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Enzymology of Nad + Synthesis
Abstract
Beyond its role as an essential coenzyme in numerous oxidoreductase reactions as well as respiration, there is growing recognition that NAD+ fulfills many other vital regulatory functions both as a substrate and as an allosteric effector. This review describes the enzymes involved in pyridine nucleotide metabolism, starting with a detailed consideration of the anaerobic and aerobic pathways leading to quinolinate, a key precursor of NAD+. Conversion of quinolinate and 5'-phosphoribosyl-1'-pyrophosphate to NAD+ and diphosphate by phosphoribosyltransferase is then explored before proceeding to a discussion the molecular and kinetic properties of NMN adenylytransferase. The salient features of NAD+ synthetase as well as NAD+ kinase are likewise presented. The remainder of the review encompasses the metabolic steps devoted to (a) the salvaging of various niacin derivatives, including the roles played by NAD+ and NADH pyrophosphatases, nicotinamide deamidase, and NMN deamidase, and (b) utilization of niacins by nicotinate phosphoribosyltransferase and nicotinamide phosphoribosyltransferase.
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Holm, L., & Sander, C. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1489 · Cited by 3,984
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Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.003 · Cited by 911
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Metadata
- Authors
- Magni, G., Amici, A., Emanuelli, M., Raffaelli, N., & Ruggieri, S.
- Venue
- Advances in Enzymology - and Related Areas of Molecular Biology
- Publisher
- Wiley
- Published
- 1999-01
- Volume
- 73
- Pages
- 135-182
- ISSN
- 0065-258X (ISSN-L)
- 1934-4694
- OpenAlex
- W1486865933
- Cited by
- 235
- References
- 1
- Type
- other
- Language
- en
- Open access
- closed
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- Magni, G., Amici, A., Emanuelli, M., Raffaelli, N., & Ruggieri, S. (1999). Enzymology of Nad + Synthesis. Advances in Enzymology - and Related Areas of Molecular Biology. https://doi.org/10.1002/9780470123195.ch5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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