Cited by 251Cancer-related molecular mechanisms researchMicroRNA in disease regulationRNA Research and Splicing

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Noncoding RNA s in disease

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Lekka, Evangelia, Hall, Jonathan·2018·FEBS Letters

DOI 10.1002/1873-3468.13182PMC PMC6174949

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Abstract

Noncoding RNA s are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (mi RNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of mi RNA s and long noncoding RNA s in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches.

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Figure 1 The individual steps of miRNA biogenesis.CC BY · PubMed Central

Figure 2 LncRNAs show a wide variety of functions.CC BY · PubMed Central

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Authors: Lekka, E., & Hall, J.
Affiliations: ETH Zurich (CH)
Corresponding author: Hall, Jonathan
ORCID: Lekka, Evangelia
Hall, Jonathan
Venue: FEBS Letters
Publisher: Wiley
Published: 2018-07-20
Volume: 592
Issue: 17
Pages: 2884-2900
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1002/1873-3468.13182
PMC: PMC6174949
OpenAlex: W2810324767
Cited by: 251
References: 175
Citations by year: 2026: 5 · 2025: 11 · 2024: 18 · 2023: 50 · 2022: 47 · 2021: 48 · 2020: 35 · 2019: 27 · 2018: 9
FWCI: 3.09
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: FEBS Letters (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
ETH Zürich Research Collection (cc-by)
Funders: Krebsforschung Schweiz (KLS-3816-02-2016)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: non-coding RNA, microRNA, long non-coding RNA, disease pathophysiology, cancer, cardiovascular disease, neurological disorders, therapeutic target
MeSH terms: Cardiovascular Diseases, Gene Expression Regulation, Humans, Neoplasms, Nervous System Diseases, Genetic Predisposition to Disease, RNA, Untranslated, Genetic Association Studies, RNA, Long Noncoding

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