The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
Mitochondrial dysfunction in aging
Abstract
Aging is a complex process that features a functional decline in many organelles. Although mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of mitochondrial quality control (MQC) in aging is still poorly understood. A growing body of evidence points out that reactive oxygen species (ROS) stimulates mitochondrial dynamic changes and accelerates the accumulation of oxidized by-products through mitochondrial proteases and mitochondrial unfolded protein response (UPRmt). Mitochondrial-derived vesicles (MDVs) are the first line of MQC to dispose of oxidized derivatives. Besides, mitophagy helps remove partially damaged mitochondria to ensure that mitochondria are healthy and functional. Although abundant interventions on MQC have been explored, over-activation or inhibition of any type of MQC may even accelerate abnormal energy metabolism and mitochondrial dysfunction-induced senescence. This review summarizes mechanisms essential for maintaining mitochondrial homeostasis and emphasizes that imbalanced MQC may accelerate cellular senescence and aging. Thus, appropriate interventions on MQC may delay the aging process and extend lifespan.
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Cited by
Application of Antioxidant Compounds in Bone Defect Repair
Wang, J., Zhang, Y., Tang, Q., Zhang, Y., Yin, Y., & Chen, L. (2024) · Antioxidants · doi:10.3390/antiox13070789 · Cited by 39
Metadata
- Authors
- Guo, Y., Guan, T., Shafiq, K., Yu, Q., Jiao, X., Na, D., Li, M., Zhang, G., & Kong, J.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 88
- Pages
- 101955
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W4376604893
- Cited by
- 339
- References
- 219
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guo, Y., Guan, T., Shafiq, K., Yu, Q., Jiao, X., Na, D., Li, M., Zhang, G., & Kong, J. (2023). Mitochondrial dysfunction in aging. Ageing Research Reviews. https://doi.org/10.1016/j.arr.2023.101955
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