Cited by 180Musculoskeletal pain and rehabilitationOsteoarthritis Treatment and MechanismsLower Extremity Biomechanics and Pathologies

Prognosis of pain and physical functioning in patients with knee osteoarthritis: a systematic review and meta-analysis

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de Rooij, Mariëtte, van der Leeden, Marike, Heymans, Martijn W., Holla, Jasmijn F. M., Häkkinen, Arja, Lems, Willem F., Roorda, Leo D., Veenhof, Cindy +3 more·2016·Arthritis Care & Research

Abstract

Objective: To systematically summarize the literature on the course of pain in patients with knee osteoarthritis (OA), prognostic factors that predict deterioration of pain, the course of physical functioning, and prognostic factors that predict deterioration of physical functioning in persons with knee OA. Methods: A search was conducted in PubMed, CINAHL, Embase, Psych‐INFO, and SPORTDiscus up to January 2014. A meta‐analysis and a qualitative data synthesis were performed. Results: Of the 58 studies included, 39 were of high quality. High heterogeneity across studies (I 2 >90%) and within study populations (reflected by large SDs of change scores) was found. Therefore, the course of pain and physical functioning was interpreted to be indistinct. We found strong evidence for a number of prognostic factors predicting deterioration in pain (e.g., higher knee pain at baseline, bilateral knee symptoms, and depressive symptoms). We also found strong evidence for a number of prognostic factors predicting deterioration in physical functioning (e.g., worsening in radiographic OA, worsening of knee pain, lower knee extension muscle strength, lower walking speed, and higher comorbidity count). Conclusion: Because of high heterogeneity across studies and within study populations, no conclusions can be drawn with regard to the course of pain and physical functioning. These findings support current research efforts to define subgroups or phenotypes within knee OA populations. Strong evidence was found for knee characteristics, clinical factors, and psychosocial factors as prognostics of deterioration of pain and physical functioning.

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Crossref · 10.1002/acr.22693

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  • A 3-decade prospective study suggests that PTSD symptoms amplify the predictive effect of child abuse on later-life pain outcomes.

    “results of a 3-decade prospective study suggest the presence of PTSD symptoms amplify the predictive effect of child abuse on later-life pain outcomes 77.”

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Authors
de Rooij, M., van der Leeden, M., Heymans, M. W., Holla, J. F. M., Häkkinen, A., Lems, W. F., Roorda, L. D., Veenhof, C., Sanchez‐Ramirez, D. C., de Vet, H. C. W., & Dekker, J.
Affiliations
  • Amsterdam Rehabilitation Research Centre Reade Amsterdam The Netherlands
  • Amsterdam Rehabilitation Research Centre, Reade, and VU University Medical Centre, EMGO Institute Amsterdam The Netherlands
  • Amsterdam Public Health (NL)
  • Reade (NL)
  • University of Jyväskylä (FI)
  • University Medical Center Utrecht (NL)
  • University of Alberta (CA)
  • VU University Medical Centre, EMGO Institute Amsterdam The Netherlands
Venue
Arthritis Care & Research
Publisher
Wiley
Published
2016-03-24
Volume
68
Issue
4
Pages
481-492
ISSN
  • 0893-7524 (ISSN-L)
  • 2151-464X
  • 2151-4658
OpenAlex
W1880347366
Cited by
178
References
74
Citations by year
2026: 9 · 2025: 15 · 2024: 27 · 2023: 20 · 2022: 21 · 2021: 21 · 2020: 18 · 2019: 18 · 2018: 14 · 2017: 13 · 2016: 2
FWCI
1.21
Type
journal article
Language
en
Open access
Locations
  • Arthritis Care & Research (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Royal Dutch Society for Physical Therapy
Topics
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
Keywords
knee osteoarthritis, pain, physical function, prognosis, prognostic factors, depressive symptoms, radiographic progression, walking speed, comorbidities, phenotypes
MeSH terms
Biomechanical Phenomena, Female, Health Status, Humans, Knee Joint, Male, Pain Measurement, Phenotype, Prognosis, Radiography, Risk Factors, Disease Progression, Arthralgia, Osteoarthritis, Knee

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