Cited by 139Gut microbiota and healthMenopause: Health Impacts and TreatmentsOral microbiology and periodontitis research

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

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Zhao, Hui, Chen, Juanjuan, Li, Xiaoping, Sun, Qiang, Qin, Panpan, Wang, Qi·2019·FEBS Letters

Abstract

Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome‐wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp . are depleted, while Bacteroidetes and the toluene‐producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis‐related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.

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  • Menopause reshapes the community: premenopausal women display higher Firmicutes-to-Bacteroidetes ratios and higher levels of Roseburia, whereas the post-menopausal decline in estrogen is accompanied by lower diversity and expansions of taxa linked to cardiometabolic risk.

    “Menopause further reshapes the community: premenopausal women display higher Firmicutes-to-Bacteroidetes ratios and higher levels of Roseburia, whereas the post-menopausal decline in estrogen is accompanied by lower diversity and expansions of taxa linked to cardiometabolic risk.48–50”

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Authors
Zhao, H., Chen, J., Li, X., Sun, Q., Qin, P., & Wang, Q.
Affiliations
  • BGI Group (China) (CN)
  • University of Toronto (CA)
Corresponding author
Wang, Qi
Venue
FEBS Letters
Publisher
Wiley
Published
2019-07-17
Volume
593
Issue
18
Pages
2655-2664
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2956063300
Cited by
138
References
50
Citations by year
2026: 20 · 2025: 27 · 2024: 23 · 2023: 17 · 2022: 28 · 2021: 19 · 2020: 3
FWCI
4.22
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Shenzhen Government
  • Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20160229172757249, JCYJ20170817145523036)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
gut microbiota, menopause, postmenopausal women, premenopausal women, estrogen deficiency, Firmicutes, Roseburia, Bacteroidetes, pentose phosphate pathway, microbial metabolites, metagenome-wide association study
MeSH terms
Gastrointestinal Microbiome, Female, Humans, Middle Aged, Phenotype, Quality of Life, Premenopause, Postmenopause

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