NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

Li, Minghui; Sun, Xuetan; Zhang, Ning; Wang, Wei; Yang, Yang; Jia, Huizhen; Liu, Wenguang

doi:10.1002/advs.201800155

Cited by 153Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryPhotodynamic Therapy Research Studies

NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

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Li, Minghui, Sun, Xuetan, Zhang, Ning, Wang, Wei, Yang, Yang, Jia, Huizhen, Liu, Wenguang·2018·Advanced Science

DOI 10.1002/advs.201800155PMC PMC6051140

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Abstract

Carrier‐free nanoparticles with high drug loading have attracted increasing attention; however, in situ on‐demand drug release remains a challenge. Here, a novel near‐infrared (NIR) laser‐induced blasting carrier‐free nanodrug delivery system is designed and fabricated by coating doxorubicin (DOX) nanoparticles (DNPs) with a polydopamine film (PDA) that would prolong the blood circulation time of DNPs and avoid the preleakage of the DOX during blood circulation. Meanwhile, the NH 4 HCO 3 is introduced to trigger in situ “bomb‐like” release of DOX for the production of carbon dioxide (CO 2) and ammonia (NH 3) gases driven by NIR irradiated photothermal effect of PDA. Both in vitro and in vivo studies demonstrate that the carrier‐free nanovectors with high drug loading efficiency (85.8%) prolong tumor accumulation, enhance chemotherapy, achieve the synergistic treatment of chemotherapy and photothermal treatment, and do not induce any foreign‐body reaction over a three‐week implantation. Hence, the delicate design opens a self‐assembly path to develop PDA‐based NIR‐responsive multifunctional carrier‐free nanoparticles for tumor therapy.

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Construction of carrier-free nanocarriers notably enhanced drug loading efficiency and avoided the risk of systemic toxicity associated with introduction of exogenous materials.
“In this study, the construction of carrier-free nanocarriers notably enhanced drug loading efficiency, as well as avoiding the risk of systemic toxicity associated with the introduction of exogenous materials (44).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [44]

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Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles: Synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo
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Photothermal and Photocatalytic Glycol Chitosan and Polydopamine‐Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO 1‐x I) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds
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A biopolymer-based and inflammation-responsive nanodrug for rheumatoid arthritis treatment via inhibiting JAK-STAT and JNK signalling pathways
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Authors: Li, M., Sun, X., Zhang, N., Wang, W., Yang, Y., Jia, H., & Liu, W.
Affiliations: Tianjin University (CN)
Corresponding author: Jia, Huizhen
Liu, Wenguang
ORCID: Li, Minghui
Zhang, Ning
Wang, Wei
Yang, Yang
Liu, Wenguang
Venue: Advanced Science
Publisher: Wiley
Published: 2018-05-09
Volume: 5
Issue: 7
Pages: 1800155-1800155
ISSN: 2198-3844 (ISSN-L)
DOI: 10.1002/advs.201800155
PMC: PMC6051140
OpenAlex: W2803031642
Cited by: 153
References: 41
Citations by year: 2026: 4 · 2025: 9 · 2024: 15 · 2023: 19 · 2022: 21 · 2021: 35 · 2020: 28 · 2019: 18 · 2018: 4
FWCI: 8.50
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Advanced Science (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (51703161, 51733006, 31771030)
Natural Science Foundation of Tianjin Municipal Science and Technology Commission (17JCQNJC02900)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Keywords: carrier-free nanoparticles, polydopamine coating, near-infrared photothermal effect, in situ drug release, photothermal therapy, chemotherapy, tumor accumulation, drug loading efficiency, foreign body reaction

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NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

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