects of host chemicals on microbial virulence and potential new antivirulence strategies

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Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

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Anti-complement factor H (CFH) autoantibodies could delay pristane-induced lupus nephritis

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Group B Streptococcus Surface Protein β: Structural Characterization of a Complement Factor H–Binding Motif and Its Contribution to Immune Evasion

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Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade

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Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis

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An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration

Biggs, R. M., Makou, E., Lauder, S., Herbert, A. P., Barlow, P. N., & Katti, S. K. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.12.30 · Cited by 4 · see citing works

Factor H-related protein 1 in systemic lupus erythematosus

Kleer, J. S., Klehr, J., Dubler, D., Infanti, L., Chizzolini, C., Huynh‐Do, U., Ribi, C., & Trendelenburg, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1447991 · Cited by 4 · see citing works

Contribution of functional and quantitative genetic variants of Complement Factor H and Factor H-Related (FHR) proteins on renal pathology

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Pregnancy-related Thrombotic Microangiopathy has a spectrum of underlying causes

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Contribución de variantes funcionales y cuantitativas del Factor H y las proteínas FHRs (Factor H-Related proteins) del Complemento en patología renal

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Microbial complement evasion and vaccine development

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The impact of complement factor H-related protein gene deletions on kidney transplantationPreprint

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Discovery and characterization of vertebrate sialoglycan-binding proteins

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Complement therapeutic factor H-IgG proteins as pre-exposure prophylaxes against Lyme borreliae infections

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A key regulator of missing-self innate immunity is polymorphic and under diversifying selection

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Factor H-related proteins as a protective evolutionary mechanism against microbial infections

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Glycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation

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Papel da serinoprotease Sat na patogênese da sepse causada por Escherichia coli.

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Charakterisierung von Komplementinteragierenden Proteinen von Borrelia recurrentis und Entwicklung spezifischer Immunoassays für die Serodiagnostik des epidemischen Läuserückfallfiebers

Röttgerding, F. (2023) · doi:10.21248/gups.75305

Where Does Biomimetic Membrane Technology Fit into Biological Engineering?

Martin, D. K., & Vilgrain, I. (2025) · Springer eBooks · doi:10.1007/978-3-031-90594-0_4

Biological engineering as an approach to construct smart nanostructured systems

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Antifactor H Autoantibody Characterization in Atypical Hemolytic Uremic Syndrome

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Reflecting on chiral chimeric cancer and microbes: ambidextrous metabolism—the real danger?

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The Impact of Complement Factor H‐Related Protein Gene Deletions on Kidney Transplantation

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Towards antibody-based immunotherapy development for platinum-resistant high-grade serous ovarian cancer

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Mechanisms of complement subversion in infection & cancer

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Molecular Mechanisms of Target Recognition in an Innate Immune System: Interactions Among Factor H, C3b, and Target in the Alternative Pathway of Human Complement

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Dual interaction of factor H with C3d and glycosaminoglycans in host–nonhost discrimination by complement

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The lectin self of complement factor H

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Complement control protein factor H: The good, the bad, and the inadequate

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