The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Highly Efficient Self‐Healable and Dual Responsive Cellulose‐Based Hydrogels for Controlled Release and 3D Cell Culture
Abstract
To face the increasing demand of self‐healing hydrogels with biocompatibility and high performances, a new class of cellulose‐based self‐healing hydrogels are constructed through dynamic covalent acylhydrazone linkages. The carboxyethyl cellulose‐graft‐dithiodipropionate dihydrazide and dibenzaldehyde‐terminated poly(ethylene glycol) are synthesized, and then the hydrogels are formed from their mixed solutions under 4‐amino‐DL‐phenylalanine (4a‐Phe) catalysis. The chemical structure, as well as microscopic morphologies, gelation times, mechanical and self‐healing performances of the hydrogels are investigated with 1 H NMR, Fourier transform infrared spectroscopy, atomic force microscopy, rheological and compression measurements. Their gelation times can be controlled by varying the total polymer concentration or 4a‐Phe content. The resulted hydrogels exhibit excellent self‐healing ability with a high healing efficiency (≈96%) and good mechanical properties. Moreover, the hydrogels display pH/redox dual responsive sol‐gel transition behaviors, and are applied successfully to the controlled release of doxorubicin. Importantly, benefitting from the excellent biocompatibility and the reversibly cross‐linked networks, the hydrogels can function as suitable 3D culture scaffolds for L929 cells, leading to the encapsulated cells maintaining a high viability and proliferative capacity. Therefore, the cellulose‐based self‐healing hydrogels show potential applications in drug delivery and 3D cell culture for tissue engineering.
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Cites
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Self-citationDynamic Covalent Polymer Networks: from Old Chemistry to Modern Day Innovations
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Self-healing gels based on constitutional dynamic chemistry and their potential applications
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Cited by
Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties
Zhao, X., Chen, X., Yuk, H., Lin, S., Liu, X., & Parada, G. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01088 · Cited by 1,161
Hydrogels Based on Schiff Base Linkages for Biomedical Applications
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Stimuli‐Responsive Biomolecule‐Based Hydrogels and Their Applications
Vázquez‐González, M., & Willner, I. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201907670 · Cited by 444
Zhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00071 · Cited by 394
Qin, Y., Mo, J., Liu, Y., Zhang, S., Wang, J., Fu, Q., Wang, S., & Nie, S. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202201846 · Cited by 382
Metadata
- Authors
- Yang, X., Liu, G., Peng, L., Guo, J., Tao, L., Yuan, J., Chang, C., Wei, Y., & Zhang, L.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2017-09-04
- Volume
- 27
- Issue
- 40
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2751664894
- Cited by
- 403
- References
- 46
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, X., Liu, G., Peng, L., Guo, J., Tao, L., Yuan, J., Chang, C., Wei, Y., & Zhang, L. (2017). Highly Efficient Self‐Healable and Dual Responsive Cellulose‐Based Hydrogels for Controlled Release and 3D Cell Culture. Advanced Functional Materials. https://doi.org/10.1002/adfm.201703174
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