The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
Open accessAbstract
Mitochondria are essential organelles within the cell where most ATP is produced through oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are encoded by the mitochondrial DNA (mt DNA). One consequence of OXPHOS is the production of mitochondrial reactive oxygen species (ROS), whose role in mediating cellular damage, particularly in damaging mt DNA during ageing, has been controversial. There are subsets of neurons that appear to be more sensitive to ROS‐induced damage, and mitochondrial dysfunction has been associated with several neurodegenerative disorders. In this review, we will discuss the current knowledge in the field of mt DNA and neurodegeneration, the debate about ROS as a pathological or beneficial contributor to neuronal function, bona fide mt DNA diseases, and insights from mouse models of mt DNA defects affecting the central nervous system.
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Cites
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Cited by
Juan, C. A., Pérez de la Lastra, J. M., Plou, F. J., & Pérez-Lebeña, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094642 · Cited by 2,810
The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders
Tarafdar, A., & Pula, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123824 · Cited by 373
Mitochondrial dysfunction in aging
Guo, Y., Guan, T., Shafiq, K., Yu, Q., Jiao, X., Na, D., Li, M., Zhang, G., & Kong, J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101955 · Cited by 339
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Aging of the cells: Insight into cellular senescence and detection Methods.
Mohamad Kamal, N. S., Safuan, S., Shamsuddin, S., & Foroozandeh, P. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151108 · Cited by 287
Metadata
- Authors
- Nissanka, N., & Moraes, C. T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2018-01-09
- Volume
- 592
- Issue
- 5
- Pages
- 728-742
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2776177791
- Cited by
- 444
- References
- 140
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
