Mechanisms of Bone Remodeling

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244 · see citing works

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608 · see citing works

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

Cummings, S. R., Martin, J. S., McClung, M. R., Siris, E. S., Eastell, R., Reid, I. R., Delmas, P., Zoog, H. B., Austin, M., Wang, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809493 · Cited by 3,489 · see citing works

Mechanisms of Bone Metastasis

Roodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,752 · see citing works

Minireview: The OPG/RANKL/RANK System

Khosla, S. (2001) · Endocrinology · doi:10.1210/endo.142.12.8536 · Cited by 1,515 · see citing works

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · see citing works

Tetracycline-based histological analysis of bone remodeling

Frost, H. M. (1969) · Calcified Tissue Research · doi:10.1007/bf02058664 · Cited by 1,111 · see citing works

Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,086 · see citing works

Cellular mechanisms of bone remodeling

Eriksen, E. F. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9153-1 · Cited by 824 · see citing works

Wnt signaling in osteoblasts and bone diseases

Westendorf, J. J., Kahler, R. A., & Schroeder, T. M. (2004) · Gene · doi:10.1016/j.gene.2004.06.044 · Cited by 805 · see citing works

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

Padhi, D., Jang, G. R., Stouch, B., Fang, L., & Posvar, E. L. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.173 · Cited by 786 · see citing works

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works

Prevention of spinal osteoporosis in oophorectomised women

Lindsay, R., Hart, D. M., Forrest, C., & Baird, C. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92592-1 · Cited by 706 · see citing works

SOST is a target gene for PTH in bone

Keller, H., & Kneissel, M. (2005) · Bone · doi:10.1016/j.bone.2005.03.018 · Cited by 618 · see citing works

Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease.

ERIKSEN, E. F. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-4-379 · Cited by 601 · see citing works

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bonePreprint

Murshed, M., Harmey, D., Millán, J. L., McKee, M. D., & Karsenty, G. (2005) · Genes & Development · doi:10.1101/gad.1276205 · Cited by 599 · see citing works

Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone

Robinson, J. A., Chatterjee‐Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y. P., Sauter, L., Babij, P., Brown, E. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602308200 · Cited by 522 · see citing works

Networks and hubs for the transcriptional control of osteoblastogenesis

Lian, J. B., Stein, G. S., Javed, A., van Wijnen, A. J., Stein, J. L., Montecino, M. A., Hassan, M. Q., Gaur, T., Lengner, C. J., & Young, D. W. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9001-5 · Cited by 469 · see citing works

Circulating Osteoblast-Lineage Cells in Humans

Eghbali-Fatourechi, G. Z., Lamsam, J., Fraser, D., Nagel, D., Riggs, B. L., & Khosla, S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044264 · Cited by 418 · see citing works

Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic Markers

Hauge, E. M., Qvesel, D., Eriksen, E. F., Mosekilde, L., & Melsen, F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1575 · Cited by 397 · see citing works

Beta-Catenin Signaling Plays a Disparate Role in Different Phases of Fracture Repair: Implications for Therapy to Improve Bone Healing

Chen, Y., Whetstone, H., Lin, A. C., Nadesan, P., Wei, Q., Poon, R. W. M., & Alman, B. A. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040249 · Cited by 391 · see citing works

Outpatient Waiting Time

DEBONO, E. F. (1963) · The Lancet · doi:10.1016/s0140-6736(63)90800-6 · Cited by 370 · see citing works

Cancellous bone remodeling in type i (postmenopausal) osteoporosis: Quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels

Eriksen, E. F., Hodgson, S. F., Eastell, R., Riggs, B., Cedel, S. L., & O’Fallon, W. M. (1990) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650050402 · Cited by 366 · see citing works

Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue

Cardoso, L., Herman, B. C., Verborgt, O., Laudier, D., Majeska, R. J., & Schaffler, M. B. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081210 · Cited by 340 · see citing works

Vascular Biology and the Skeleton

Brandi, M. L., & Collin‐Osdoby, P. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050917 · Cited by 334 · see citing works

Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro

Spencer, G. J., Utting, J. C., Etheridge, S. L., Arnett, T. R., & Genever, P. G. (2006) · Journal of Cell Science · doi:10.1242/jcs.02883 · Cited by 334 · see citing works

Perspectives bone histomorphometry in glucocorticoid-induced osteoporosis

Dempster, D. W. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040202 · Cited by 319 · see citing works

Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling

Ryu, J., Kim, H. J., Chang, E., Huang, H., Banno, Y., & Hong‐Hee, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601430 · Cited by 318 · see citing works

Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis.

Pacifici, R., Rifas, L., Teitelbaum, S. L., Slatopolsky, E., McCracken, R., Bergfeld, M. A., Lee, W., Avioli, L. V., & Peck, W. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.13.4616 · Cited by 303 · see citing works

Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation

van Bezooijen, R. L., Svensson, J. P., Eefting, D., Visser, A., van der Horst, G., Karperien, M., Quax, P. H. A., Vrieling, H., Papapoulos, S. E., ten Dijke, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061002 · Cited by 283 · see citing works

Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females

Recker, R. R., Kimmel, D. B., Parfitt, M. A., Davies, M. K., Keshawarz, N. M., & Hinders, S. M. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030203 · Cited by 277 · see citing works

Effects of denosumab on bone histomorphometry: The FREEDOM and STAND studies

Reid, I. R., Miller, P. D., Brown, J. P., Kendler, D. L., Fahrleitner‐Pammer, A., Valter, I., Maasalu, K., Bolognese, M. A., Woodson, G. C., Bone, H. G., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.149 · Cited by 250 · see citing works

Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?

Karsdal, M. A., Martin, T. J., Bollerslev, J., Christiansen, C., & Henriksen, K. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070109 · Cited by 242 · see citing works

Reconstruction of the resorptive site in iliac trabecular bone: A kinetic model for bone resorption in 20 normal individuals

Eriksen, E. F., Melsen, F., & Mosekilde, L. (1984) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(84)90065-1 · Cited by 196 · see citing works

A randomized study on the effects of estrogen/gestagen or high dose oral calcium on trabecular bone remodeling in postmenopausal osteoporosis

Steiniche, T., Hasling, C., Charles, P., Eriksen, E. F., Mosekilde, L., & Melsen, F. (1989) · Bone · doi:10.1016/8756-3282(89)90126-9 · Cited by 192 · see citing works

Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing a kinetic model for matrix and mineral apposition

Eriksen, E. F., Gundersen, H. J. G., Melsen, F., & Mosekilde, L. (1984) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(84)90066-3 · Cited by 191 · see citing works

TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro

Hens, J. R., Wilson, K. M., Dann, P. R., Chen, X., Horowitz, M. C., & Wysolmerski, J. J. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050210 · Cited by 185 · see citing works

Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone

Tombran‐Tink, J., & Barnstable, C. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.076 · Cited by 163 · see citing works

Gene Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblasts Revealed by Microarray and Bioinformatics

Qin, L., Qiu, P., Wang, L., Li, X., Swarthout, J. T., Soteropoulos, P., Tolias, P. P., & Partridge, N. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212226200 · Cited by 161 · see citing works

Hormone Replacement Therapy Prevents Osteoclastic Hyperactivity: A Histomorphometric Study in Early Postmenopausal Women

Eriksen, E. F., Langdahl, B. L., Vesterby, A., Rungby, J., & Kassem, M. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1217 · Cited by 151 · see citing works

Demonstration of cellular aging and senescence in serially passaged long-term cultures of human trabecular osteoblasts

Kassem, M. S., Ankersen, L., Eriksen, E. F., Clark, B. F. C., & Rattan, S. I. S. (1997) · Osteoporosis International · doi:10.1007/bf02652556 · Cited by 131 · see citing works

A quantitative evaluation of osteoblast-osteocyte relationships on growing endosteal surface of rabbit tibiae

Marotti, G., Ferretti, M., Muglia, M. A., Palumbo, C., & Palazzini, S. (1992) · Bone · doi:10.1016/8756-3282(92)90452-3 · Cited by 111 · see citing works

Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat

Silvestrini, G., Ballanti, P., Patacchioli, F. R., Leopizzi, M., Gualtieri, N., Monnazzi, P., Tremante, E., Sardella, D., & BONUCCI, E. (2005) · The Histochemical Journal · doi:10.1007/s10735-004-3839-1 · Cited by 105 · see citing works

Osteoclast Deficiency Results in Disorganized Matrix, Reduced Mineralization, and Abnormal Osteoblast Behavior in Developing Bone

Dai, X.-M., Zong, X.-H., Akhter, M. P., & Stanley, E. R. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040514 · Cited by 105 · see citing works

A reconstruction of the remodelling cycle in normal human cortical iliac bone

Agerbæk, M., Eriksen, E. F., Kragstrup, J., Mosekilde, L., & Melsen, F. (1991) · Bone and Mineral · doi:10.1016/0169-6009(91)90039-3 · Cited by 105 · see citing works

rhBMP-2, rhVEGF165, rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells

Li, G., Cui, Y., McIlmurray, L., et al. (2005) · Journal of Orthopaedic Research® · doi:10.1016/j.orthres.2004.12.005 · Cited by 95 · see citing works

Insulin-Like Growth Factor System Components and the Coupling of Bone Formation to Resorption

Mohan, S., & Baylink, D. J. (2008) · Hormone Research · doi:10.1159/000184833 · Cited by 83 · see citing works

Myeloma cell‐induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast‐myeloma hybrid cells

Andersen, T. L., Søe, K., Søndergaard, T. E., Plesner, T., & Delaissé, J. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07980.x · Cited by 80 · see citing works

Formation of osteoblast‐like cells from human mononuclear bone marrow cultures

Kassem, M. S., Risteli, L., Mosekilde, L., Melsen, F., & Eriksen, E. F. (1991) · Apmis · doi:10.1111/j.1699-0463.1991.tb05149.x · Cited by 74 · see citing works

Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases

Polascik, T. J. (2008) · Drug Design Development and Therapy · doi:10.2147/dddt.s3169 · Cited by 64 · see citing works

Osteocytes as multifunctional cells.

Bonewald, L. F. (2006) · PubMed · Cited by 60 · see citing works

Endothelin-1 down-regulates the expression of vascular endothelial growth factor-A associated with osteoprogenitor proliferation and differentiation

Veillette, C., & von Schroeder, H. P. (2003) · Bone · doi:10.1016/j.bone.2003.10.009 · Cited by 53 · see citing works

Osteocyte biology: its implications for osteoporosis.

Bonewald, L. F. (2004) · PubMed · Cited by 52 · see citing works

Neovascularization and mandibular condylar bone remodeling in adult rats under mechanical strain

Xiong, H. (2005) · Frontiers in bioscience · doi:10.2741/1508 · Cited by 46 · see citing works

The Excess Risk of Major Osteoporotic Fractures in Hypothyroidism Is Driven by Cumulative Hyperthyroid as Opposed to Hypothyroid Time: An Observational Register-Based Time-Resolved Cohort Analysis

Abrahamsen, B., Jørgensen, H. L., Laulund, A. S., Nybo, M., Bauer, D. C., Brix, T. H., & Hegedüs, L. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2416 · Cited by 98 · see citing works

An inhibitory role for caspase‐3 at the late stage of RANKL‐induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages

Katao, Y., Shishido, M., Inami, K., Matsumoto, N., & Sawai, H. (2014) · Cell Biology International · doi:10.1002/cbin.10263 · Cited by 4 · see citing works

64Cu-RGD and microPET/CT as an imaging biomarker for osteoclast number in mouse models of negative and positive osteoclast regulation

Zheleznyak, A., Wadas, T. J., Sherman, C., et al. (2009) · Journal of Nuclear Medicine

The effects of tumor necrosis factor-α on osteoclast formation depend on the haematopoietic precursors

Portenier, J., Dolder, S., Wetterwald, A., et al. (2006) · Bone · doi:10.1016/j.bone.2006.01.113

Inhibitory Effect of Agrocybe Chaxingu (Chaxines) on RANKL-Induced Osteoclast Differentiation in RAW246.7 Cells: Possible Prevention of Osteoporosis

Konno, S., Elyaguov, J., Dixon, A., et al. (2022) · American Journal of Medical and Clinical Sciences · doi:10.33425/2832-4226/22005 · Cited by 1 · see citing works

RANKL as the master regulator of osteoclast differentiation

Takayanagi, H. (2021) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01191-1 · Cited by 175 · see citing works