The DOI matches its Crossref record; 174 of the 175 references it cites were found in a registry or an index.
Noncoding RNA s in disease
Open accessAbstract
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (mi RNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of mi RNA s and long noncoding RNA s in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches.
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“ncRNAs may influence the pathophysiology of depression by regulating neuronal function, neurotransmitter release, and microglia (Fig. 4).213,221,222”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [213]
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“noncoding RNAs (ncRNAs), which do not code for peptides or proteins.213,214”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [213]
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RetractedThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Metadata
- Authors
- Lekka, E., & Hall, J.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Hall, Jonathan
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2018-07-20
- Volume
- 592
- Issue
- 17
- Pages
- 2884-2900
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- PMC
- PMC6174949
- OpenAlex
- W2810324767
- Cited by
- 251
- References
- 175
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 18 · 2023: 50 · 2022: 47 · 2021: 48 · 2020: 35 · 2019: 27 · 2018: 9
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- FEBS Letters (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Funders
- Krebsforschung Schweiz (KLS-3816-02-2016)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- non-coding RNA, microRNA, long non-coding RNA, disease pathophysiology, cancer, cardiovascular disease, neurological disorders, therapeutic target
- MeSH terms
- Cardiovascular Diseases, Gene Expression Regulation, Humans, Neoplasms, Nervous System Diseases, Genetic Predisposition to Disease, RNA, Untranslated, Genetic Association Studies, RNA, Long Noncoding
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