The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Hollow‐Core, Magnetic, and Mesoporous Double‐Shell Nanostructure: In Situ Decomposition/Reduction Synthesis, Bioimaging, and Drug‐Delivery Properties
Abstract
A novel in situ decomposition/reduction approach is developed to manufacture hollow core, magnetic, and mesoporous double‐shell nanostructures (HMMNSs) via in situ decomposition and reduction of a β‐FeOOH nanorod core and organosilicate‐incorporated silica‐shell precursor. The formed HMMNSs are then aminated by silanization for further covalent conjugation to rhodamine B isothiocyanate (RBITC) and poly(ethylene glycol) (PEG) chains. The resultant RBITC‐grafted and PEGylated nanocomposites (HMMNS–R/Ps) have excellent blood compatibility and very low cytotoxicity towards HeLa and MCF‐7 cells, and can be taken up by cancer cells effectively in a dose‐dependent manner, as confirmed by in vitro flow cytometry, confocal luminescence imaging, and magnetic resonance imaging (MRI) studies. In vivo MRI studies coupled with Prussian blue staining of slides from different organs show that the nanocomposites preferentially accumulate in liver and spleen after intravenous injection, which suggests a potential application of the nanocomposites as MRI contrast agents. Importantly, the HMMNS–R/P nanocomposites show high loading capacity for water‐insoluble anticancer drugs (docetaxel or camptothecin) owing to the presence of a large inner cavity and enhanced surface area and pore volume. Furthermore, the drug‐loaded nanocomposites exhibit greater cytotoxicity than the corresponding free drugs. These results confirm that the HMMNS–R/P nanocomposites are promising candidates for simultaneous bioimaging and drug delivery.
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Cites
Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications
Gao, J., Gu, H., & Xu, B. (2009) · Accounts of Chemical Research · doi:10.1021/ar9000026 · Cited by 1,907
Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200601191 · Cited by 1,699
Cited by
Synthesis, Properties, and Applications of Hollow Micro-/Nanostructures
Wang, X., Feng, J., Bai, Y., Zhang, Q., & Yin, Y. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00731 · Cited by 1,456
Mesoporous silica nanoparticles in drug delivery and biomedical applications
Wang, Y., Zhao, Q., Han, N., Bai, L., Li, J., Liu, J., Che, E., Hu, L., Zhang, Q., Jiang, T., et al. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2014.09.014 · Cited by 1,192
Hollow‐Structured Mesoporous Materials: Chemical Synthesis, Functionalization and Applications
Li, Y., & Shi, J. (2014) · Advanced Materials · doi:10.1002/adma.201305319 · Cited by 759
Self-citationNew forms of superparamagnetic nanoparticles for biomedical applications
Xu, C., & Sun, S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.008 · Cited by 349
Chen, Y., Chen, H.-R., & Shi, J.-L. (2014) · Accounts of Chemical Research · doi:10.1021/ar400091e · Cited by 324
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Metadata
- Authors
- Wu, H., Zhang, S., Zhang, J., Liu, G., Shi, J., Zhang, L., Cui, X., Ruan, M., He, Q., & Bu, W.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2011-04-08
- Volume
- 21
- Issue
- 10
- Pages
- 1850-1862
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2090637305
- Cited by
- 170
- References
- 2
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wu, H., Zhang, S., Zhang, J., Liu, G., Shi, J., Zhang, L., Cui, X., Ruan, M., He, Q., & Bu, W. (2011). A Hollow‐Core, Magnetic, and Mesoporous Double‐Shell Nanostructure: In Situ Decomposition/Reduction Synthesis, Bioimaging, and Drug‐Delivery Properties. Advanced Functional Materials. https://doi.org/10.1002/adfm.201002337
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