Microbial tryptophan catabolites in health and disease
Open accessAbstract
Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These metabolites are suggested to activate the immune system through binding to the aryl hydrocarbon receptor (AHR), enhance the intestinal epithelial barrier, stimulate gastrointestinal motility, as well as secretion of gut hormones, exert anti-inflammatory, anti-oxidative or toxic effects in systemic circulation, and putatively modulate gut microbial composition. Tryptophan catabolites thus affect various physiological processes and may contribute to intestinal and systemic homeostasis in health and disease.
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Healthy ageing correlates with increased indoles, gut bacterial tryptophan degradation products that mediate immune homeostasis via aryl hydrocarbon and IL-10 receptors.
“healthy ageing correlates with an increased presence of certain indoles, which are gut bacterial degradation products of tryptophan that mediate immune homeostasis upon binding to aryl hydrocarbon receptors and IL-10 receptors15–17”
From Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy (2023) · cites this paper as [15]
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- Authors
- Roager, H. M., & Licht, T. R.
- Affiliations
- University of Copenhagen (DK)
- Technical University of Denmark (DK)
- Corresponding author
- Roager, Henrik M.
- Licht, Tine R.
- Venue
- Nature Communications
- Published
- 2018-08-17
- Volume
- 9
- Issue
- 1
- Pages
- 3294-3294
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6098093
- OpenAlex
- W2886401819
- Cited by
- 2,236
- References
- 121
- Citations by year
- 2026: 414 · 2025: 402 · 2024: 366 · 2023: 288 · 2022: 277 · 2021: 257 · 2020: 166 · 2019: 59 · 2018: 5 · 2017: 1
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
- Funders
- Innovationsfonden (0603‐00487B)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- tryptophan catabolites, gut microbiota, aryl hydrocarbon receptor, intestinal epithelial barrier, gastrointestinal motility, gastrointestinal hormones, anti-inflammatory activity, oxidative stress, microbial metabolites, intestinal homeostasis
- MeSH terms
- Animals, Bacteria, Digestive System, Disease, Health, Humans, Tryptophan, Receptors, Aryl Hydrocarbon
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