The DOI matches its Crossref record; 197 of the 197 references it cites were found in a registry or an index.
Determinants of metastatic competency in colorectal cancer
Open accessAbstract
Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early‐stage disease has significantly improved over the last decades, the mechanisms underlying metastasis – the main cause of death – remain poorly understood. Correspondingly, no effective therapy is currently available for advanced or metastatic disease. There is increasing evidence that colorectal cancer is hierarchically organized and sustained by cancer stem cells, in concert with various stromal cell types. Here, we review the interplay between cancer stem cells and their microenvironment in promoting metastasis and discuss recent insights relating to both patient prognosis and novel targeted treatment strategies. A better understanding of these topics may aid the prevention or reduction of metastatic burden.
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TGF-β signaling in health and disease
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Metadata
- Authors
- Tauriello, D. V. F., Calon, A., Lonardo, E., & Batlle, E.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 11
- Issue
- 1
- Pages
- 97-119
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W2571903415
- Cited by
- 258
- References
- 197
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tauriello, D. V. F., Calon, A., Lonardo, E., & Batlle, E. (2017). Determinants of metastatic competency in colorectal cancer. Molecular Oncology. https://doi.org/10.1002/1878-0261.12018
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
