The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Design of Hybrid MnO2‐Polymer‐Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment
Abstract
Manganese dioxide (MnO 2) nanoparticles (NPs) were discovered in previous work to be effective in improving tumor oxygenation (hypoxia) and reducing H 2 O 2 and acidity in the tumor microenvironment (TME) via local injection. To develop MnO 2 formulations useful for clinical application, hybrid NPs are designed with tailored hydrophobicity and structure suitable for intravenous injection, with good blood circulation, biocompatibility, high tumor accumulation, and programmable oxygen generation rate. Two different hybrid NPs are constructed by embedding polyelectrolyte‐MnO 2 (PMD) in hydrophilic terpolymer/protein‐MnO 2 (TMD) or hydrophobic polymer/lipid‐MnO 2 (LMD) matrices. The in vitro reactivity of the MnO 2 toward H 2 O 2 is controlled by matrix material and NP structure and dependent on pH with up to two‐fold higher O 2 generation rate at acidic (tumor) pH than at systemic pH. The hybrid NPs are found to be safe to cells in vitro and organs in vivo and effectively decrease tumor hypoxia and hypoxia‐inducible‐factor‐1alpha through local or systemic administration. Fast acting TMD reduces tumor hypoxia by 70% in 0.5 h by local injection. Slow acting LMD exhibits superior tumor accumulation and retention through the systemic administration and decreased hypoxia by 45%. These findings encourage a broader use of hybrid MD NPs to overcome TME factors for cancer treatment.
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Cites
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Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
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Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707
Hypoxia, DNA repair and genetic instability
Bristow, R. G., & Hill, R. P. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2344 · Cited by 1,140
Hydrogen peroxide in the human body
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Cited by
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation
Zhu, P., Chen, Y., & Shi, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b00999 · Cited by 572
Song, G., Chen, Y., Liang, C., Yi, X., Liu, J., Sun, X., Shen, S., Yang, K., & Liu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201602111 · Cited by 394
Gong, Z., & Dai, Z. (2021) · Advanced Science · doi:10.1002/advs.202002178 · Cited by 320
Manganese salts function as potent adjuvants
Zhang, R., Wang, C., Guan, Y., Wei, X., Sha, M., Yi, M., Jing, M., Lv, M., Guo, W., Xu, J., et al. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00669-w · Cited by 313
He, T., Jiang, C., He, J., Zhang, Y., He, G., Wu, J., Lin, J., Zhou, X., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202008540 · Cited by 304
Metadata
- Authors
- Gordijo, C. R., Abbasi, A. Z., Amini, M. A., Lip, H. Y., Maeda, A., Cai, P., O'Brien, P. J., DaCosta, R. S., Rauth, A. M., & Wu, X. Y.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2015-02-18
- Volume
- 25
- Issue
- 12
- Pages
- 1858-1872
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2111722444
- Cited by
- 209
- References
- 5
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gordijo, C. R., Abbasi, A. Z., Amini, M. A., Lip, H. Y., Maeda, A., Cai, P., O'Brien, P. J., DaCosta, R. S., Rauth, A. M., & Wu, X. Y. (2015). Design of Hybrid MnO2‐Polymer‐Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment. Advanced Functional Materials. https://doi.org/10.1002/adfm.201404511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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