Compositional and functional features of the female premenopausal and postmenopausal gut microbiota
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Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome‐wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp . are depleted, while Bacteroidetes and the toluene‐producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis‐related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.
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Menopause reshapes the community: premenopausal women display higher Firmicutes-to-Bacteroidetes ratios and higher levels of Roseburia, whereas the post-menopausal decline in estrogen is accompanied by lower diversity and expansions of taxa linked to cardiometabolic risk.
“Menopause further reshapes the community: premenopausal women display higher Firmicutes-to-Bacteroidetes ratios and higher levels of Roseburia, whereas the post-menopausal decline in estrogen is accompanied by lower diversity and expansions of taxa linked to cardiometabolic risk.48–50”
From Gut dysbiosis in oncology: a risk factor for immunoresistance (2026) · cites this paper as [50]
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- Authors
- Zhao, H., Chen, J., Li, X., Sun, Q., Qin, P., & Wang, Q.
- Affiliations
- BGI Group (China) (CN)
- University of Toronto (CA)
- Corresponding author
- Wang, Qi
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2019-07-17
- Volume
- 593
- Issue
- 18
- Pages
- 2655-2664
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2956063300
- Cited by
- 138
- References
- 50
- Citations by year
- 2026: 20 · 2025: 27 · 2024: 23 · 2023: 17 · 2022: 28 · 2021: 19 · 2020: 3
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shenzhen Government
- Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20160229172757249, JCYJ20170817145523036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, menopause, postmenopausal women, premenopausal women, estrogen deficiency, Firmicutes, Roseburia, Bacteroidetes, pentose phosphate pathway, microbial metabolites, metagenome-wide association study
- MeSH terms
- Gastrointestinal Microbiome, Female, Humans, Middle Aged, Phenotype, Quality of Life, Premenopause, Postmenopause
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