The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution
Abstract
The characterization of near‐infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN‐TA) with the average size of 50–100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN‐TA‐ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN‐TA‐ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN‐TA‐ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN‐TA‐ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN‐TA‐ICG in major organs. This is the first report of MSN functionalized with NIR‐ICG capable of optical imaging in vivo.
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Cites
In vivo cancer targeting and imaging with semiconductor quantum dots
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In vivo near-infrared fluorescence imaging
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Mesoporous Materials for Drug Delivery
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Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
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Mesoporous silica nanoparticles deliver DNA and chemicals into plants
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In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
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Cited by
Zhao, Y., Trewyn, B. G., Slowing, I. I., & Lin, V. S.-Y. (2009) · Journal of the American Chemical Society · doi:10.1021/ja901831u · Cited by 771
Mesoporous silica nanoparticles in medicine—Recent advances
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Mesoporous silica nanoparticles for therapeutic/diagnostic applications
Jafari, S., Derakhshankhah, H., Alaei, L., Fattahi, A., Varnamkhasti, B. S., & Saboury, A. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.167 · Cited by 566
Metadata
- Authors
- Lee, C., Cheng, S., Wang, Y., Chen, Y., Chen, N., Souris, J., Chen, C., Mou, C., Yang, C., & Lo, L.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2009-01-08
- Volume
- 19
- Issue
- 2
- Pages
- 215-222
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2152081013
- Cited by
- 300
- References
- 45
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, C., Cheng, S., Wang, Y., Chen, Y., Chen, N., Souris, J., Chen, C., Mou, C., Yang, C., & Lo, L. (2009). Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution. Advanced Functional Materials. https://doi.org/10.1002/adfm.200800753
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