The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy
Abstract
Synergistic therapy that combines chemo‐, gene‐, or photothermal means shows great potential for enhancing the therapeutic effects on cancers. Tumor‐targeted nanoparticles based on a doxorubicin (DOX)‐gated mesoporous silica nanocore (MSN) encapsulated with permeability glycoprotein (P‐gp) small interfering RNA (siRNA) and a polydopamine (PDA) outer layer for DOX loading and folic acid decoration are designed. The multifunctional nanoplatform tactfully integrates chemo‐ (DOX), gene‐ (P‐gp siRNA), and photothermal (PDA layer) substances in one system. In vitro results reveal that DOX release behaviors are both pH‐ and thermal‐responsive and the release of co‐delivered P‐gp siRNA is also pH‐dependent due to the pH‐cleavable DOX gatekeeper on MSN. In addition, due to the near‐infrared light‐responsive PDA outer layer and folic acid conjugation, the nanoparticles exhibit outstanding photothermal activity and selective cell targeting ability. Subsequently, in vitro and in vivo antitumor experiments both demonstrate the enhanced antitumor efficacy of the multifunctional nanoparticles, indicating the significance of synergistic therapy combining chemo‐, gene‐, and photothermal treatments in one system.
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Cites
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Cited by
Recent progress in drug delivery
Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.003 · Cited by 818
Self-citationZeng, X., Luo, M., Liu, G., Wang, X., Tao, W., Lin, Y., Ji, X., Nie, L., & Mei, L. (2018) · Advanced Science · doi:10.1002/advs.201800510 · Cited by 598
Self-citationZeng, W., Zhang, H., Deng, Y., Jiang, A., Bao, X., Guo, M., Li, Z., Wu, M., Ji, X., Zeng, X., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124494 · Cited by 256
Self-citationKankala, R. K., Liu, C.-G., Yang, D.-Y., Wang, S.-B., & Chen, A.-Z. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.123138 · Cited by 157
NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release
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Metadata
- Authors
- Cheng, W., Nie, J., Gao, N., Liu, G., Tao, W., Xiao, X., Jiang, L., Liu, Z., Zeng, X., & Mei, L.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2017-10-10
- Volume
- 27
- Issue
- 45
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2761920910
- Cited by
- 304
- References
- 48
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, W., Nie, J., Gao, N., Liu, G., Tao, W., Xiao, X., Jiang, L., Liu, Z., Zeng, X., & Mei, L. (2017). A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy. Advanced Functional Materials. https://doi.org/10.1002/adfm.201704135
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