Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology

Millán, José Luis

doi:10.1002/3527608060

Cited by 421Alkaline Phosphatase Research StudiesBone and Dental Protein StudiesBiochemical and Molecular Research

Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology

Millán, José Luis·2006·Wiley eBooks

DOI 10.1002/3527608060

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Abstract

PART I: GENE AND PROTEIN STRUCTURE 1 Gene Structure 2 Developmental Expression 3 Gene Regulation 4 Protein Structure and Functional Domains 5 Enzymatic Properties 6 Epitope Maps PART II: IN VIVO FUNCTIONS 7 The In Vivo Role of TNAP 8 Knockout Mouse Models PART III: AP EXPRESSION IN HEALTH AND DISEASE 9 APs as Physiological and Disease Markers 10 Neoplastic Expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP Isozymes PART IV: USES OF APS IN INDUSTRY AND BIOTECHNOLOGY 11 Applications of Recombinant APs 12 Use of APs in Prodrug Converting Strategies 13 APs as Therapeutic Agents 14 APs in the Food Industry 15 Veterinary Uses of AP Determinations 16 Methodologies

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Phosphatase enzymes such as alkaline phosphatase accelerate polyphosphate depolymerization.
“Although polyP depolymerization is thermodynamically favored in aqueous environments, the kinetics are slow at neutral pH [29], but accelerated by phosphatase enzymes such as alkaline phosphatase (APase) [30].”
From A Review of Phosphate Mineral Nucleation in Biology and Geobiology (2013) · cites this paper as [30]

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Authors: Millán, J. L.
Venue: Wiley eBooks
Publisher: Wiley
Published: 2006-01-09
DOI: 10.1002/3527608060
OpenAlex: W625374770
Cited by: 421
References: 91
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 17 · 2020: 31 · 2019: 31 · 2018: 20 · 2017: 24 · 2016: 23 · 2015: 30 · 2014: 24 · 2013: 23 · 2012: 14
FWCI: 32.05
Type: book
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Wiley eBooks (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: tissue-nonspecific alkaline phosphatase, placental alkaline phosphatase, GCAP, IAP, isozymes, gene structure, developmental gene expression, gene expression regulation, protein structure, enzyme properties, epitope mapping, knockout mouse models, disease markers, prodrug activation, therapeutic enzymes, food industry applications, veterinary diagnostics

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Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology

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