The DOI matches its Crossref record; 174 of the 175 references it cites were found in a registry or an index.
Noncoding RNA s in disease
Open accessAbstract
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (mi RNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of mi RNA s and long noncoding RNA s in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches.
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“ncRNAs may influence the pathophysiology of depression by regulating neuronal function, neurotransmitter release, and microglia (Fig. 4).213,221,222”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [213]
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“noncoding RNAs (ncRNAs), which do not code for peptides or proteins.213,214”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [213]
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1 retracted
Li, B., Lü, Y., Wang, H., Han, X., Mao, J., Li, J., Yu, L., Wang, B., Fan, S., Yu, X., et al. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.01.045 · Cited by 91
RetractedThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Gupta, R. A., Shah, N., Wang, K., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,205
Origins and Mechanisms of miRNAs and siRNAs
Carthew, R. W., & Sontheimer, E. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.035 · Cited by 5,161
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Research works printed but not linked: 1
- 10.5732/cjc.30.0371 · DOI
Cited by
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Friedrich, M., & Aigner, A. M. (2022) · BioDrugs · doi:10.1007/s40259-022-00549-3 · Cited by 428
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
Parama, D., Boruah, M., Yachna, K., Rana, V., Banik, K., Harsha, C., Thakur, K. K., Dutta, U., Arya, A., Mao, X., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118182 · Cited by 155
MicroRNAs in Alzheimer’s Disease: Diagnostic Markers or Therapeutic Agents?
Angelucci, F., Čechová, K., Vališ, M., Kuča, K., Zhang, B., & Hort, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00665 · Cited by 145
Metadata
- Authors
- Lekka, E., & Hall, J.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Hall, Jonathan
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2018-07-20
- Volume
- 592
- Issue
- 17
- Pages
- 2884-2900
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- PMC
- PMC6174949
- OpenAlex
- W2810324767
- Cited by
- 251
- References
- 175
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 18 · 2023: 50 · 2022: 47 · 2021: 48 · 2020: 35 · 2019: 27 · 2018: 9
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- FEBS Letters (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Funders
- Krebsforschung Schweiz (KLS-3816-02-2016)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- non-coding RNA, microRNA, long non-coding RNA, disease pathophysiology, cancer, cardiovascular disease, neurological disorders, therapeutic target
- MeSH terms
- Cardiovascular Diseases, Gene Expression Regulation, Humans, Neoplasms, Nervous System Diseases, Genetic Predisposition to Disease, RNA, Untranslated, Genetic Association Studies, RNA, Long Noncoding
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